Members' Directory

Biography: 1982-1984 Master Thesis, Department of Biochemistry, University of Bergen
1985-1991 Dr.scient. Thesis, Laboratory of Biotechnology, University of Bergen
1989-1990 Scientist, Marine Genetics A/S, Bergen
1999-1991 Assoc. professor, Laboratory of Biotechnology, University of Bergen
1992-1995 Post-doc., Gene Expression (Stewart group), EMBL Heidelberg
1995-2001 Assoc. professor, Department of Molecular Biology, University of Bergen
2001-2002 Visiting scientist, Adolf Butenandt Institut, LMU München (w/Prof. P. Becker)
2002-curr Professor, Department of Molecular Biology, University of Bergen
2003-curr Senior scientist, Computational Biology Unit, Bergen Center for Computational Science, University of Bergen
2005 - 2010, Vice dean for education, Faculty of Mathematics and Natural Sciences, University of Bergen
2010 Visiting scientist, National Institute for Medical Research, MRC, Mill Hill, London (w/S. Gamblin; W.R. Taylor)

Biography: 1997: Master of Science (Biology) - University of Aarhus, Denmark
1999: PhD - Laboratory of Joergen Kjems, University of Aarhus, Denmark
2000-2004: Post doctoral fellow - Laboratory of Iain Mattaj, EMBL, Heidelberg, Germany
2004-2006: 'Ramon y Cajal' researcher - Institute for Biomedical Research, Barcelona, Spain
2007- : Principal Investigator - Andalusian Centre for Developmental Biology, Seville, Spain

Biography: Present Position
Lecturer in the Dept. Of Biothecnology and Biosciences, University of Milano ? Bicocca.

Reaserch Project: Mechanisms of alternative pre-mRNA processing and their role in human disease
In higher eukaryotes, many alternative splicing events involve the choice of alternative terminal exons. Studies on the definition of the terminal exon have shown that processing involves interactions between splicing factors at the 3' splice site of the last exon and components of the 3'-end processing complex at the poly(A) site. To eleucidate the role of polyadenylation factors on the definition of 3?-terminal exons we are concentrating on the study of the mammalian 3?-end processing factor CFI. Our working hypothesis is that CF Im might be the factor that together with some SR proteins couples pre-mRNA 3'-end processing and splicing.
To study the role of the interaction between CF Im and SR proteins in determining the cell?type specific alternative processing patterns we use two model transcripts: the calcitonin/calcitonin gene related peptide (CT/CGRP) and the ß-tropomyosin. Moreover, we are studying how alterations of the expression of these processing factors might be involved in the ethiology of human genetic diseases and in cancer. We want to investigate the mechanism that causes aberrant processing of the glutamate transporter EAAT2 (GLT?1) in patients with sporadic amyotrophic lateral sclerosis and of the LGI1 pre-mRNA in brain tumors.

Reaserch Experience
1994 -2000 Assistant in Prof. W. Keller's laboratory, Cell Biology Department, Biozentrum, University Basel, Switzerland
1992 - July 1994: Post-doctoral Fellow in Dr. E. Boncinelli's laboratory, DIBIT, H S. Raffaele, Milan, Italy.
October 1988 - March 1992: Post-doctoral Fellow in Dr. A.I Lamond's laboratory, European Molecular Biology Laboratory, Heidelberg, Germany.

Biography: 1982 Graduate in Biology (Univ. Complutense of Madrid, Spain)
1986 PhD in Biology (Univ. Complutense of Madrid and Centro de Investigaciones Biológicas-CSIC, Spain)
1987-1988 Post-Doctoral scientist, Centro de Investigaciones Biológicas-CSIC, Madrid, Spain.
1988-1991 Post-Doctoral scientist, Institut für Molekularbiologie und Tumorforschung. (Lab Prof. M. Beato), Philipps-Universität Marburg, Germany.
1991-1994 Post-Doctoral researcher, EMBL Gene Expression Program (Lab. Dr. H. G. Stunnenberg). Heidelberg, Germany.
1995-1996 Research Associate, Instituto de Investigaciones Biomédicas-CSIC, Madrid, Spain.
Since 1997 Staff Scientist and Research Group Leader at the Instituto De Biomedicina de Valencia (CSIC)., Valencia, Spain.

Research interests: Unraveling the molecular mechanisms through which Nuclear Hormone Receptor signalling (mainly Retinoic Acid and Thyroid Hormone) influences cell differentiation in mammalian neural cells.

Biography: I discovered EMBL trough a summer training at EMBL from april to sept 2000, with Matthias Hentze. Then went on with the PhD programme in Matthias Hentze's lab from sept 2000 to april 2003

Postdoc at Rockefeller University, New York - USA, lab of Robert Darnell from june 2003 to dec. 2004

Scientific expert for Amgen Europe (biotechnology industry)- based in Paris, France. Since January 2005

If you are interested to know more, don't hesitate to get in contact !

Biography: 1987 PhD "summa cum laude", with G. Schütz, DKFZ Heidelberg
7/88 - 6/91 Postdoctoral fellow, Laboratory of Carl Wu,
National Cancer Institute, NIH, USA
7/91 - 4/99 Group leader at European Molecular Biology Laboratory
(EMBL), Heidelberg
4/96 Habilitation at Ruprecht-Karls Universität, Heidelberg
"Venia legendi" (teaching certificate in molecular biology)
1/97 - 12/98 Executive Editor of "Nucleic Acids Research" (Oxford University Press, Oxford, UK)
since 4/99 Professor (C4) of Molecular Biology,
Adolf Butenandt Institut, Ludwig- Maximillians- Universität, München
2000 Elected Member of EMBO

Biography: I received a Ph.D. in molecular biology and biochemistry in July 2004 from the University of Nancy, Lorraine, France. I joined EMBL in July 2004 as a postdoctoral researcher in the group of Elisa Izaurralde. In July 2006 I followed Elisa Izaurralde to the Department of Biochemistry at the Max Planck Institute for Developmental Biology, Tübingen, Germany. In January 2007, I went back to France, as a team leader (CNRS-CR2).

Biography: Born in Milan, Italy, on Sep.9, 1963
Two daughters, born in 1995 and 2002

Nov.1982-Feb.1987: Laurea degree in Biology at the University of Milan, Italy; graduated cum laude
Apr.1987-Aug.1989: research fellow at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, in the group of Prof. R.Cortese, Gene Expression Programme
Sep.1989-Aug.1991: postdoctoral fellow at the EMBL, Gene Expression Programme, in the group of Dr. D.Tollervey
Sep.1991-at present: staff member of the Dept. of Genetics and Microbiology (now Dept. of Biomolecular Sciences and Biotechnology), University of Milan, Italy