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- Hoflack Group
Agustin AlconadaCurrent information Patent attorney, ABG Patentes S.L. Avenida de Burgos 16D Madrid, Spain E-mail Nationality: SpanishEMBL information Postdoctoral Fellow Hoflack Group Cell Biology and Biophysics From 1994 to 1997
Ben DistelCurrent information Associate Professor, University of Amsterdam Academic Medical Center, K1-259
Department of Medical Biochemistry
Meibergdreef 15 Amsterdam, Netherlands E-mail Nationality: DutchEMBL information Visitor Hoflack Group Cell Biology and Biophysics From 1993 to 1994
Current information Professor, Technical University of Dresden BIOTEC,
Tatzberg 47-51 Dresden, Germany E-mail Nationality: FrenchEMBL information Group Leader Hoflack Group Cell Biology and Biophysics From 1987 to 1996 Biography Hide biographyBiography: 1982: PhD, University of Sciences, Lille, France
1984-1985: Post-doctoral training at Washington University, St-Louis, USA
1986-1987: Research scientist, Centre National de la Recherche Scientifique, Lille
1988-1996: Group Leader, at EMBL, Heidelberg
1997-2001: CNRS Research Director at the Institut de Biologie de Lille, Lille, France
2002-present: Professor of Proteomics at TU-Dresden
Roland Le BorgneCurrent information Group Leader, Institut de Génétique et du Développement CNRS UMR 6061
Université de Rennes 1-Faculté de Médecine
2 avenue du Pr L. Bernard
CS 34 317 Rennes, France E-mail Nationality: FrenchEMBL information Predoctoral Fellow Hoflack Group Cell Biology and Biophysics From 1992 to 1996 Research interests: Asymmetric cell division, cell polarity, membrane trafficking, developmental cell biology, Drosophila, , summary: Cell-cell signaling is a central process in the formation of multicellular organisms. Work in my lab aims at understanding the role of membrane trafficking during cell-cell signaling within polarized epithelial cells. In particular, we are studying the regulation of Notch receptor signaling using a combination of fly genetics and cutting-edge cell biology methodologies , , Biography Hide biographyBiography: Since 2006 - Group leader, ATIP Biologie du Développement, CNRS UMR 6061_
1999-2005 - Researcher, Ecole Normale Supérieure, CNRS UMR 8542_
1996-1998 - Post-doctoral fellow, Institut de Biologie de Lille _
1992-1995 - PhD Cell biology department, EMBL_1992 - DEA Biologie Santé, Université de Montpellier
1 - Smith C.A., Lau K.M., Rahmani Z., Dho S.E., Brothers G., She Y.M., Berry D.M., McGill M.A., Bonneil E., Thibault P., Schweisguth F., Le Borgne R. and McGlade C.J. aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb. (2007) EMBO J., jan 4, ahead publication
2 - Le Borgne, R. (2006). Regulation of Notch signalling by endocytosis and endosomal sorting. Curr. Opin. Cell Biol. 18(2), 213-22.__
3 - Langevin,L., Le Borgne, R., (equal contribution), Rosenfeld, F., Gho,M., Schweisguth, F. and Bellaïche, Y. (2005). Lethal giant larvae controls the localisation of the Notch signalling regulators Numb, Neuralized and Sanpodo in Drosophila sensory organ precursor cells. Curr. Biol. 15, 955-62.__
4- Le Borgne, R., Bardin, A. and Schweisguth F. (2005) Roles of receptor and ligand endocytosis in the regulation of Notch signaling. Development 132, 1751-62.__
5 - Le Borgne, R., Remaud, S., Hamel,S., and Schweisguth F (2005). The E3 ubiquitin ligases Mind bomb and Neuralized have distinct and complementary functions in the regulation of Delta and Serrate activity in drosophila. PLoS Biology 3, e96.__
7 - Le Borgne, R. and Schweisguth, F. (2003). Unequal segregation of Neuralized biases Notch activation during asymmetric cell division. Dev. Cell 5(1), 139-148.__
8 - Le Borgne, R. and Schweisguth, F. (2003). Notch signaling: endocytosis makes Delta signal better. Curr. Biol. 23, R273-R275.__
10 - Le Borgne, R., Bellaïche, Y. and Schweisguth, F.(2002) ,Curr. Biol. 12, 95-104.
Fabienne MauxionCurrent information CNRS position, CGM-CNRS UPR2167 CGM
Avenue de la terrasse Gif-sur-Yvette Cedex, France E-mail Nationality: FrenchEMBL information Postdoctoral Fellow Hoflack Group Cell Biology and Biophysics From 1991 to 1996
Hélène Munier-LehmannCurrent information permanent position at INSERM, Pasteur Institute Paris Institut Pasteur
Unité de Chimie et Biocatalyse
28 Rue du Dr Roux Paris cedex 15, France E-mail Nationality: FrenchEMBL information Postdoctoral Fellow Hoflack Group Cell Biology and Biophysics From 1993 to 1996
Stéphane MéresseCurrent information Chargé de Recherche CNRS, INSERM-CNRS Centre d'Immunologie de Marseille Luminy Case 906, Parc Scientifique de Luminy Marseille Cedex 9, France E-mail Nationality: FrenchEMBL information Postdoctoral Fellow Hoflack Group Cell Biology and Biophysics From 1989 to 1992
Current information Group Leader, Institut Jacques Moniod, CNRS Universites Paris VI et VII,
2 place Jussieu
5eme etage Paris Cedex 05, France E-mail Nationality: FrenchEMBL information Postdoctoral Fellow Hoflack Group Cell Biology and Biophysics From 1991 to 1993 Biography Hide biographyBiography: Anne Schmidt
PhD in Cellular and Molecular Biology obtained at the University of Montpellier (march 1991).
Post-doctoral position at EMBL in the Cell Biology Department (EMBO Fellow, march 1991- may 1993).
Post-doctoral position at the University of Heidelberg, Department of Neurobiology (SFB and MPI post-doctoral positions).
Current status: Group leader at the CNRS (French National Center for Scientific Research), research group ?Role of lipid modifications in membrane dynamics?.
Area of research: We are currently trying to unravel the molecular mechanisms that underlie the function of lipid-binding and lipid-modifying proteins in membrane deformations. More precisely, our interest is focused on a family of proteins referred to as endophilins that are involved in vesicle budding from diverse intracellular compartments. We are working on a key functional aspect of these proteins, i.e. their intrinsic acyl-transferase activity and are trying to understand the role of this enzymatic property in vesicle budding and fission.