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About 5 results

  1. Heather Bond

    Current information Researcher, University of Catanzaro Department of Experimental Medicine
    Viale Europa
    Loc. Germaneto     Catanzaro, Italy E-mail Nationality: British
    EMBL information Postdoctoral Fellow Howell Group Cell Biology and Biophysics From 1985 to 1988 Biography Hide biography
    Biography: Currently working on a novel zinc finger protein isolated from CD34 hematopoietic cells.

  2. Eileen Devaney

    Current information Reader, University of Glasgow University Avenue Glasgow, United Kingdom E-mail Nationality: British
    EMBL information Postdoctoral Fellow Howell Group Cell Biology and Biophysics From 10.1983 to 04.1985

  3. Kathryn E. Howell

    Current information Professor, University of Colorado School of Medicine S/M Cell and Developmental Biology - Cell and Developmental Biology
    Campus Box 8108
    Research One South (RC1-South), Room 12123     Aurora, USA E-mail Nationality: American
    EMBL information Group Leader Howell Group Cell Biology and Biophysics From 01.1981 to 12.1988 Biography Hide biography
    Biography: I was trained in Cell Biology in the laboratory of George Palade at the Rockefeller University and at Yale University. I joined EMBL in 1981 as group leader in the Cell Biology Division and worked on trafficking in the endocytic and secretory pathways. In 1989 I moved to the University of Colorado School of Medicine in Denver, CO and since that time have focused on understanding the structural-functional relationships of the Golgi complex. We are currently using 2 global approaches in our studies. The first approach uses high voltage electron microscopy, tomography and modeling to study the high resolution (5nm) 3-D structure of the Golgi ribbon. This project is in collaboration with J. Richard Macintosh and uses the facilities of the Laboratory for 3-D Fine Structure on the Boulder Campus of the U. of CO. From our structural work we have formulated two hypotheses that we test using a variety cell and molecular techniques. The first hypothesis is that molecules leave the Golgi from multiple trans-cisternae and that only molecules exiting in clathrin coated vesicles/tubules exit from the trans-most cisterna. The observation that the endoplasmic reticulum adheres to multiple trans-cisternae led to the second hypothesis which is that the adherent ER is important for trans-Golgi function.
    Proteomics is the second approach that we have been using and this project is in collaboration with John R. Yates, III at the Scripps Institute. We have established the basic proteome of the Golgi from rat liver and are using this information to characterize the molecules that move in the different populations of vesicles/tubules that form from the Golgi complex. Our focus is to characterize the molecular composition of the vesicles/tubules that exit the Golgi and determine how these molecules are modified to fulfill that function.
    For my extracurricular activities I serve on the council for the American Society for Cell Biology.

  4. Jean Salamero

    Current information Research Director (CNRS), Institut Curie /CNRS 26, Rue Ulm Paris Cedex 05, France Nationality: French
    EMBL information Postdoctoral Fellow Howell Group Cell Biology and Biophysics From 02.1987 to 08.1988

  5. Maria Laura Scarino

    Current information Staff Scientist, Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione (INRAN) Via Ardeatina 546 Rome, Italy E-mail Nationality: Italian
    EMBL information Postdoctoral Fellow Howell Group Cell Biology and Biophysics From 1984 to 1986