Heidelberg, 16 May 2013 Strengthening EMBL-Argentine relations On 9 May, the Argentinean flag flew over EMBL’s headquarters in Heidelberg, Germany, as the laboratory welcomed Lino Barañao, Argentine Minister of Science, Technology and Productive Innovation, and Agueda Menvielle, National Directress of International Relations. The visit took place in the context of a continuing commitment by EMBL and the Argentine Republic to enhance strategic scientific cooperation.
Heidelberg, Hinxton, Hamburg, 14 May 2013 But what does it do? It is now easier to pinpoint exactly what molecules a phosphatase – a type of protein that’s essential for cells to react to their environment – acts upon in human cells, thanks to the free online database DEPOD, created by EMBL scientists. Published today in Science Signaling, the overview of interactions could even help explain unforeseen side-effects of drugs.
Heidelberg, 24 April 2013 Pushing the boundaries of transcription Like musicians in an orchestra who have the same musical score but start and finish playing at different intervals, cells with the same genes start and finish transcribing them at different points in the genome. For the first time, researchers at EMBL have described the striking diversity of messenger RNAs (mRNAs) that such start and end variation produces, even from the simple genome of yeast cells. Their findings are published today in Nature.
- Nature - News and Views , 30 April 2013 Molecular biology: The ends justify the means
Hinxton, 11 April 2013 Perfect proteins preferred Uncontrolled inflammation has been linked to the onset of many diseases, from rheumatoid arthritis to certain cancers. One of the key enzymes in triggering inflammation, the Tank-binding kinase I (TBKI), is attracting an increasing attention as a potential drug-target in the fight against several diseases. Researchers at EMBL Grenoble have published the high-resolution 3D structure of this enzyme, both in its active and its inactive forms, in Cell Reports. This finding could have widespread consequences for the design of new drug-candidates.
Grenoble, 18 March 2013 Zooming in on inflammation Uncontrolled inflammation has been linked to the onset of many diseases, from rheumatoid arthritis to certain cancers. One of the key enzymes in triggering inflammation, the Tank-binding kinase I (TBKI), is attracting an increasing attention as a potential drug-target in the fight against several diseases. Researchers at EMBL Grenoble have published the high-resolution 3D structure of this enzyme, both in its active and its inactive forms, in Cell Reports. This finding could have widespread consequences for the design of new drug-candidates.
Heidelberg, 11 March 2013 Havoc in biology’s most-used human cell line HeLa cells are the world’s most commonly used human cell lines for research. In a study published today in G3: Genes, Genomes and Genetics online, scientists at EMBL announce the successful sequencing of the genome of a HeLa cell line. It provides a high-resolution genomic reference that reveals the striking differences between the HeLa genome and that of normal human cells. The study could improve the way HeLa cells are used to model human biology.
Heidelberg/Aarhus, 5 March 2013 Denmark joins the Nordic EMBL Partnership for Molecular Medicine The Nordic EMBL Partnership for Molecular Medicine renews its partnership agreement for an extended period of 10 years, and expands the Nordic EMBL network with the official opening of the Danish Research Institute of Translational Neuroscience (DANDRITE) at Aarhus University, which will become its Danish node.
Heidelberg, 28 February 2013 Zeroing in on heart disease Studies screening the genome of hundreds of thousands of individuals have linked more than 100 regions in the genome to the risk of developing cardiovascular disease. Researchers from EMBL and the University of Heidelberg are taking these results one step further by pinpointing the exact genes that could have a role in the onset of the disease. Their findings are published today in the Public Library of Science (PLoS) Genetics.
Heidelberg, 28 February 2013 DNA’s twisted communication Gene expression needs to be finely controlled during embryo development. Fgf8 is one of these regulation factors that control how the limbs, the head and the brain grow. Researchers at EMBL have elucidated how Fgf8 in mammal embryos is, itself, controlled by a series of interdependent regulatory elements. Their findings, published today in Developmental Cell, shed new light on the importance of the genome’s architecture for gene regulation.