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- Howell Group
Heather BondCurrent information Researcher, University of Catanzaro Department of Experimental Medicine
Loc. Germaneto Catanzaro, Italy E-mail Nationality: BritishEMBL information Postdoctoral Fellow Howell Group Cell Biology and Biophysics From 1985 to 1988 Biography Hide biographyBiography: Currently working on a novel zinc finger protein isolated from CD34 hematopoietic cells.
Eileen DevaneyCurrent information Reader, University of Glasgow University Avenue Glasgow, United Kingdom E-mail Nationality: BritishEMBL information Postdoctoral Fellow Howell Group Cell Biology and Biophysics From 10.1983 to 04.1985
Current information Professor, University of Colorado School of Medicine S/M Cell and Developmental Biology - Cell and Developmental Biology
Campus Box 8108
Research One South (RC1-South), Room 12123 Aurora, USA E-mail Nationality: AmericanEMBL information Group Leader Howell Group Cell Biology and Biophysics From 01.1981 to 12.1988 Biography Hide biographyBiography: I was trained in Cell Biology in the laboratory of George Palade at the Rockefeller University and at Yale University. I joined EMBL in 1981 as group leader in the Cell Biology Division and worked on trafficking in the endocytic and secretory pathways. In 1989 I moved to the University of Colorado School of Medicine in Denver, CO and since that time have focused on understanding the structural-functional relationships of the Golgi complex. We are currently using 2 global approaches in our studies. The first approach uses high voltage electron microscopy, tomography and modeling to study the high resolution (5nm) 3-D structure of the Golgi ribbon. This project is in collaboration with J. Richard Macintosh and uses the facilities of the Laboratory for 3-D Fine Structure on the Boulder Campus of the U. of CO. From our structural work we have formulated two hypotheses that we test using a variety cell and molecular techniques. The first hypothesis is that molecules leave the Golgi from multiple trans-cisternae and that only molecules exiting in clathrin coated vesicles/tubules exit from the trans-most cisterna. The observation that the endoplasmic reticulum adheres to multiple trans-cisternae led to the second hypothesis which is that the adherent ER is important for trans-Golgi function.
Proteomics is the second approach that we have been using and this project is in collaboration with John R. Yates, III at the Scripps Institute. We have established the basic proteome of the Golgi from rat liver and are using this information to characterize the molecules that move in the different populations of vesicles/tubules that form from the Golgi complex. Our focus is to characterize the molecular composition of the vesicles/tubules that exit the Golgi and determine how these molecules are modified to fulfill that function.
For my extracurricular activities I serve on the council for the American Society for Cell Biology.
Jean SalameroCurrent information Research Director (CNRS), Institut Curie /CNRS 26, Rue Ulm Paris Cedex 05, France Nationality: FrenchEMBL information Postdoctoral Fellow Howell Group Cell Biology and Biophysics From 02.1987 to 08.1988