Members' Directory

Biography: Present Position
Lecturer in the Dept. Of Biothecnology and Biosciences, University of Milano ? Bicocca.

Reaserch Project: Mechanisms of alternative pre-mRNA processing and their role in human disease
In higher eukaryotes, many alternative splicing events involve the choice of alternative terminal exons. Studies on the definition of the terminal exon have shown that processing involves interactions between splicing factors at the 3' splice site of the last exon and components of the 3'-end processing complex at the poly(A) site. To eleucidate the role of polyadenylation factors on the definition of 3?-terminal exons we are concentrating on the study of the mammalian 3?-end processing factor CFI. Our working hypothesis is that CF Im might be the factor that together with some SR proteins couples pre-mRNA 3'-end processing and splicing.
To study the role of the interaction between CF Im and SR proteins in determining the cell?type specific alternative processing patterns we use two model transcripts: the calcitonin/calcitonin gene related peptide (CT/CGRP) and the ß-tropomyosin. Moreover, we are studying how alterations of the expression of these processing factors might be involved in the ethiology of human genetic diseases and in cancer. We want to investigate the mechanism that causes aberrant processing of the glutamate transporter EAAT2 (GLT?1) in patients with sporadic amyotrophic lateral sclerosis and of the LGI1 pre-mRNA in brain tumors.

Reaserch Experience
1994 -2000 Assistant in Prof. W. Keller's laboratory, Cell Biology Department, Biozentrum, University Basel, Switzerland
1992 - July 1994: Post-doctoral Fellow in Dr. E. Boncinelli's laboratory, DIBIT, H S. Raffaele, Milan, Italy.
October 1988 - March 1992: Post-doctoral Fellow in Dr. A.I Lamond's laboratory, European Molecular Biology Laboratory, Heidelberg, Germany.

Biography: BSc (hons) Imperial College, University of London, 1988
PhD EMBL and University of London, 1991
Postdoctoral Fellow, EMBL, 1991-1992
Postdoctoral Fellow, Center for Cancer Research, MIT, 1992-1996
Research Fellow, Center for Cancer Research, MIT, 1996-1998
Assistant Professor, University of Toronto, 1998-2002
Associate Professor, University of Toronto, 2002-present

Biography: 1985-92 University of Giessen, subject biology
1990-1992 Diploma thesis in the lab of Dr. Angus I. Lamond, Gene Expression program, EMBL
1992-1996 PhD thesis in the same lab, entitled 'Cloning and Characterization of the Coiled Body Protein p80 Coilin'
1996-2000 Postdoctoral fellow at the Max-Planck Institut für Entwicklungsbiologie in Tübingen in the lab of Prof. Christiane Nüsslein-Volhard
since 2000 Group Leader in the Central Research at Bayer AG

Biography: * "Laurea": 1990 University of Pavia
* "Specializzazione" in Applied Genetics & Pre-Doc training:1990-1993 IGBE-CNR, Pavia
* Post-doc: 1992-1995 EMBL, Heidelberg,Gene Expression Programme,in the laboratory of Angus Lamond,
* Post-Doc: 1996-1997 European Institute of Oncology, Milan. In the laboratory of P.G. Pelicci
* Product Specialist: 1997-1998 BIOSENSE, Milan.
* Research Assistant: 1999-2002 Lab. Human Genetics, Dept. Genetics and Microbiology, University of Pavia
* Assistant Professor: 2002 to present, Lab. of Genetics and Molecular Biology of Microorganism, Dept. of Biology and Biotechnology, University of Pavia

Biography: My group works on the functional organisation of mammalian cell nuclei and the mechanism and regulation of the pre-mRNA splicing machinery. We have a particuar interest in the structure and function of subnuclear bodies and nuclear compartments, which we study using a combination of biochemistry, proteomics and in vivo imaging techniques. For further information please consult our laboratory website at; www.LamondLab.com

Biography: 1993-96 Ph.D at EMBL (Group of A. Lamond, Gene Expression)
1996-99 Fellow at UCSF
1999- Assistant Professor UC Berkeley