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Heidelberg, Hinxton, Hamburg, 14 May 2013 But what does it do? It is now easier to pinpoint exactly what molecules a phosphatase – a type of protein that’s essential for cells to react to their environment – acts upon in human cells, thanks to the free online database DEPOD, created by EMBL scientists. Published today in Science Signaling, the overview of interactions could even help explain unforeseen side-effects of drugs.
Heidelberg, 24 April 2013 Pushing the boundaries of transcription Like musicians in an orchestra who have the same musical score but start and finish playing at different intervals, cells with the same genes start and finish transcribing them at different points in the genome. For the first time, researchers at EMBL have described the striking diversity of messenger RNAs (mRNAs) that such start and end variation produces, even from the simple genome of yeast cells. Their findings are published today in Nature.
- Nature - News and Views , 30 April 2013 Molecular biology: The ends justify the means
Heidelberg, 11 March 2013 Havoc in biology’s most-used human cell line HeLa cells are the world’s most commonly used human cell lines for research. In a study published today in G3: Genes, Genomes and Genetics online, scientists at EMBL announce the successful sequencing of the genome of a HeLa cell line. It provides a high-resolution genomic reference that reveals the striking differences between the HeLa genome and that of normal human cells. The study could improve the way HeLa cells are used to model human biology.
Heidelberg/Aarhus, 5 March 2013 Denmark joins the Nordic EMBL Partnership for Molecular Medicine The Nordic EMBL Partnership for Molecular Medicine renews its partnership agreement for an extended period of 10 years, and expands the Nordic EMBL network with the official opening of the Danish Research Institute of Translational Neuroscience (DANDRITE) at Aarhus University, which will become its Danish node.
Heidelberg, 28 February 2013 Zeroing in on heart disease Studies screening the genome of hundreds of thousands of individuals have linked more than 100 regions in the genome to the risk of developing cardiovascular disease. Researchers from EMBL and the University of Heidelberg are taking these results one step further by pinpointing the exact genes that could have a role in the onset of the disease. Their findings are published today in the Public Library of Science (PLoS) Genetics.
Heidelberg, 28 February 2013 DNA’s twisted communication Gene expression needs to be finely controlled during embryo development. Fgf8 is one of these regulation factors that control how the limbs, the head and the brain grow. Researchers at EMBL have elucidated how Fgf8 in mammal embryos is, itself, controlled by a series of interdependent regulatory elements. Their findings, published today in Developmental Cell, shed new light on the importance of the genome’s architecture for gene regulation.
Heidelberg, 11 February 2013 One disease, two mechanisms While prostate cancer is the most common cancer in elderly Western men it also, but more rarely, strikes patients aged between 35 and 50. Scientists at EMBL, in collaboration with several other research teams in Germany, have discovered that early-onset prostate cancers are triggered by a different mechanism from that which causes the disease at a later age. Their findings are published today in Cancer Cell, and might have important medical implications.
Hamburg, 4 February 2013 Learning from the linker Induced pluripotent stem cells (iPS cells) represent a milestone in stem cell research, however many of the biochemical processes that underlie reprogramming are still not understood. Scientists from the EMBL Hamburg and from the Max Planck Institute for Molecular Biomedicine in Münster, Germany now shed new light on this process. In a study published today in Nature Cell Biology, the scientists describe important details about the structure of the transcription factor Oct4, known to play a crucial role in the reprogramming of terminally differentiated cells.
Hinxton, 31 January 2013 The mutation police Scientists at the EMBL-European Bioinformatics Institute (EMBL-EBI) and the MRC Laboratory of Molecular Biology in the UK have discovered how our genome keeps the effects of mutations in check. The discovery, published in the journal Cell, will help in the study of diseases such as cancer and neurodegeneration.
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