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Staff at EMBL

CP-60003216

Prof. Iain Mattaj

Director General
Director General

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Personal Assistant
Kirsi Heerde
Room: 209-212
Tel: +49 6221 387- 8201
Fax: +49 6221 387- 8211
E-mail: dg-office@embl.org

Biography

PhD 1979, University of Leeds, UK.
Postdoctoral work at the Friedrich Miescher Institute and the Biocenter, Basel, Switzerland.
Group Leader at EMBL since 1985.
Programme Coordinator since 1990.
Scientific Director of EMBL 1999-2005.
Director General since 2005.

Publications

Total: 221 publication(s)

2014

Yokoyama H, Koch B, Walczak R, Ciray-Duygu F, González-Sánchez JC, Devos DP, Mattaj IW, Gruss OJ. (2014)
The nucleoporin MEL-28 promotes RanGTP-dependent γ-tubulin recruitment and microtubule nucleation in mitotic spindle formation
Nat Commun 5:3270. doi:10.1038/ncomms4270
Europe PMC | doi


2013

Yokoyama H, Nakos K, Santarella-Mellwig R, Rybina S, Krijgsveld J, Koffa MD, Mattaj IW. (2013)
CHD4 is a RanGTP-dependent MAP that stabilizes microtubules and regulates bipolar spindle formation
Curr. Biol. 23(24):2443-2451. doi:10.1016/j.cub.2013.09.062
Europe PMC | doi

Dekker J, Wysocka J, Mattaj I, Lieberman Aiden E, Pikaard C. (2013)
Nuclear biology: what's been most surprising?
Cell 152(6):1207-1208. doi:10.1016/j.cell.2013.02.041
Europe PMC | doi

Santarella-Mellwig R, Pruggnaller S, Roos N, Mattaj IW, Devos DP. (2013)
Three-dimensional reconstruction of bacteria with a complex endomembrane system
PLoS Biol. 11(5):e1001565. doi:10.1371/journal.pbio.1001565
Europe PMC | doi


2012

Mall M, Walter T, Gorjánácz M, Davidson IF, Nga Ly-Hartig TB, Ellenberg J, Mattaj IW. (2012)
Mitotic lamin disassembly is triggered by lipid-mediated signaling
J. Cell Biol. 198(6):981-990. doi:10.1083/jcb.201205103
Europe PMC | doi

Tooze J, Mattaj I, Rorth P, Pulverer B. (2012)
Evolution and revolution at The EMBO Journal
EMBO J 31(15):3231-3233. doi:10.1038/emboj.2012.208
doi

Asencio C, Davidson IF, Santarella-Mellwig R, Ly-Hartig TB, Mall M, Wallenfang MR, Mattaj IW, Gorjánácz M. (2012)
Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis
Cell 150(1):122-135. doi:10.1016/j.cell.2012.04.043
Europe PMC | doi

Borrego-Pinto J, Jegou T, Osorio DS, Auradé F, Gorjánácz M, Koch B, Mattaj IW, Gomes ER. (2012)
Samp1 is a component of TAN lines and is required for nuclear movement
J. Cell. Sci. 125(Pt 5):1099-1105. doi:10.1242/jcs.087049
Europe PMC | doi


2011

Symens N, Walczak R, Demeester J, Mattaj I, De Smedt SC, Remaut K. (2011)
Nuclear inclusion of nontargeted and chromatin-targeted polystyrene beads and plasmid DNA containing nanoparticles
Mol. Pharm. 8(5):1757-1766. doi:10.1021/mp200120v
Europe PMC | doi

Simons K, Mattaj IW. (2011)
Retrospective. Lennart Philipson (1929-2011)
Science 333(6043):711. doi:10.1126/science.1210990
Europe PMC | doi


2010

Mattaj IW. (2010)
It's the Technology, Stupid
Mol. Biol. Cell 21(22):3805-3806. doi:10.1091/mbc.e10-04-0342
Europe PMC | doi

Mattaj IW, Müller CW. (2010)
Solving the NES problem
Nat. Struct. Mol. Biol. 17(11):1288-1289. doi:10.1038/nsmb1110-1288
Europe PMC | doi

Yavuz S, Santarella-Mellwig R, Koch B, Jaedicke A, Mattaj IW, Antonin W. (2010)
NLS-mediated NPC functions of the nucleoporin Pom121
FEBS Lett. 584(15):3292-3298. doi:10.1016/j.febslet.2010.07.008
Europe PMC | doi

Mattaj IW. (2010)
Coordinated action needed for Europe's research programmes
Nature 465(7301):1005. doi:10.1038/4651005a
Europe PMC | doi

Santarella-Mellwig R, Franke J, Jaedicke A, Gorjanacz M, Bauer U, Budd A, Mattaj IW, Devos DP. (2010)
The compartmentalized bacteria of the planctomycetes-verrucomicrobia-chlamydiae superphylum have membrane coat-like proteins
PLoS Biol. 8(1):e1000281. doi:10.1371/journal.pbio.1000281
Europe PMC | doi


2009

Yokoyama H, Rybina S, Santarella-Mellwig R, Mattaj IW, Karsenti E. (2009)
ISWI is a RanGTP-dependent MAP required for chromosome segregation
J. Cell Biol. 187(6):813-829. doi:10.1083/jcb.200906020
Europe PMC | doi

Platani M, Santarella-Mellwig R, Posch M, Walczak R, Swedlow JR, Mattaj IW. (2009)
The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex
Mol. Biol. Cell 20(24):5260-5275. doi:10.1091/mbc.e09-05-0377
Europe PMC | doi

Gorjánácz M, Mattaj IW. (2009)
Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans
J. Cell. Sci. 122(Pt 12):1963-1969. doi:10.1242/jcs.044750
Europe PMC | doi


2008

Casanova CM, Rybina S, Yokoyama H, Karsenti E, Mattaj IW. (2008)
Hepatoma up-regulated protein is required for chromatin-induced microtubule assembly independently of TPX2
Mol. Biol. Cell 19(11):4900-4908. doi:10.1091/mbc.e08-06-0624
Europe PMC | doi

Hawryluk-Gara LA, Platani M, Santarella R, Wozniak RW, Mattaj IW. (2008)
Nup53 is required for nuclear envelope and nuclear pore complex assembly
Mol. Biol. Cell 19(4):1753-1762. doi:10.1091/mbc.e07-08-0820
Europe PMC | doi

Yokoyama H, Gruss OJ, Rybina S, Caudron M, Schelder M, Wilm M, Mattaj IW, Karsenti E. (2008)
Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate
J. Cell Biol. 180(5):867-875. doi:10.1083/jcb.200706189
Europe PMC | doi

Galy V, Antonin W, Jaedicke A, Sachse M, Santarella R, Haselmann U, Mattaj I. (2008)
A role for gp210 in mitotic nuclear-envelope breakdown
J. Cell. Sci. 121(Pt 3):317-328. doi:10.1242/jcs.022525
Europe PMC | doi

Kitao S, Segref A, Kast J, Wilm M, Mattaj IW, Ohno M. (2008)
A compartmentalized phosphorylation/dephosphorylation system that regulates U snRNA export from the nucleus
Mol. Cell. Biol. 28(1):487-497. doi:10.1128/mcb.01189-07
Europe PMC | doi

Mattaj I. (2008)
Comments from the European Molecular Biology Laboratory
Dis Model Mech 1(1):16. doi:10.1242/dmm.000794
Europe PMC | doi

Cohen M, Santarella R, Wiesel N, Mattaj I, Gruenbaum Y. (2008)
Electron microscopy of lamin and the nuclear lamina in Caenorhabditis elegans
Methods Cell Biol. 88:411-429. doi:10.1016/s0091-679x(08)00421-4
Europe PMC | doi


2007

Arai K, Cech T, Chameau JL, Horn P, Mattaj I, Potocnik J, Wiley J. (2007)
The future of research universities. Is the model of research-intensive universities still valid at the beginning of the twenty-first century?
EMBO Rep. 8(9):804-810. doi:10.1038/sj.embor.7401052
Europe PMC | doi

Fortes P, Longman D, McCracken S, Ip JY, Poot R, Mattaj IW, Cáceres JF, Blencowe BJ. (2007)
Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation
FEBS Lett. 581(16):3087-3097. doi:10.1016/j.febslet.2007.05.066
Europe PMC | doi

Gorjánácz M, Jaedicke A, Mattaj IW. (2007)
What can Caenorhabditis elegans tell us about the nuclear envelope?
FEBS Lett. 581(15):2794-2801. doi:10.1016/j.febslet.2007.03.052
Europe PMC | doi

Mattaj IW, Tocchini-Valentini GP. (2007)
Laying solid foundations for Europe
Nature 447(7143):377-378. doi:10.1038/447377a
Europe PMC | doi

Ribbeck K, Raemaekers T, Carmeliet G, Mattaj IW. (2007)
A role for NuSAP in linking microtubules to mitotic chromosomes
Curr. Biol. 17(3):230-236. doi:10.1016/j.cub.2006.11.050
Europe PMC | doi

Franz C, Walczak R, Yavuz S, Santarella R, Gentzel M, Askjaer P, Galy V, Hetzer M, Mattaj IW, Antonin W. (2007)
MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly
EMBO Rep. 8(2):165-172. doi:10.1038/sj.embor.7400889
Europe PMC | doi

Gorjánácz M, Klerkx EP, Galy V, Santarella R, López-Iglesias C, Askjaer P, Mattaj IW. (2007)
Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly
EMBO J. 26(1):132-143. doi:10.1038/sj.emboj.7601470
Europe PMC | doi

Gorjánácz M, Mattaj IW, Rietdorf J. (2007)
Some Like It Hot
Imaging & Microscopy 9(1):28-29.
Europe PMC


2006

Ulbert S, Antonin W, Platani M, Mattaj IW. (2006)
The inner nuclear membrane protein Lem2 is critical for normal nuclear envelope morphology
FEBS Lett. 580(27):6435-6441. doi:10.1016/j.febslet.2006.10.060
Europe PMC | doi

Galy V, Askjaer P, Franz C, López-Iglesias C, Mattaj IW. (2006)
MEL-28, a novel nuclear-envelope and kinetochore protein essential for zygotic nuclear-envelope assembly in C. elegans
Curr. Biol. 16(17):1748-1756. doi:10.1016/j.cub.2006.06.067
Europe PMC | doi

Ribbeck K, Groen AC, Santarella R, Bohnsack MT, Raemaekers T, Köcher T, Gentzel M, Görlich D, Wilm M, Carmeliet G, Mitchison TJ, Ellenberg J, Hoenger A, Mattaj IW. (2006)
NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules
Mol. Biol. Cell 17(6):2646-2660. doi:10.1091/mbc.e05-12-1178
Europe PMC | doi

Ulbert S, Platani M, Boue S, Mattaj IW. (2006)
Direct membrane protein-DNA interactions required early in nuclear envelope assembly
J. Cell Biol. 173(4):469-476. doi:10.1083/jcb.200512078
Europe PMC | doi

Koffa MD, Casanova CM, Santarella R, Köcher T, Wilm M, Mattaj IW. (2006)
HURP is part of a Ran-dependent complex involved in spindle formation
Curr. Biol. 16(8):743-754. doi:10.1016/j.cub.2006.03.056
Europe PMC | doi

Mansfeld J, Güttinger S, Hawryluk-Gara LA, Panté N, Mall M, Galy V, Haselmann U, Mühlhäusser P, Wozniak RW, Mattaj IW, Kutay U, Antonin W. (2006)
The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells
Mol. Cell 22(1):93-103. doi:10.1016/j.molcel.2006.02.015
Europe PMC | doi

Czaplinski K, Mattaj IW. (2006)
40LoVe interacts with Vg1RBP/Vera and hnRNP I in binding the Vg1-localization element
RNA 12(2):213-222. doi:10.1261/rna.2820106
Europe PMC | doi

Schetter A, Askjaer P, Piano F, Mattaj I, Kemphues K. (2006)
Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegans
Dev. Biol. 289(2):360-371. doi:10.1016/j.ydbio.2005.10.038
Europe PMC | doi


2005

Mattaj I. (2005)
EMBL's fourth decade
EMBO Rep. 6(10):904-907. doi:10.1038/sj.embor.7400546
Europe PMC | doi

Franz C, Askjaer P, Antonin W, Iglesias CL, Haselmann U, Schelder M, de Marco A, Wilm M, Antony C, Mattaj IW. (2005)
Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates
EMBO J. 24(20):3519-3531. doi:10.1038/sj.emboj.7600825
Europe PMC | doi

Czaplinski K, Köcher T, Schelder M, Segref A, Wilm M, Mattaj IW. (2005)
Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis
Dev. Cell 8(4):505-515. doi:10.1016/j.devcel.2005.01.012
Europe PMC | doi

Becskei A, Mattaj IW. (2005)
Quantitative models of nuclear transport
Curr. Opin. Cell Biol. 17(1):27-34. doi:10.1016/j.ceb.2004.12.010
Europe PMC | doi

Antonin W, Mattaj IW. (2005)
Nuclear pore complexes: round the bend?
Nat. Cell Biol. 7(1):10-12. doi:10.1038/ncb0105-10
Europe PMC | doi

Hetzer MW, Walther TC, Mattaj IW. (2005)
Pushing the envelope: structure, function, and dynamics of the nuclear periphery
Annu. Rev. Cell Dev. Biol. 21:347-380. doi:10.1146/annurev.cellbio.21.090704.151152
Europe PMC | doi

Antonin W, Franz C, Haselmann U, Antony C, Mattaj IW. (2005)
The integral membrane nucleoporin pom121 functionally links nuclear pore complex assembly and nuclear envelope formation
Mol. Cell 17(1):83-92. doi:10.1016/j.molcel.2004.12.010
Europe PMC | doi


2004

Petosa C, Schoehn G, Askjaer P, Bauer U, Moulin M, Steuerwald U, Soler-López M, Baudin F, Mattaj IW, Müller CW. (2004)
Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex
Mol. Cell 16(5):761-775. doi:10.1016/j.molcel.2004.11.018
Europe PMC | doi

Yamada M, Mattaj IW, Yoneda Y. (2004)
An ATP-dependent activity that releases RanGDP from NTF2
J. Biol. Chem. 279(35):36228-36234. doi:10.1074/jbc.m403101200
Europe PMC | doi

Hachet V, Köcher T, Wilm M, Mattaj IW. (2004)
Importin alpha associates with membranes and participates in nuclear envelope assembly in vitro
EMBO J. 23(7):1526-1535. doi:10.1038/sj.emboj.7600154
Europe PMC | doi

Mattaj IW. (2004)
Sorting out the nuclear envelope from the endoplasmic reticulum
Nat. Rev. Mol. Cell Biol. 5(1):65-69. doi:10.1038/nrm1263
Europe PMC | doi


2003

Galy V, Mattaj IW, Askjaer P. (2003)
Caenorhabditis elegans nucleoporins Nup93 and Nup205 determine the limit of nuclear pore complex size exclusion in vivo
Mol. Biol. Cell 14(12):5104-5115. doi:10.1091/mbc.e03-04-0237
Europe PMC | doi

Walther TC, Askjaer P, Gentzel M, Habermann A, Griffiths G, Wilm M, Mattaj IW, Hetzer M. (2003)
RanGTP mediates nuclear pore complex assembly
Nature 424(6949):689-694. doi:10.1038/nature01898
Europe PMC | doi

Schatz CA, Santarella R, Hoenger A, Karsenti E, Mattaj IW, Gruss OJ, Carazo-Salas RE. (2003)
Importin alpha-regulated nucleation of microtubules by TPX2
EMBO J. 22(9):2060-2070. doi:10.1093/emboj/cdg195
Europe PMC | doi

Walther TC, Alves A, Pickersgill H, Loïodice I, Hetzer M, Galy V, Hülsmann BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V. (2003)
The conserved Nup107-160 complex is critical for nuclear pore complex assembly
Cell 113(2):195-206. doi:10.1016/s0092-8674(03)00235-6
Europe PMC | doi

Becskei A, Mattaj IW. (2003)
The strategy for coupling the RanGTP gradient to nuclear protein export
Proc. Natl. Acad. Sci. U.S.A. 100(4):1717-1722. doi:10.1073/pnas.252766999
Europe PMC | doi


2002

Mazza C, Segref A, Mattaj IW, Cusack S. (2002)
Co-crystallization of the human nuclear cap-binding complex with a m7GpppG cap analogue using protein engineering
Acta Crystallogr. D Biol. Crystallogr. 58(Pt 12):2194-2197. doi:10.1107/s0907444902015445
Europe PMC | doi

Askjaer P, Galy V, Hannak E, Mattaj IW. (2002)
Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos
Mol. Biol. Cell 13(12):4355-4370. doi:10.1091/mbc.e02-06-0346
Europe PMC | doi

Gruss OJ, Wittmann M, Yokoyama H, Pepperkok R, Kufer T, Silljé H, Karsenti E, Mattaj IW, Vernos I. (2002)
Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells
Nat. Cell Biol. 4(11):871-879. doi:10.1038/ncb870
Europe PMC | doi

Mazza C, Segref A, Mattaj IW, Cusack S. (2002)
Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex
EMBO J. 21(20):5548-5557. doi:10.1093/emboj/cdf538
Europe PMC | doi

Massenet S, Pellizzoni L, Paushkin S, Mattaj IW, Dreyfuss G. (2002)
The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway
Mol. Cell. Biol. 22(18):6533-6541. doi:10.1128/mcb.22.18.6533-6541.2002
Europe PMC | doi

Kuersten S, Arts GJ, Walther TC, Englmeier L, Mattaj IW. (2002)
Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains
Mol. Cell. Biol. 22(16):5708-5720. doi:10.1128/mcb.22.16.5708-5720.2002
Europe PMC | doi

Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. (2002)
Ran binds to chromatin by two distinct mechanisms
Curr. Biol. 12(13):1151-1156. doi:10.1016/s0960-9822(02)00927-2
Europe PMC | doi

Walther TC, Pickersgill HS, Cordes VC, Goldberg MW, Allen TD, Mattaj IW, Fornerod M. (2002)
The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import
J. Cell Biol. 158(1):63-77. doi:10.1083/jcb.200202088
Europe PMC | doi

Hetzer M, Gruss OJ, Mattaj IW. (2002)
The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly
Nat. Cell Biol. 4(7):E177-84. doi:10.1038/ncb0702-e177
Europe PMC | doi

Ohno M, Segref A, Kuersten S, Mattaj IW. (2002)
Identity elements used in export of mRNAs
Mol. Cell 9(3):659-671. doi:10.1016/s1097-2765(02)00454-9
Europe PMC | doi


2001

Hetzer M, Meyer HH, Walther TC, Bilbao-Cortes D, Warren G, Mattaj IW. (2001)
Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly
Nat. Cell Biol. 3(12):1086-1091. doi:10.1038/ncb1201-1086
Europe PMC | doi

Kuersten S, Ohno M, Mattaj IW. (2001)
Nucleocytoplasmic transport: Ran, beta and beyond
Trends Cell Biol. 11(12):497-503. doi:10.1016/s0962-8924(01)02144-4
Europe PMC | doi

Koffa MD, Clements JB, Izaurralde E, Wadd S, Wilson SA, Mattaj IW, Kuersten S. (2001)
Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway
EMBO J. 20(20):5769-5778. doi:10.1093/emboj/20.20.5769
Europe PMC | doi

Englmeier L, Fornerod M, Bischoff FR, Petosa C, Mattaj IW, Kutay U. (2001)
RanBP3 influences interactions between CRM1 and its nuclear protein export substrates
EMBO Rep. 2(10):926-932. doi:10.1093/embo-reports/kve200
Europe PMC | doi

Walther TC, Fornerod M, Pickersgill H, Goldberg M, Allen TD, Mattaj IW. (2001)
The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins
EMBO J. 20(20):5703-5714. doi:10.1093/emboj/20.20.5703
Europe PMC | doi

Mazza C, Ohno M, Segref A, Mattaj IW, Cusack S. (2001)
Crystal structure of the human nuclear cap binding complex
Mol. Cell 8(2):383-396. doi:10.1016/s1097-2765(01)00299-4
Europe PMC | doi

Carazo-Salas RE, Gruss OJ, Mattaj IW, Karsenti E. (2001)
Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly
Nat. Cell Biol. 3(3):228-234. doi:10.1038/35060009
Europe PMC | doi

Segref A, Mattaj IW, Ohno M. (2001)
The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export
RNA 7(3):351-360. doi:10.1017/s1355838201002278
Europe PMC | doi

Gruss OJ, Carazo-Salas RE, Schatz CA, Guarguaglini G, Kast J, Wilm M, Le Bot N, Vernos I, Karsenti E, Mattaj IW. (2001)
Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity
Cell 104(1):83-93. doi:10.1016/s0092-8674(01)00193-3
Europe PMC | doi


2000

Fortes P, Inada T, Preiss T, Hentze MW, Mattaj IW, Sachs AB. (2000)
The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation
Mol. Cell 6(1):191-196. doi:10.1016/s1097-2765(00)00020-4
Europe PMC | doi

Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. (2000)
GTP hydrolysis by Ran is required for nuclear envelope assembly
Mol. Cell 5(6):1013-1024. doi:10.1016/s1097-2765(00)80266-x
Europe PMC | doi

Ohno M, Segref A, Bachi A, Wilm M, Mattaj IW. (2000)
PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation
Cell 101(2):187-198. doi:10.1016/s0092-8674(00)80829-6
Europe PMC | doi

Varani L, Gunderson SI, Mattaj IW, Kay LE, Neuhaus D, Varani G. (2000)
The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein
Nat. Struct. Biol. 7(4):329-335. doi:10.1038/74101
Europe PMC | doi

Vagner S, Rüegsegger U, Gunderson SI, Keller W, Mattaj IW. (2000)
Position-dependent inhibition of the cleavage step of pre-mRNA 3'-end processing by U1 snRNP
RNA 6(2):178-188. doi:10.1017/s1355838200991854
Europe PMC | doi

Vagner S, Vagner C, Mattaj IW. (2000)
The carboxyl terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3'-end processing and splicing
Genes Dev. 14(4):403-413.
Europe PMC

Hetzer M, Mattaj IW. (2000)
An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins
J. Cell Biol. 148(2):293-303. doi:10.1083/jcb.148.2.293
Europe PMC | doi


1999

Fortes P, Kufel J, Fornerod M, Polycarpou-Schwarz M, Lafontaine D, Tollervey D, Mattaj IW. (1999)
Genetic and physical interactions involving the yeast nuclear cap-binding complex
Mol. Cell. Biol. 19(10):6543-6553.
Europe PMC

Fortes P, Bilbao-Cortés D, Fornerod M, Rigaut G, Raymond W, Séraphin B, Mattaj IW. (1999)
Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition
Genes Dev. 13(18):2425-2438. doi:10.1101/gad.13.18.2425
Europe PMC | doi

Askjaer P, Bachi A, Wilm M, Bischoff FR, Weeks DL, Ogniewski V, Ohno M, Niehrs C, Kjems J, Mattaj IW, Fornerod M. (1999)
RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase
Mol. Cell. Biol. 19(9):6276-6285.
Europe PMC

Carazo-Salas RE, Guarguaglini G, Gruss OJ, Segref A, Karsenti E, Mattaj IW. (1999)
Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation
Nature 400(6740):178-181. doi:10.1038/22133
Europe PMC | doi

Mattaj IW, Conti E. (1999)
Cell biology. Snail mail to the nucleus
Nature 399(6733):208-210. doi:10.1038/20322
Europe PMC | doi

Ségault V, Will CL, Polycarpou-Schwarz M, Mattaj IW, Branlant C, Lührmann R. (1999)
Conserved loop I of U5 small nuclear RNA is dispensable for both catalytic steps of pre-mRNA splicing in HeLa nuclear extracts
Mol. Cell. Biol. 19(4):2782-2790.
Europe PMC

Wilson KF, Fortes P, Singh US, Ohno M, Mattaj IW, Cerione RA. (1999)
The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction
J. Biol. Chem. 274(7):4166-4173. doi:10.1074/jbc.274.7.4166
Europe PMC | doi

Ohno M, Mattaj IW. (1999)
Meiosis: MeiRNA hits the spot
Curr. Biol. 9(2):R66-9. doi:10.1016/s0960-9822(99)80013-x
Europe PMC | doi

Englmeier L, Olivo JC, Mattaj IW. (1999)
Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis
Curr. Biol. 9(1):30-41. doi:10.1016/s0960-9822(99)80044-x
Europe PMC | doi


1998

Arts GJ, Kuersten S, Romby P, Ehresmann B, Mattaj IW. (1998)
The role of exportin-t in selective nuclear export of mature tRNAs
EMBO J. 17(24):7430-7441. doi:10.1093/emboj/17.24.7430
Europe PMC | doi

Arts GJ, Fornerod M, Mattaj IW. (1998)
Identification of a nuclear export receptor for tRNA
Curr. Biol. 8(6):305-314. doi:10.1016/s0960-9822(98)70130-7
Europe PMC | doi

Ohno M, Fornerod M, Mattaj IW. (1998)
Nucleocytoplasmic transport: the last 200 nanometers
Cell 92(3):327-336. doi:10.1016/s0092-8674(00)80926-5
Europe PMC | doi

Mattaj IW, Englmeier L. (1998)
Nucleocytoplasmic transport: the soluble phase
Annu. Rev. Biochem. 67:265-306. doi:10.1146/annurev.biochem.67.1.265
Europe PMC | doi

Mattaj IW. (1998)
Ribonucleoprotein assembly: clues from spinal muscular atrophy
Curr. Biol. 8(3):R93-5. doi:10.1016/s0960-9822(98)70055-7
Europe PMC | doi

Gunderson SI, Polycarpou-Schwarz M, Mattaj IW. (1998)
U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase
Mol. Cell 1(2):255-264. doi:10.1016/s1097-2765(00)80026-x
Europe PMC | doi


1997

Palacios I, Hetzer M, Adam SA, Mattaj IW. (1997)
Nuclear import of U snRNPs requires importin beta
EMBO J. 16(22):6783-6792. doi:10.1093/emboj/16.22.6783
Europe PMC | doi

Izaurralde E, Kutay U, von Kobbe C, Mattaj IW, Görlich D. (1997)
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
EMBO J. 16(21):6535-6547. doi:10.1093/emboj/16.21.6535
Europe PMC | doi