Karsenti Group
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| Spindle assembly. | Spindle assembly around chromatin beads. | Heald, R., R. Tournebize, T. Blank, R. Sandaltzopoulos, P. Becker, A. Hyman, and E. Karsenti, Self organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts. Nature, 1996. 382: p. 420-425. | |
| Microtubules dynamics I | Microtubules dynamics in an interphasic egg extract |
Fòlix, M.A., P. Clarke, J. Coleman, F. Verde, and E. Karsenti, Frog egg extracts as a system to study mitosis. The cell cycle: a practical approach, 1993, Oxford New York Tokyo: IRL Press. 253-283. Heald, R., R. Tournebize, A. Habermann, E. Karsenti, and A. Hyman, Spindle assembly in Xenopus egg extracts: Respective roles of centrosomes and microtubule self organization. J. Cell Biol., 1997. 138: p. 615-628. |
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| Microtubules dynamics M | Microtubules dynamics in a mitotic extract |
Fòlix, M.A., P. Clarke, J. Coleman, F. Verde, and E. Karsenti, Frog egg extracts as a system to study mitosis. The cell cycle: a practical approach, 1993, Oxford New York Tokyo: IRL Press. 253-283. Heald, R., R. Tournebize, A. Habermann, E. Karsenti, and A. Hyman, Spindle assembly in Xenopus egg extracts: Respective roles of centrosomes and microtubule self organization. J. Cell Biol., 1997. 138: p. 615-628. |
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| MT dynamics, without exogenous Ran addition |
Centrosomal microtubule dynamics in M-phase extract (the endogenous Ran is mostly in a GDP-bound state) |
on arrival
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| Dynamics in extract supplemented with RanT24N | The dynamics of M-phase microtubules is not affected by addition of 18 µM Ran(T24N) to the extract |
on arrival
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| Dynamics in extract supplemented with RanQ69L-GTP | M-phase microtubules are stabilized upon addition of as little as 4µM Ran(Q69L)-GTP to the extract |
on arrival
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