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- Kafatos Group
Bruno ArcaCurrent information Researcher, University of Napoli Federico II Department of Structural and Funtional Biology
Complesso Universitario Di Monte S. Angelo
Via Cinthia Naples, Italy E-mail Nationality: ItalianEMBL information Postdoctoral Fellow Kafatos Group Directors Research From 1999 to 2000 Biography Hide biographyBiography: PLACE AND DATE OF BIRTHDAY: Napoli (Italy) - November 19, 1957
Degree in Biology. University "Federico II", Naples, Italy.
PhD in Cellular Biology, University of Pavia, Italy.
- From June 2002. Assistant Professor of Molecular Biology, Department of Structural and Functional Biology, University "Federico II", Naples, Italy.
- January 1996 - May 2002. Research Associate. Dept. of Public Health Parasitology Unit, University "La Sapienza", Rome, Italy. Prof. M. Coluzzi group. (From July 1999 to June 2000 at EMBL).
- 1990 -1995. IMBB- and EU-Postdoctoral fellow. Insect Molecular Genetics Group, Institute of Molecular Biology & Biotechnology (Heraklion, Crete, Greece). Supervisor: Prof. C. Savakis.
- 1989 -1990. CNR fellow. CNR Institute of Cybernetics, Arco Felice (Naples, Italy). Dr. L. De Petrocellis laboratory.
- 1986 -1989. Post-degree training. Department of Genetics, General and Molecular Biology (DGBM), University "Federico II", Naples, Italy. Prof. Laura Fucci laboratory.
Molecular biology studies on the malaria vector Anopheles gambiae with special emphasis on the salivary glands, transgenesis and host-parasite interactions. Transposable elements.
Current information Professor, Catholic University of Leuven Faculty of Medicine, Developmental and Molecular Genetics Section (VIB11) Leuven, Belgium E-mail Nationality: ItalianEMBL information Postdoctoral Fellow Kafatos Group Directors Research From 06.1994 to 03.1996 Research interests: Synaptic plasticity, mental retardation, Fragile X Syndrome, non coding RNAs, mRNA transport and translation
Current information Group Leader, CIC bioGUNE Technology Park
Building 801-A Derio, Spain E-mail Nationality: SpanishEMBL information Postdoctoral Fellow Kafatos Group Directors Research From 1995 to 2000 Research interests: Drosophila, development, Ecdysone, steroid hormones, growth, cholesterol, SUMO, ubiquitin-like, SALL, spalt-like, genetic syndromes, rare diseases, wing, imaginal discs Biography Hide biographyBiography: Rosa Barrio got her master degree in Biology (specialty: Biochemistry and Molecular Biology) from the Autonoma University of Madrid (UAM) in 1988. She did her Ph. D. in the Center of Molecular Biology ?Severo Ochoa? (CBMSO), a mixer centre between the UAM and the Consejo Superior de Investigaciones Científicas (CSIC). During her Ph. D., granted by the Basque Government, she studied the ubiquitin genes using Drosophila melanogaster as a model system. After she got her Ph. D. in 1993 she moved to the laboratory of Professor Fotis C. Kafatos in Harvard University (USA) and soon after she was granted by the Human Capital and Mobility Program form the European Union to continue her research in Crete. In 1995 she was granted by the Spanish Ministery of Education to move to the European Molecular Biology Laboratory (EMBL, Heidelberg, Germany), always under the supervision of Professor Kafatos, where she continued her research on Spalt proteins and BPM signaling during the wing and nervous system development in Drosophila. In 2001 she moved to the CBMSO (UAM/CSIC) in Madrid, to work with Dr. J. F. de Celis in the laboratory of Professor Antonio García-Bellido, and she obtained a Ramón y Cajal contract in 2003. Since December 2004 she is in charge of the Laboratory 1 in the Functional Genomics Unit at CIC bioGUNE, where she will continue her research on Spalt transcription factors and BPM signaling in Drosophila.
Current information Head of the Genomics Group, Institute of Chemical Biology and Fundamental Medicine Department of Molecular and Cellular Biology
Acad. Lavrent'eva, 8 Novosibirsk, Russian Federation E-mail Nationality: RussianEMBL information Research Technician Kafatos Group Directors Research From 2002 to 02.2005
Stephanie BlandinCurrent information Team Leader, IBMC UPR9022
15 rue René Descartes Strasbourg Cedex, France E-mail Nationality: FrenchEMBL information Postdoctoral Fellow Kafatos Group Directors Research From 2000 to 2005 Biography Hide biographyBiography: field of interest: immune responses of the malaria vector, the mosquito Anopheles gambiae
joint PhD EMBL/ULP Strasbourg
master in immunology Pasteur Institute/Paris 6
ENS Ulm (BCPST 97)
Claudia BlassCurrent information Technician, University of Heidelberg Dep. of Cell and Molecular Biology, Prof. Boutros
Medical Faculty in Mannheim
Centrum fuer Biomedizin und Medizintechnik Mannheim (CBTM)
Ludolf-Krehl-Strasse 13-17 Mannheim, Germany E-mail Nationality: GermanEMBL information Research Technician Kafatos Group Directors Research From 1995 to 2006
Current information Research Associate - Senior Scientific Officer, University of Reading The BioCentre
Transcriptomics & DNA Analysis Unit
Whiteknights - PO Box 221 Reading, United Kingdom E-mail Nationality: RussianEMBL information Postdoctoral Fellow Kafatos Group Directors Research From 1994 to 1998
Current information Professor, Imperial College London Division of Cell and Molecular Biology
Room 6167, Sir Alexander Fleming Building
South Kensington Campus London, United Kingdom E-mail Nationality: CypriotEMBL information Staff Scientist Kafatos Group Directors Research From 2000 to 2005 Research interests: - innate immunity, - functional genomics, - comparative evolutionary genomics, - systems biology, - tropical diseases, - Anopheles, - Plasmodium, - Malaria, - Disease vectors Biography Hide biographyBiography: Before my appointment by Imperial College in June 2005, I was a Staff Scientist at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. My research was focused on genomics and post genomics: sequencing of the genome of the malaria mosquito Anopheles gambiae and comparative analysis with the Drosophila genome, especially on genomics of innate immunity. I was involved in the establishment of the DNA microarray technology at EMBL, and by using this technology I developed together with my team and colleagues various DNA microarray platforms for A. gambiae, which were used to explore the immune system of the mosquito and detect mechanisms of refractoriness to malaria, monitor developmental and spatial gene expression, identify immune transcriptional networks, characterise responses to parasites and viruses and study insecticide resistance. In parallel, we developed a genomic platform to synthesize double stranded RNA for all mosquito genes towards genome-wide RNAi screens. One of our key collaborative discoveries, which attracted great public attention and was one of the most influential in the malaria field, was the identification of a fine balance of agonists and antagonists of malaria parasite development in the mosquito. We also discovered that parasites are recognised by mosquito NF-kappaB signalling pathways initiating a response that limits the infection. These research directions are continued at Imperial College, supported with funding by BBSRC, the Wellcome Trust, WHO/TDR, EC and NIH/NIAID.
Current information Graduate Student, Johns Hopkins Bloomberg School of Pulic Health 615 North Wolfe Street Baltimore, USA E-mail Nationality: AmericanEMBL information Research Technician Kafatos Group Directors Research From 2002 to 2003 Biography Hide biographyBiography: EDUCATION
Graduate Student in the Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health in Baltimore, MD USA (2003-2008)
A.B. Molecular and Cell Biology, Emphasis Genetics and Development
University of California, Berkeley, California USA (2000)
European Molecular Biology Laboratory-Heidelberg, Germany (March 2002-July 2003)
§ Anopheles gambiae transgenesis with multiple fluorescent markers (dsRED, EGFP) and multiple transposable element gene vectors (piggyBac, Minos) with eventual extension to in vivo reverse genetics.
§ Reverse genetics with through generation of dominant negative (RNAi) and inducible dominant positive (transgenesis) mutants in An. gambiae.
Centers for Disease Control and Prevention, National Center for Infectious Disease Division of Parasitic Disease/Entomology Branch (Sept. 2000?Feb. 2002)
Emerging Infectious Diseases Laboratory Research Fellow
§ Germline transformation of the malaria mosquito Anopheles gambiae with a piggyBac transposable element vector.
§ Development and optimization of the existing protocol for microinjection of An. gambiae.
§ Molecular and genetic analysis of An. gambiae transformants.
§ Dissection of Plasmodium vivax and P. falciparum infected transgenic Anopheles stephensi to determine efficacy of refractory phenotype.
§ Culturing of Anopheles cell lines for in vitro excision and transposition assays of piggyBac function.
§ Culturing of Anopheles mosquito stocks.
§ Assisted in surveillance of WNV in Atlanta Metro during 2001 Season.
§ Assisted in coordination of CDC emergency response during 2001 Anthrax Bioterror Crisis.
Current information Associate Professor, John Hopkins Bloomberg School of Pubic Health 615 North Wolfe Street, Suite E3630 Baltimore, USA E-mail Nationality: GreekEMBL information Postdoctoral Fellow Kafatos Group Directors Research From 1996 to 2001 Biography Hide biographyBiography: Born in Stockholm, Sweden 1966.
U.C. in Ecoengineering from Mid-Sweden University, Östersund, Sweden (06/1987).
Thesis supervisor: Dr. Lars Thofelt
Thesis title: "Dictamnus creticus, a herb form the Dikti mountain of Crete"
B.Sc. in Microbiology from the Department of Biology, Stockholm University, Stockholm, Sweden (06/1990).
Thesis supervisor: Prof. Uno Lindberg
Thesis title: "Transphosphorylation of ADP-f-actin as a possible step in muscle contraction".
M.S. in Molecular Biology from the Department of Biology, University of Crete, Heraklion, Greece (06/1992).
Supervisor: Prof. Christos Louis
Visiting Fellow/Special Student at the Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts, USA (02/1993 ? 02/1994).
Activity: Cytogenetic mapping and differential display of tissue specific genes of the mosquito An. gambiae.
Host supervisor: Prof. Fotis C. Kafatos
Ph.D. in Biology from the Department of Biology, University of Crete and the Institute of Molecular Biology & Biotechnology, Foundation of Research and Technology-Hellas, Heraklion, Greece (02/1996).
Thesis project: Species differentiation, genome analysis, genome mapping and isolation of tissue and sex specific genes of the mosquito An. gambiae.
Thesis supervisor: Prof. Christos Louis
Postdoctoral fellow at the European Molecular Biology Laboratory, in Prof. Fotis C. Kafatos lab, Heidelberg, Germany (03/1996 ? 03/2001)
Project: Molecular interactions between the mosquito An. gambiae and the malaria parasite P. berghei.
Senior Lecturer at Imperial College of Science, Technology and Medicine, Department of Biological Sciences / Centre for Molecular Microbiology & Infection, London, UK (04/2001- present)
Anastasios KoutsosCurrent information Senior Account Manager, Life Sciences Sector, College Hill Life Sciences Floor 1
The Registry, Royal Mint Court, London, United Kingdom E-mail Nationality: GreekEMBL information Predoctoral Fellow Kafatos Group Directors Research From 2002 to 2007
Current information Group Leader, IBMC UPR9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire (IBMC)
15 rue Descartes, Strasbourg, France E-mail Nationality: RussianEMBL information Staff Scientist Kafatos Group Directors Research From 1999 to 2002 Biography Hide biographyBiography: 2001 Habilitation à Dirigee des Recherches
Université Louis Pasteur, Strasbourg, France
October 1994 Ph.D. in Genetics
Department of Genetics and Breeding, St.Petersburg State University, Russia (Thesis supervisor: Prof. L.A.Lutova)
Juin 1988 Diploma in Plant Genetics, St.Petersburg State University, Russia
Oct. 2002 Chargée de Recherche 1 (Research Assistant) du CNRS
Institut de Biologie Moléculaire et Cellulaire (IBMC), Strasbourg, France, UPR 9022, Research area: Functional analysis of mosquito immune responses during Plasmodium infection
2001-Oct. 2002 Staff Scientist
European Molecular Biology Laboratory (EMBL)
Group Leader: Prof. Fotis C. Kafatos
1999-2001 Postdoctoral Fellow
European Molecular Biology Laboratory (EMBL)
Group Leader: Prof. Fotis C. Kafatos
1995-1998 Research Fellow
Institut de Biologie Moléculaire et Cellulaire du CNRS
Université Louis Pasteur, Strasbourg, France
UPR 9022 - Réponse Immunitaire et Developpement chez les Insectes
Head: Prof. Jules A. Hoffmann, Adviser: Prof. Jean-Marc Reichhart
1992-1995 Scientific Researcher
St.Petersburg State University, St.Petersburg, Russia
Department of Genetics and Breeding
Head: Prof. Sergey G. Inge-Vechtomov, Advisor: Prof. Ludmila A. Lutova
Current information Researcher, IMBB - Institute of Molecular Biology and Biotechnology Foundation for Research and Technology Hellas,
IMBB/FORTH - Dept. Biol.,
Vassilika Vouton, P.O. Box 1385 Heraklion, Crete, Greece E-mail Nationality: GreekEMBL information Postdoctoral Fellow Kafatos Group Directors Research From 06.1997 to 08.2001
Belen MinanaCurrent information Senior Research Technician, Center for Genomic Regulation (CRG) Regulation of Alternative Splicing
Lab 681 (6th floor)
PRBB - Barcelona Biomedical Research Parc
C/ Dr. Aiguader, 88 6ª. Barcelona, Spain E-mail Nationality: SpanishEMBL information Research Technician Kafatos Group Directors Research From 1994 to 2003 Research interests: Alternative splicing, Splicing, microarray, real time qPCR Biography Hide biographyBiography: May '94 - March'01 Research Technician at Kafatos Group (EMBL-Heidelberg)
March '01 - July '03 Research Technician at Genomics Core Facility
August'03 - until now Research Technician at CRG (Barcelona)
March' 08 phD in Biomedical Research from the Universitat Pompeu Fabra
Current information Group Leader, Institute of Molecular Medicine Cell Biology of the Immune System Unit; Institute of Molecular Medicine
Sala P3-B-40; Edifício Egas Moniz; Av. Prof. Egas Moniz Lisbon, Portugal E-mail Nationality: PortugueseEMBL information Predoctoral Fellow Kafatos Group Directors Research From 09.1998 to 08.2002 Research interests: Innate Immunity, Antigen Presentation, Alternative Splicing, RNAi, Systems Biology Biography Hide biographyBiography: December 18, 2003
PhD degree in Medicine (Cell and Molecular Biology) from the European Molecular Biology Laboratory (Heidelberg, Germany) and Lisbon Medical Scool, University of Lisbon (Lisbon, Portugal).
PhD thesis work at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
Thesis Title: Role and molecular mechanisms of phagocytosis in innate immunity of the human malaria vector, Anopheles gambiae
Thesis Advisory Committee: Prof. Fotis Kafatos (group leader); Dr. Matthias Hentze (second supervisor); Prof. Jules Hoffmann (outside referee); Prof. Maria do Carmo-Fonseca (University supervisor)
Medical Internship (Internal Medicine; Hepatology; Infectious Disease). Supervisors: Prof. M. Carneiro de Moura; Prof. F. Ramalho and Prof. F. Antunes. Santa Maria Hospital, Lisbon, Portugal
Medical Degree. University of Lisbon. Lisbon, Portugal
Current information Assistant Professor, National Istitute of Allergy and Infectious Diseseases (NIH) Mosquito Immunity and Vector Competence Section
Twinbrook III, Room 2E20
12735 Twinbrook Parkway, MSC 8132
Bethesda, USA E-mail Nationality: GuatemalanEMBL information Postdoctoral Fellow Kafatos Group Directors Research From 1994 to 1998 Biography Hide biographyBiography: I started my academic career in Guatemala City, Guatemala, with a BS in Biology (1981), and a degree as a Medical Doctor(1985). I obtained my PhD in Biochemistry (1992) at the University of Arizona, USA. I did my post-doctoral training with Fotis Kafatos at Harvard University (1993-94) and EMBL (1994-98). I am currently working as an Assistant Professor at Colorado State University, USA.
My main areas of interest are the cell biology of plasmodium invasion of mosquito cells, the signal transduction that leads to activation of mosquito immune genes and their effect on malaria transmission. I love science, especially biological research. The biggest success in my career would be to contribute to a better understanding of malaria transmission, and that this work, together with that of other teams, leads to an improvement in the quality of life of people from developing countries.