Heidelberg, 4 March 2015 Best of three worlds By combining three different kinds of microscopy, scientists at EMBL Heidelberg have been able to determine, for the first time, how cellular machines move in relation to each other as the cell’s membrane bends inwards to form a vesicle that carries material into the cell. Whether it’s a white blood cell engulfing a bacterial invader or a microbe gobbling up supper, cells often take in large items by bending their own membrane around them and folding it inwards, like poking in a finger on a glove. This seemingly mundane process involves around 50 different molecules, and Marko Kaksonen’s lab at EMBL Heidelberg is set on untangling just how they do it.
Hinxton, 27 February 2015 Jeffrey Barrett to lead CTTV Jeffrey Barrett has been appointed as the founding Director of the Centre for Therapeutic Target Validation (CTTV), a unique public-private partnership between EMBL-EBI, GSK and the Wellcome Trust Sanger Institute on the Wellcome Genome Campus in the UK. Barrett has been involved in the CTTV since its inception in 2014 and will begin his new role on 1 May 2015.
Hamburg, 20 February 2015 Attack from all sides Tuberculosis – a disease that knows no boundaries, kills millions of people per year worldwide and is developing resistance to current drug therapies at an alarming rate. In order to develop urgently needed new treatment regimes, it is critical to achieve a complete understanding of how Mycobacterium tuberculosis (Mtb) – the bacterium that causes the disease – infects, survives and develops. But despite decades of considerable global research efforts, the mechanisms by which Mtb infects and survives in the human body are still largely a mystery. For such a widespread and complex problem, a multi-disciplinary research approach seems the way to go. A paper published today in the journal PLoS Pathogens by Matthias Wilmanns and collaborators from Switzerland, Poland, and France, illustrates the power of bringing together specialists in different areas
Grenoble, 19 February 2015 Shining light onto the fabric of life For its first LearningLAB of 2015, EMBL’s European Learning Laboratory for the Life Sciences (ELLS) made the science of protein structure crystal clear for a group of 22 science teachers from all over Europe. The two-day event held in Grenoble was set up in partnership with the EU-funded project FluPharm. It gave the participants a 360° view of how crystallography can deepen our understanding of the relationship between the structure and function of biological molecules, and lead scientists towards innovative treatments against diseases.
Heidelberg, 16 February 2015 Fight or flight? If you heard chilling screams echoing around the EMBL Advanced Training Centre at the end of last year, don’t fret. Rather than a giant spider scuttling towards a group of arachnophobes, or a cohort of mytophobes who have been plunged into darkness, Cornelius Gross, deputy head of EMBL Monterotondo, was using sound and imagery to illustrate how the study of fear is helping researchers better understand human behaviour. The recording of the lecture is now available online as video on demand.