Members' Directory

Biography: July 2011 - July 2012 postdoc University of California San Francisco (UCSF)
Aug 2010 - Dec 2010 postdoc University of Edinburgh, UK
Oct 2008 - July 2010 postdoc EMBL-Monterotondo, Italy
Feb 2004 - Sept 2008 predoc EMBL-Monterotondo, Italy
Oct 2000 - June 2001 University of Glasgow, UK
Oct 1998 - Jan 2004 University of Vienna, Austria

Biography: Patrick Baeuerle has served as Micromet's Chief Scientific Officer since October 1998. From February 1996 to September 1998, Patrick headed the drug discovery activities of Tularik, Inc., in South San Francisco, California, as Director, Drug Discovery. From October 1994 to February 1996, he served as a full Professor and Chairman of Biochemistry at the Medical Faculty of Freiburg University, Germany. In 1989, Patrick was awarded a group leader position at the Gene Center in Martinsried, Germany, where he did research on transcription factor NF-kappaB. According to a survey by the Institute for Scientific Information (ISI, Philadelphia, PA, USA), he was Germany's most frequently cited biomedical scientist of the past decade, and 38th worldwide. He has published more than 200 scientific papers, and four educational children books on biology. Patrick was appointed Honorary Professor of Immunology at the University of Munich in 2000. He performed his Ph.D. work at the Max Planck Institute for Psychiatry in Martinsried and at the European Molecular Biology Laboratory (EMBL) in Heidelberg, obtained a Ph.D. degree in biology from the University of Munich, and performed his post-doctoral research with David Baltimore at the Whitehead Institute of the Massachusetts Institute of Technology, Cambridge, MA.

Biography: My prime interest is the relationship between the structures of proteins and their biochemical and biological functions. This encompasses studies of their covalent structures, tertiary structures and assembly into functional complexes. Approaches employed include structure-function studies of muteins, molecular modelling, empirical tertiary structure determination by NMR or X-ray crystallography and chemical modifications. More recently, I have applied techniques of mass spectrometry and two-dimensional electrophoresis to the study differential expression of proteins in pathogenic oral bacteria and to the characterization of proteins and their post-translational modifications.

Biography: Education:
1972-1976 Degree with honours in Biological Sciences
University of Rome, IT
1976 Course in Marine Biology
Station Biologique, Roscoff, FR
1977 EMBO course 'Electron microscopy of nucleic acids'
EMBL, Heidelberg, DE
1987 EMBO course 'Antibodies in cell biology'
EMBL, Heidelberg, DE

Current position:
from 2000 Full Professor of Molecular Biology
University of Siena, IT

Previous positions:
1976-1978 Post-doctoral research associate
Centro Acidi Nucleici CNR, Rome, IT
1978-80 Post-doctoral long-term EMBO fellow
EMBL, Heidelberg, DE
1981-1986 Staff scientist
Dpt. of Genetics and Molecular Biology
University of Rome ?La Sapienza?, IT
1983 Visiting scientist
EMBL, Heidelberg, DE
1986-1998 Staff scientist
Dpt. of Evolutionary Biology
University of Siena, IT
1998-2000 Associate Professor of Molecular Biology
University of Siena, IT

Group leader and Co-ordinator of the research activities of the Laboratory of Molecular Biology at the Department of Evolutionary Biology (University of Siena)

Organization of courses and meetings
1994 EC COMET course 'PCR technology and its applications' Siena
1997, 1999, 2002 EMBO Workshop 'Lymphocyte antigen receptor and coreceptor signaling' Siena
Memberships:
Editorial Board Eur. J. Immunol.
Advisory Board Journal of Mol. Biol. Biotechnol. and Signal Transduction
Ad hoc reviewer of Blood, J. Biol. Chem., EMBO Reports, FEBS Lett, J. Cell. Physiol. , Hum.Mut., Tissue and Cell, Biochem. Pharmacol.
Member of the Italian Society of Biophysics and Molecular Biology and of the Italian Society of Immunology
Expert for the evaluation EC projects IV and V FP, INTAS, Wellcome Trust
Referee for the Italian National Institute of Health and the Italian Association for Cancer Research
Supervisor in the Open University PhD Program

Biography: Baldin V. et al., (1997) Oncogene, 14, 2485-2495.
'Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implication for growth control'
Baldin V. et al., (1997) Biochem. Biophys. Res. Commun.,236, 130-134.
'Evidence for a mammalian Nim1-like kinase pathway controlling G1/S transition'
Baldin V., et al., (1997) J. Biol. Chem., 272, 32731-32734.
'Phosphorylation of human CDC25B phosphatase by CDK1-cyclin A triggers its proteasome-dependent degradation'
Cans C., Ducommun B. and Baldin V. (1999)Molecular Biology Reports, 26, 53-57.
'Proteasome-dependent degradation of human CDC25B phosphatase'
Mils V., Baldin V., et al.,(2000) Oncogene, 19, 1257-1265.
'Specific interaction between 14.3.3 isoforms and the human CDC25B phosphatase'
Davezac N., Baldin V., et al., (2000) Oncogene, 19, 2179-2185.
'Regulation of CDC25B phosphatase subcellular localisation'
Baldin V. (2000) Progress in Cell Cycle Research, 4, 49-60 (Review).
'14-3-3 proteins and growth control'
*Davezac N., *Baldin V.,.(in press) Oncogene.
'Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase. A potential role for pEg3 in cell cycle regulation.' (* equal contribution).
Baldin V., Pelpel K., Cazalés M. Cans C. and Ducommun B. (in press) J. Biol. Chem.
'Nuclear localisation of CDC25B1 and serine 146 integrity are required for induction of mitosis'

Biography: Étudiant en électronique, passionné de modélisme, d'informatique, d'électronique, de robotique et de plein d'autres trucs. :-)
Actuellement en 3e année de licence Systèmes Embarqués.
Ah, et Alsacien ;-)

Biography: Following my PhD studies at EMBL in 2001, I did my postdoctoral studies in the group of Kenneth R. Chien, and subsequently Ju Chen, at University of California San Diego (UCSD), USA. In 2007 I moved to Milan, Italy where I started up my own group as an Assistant Telethon Scientist hosted by the National Research Council. In 2010 I got a permanent position at the National Research Council in Milan.