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Androulla ChristodoulouCurrent information Between Jobs Cyprus E-mail Nationality: CypriotEMBL information Postdoctoral Fellow Mattaj Group Directors Research From 09.2007 to 12.2010
Current information Professor, Imperial College London Division of Cell and Molecular Biology
Room 6167, Sir Alexander Fleming Building
South Kensington Campus London, United Kingdom E-mail Nationality: CypriotEMBL information Staff Scientist Kafatos Group Directors Research From 2000 to 2005 Research interests: - innate immunity, - functional genomics, - comparative evolutionary genomics, - systems biology, - tropical diseases, - Anopheles, - Plasmodium, - Malaria, - Disease vectors Biography Hide biographyBiography: Before my appointment by Imperial College in June 2005, I was a Staff Scientist at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. My research was focused on genomics and post genomics: sequencing of the genome of the malaria mosquito Anopheles gambiae and comparative analysis with the Drosophila genome, especially on genomics of innate immunity. I was involved in the establishment of the DNA microarray technology at EMBL, and by using this technology I developed together with my team and colleagues various DNA microarray platforms for A. gambiae, which were used to explore the immune system of the mosquito and detect mechanisms of refractoriness to malaria, monitor developmental and spatial gene expression, identify immune transcriptional networks, characterise responses to parasites and viruses and study insecticide resistance. In parallel, we developed a genomic platform to synthesize double stranded RNA for all mosquito genes towards genome-wide RNAi screens. One of our key collaborative discoveries, which attracted great public attention and was one of the most influential in the malaria field, was the identification of a fine balance of agonists and antagonists of malaria parasite development in the mosquito. We also discovered that parasites are recognised by mosquito NF-kappaB signalling pathways initiating a response that limits the infection. These research directions are continued at Imperial College, supported with funding by BBSRC, the Wellcome Trust, WHO/TDR, EC and NIH/NIAID.
Maria Polycarpou-SchwarzCurrent information Scientist, DKFZ Im Neuenheimer Feld 280
Molecular RNA Biology and Cancer B150 Heidelberg, Germany E-mail Nationality: CypriotEMBL information Technical Assistant Directors Research From 1989 to 2008