Members' Directory

Biography: My first postdoctoral position was at the Beatson Institute for Cancer Research in Glasgow. There I worked with Dr Paul Harrison on mechanisms of specific gene regulation in erythroid cells. I then moved to the European Molecular Biology Laboratory in Heidelberg to work with Dr Thomas Graf on the transforming properties of the oncoprotein c-Myb; initially I was an EMBO fellow and subsequently was appointed as a staff scientist for five years. I moved to the Institute of Molecular Medicine in Oxford in 1995 as a Wellcome Trust Senior Research Fellow, and have recently transferred my group to the University of Birmingham Medical School. Since returning to the UK my research has been concentrated on studying the mechanisms that control how blood cells develop from progenitors in the embryo and adult. Following on from my work in Germany, the main focus of the research concerns the c-Myb transcription factor, which is crucial early in blood cell development. We are using a number of genetic strategies, including Cre-loxP technology, to bring about specific modification of c-Myb activity in progenitors and in cells committed to defined blood cell lineages.

Biography: Born in Vienna (sept 1944), raised in Venezuela, PhD in 1969 in Tuebingen. After being a group leader at the Max Planck Institute of Virology in Tuebingen and at the German Cancer Center in Heidelberg joined the EMBL as a Programme Coordinator between 1983 and 1998. Recipient of several prizes, (such as the Paul Ehrlich Prize), member of multiple editorial boards, including Cell (1984-1991), member of EMBO and Academia Europaea.
Main accomplishments include demonstration of oncogene coperativity, co-discovery of several viral oncogenes [Myb, Myc, (originally called Mac) and ErbB], the finding that block of differentiation is an important feature of leukemia formation and that specific transcription factors can reverse blood cell differentiation, reprogramming lineages into other lineages. Current interests are how hematopoietic stem cells and multilineage progenitors decide what to become, in particular the role of transcription factors in this process.

Biography: EDUCATION:
1984 - 1990 Study of Biology/Univ. of Regensburg and Univ. of Colorado,
Boulder, USA
1989 - 1990 Diploma Thesis at the Univ. of Colorado, Boulder, USA
1990 M.Sc., with Distinction
1990 - 1994 Ph.D. Thesis at the EMBL, Heidelberg, Germany (Thomas Graf)
1994 Ph.D. Thesis, with Destinction
2001 Habilitation (Physiological Chemistry), Univ. of Ulm, Germany
2005 Professorship, Univ. of Ulm, Germany

PROFESSION:
1994 - 1996 Postdoctoral Fellow, Fred Hutchinson Cancer Research Center,
Seattle, USA (Harold Weintraub)
1996 - 1998 Staff Scientist, Fred Hutchinson Cancer Research Center, Seattle,
USA
1998 - 2001 Laboratory Head at Boehringer Ingelheim Pharma KG, Biberach, Germany
2001 Group Leader at Boehringer Ingelheim Austria GmbH, Vienna, Austria
2002 Director of NCE Lead Discovery, Boehringer Ingelheim Austria GmbH,
Vienna, Austria
2006 Vice President, Oncology Research

Biography: B.Sc.- Biology and Biotechnology, Worcester Polytechnic Institute, Worcester Massachussetts,
Ph.D. - Immunology University of Alabama at Birmingham with Dr. Max D. Cooper (HHMI, National Academy of Sciences)
Postdoc. - EMBL with Dr. Thomas Graf

Biography: 1984-1986 undergraduate student in biochemistry, University of Tübingen
1986-1990 graduate student, UC Berkeley, Mina Bissell lab
1990 Ph.D., University of California Berkeley
1991-1995 Postdoc with Thomas Graf, differentiation program, EMBL
1996-1999 Staff scientist, Cell regulation program, EMBL
1999-present Group leader (associate professor),
Centre d'immunologie de Marseile Luminy (CIML)