Dunja Ferring-Appel Director's Research EMBL Meyerhofstrasse 1 D-69117 Heidelberg Germany Phone: +49-6221-387-8502 Fax: +49-6221-387-8518 email: ferring@embl.de

 

Characterization of IRP 1 and 2 knock-out Mice

Together with Bruno I analyze IRP1 and 2 K.O. mice looking for phenotypic changes in the body due to the lack of these proteins...

Publications

Galy B., D. Ferring-Appel, S. Kaden, H.J. Gröne, and M.W. Hentze. Iron regulatory proteins are essential for intestinal function and control key iron absorption mnolecules in the duodenum. Cell Metab. In press.

Galy B., S.M. Holter, T. Klopstock, D. Ferring, L. Becker, S. Kaden, W. Wurst, H.J. Grone, and M.W. Hentze. (2006) Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse. Nat Genet. 38:967-969

Galy B., D. Ferring, and M.W. Hentze. (2005a) Generation of conditional alleles of the murine iron regulatory protein (IRP)-1 and -2 genes. Genesis. 43:181-88

Galy B., D. Ferring, B. Minana, O. Bell, H.G. Janser, M. Muckenthaler, K. Schumann, and M.W. Hentze. (2005b) Altered body iron distribution and microcytosis in mice deficient for Iron Regulatory Protein 2 (IRP2). Blood. 106:2580-89

Galy B., D. Ferring, M. Benesova, V. Benes, and M.W. Hentze. (2004) Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo. RNA. 10:1019-25

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last update:    12/2007

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