Members' Directory

Biography: EDUCATION
1987 M.S. Theoretical Physics & Mathematics, Faculty of Physics, Odessa University, ex-USSR (Summa Cum Laude)
1996 Ph.D. Crystallography of Biological Macromolecules and Biochemistry, Pasteur Institute and Paris-Sud University, France (Avec les Félicitations du Jury)

FACULTY APPOINTMENTS
2006- Associate Professor – University of Pennsylvania School of Medicine
2001-2006 Principal Scientist - Boston Biomedical Research Institute (BBRI).
1998-2001 Staff Scientist - Boston Biomedical Research Institute.

PREDOCTORAL AND POSTDOCTORAL APPOINTMENTS
1996-1998 Postdoctoral Fellow - Rosenstiel Center, Brandeis University, Massachusetts. Group of C. Cohen.
1993-1996 Graduate Student - Pasteur Institute, Paris, France. Group of P.M. Alzari.
1992-1993 Pre-doctoral Trainee - EMBL Heidelberg, Germany. Group of D. Suck.

SELECTED PUBLICATIONS
Chereau D, Boczkowska M, Skwarek-Maruszewska, A, Fujiwara I, Rebowski G, Hayes DB, Lappalainen P, Pollard TD, Dominguez R. “Leiomodin is an actin filament nucleator in muscle cells” Science (2008) 320:239-243.
Ferron F, Rebowski G, Lee SH, Dominguez R. Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP. EMBO J. (2007) 26:4597-4606.
Lee SH, Hayes DB, Rebowski G, Tardieux I, Dominguez R. Toxofilin from Toxoplasma gondii forms a ternary complex with an anti-parallel actin dimer. PNAS (2007) 104:16122-16127.
Chereau D, Kerff F, Graceffa P, Grabarek Z, Langsetmo K, Dominguez R. Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly. PNAS (2005) 102:16644-16649.
Terrak M, Kerff F, Langsetmo K, Tao T, Dominguez R. Structural Basis of Protein Phosphatase 1 Regulation. Nature (2004) 429:780-784.

Biography: 1989-92 Ph.D. student, Max-Planck-Institute for Biochemistry, Martinsried
1992-93 Postdoc, Max-Planck-Institute for Biochemistry, Martinsried
1994-96 Postdoc, EMBL Heidelberg
1997-00 Group Leader, IMT, University Marburg
2001 Group Leader, Max-Planck-Institute for Biophysical Chemistry, Goettingen
since 10/01 Professor and Head of Department for Molecular Structural Biology,
University Goettingen

Biography: I am Professor of Bioinformatics in the Department of Computing Science, and Director of the Bioinformatics Research Centre where I head the Systems Biology group. I hold a PhD in Computing from Imperial College, London where my research was into modelling concurrent systems using computational logic, and was a member of the team which developed the PARLOG parallel logic programming system. I was an EPSRC Research Fellow at the European Bioinformatics Institute in 1998, and a Leverhulme Research Fellow (2000) in the Department of Biochemistry and Molecular Biology, UCL when I worked on the design and development of the TOPS protein topology computational system. My current research activities centre around Systems Biology, Synthetic Biology and Bioinformatics. Specifically they include methods to represent and analyse biochemical networks, developing computational models of protein topology and associated pattern discovery methods for protein classification, and the use of Grid technologies to support eScience for bioinformatics. The main computational approaches I use are machine learning, graph theory and concurrency analysis.

Biography: 1993-1997 PhD in structural biology "influence of DNA methylation on DNA condensation and structural variablity"
1998-2000 Post-doctorate in EMBL Hedielberg "crystal structure of the P abyssi Sm-like protein"
2000-2000 Assistant professor at Pierre et Marie Curie University "crystal structures of protein implicated in antibiotics resistance"
2008-... Professor at Paris Diderot university "structural studies of macromolecular assemblies"

Biography: Dr. Uwe H. Sauer, assoc. Professor, senior Group Leader
Umeå Centre for Molecular Pathogenesis, UCMP
Umeå University
SE-901 87 Umeå, Sweden

Telephone +46 90 785 6784
Telefax +46 90 77 80 07
E-mail uwe@ucmp.umu.se

Born: January 7, 1961, Citizenship: German

Appointments:
03/09 - Assoc. Professor, senior group leader in BioCrystallography and BioInformatics, UCMP, Umeå University, SE
08/97 - Group Leader, UCMP, Umeå University, Umeå, Sweden
08/95-07/97 Post-Doctoral Researcher, Swedish University of Agricultural Sciences (SLU), Dept. of Mol. Biol., BMC, Uppsala, Sweden
09/88-06/91 Research Assistant, Inst. of Mol. Biol., Univ. of Oregon, USA
09/85-08/86 Research Assistant, Computing Center of the University of Stuttgart, Stuttgart, Germany

Other professional activities
2006 - Member of the board of the Bioinformatics network in Sweden
1999 - 2001 Member of the board of the Umeå Inst. of Technology.
1997 - Member of the Scientific board of the High Performance Computing Center North, HPC2N
1998 Co-Director, the planning committee of the "Natl. BioInformatics Research Center Umeå"

Education:
Ph.D. Molecular Biology & Biophysics, EMBL, and University of Heidelberg, Germany, in the group of Dr. D. Suck 1991-1995
M.Sc. Inst. of Mol. Biol. and HHMI, University of Oregon, USA, group of Prof. B.W. Matthews, 1991
M.Sc. Physics, University of Oregon, 1988
B.S. Physics, University of Stuttgart, Germany 1986

Patent filed
2001, Nov. 27 Swedish Pat. request. nr. 0103960-1 "An eukaryotic protein
expression system based on the nematode C. elegans"
2002, Nov. 26 International patent application (PCT/SE02/02170) "Production of human proteins in C. elegans."

Company founded
2002, May Co-Founder and CEO of neXyte Inc., a biotechnology company focused on production of eukaryotic proteins in C. elegans.

Biography: see
http://www.linkedin.com/in/holgerschwarz

Biography: 2009 - current: Manager for System Technology and Process Design at Proteros Biostructures GmbH
2008 - 2009: Team Leader Protein Crystallography at Proteros Biostructures GmbH
2007 - 2008: Staff Scientist Protein Crystallography at Proteros Biostructures GmbH
2006 - 2007: Postdoc in the lab of D. Suck at EMBL Heidelberg
2002 - 2006: PhD Thesis "X-ray crystallographic studies of the S. cerevisiae Aminoacyl-tRNA-synthetase complex" in the lab of D. Suck at EMBL Heidelberg
2000-2002: Diploma studies in molecular biology on microtubuli associated proteins in the group of F. Propst at the University of Vienna
1999 - 2000: BSc. Course in Genetics at the University of Glasgow
1997 - 1999: BSc. studies in Biology at the University of Vienna