An exemple of application

AGADIR1s and 2s have been succesfully used to stabilize proteins through helix stabilisation:

Villegas, V., Viguera, A.R., Avilés, F.X. & Serrano, L. (1996).

Stabilisation of proteins by rational design of a-helix stability using helix/coil transition theory. Folding & Design, 1,29-34.

Muñoz, V. & Serrano, L. (1996).

Local vs non-local interactions in protein folding and stability. An experimentalist point of view. Folding & Design. 1, R71-R77.

López-Hernández, E., Cronet, P., Serrano, L. & Muñoz, V. (1997).

Kinetics of CheY mutants with enhanced native a-helix propensities. J. Mol. Biol. 266, 610-620.

Viguera, A.R., Villegas, V., Avilés, F.X. & Serrano, L. (1996).

Favourable native-like helical local interactions can accelerate protein folding. Folding & Design, 2, 23-33.