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Staff at EMBL

Prof. Matthias Hentze

Director, Co-Director of MMPU
Director Hentze Group Molecular Medicine Partnership Unit Resource Development Alumni Relations EMBL International Centre for Advanced Training (EICAT) Joint appointment: Genome Biology Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Personal Assistant
Nina Papritz
Room: ATC B2402
Tel: +49 6221 387-8909
Fax: +49 6221 387-8144
E-mail: director@embl.org
Administrative Assistant, Director's Office
Esther Liebig
Room: ATC B2402
Tel: +49 6221 387-8914
Fax: +49 6221 387-8144
E-mail: director@embl.org

Biography

MD 1984, University of Münster.
Postdoctoral training at the NIH, Bethesda.
Group Leader at EMBL since 1989.
Senior Scientist since 1998.
Co-Director of the EMBL/University of Heidelberg Molecular Medicine Partnership Unit since 2002.
Associate Director of EMBL since 2005.
ERC Advanced Investigator since 2011.
Director of EMBL since 2013.

Publications

Resistance of Ferroportin to Hepcidin Binding causes Exocrine Pancreatic Failure and Fatal Iron Overload. Altamura, S., Kessler, R., Grone, H.J., Gretz, N., Hentze, M.W., Galy, B. & Muckenthaler, M.U. Cell Metab. 2014 Aug 5;20(2):359-67. doi: 10.1016/j.cmet.2014.07.007. Europe PMC

A versatile assay for RNA-binding proteins in living cells. Strein, C., Alleaume, A.M., Rothbauer, U., Hentze, M.W. & Castello, A. RNA. 2014 Mar 24. Europe PMC

mRNA 3'end processing: A tale of the tail reaches the clinic. Hollerer, I., Grund, K., Hentze, M.W. & Kulozik, A.E. EMBO Mol Med. 2014 Jan 1;6(1):16-26. doi: 10.1002/emmm.201303300. Europe PMC

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Mleczko-Sanecka, K., Roche, F., da Silva, A.R., Call, D., D'Alessio, F., Ragab, A., Lapinski, P.E., Ummanni, R., Korf, U., Oakes, C., Damm, G., D'Alessandro, L.A., Klingmuller, U., King, P.D., Boutros, M., Hentze, M.W. & Muckenthaler, M.U. Blood. 2014 Mar 6;123(10):1574-85. doi: 10.1182/blood-2013-07-515957. Epub 2014Jan 2. Europe PMC

Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria. Chung, J., Anderson, S.A., Gwynn, B., Deck, K.M., Chen, M.J., Langer, N.B., Shaw, G.C., Huston, N.C., Boyer, L.F., Datta, S., Paradkar, P.N., Li, L., Wei, Z., Lambert, A.J., Sahr, K., Wittig, J.G., Chen, W., Lu, W., Galy, B., Schlaeger, T.M., Hentze, M.W., Ward, D.M., Kaplan, J., Eisenstein, R.S., Peters, L.L. & Paw, B.H. J Biol Chem. 2014 Mar 14;289(11):7835-43. doi: 10.1074/jbc.M114.547778. Epub 2014Feb 7. Europe PMC

Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond. Danckwardt, S., Hentze, M.W. & Kulozik, A.E. J Mol Med (Berl). 2013 Nov;91(11):1257-71. doi: 10.1007/s00109-013-1074-5. Epub2013 Aug 17. Europe PMC

The RNA-binding protein repertoire of embryonic stem cells. Kwon, S.C., Yi, H., Eichelbaum, K., Fohr, S., Fischer, B., You, K.T., Castello, A., Krijgsveld, J., Hentze, M.W. & Kim, V.N. Nat Struct Mol Biol. 2013 Sep;20(9):1122-30. doi: 10.1038/nsmb.2638. Epub 2013Aug 4. Europe PMC

Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function. Casarrubea, D., Viatte, L., Hallas, T., Vasanthakumar, A., Eisenstein, R.S., Schumann, K., Hentze, M.W. & Galy, B. J Mol Med (Berl). 2013 Jul;91(7):871-81. doi: 10.1007/s00109-013-1008-2. Epub2013 Mar 1. Europe PMC

Making sense of nonsense. Hentze, M.W. & Izaurralde, E. Nat Struct Mol Biol. 2013 Jun;20(6):651-3. doi: 10.1038/nsmb.2601. Europe PMC

RNA-binding proteins in Mendelian disease. Castello, A., Fischer, B., Hentze, M.W. & Preiss, T. Trends Genet. 2013 May;29(5):318-27. doi: 10.1016/j.tig.2013.01.004. Epub 2013Feb 15. Europe PMC

Circular RNAs: splicing's enigma variations. Hentze, M.W. & Preiss, T. EMBO J. 2013 Apr 3;32(7):923-5. doi: 10.1038/emboj.2013.53. Epub 2013 Mar 5. Europe PMC

Iron regulatory proteins control a mucosal block to intestinal iron absorption. Galy, B., Ferring-Appel, D., Becker, C., Gretz, N., Grone, H.J., Schumann, K. & Hentze, M.W. Cell Rep. 2013 Mar 28;3(3):844-57. doi: 10.1016/j.celrep.2013.02.026. Epub 2013Mar 21. Europe PMC

The IRP1-HIF-2alpha axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. Anderson, S.A., Nizzi, C.P., Chang, Y.I., Deck, K.M., Schmidt, P.J., Galy, B., Damnernsawad, A., Broman, A.T., Kendziorski, C., Hentze, M.W., Fleming, M.D., Zhang, J. & Eisenstein, R.S. Cell Metab. 2013 Feb 5;17(2):282-90. doi: 10.1016/j.cmet.2013.01.007. Europe PMC

System-wide identification of RNA-binding proteins by interactome capture. Castello, A., Horos, R., Strein, C., Fischer, B., Eichelbaum, K., Steinmetz, L.M., Krijgsveld, J. & Hentze, M.W. Nat Protoc. 2013 Feb 14;8(3):491-500. doi: 10.1038/nprot.2013.020. Epub 2013 Feb14. Europe PMC

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation. D'Alessio, F., Hentze, M.W. & Muckenthaler, M.U. J Hepatol. 2012 Nov;57(5):1052-60. doi: 10.1016/j.jhep.2012.06.015. Epub 2012 Jun21. Europe PMC

From cis-regulatory elements to complex RNPs and back. Gebauer, F., Preiss, T. & Hentze, M.W. Cold Spring Harb Perspect Biol. 2012 Jul 1;4(7):a012245. doi:10.1101/cshperspect.a012245. Europe PMC

PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding. Moretti, F., Kaiser, C., Zdanowicz-Specht, A. & Hentze, M.W. Nat Struct Mol Biol. 2012 May 27;19(6):603-8. doi: 10.1038/nsmb.2309. Europe PMC

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins. Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B.M., Strein, C., Davey, N.E., Humphreys, D.T., Preiss, T., Steinmetz, L.M., Krijgsveld, J. & Hentze, M.W. Cell. 2012 Jun 8;149(6):1393-406. Epub 2012 May 31. Europe PMC

Automated High-Throughput RNAi Screening in Human Cells Combined with Reporter mRNA Transfection to Identify Novel Regulators of Translation. Casanova, C.M., Sehr, P., Putzker, K., Hentze, M.W., Neumann, B., Duncan, K.E. & Thoma, C. PLoS One. 2012;7(9):e45943. doi: 10.1371/journal.pone.0045943. Epub 2012 Sep 27. Europe PMC

Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins. Sanchez, M., Galy, B., Schwanhaeusser, B., Blake, J., Bahr-Ivacevic, T., Benes, V., Selbach, M., Muckenthaler, M.U. & Hentze, M.W. Blood. 2011 Nov 24;118(22):e168-79. Epub 2011 Sep 22. Europe PMC

Translational Control via Protein-Regulated Upstream Open Reading Frames. Medenbach, J., Seiler, M. & Hentze, M.W. Cell. 2011 Jun 10;145(6):902-13. Europe PMC

An efficient factor-depleted mammalian in vitro translation system. Rakotondrafara, A.M. & Hentze, M.W. Nat Protoc. 2011 May;6(5):563-71. Epub 2011 Apr 7. Europe PMC

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. Castoldi, M., Vujic Spasic, M., Altamura, S., Elmen, J., Lindow, M., Kiss, J., Stolte, J., Sparla, R., D'Alessandro, L.A., Klingmuller, U., Fleming, R.E., Longerich, T., Grone, H.J., Benes, V., Kauppinen, S., Hentze, M.W. & Muckenthaler, M.U. J Clin Invest. 2011 Apr;121(4):1386-96. doi: 10.1172/JCI44883. Europe PMC

p38 MAPK controls prothrombin expression by regulated RNA 3' end processing. Danckwardt, S., Gantzert, A.S., Macher-Goeppinger, S., Probst, H.C., Gentzel, M., Wilm, M., Grone, H.J., Schirmacher, P., Hentze, M.W. & Kulozik, A.E. Mol Cell. 2011 Feb 4;41(3):298-310. Europe PMC

Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame. Moretti, F., Thermann, R. & Hentze, M.W. RNA. 2010 Dec;16(12):2493-502. Epub 2010 Oct 21. Europe PMC

Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Cohen, L.A., Gutierrez, L., Weiss, A., Leichtmann-Bardoogo, Y., Zhang, D.L., Crooks, D.R., Sougrat, R., Morgenstern, A., Galy, B., Hentze, M.W., Lazaro, F.J., Rouault, T.A. & Meyron-Holtz, E.G. Blood. 2010 Sep 2;116(9):1574-84. doi: 10.1182/blood-2009-11-253815. Epub 2010May 14. Europe PMC

Iron regulatory proteins secure mitochondrial iron sufficiency and function. Galy, B., Ferring-Appel, D., Sauer, S.W., Kaden, S., Lyoumi, S., Puy, H., Kolker, S., Grone, H.J. & Hentze, M.W. Cell Metab. 2010 Aug 4;12(2):194-201. Europe PMC

The REM phase of gene regulation. Hentze, M.W. & Preiss, T. Trends Biochem Sci. 2010 Aug;35(8):423-6. Epub 2010 Jun 16. Europe PMC

Two to tango: regulation of Mammalian iron metabolism. Hentze, M.W., Muckenthaler, M.U., Galy, B. & Camaschella, C. Cell. 2010 Jul 9;142(1):24-38. Europe PMC

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Mleczko-Sanecka, K., Casanovas, G., Ragab, A., Breitkopf, K., Muller, A., Boutros, M., Dooley, S., Hentze, M.W. & Muckenthaler, M.U. Blood. 2010 Apr 1;115(13):2657-65. Epub 2009 Dec 29. Europe PMC

The role of ABCE1 in eukaryotic posttermination ribosomal recycling. Pisarev, A.V., Skabkin, M.A., Pisareva, V.P., Skabkina, O.V., Rakotondrafara, A.M., Hentze, M.W., Hellen, C.U. & Pestova, T.V. Mol Cell. 2010 Jan 29;37(2):196-210. doi: 10.1016/j.molcel.2009.12.034. Europe PMC

The SXL-UNR corepressor complex uses a PABP-mediated mechanism to inhibit ribosome recruitment to msl-2 mRNA. Duncan, K.E., Strein, C. & Hentze, M.W. Mol Cell. 2009 Nov 25;36(4):571-82. Europe PMC

Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression. Zdanowicz, A., Thermann, R., Kowalska, J., Jemielity, J., Duncan, K., Preiss, T., Darzynkiewicz, E. & Hentze, M.W. Mol Cell. 2009 Sep 24;35(6):881-8. Europe PMC

In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation. Viatte, L., Grone, H.J., Hentze, M.W. & Galy, B. J Mol Med. 2009 Sep;87(9):913-21. Epub 2009 Jun 17. Europe PMC

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2. Clerici, M., Mourao, A., Gutsche, I., Gehring, N.H., Hentze, M.W., Kulozik, A., Kadlec, J., Sattler, M. & Cusack, S. EMBO J. 2009 Jun 25;28(15):2293-2306. Europe PMC

The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay. Gehring, N.H., Lamprinaki, S., Hentze, M.W. & Kulozik, A.E. PLoS Biol. 2009 May 26;7(5):e1000120. Epub 2009 May 26. Europe PMC

Disassembly of exon junction complexes by PYM. Gehring, N.H., Lamprinaki, S., Kulozik, A.E. & Hentze, M.W. Cell. 2009 May 1;137(3):536-48. Europe PMC

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD. Casanovas, G., Mleczko-Sanecka, K., Altamura, S., Hentze, M.W. & Muckenthaler, M.U. J Mol Med. 2009 May;87(5):471-80. Epub 2009 Feb 20. Europe PMC

Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism. Ferring-Appel, D., Hentze, M.W. & Galy, B. Blood. 2009 Jan 15;113(3):679-87. Europe PMC

Translation initiation by the c-myc mRNA internal ribosome entry sequence and the poly(A) tail. Thoma, C., Fraterman, S., Gentzel, M., Wilm, M. & Hentze, M.W. RNA. 2008 Aug;14(8):1579-89. Epub 2008 Jun 12. Europe PMC

A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. Verga Falzacappa, M.V., Casanovas, G., Hentze, M.W. & Muckenthaler, M.U. J Mol Med (Berl). 2008 May;86(5):531-40. doi: 10.1007/s00109-008-0313-7. Epub2008 Apr 18. Europe PMC

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. Ivanov, P.V., Gehring, N.H., Kunz, J.B., Hentze, M.W. & Kulozik, A.E. EMBO J. 2008 Mar 5;27(5):736-47. Epub 2008 Feb 7. Europe PMC

Hfe acts in hepatocytes to prevent hemochromatosis. Vujic Spasic, M., Kiss, J., Herrmann, T., Galy, B., Martinache, S., Stolte, J., Grone, H.J., Stremmel, W., Hentze, M.W. & Muckenthaler, M.U. Cell Metab. 2008 Feb;7(2):173-8. Europe PMC

Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Galy, B., Ferring-Appel, D., Kaden, S., Grone, H.J. & Hentze, M.W. Cell Metab. 2008 Jan;7(1):79-85. Europe PMC

Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Muckenthaler, M.U., Galy, B. & Hentze, M.W. Annu Rev Nutr. 2008;28:197-213. Europe PMC

Tethering assays to investigate nonsense-mediated mRNA decay activating proteins. Gehring, N.H., Hentze, M.W. & Kulozik, A.E. Methods Enzymol. 2008;448:467-82. Europe PMC

miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes. Castoldi, M., Schmidt, S., Benes, V., Hentze, M.W. & Muckenthaler, M.U. Nat Protoc. 2008;3(2):321-9. Europe PMC

A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain. Till, S., Lejeune, E., Thermann, R., Bortfeld, M., Hothorn, M., Enderle, D., Heinrich, C., Hentze, M.W. & Ladurner, A.G. Nat Struct Mol Biol. 2007 Oct;14(10):897-903. Epub 2007 Sep 23. Europe PMC

miChip: a microarray platform for expression profiling of microRNAs based on locked nucleic acid (LNA) oligonucleotide capture probes. Castoldi, M., Benes, V., Hentze, M.W. & Muckenthaler, M.U. Methods. 2007 Oct;43(2):146-52. Europe PMC

Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays. Sanchez, M., Galy, B., Hentze, M.W. & Muckenthaler, M.U. Nat Protoc. 2007 Aug;2(8):2033-2042. Europe PMC

Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells. Fillebeen, C., Muckenthaler, M., Andriopoulos, B., Bisaillon, M., Mounir, Z., Hentze, M.W., Koromilas, A.E. & Pantopoulos, K. J Hepatol. 2007 Jul;47(1):12-22. Epub 2007 Mar 2. Europe PMC

Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals. Danckwardt, S., Kaufmann, I., Gentzel, M., Foerstner, K.U., Gantzert, A.S., Gehring, N.H., Neu-Yilik, G., Bork, P., Keller, W., Wilm, M., Hentze, M.W. & Kulozik, A.E. EMBO J. 2007 Jun 6;26(11):2658-69. Epub 2007 Apr 26. Europe PMC

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation. Thermann, R. & Hentze, M.W. Nature. 2007 Jun 14;447(7146):875-8. Epub 2007 May 16. Europe PMC

Omeprazole decreases duodenal iron absorption via inhibition of DMT-1 function. Mair, SM; Ludwiczek, S; Muckenthaler, M; Schwelberger, H; Theurl, I; Weiss, H; Hentze, M.W.; Ritter, M; Weiss, G American Journal of Hematology June 2007 82(6)

MiRNA expression in T-cell acute lymphoblastic leukaemia Kox, C; Breit, S; Castoldi, M; Kirschner-Schwabe, R; Ludwig, WD; Hentze, M.W.; Kulozik, AE; Muckenthaler, MU Klinische Pädiatrie June 2007 219(3)

Metal distribution and gene expression profile in DMT1 knockout mice Gunshin, H; Tohyama, C; Vainshtein, Y; Hentze, M.W.; Muckenthaler, M; Andrews, NC American Journal of Hematology June 2007 82(6)

Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Sanchez, M., Galy, B., Muckenthaler, M.U. & Hentze, M.W. Nat Struct Mol Biol. 2007 May;14(5):420-6. Epub 2007 Apr 8. Europe PMC

Physiologic systemic iron metabolism in mice deficient for duodenal Hfe. Spasic, M.V., Kiss, J., Herrmann, T., Kessler, R., Stolte, J., Galy, B., Rathkolb, B., Wolf, E., Stremmel, W., Hentze, M.W. & Muckenthaler, M.U. Blood. 2007 May 15;109(10):4511-7. Epub 2007 Jan 30. Europe PMC

Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Ludwiczek, S., Theurl, I., Muckenthaler, M.U., Jakab, M., Mair, S.M., Theurl, M., Kiss, J., Paulmichl, M., Hentze, M.W., Ritter, M. & Weiss, G. Nat Med. 2007 Apr;13(4):448-54. Epub 2007 Feb 11. Europe PMC

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Verga Falzacappa, M.V., Vujic Spasic, M., Kessler, R., Stolte, J., Hentze, M.W. & Muckenthaler, M.U. Blood. 2007 Jan 1;109(1):353-8. Epub 2006 Aug 31. Europe PMC

The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway. Viegas, M.H., Gehring, N.H., Breit, S., Hentze, M.W. & Kulozik, A.E. Nucleic Acids Res. 2007;35(13):4542-51. Epub 2007 Jun 22. Europe PMC

Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region. Mihailovich, M., Thermann, R., Grohovaz, F., Hentze, M.W. & Zacchetti, D. Nucleic Acids Res. 2007;35(9):2975-85. Epub 2007 Apr 16. Europe PMC

Studying translational control in Drosophila cell-free systems. Gebauer, F. & Hentze, M.W. Methods Enzymol. 2007;429:23-33. Europe PMC

A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay. Boelz, S., Neu-Yilik, G., Gehring, N.H., Hentze, M.W. & Kulozik, A.E. Biochem Biophys Res Commun. 2006 Oct 13;349(1):186-91. Epub 2006 Aug 11. Europe PMC

Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse. Galy, B., Holter, S.M., Klopstock, T., Ferring, D., Becker, L., Kaden, S., Wurst, W., Grone, H.J. & Hentze, M.W. Nat Genet. 2006 Sep;38(9):967-9. Europe PMC

Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. Sanchez, M., Galy, B., Dandekar, T., Bengert, P., Vainshtein, Y., Stolte, J., Muckenthaler, M.U. & Hentze, M.W. J Biol Chem. 2006 Aug 11;281(32):22865-74. Epub 2006 Jun 7. Europe PMC

Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay. Holbrook, J.A., Neu-Yilik, G., Gehring, N.H., Kulozik, A.E. & Hentze, M.W. EMBO Rep. 2006 Jul;7(7):722-726. Epub 2006 Jun 16. Europe PMC

IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice. Corna, G., Galy, B., Hentze, M.W. & Cairo, G. J Mol Med. 2006 Jul;84(7):551-60. Epub 2006 Jun 13. Europe PMC

Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. Kunz, J.B., Neu-Yilik, G., Hentze, M.W., Kulozik, A.E. & Gehring, N.H. RNA. 2006 Jun;12(6):1015-22. Epub 2006 Apr 6. Europe PMC

The prothrombin 20209 C-->T mutation in Jewish-Moroccan Caucasians: molecular analysis of gain-of-function of 3' end processing. Danckwardt, S., Hartmann, K., Katz, B., Hentze, M.W., Levy, Y., Eichele, R., Deutsch, V., Kulozik, A.E. & Ben-Tal, O. J Thromb Haemost. 2006 May;4(5):1078-85. Europe PMC

A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA). Castoldi, M., Schmidt, S., Benes, V., Noerholm, M., Kulozik, A.E., Hentze, M.W. & Muckenthaler, M.U. RNA. 2006 May;12(5):913-20. Epub 2006 Mar 15. Europe PMC

The molecular circuitry regulating the switch between iron deficiency and overload in mice. Mok, H., Mlodnicka, A.E., Hentze, M.W., Muckenthaler, M. & Schumacher, A. J Biol Chem. 2006 Mar 24;281(12):7946-51. Epub 2006 Jan 17. Europe PMC

Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles. Chekulaeva, M., Hentze, M.W. & Ephrussi, A. Cell. 2006 Feb 10;124(3):521-33. Europe PMC

Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation. Duncan, K., Grskovic, M., Strein, C., Beckmann, K., Niggeweg, R., Abaza, I., Gebauer, F., Wilm, M. & Hentze, M.W. Genes Dev. 2006 Feb 1;20(3):368-79. Europe PMC

Targeted disruption of the mouse mitoferrin (Slc25A37) mitochondrial solute carrier results in defective primitive and definitive erythropoiesis. Paw, Barry H.; Gwynn, Babette; Langer, Nathaniel B.; Shaw, George C.; Lambert, Amy J.; Boyer, Leah A.; Li, Liangtao; Stolte, Jens; Robledo, Raymond F.; Sahr, Kenneth E.; Schlaeger, Thorsten M.; Hentze, M.W.; Muckenthaler, Martina U.; Kaplan, Jerry; Peters, Luanne L. Blood November 2006 108(11)

The physiology of prothrombin gene expression integrates RNA polyadenylation and splicing in a novel regulatable 3 ' RNP-complex. Danckwardt, Sven; Gentzel, Marc; Gehring, Niels H.; Kaufmann, Isabelle; Neu-Yilik, Gabriele; Wilm, M.; Hentze, M.W.; Kulozjk, Andreas E. Blood 2006 108(11)

3' end processing of the prothrombin mRNA in thrombophilia. Danckwardt, S., Hartmann, K., Gehring, N.H., Hentze, M.W. & Kulozik, A.E. Acta Haematol. 2006;115(3-4):192-7. Europe PMC

Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes. Galy, B., Ferring, D. & Hentze, M.W. Genesis. 2005 Dec;43(4):181-8. Europe PMC

Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Gehring, N.H., Kunz, J.B., Neu-Yilik, G., Breit, S., Viegas, M.H., Hentze, M.W. & Kulozik, A.E. Mol Cell 2005 Oct 7;20(1):65-75. Europe PMC

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Galy, B., Ferring, D., Minana, B., Bell, O., Janser, H.G., Muckenthaler, M., Schumann, K. & Hentze, M.W. Blood 2005 Oct 1;106(7):2580-9. Epub 2005 Jun 14. Europe PMC

Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation. Hundsdoerfer, P., Thoma, C. & Hentze, M.W. Proc Natl Acad Sci U S A 2005 Sep 20;102(38):13421-6. Epub 2005 Sep 7. Europe PMC

A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila. Beckmann, K., Grskovic, M., Gebauer, F. & Hentze, M.W. Cell 2005 Aug 26;122(4):529-40. Europe PMC

Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus. Fillebeen, C., Rivas-Estilla, A.M., Bisaillon, M., Ponka, P., Muckenthaler, M., Hentze, M.W., Koromilas, A.E. & Pantopoulos, K. J Biol Chem 2005 Mar 11;280(10):9049-57. Epub 2005 Jan 6. Europe PMC

Molecular mechanisms of translational control. Gebauer, F. & Hentze, M.W. Nat Rev Mol Cell Biol 2004 Oct;5(10):827-35. Europe PMC

Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP. Thoma, C., Bergamini, G., Galy, B., Hundsdoerfer, P. & Hentze, M.W. Mol Cell 2004 Sep 24;15(6):925-35. Europe PMC

Molecular analysis of iron overload in beta2-microglobulin-deficient mice. Muckenthaler, M.U., Rodrigues, P., Macedo, M.G., Minana, B., Brennan, K., Cardoso, E.M., Hentze, M.W. & de Sousa, M. Blood Cells Mol Dis 2004 Sep-Oct;33(2):125-31. Europe PMC

Nonsense-mediated decay approaches the clinic. Holbrook, J.A., Neu-Yilik, G., Hentze, M.W. & Kulozik, A.E. Nat Genet 2004 Aug;36(8):801-8. Europe PMC

The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations. Danckwardt, S., Gehring, N.H., Neu-Yilik, G., Hundsdoerfer, P., Pforsich, M., Frede, U., Hentze, M.W. & Kulozik, A.E. Blood 2004 Jul 15;104(2):428-35. Epub 2004 Apr 01. Europe PMC

Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo. Galy, B., Ferring, D., Benesova, M., Benes, V. & Hentze, M.W. RNA 2004 Jul;10(7):1019-25. Europe PMC

An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Roy, C.N., Custodio, A.O., de Graaf, J., Schneider, S., Akpan, I., Montross, L.K., Sanchez, M., Gaudino, A., Hentze, M.W., Andrews, N.C. & Muckenthaler, M.U. Nat Genet 2004 May;36(5):481-5. Epub 2004 Apr 18. Europe PMC

Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis. Bonnah, R.A., Muckenthaler, M.U., Carlson, H., Minana, B., Enns, C.A., Hentze, M.W. & So, M. Cell Microbiol 2004 May;6(5):473-84. Europe PMC

Balancing acts: molecular control of mammalian iron metabolism. Hentze, M.W., Muckenthaler, M.U. & Andrews, N.C. Cell 2004 Apr 30;117(3):285-97. Europe PMC

Rat duodenal IRP1 activity and iron absorption in iron deficiency and after HO perfusion. Schumann, K., Brennan, K., Weiss, M., Pantopoulos, K. & Hentze, M.W. Eur J Clin Invest 2004 Apr;34(4):275-82. Europe PMC

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity. Wang, J., Chen, G., Muckenthaler, M., Galy, B., Hentze, M.W. & Pantopoulos, K. Mol Cell Biol 2004 Feb;24(3):954-65. Europe PMC

Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin. Herrmann, T., Muckenthaler, M., Van Der Hoeven, F., Brennan, K., Gehrke, S.G., Hubert, N., Sergi, C., Grone, H.J., Kaiser, I., Gosch, I., Volkmann, M., Riedel, H.D., Hentze, M.W., Stewart, A.F. & Stremmel, W. J Mol Med 2004 Jan;82(1):39-48. Europe PMC

A poly(A) tail-responsive in vitro system for cap- or IRES-driven translation from HeLa cells. Thoma, C., Ostareck-Lederer, A. & Hentze, M.W. Methods Mol Biol. 2004;257:171-80. Europe PMC

Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife. Neu-Yilik, G., Gehring, N.H., Hentze, M.W. & Kulozik, A.E. Genome Biol 2004;5(4):218. Epub 2004 Mar 30. Europe PMC

Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock. Preiss, T., Baron-Benhamou, J., Ansorge, W. & Hentze, M.W. Nat Struct Biol 2003 Dec;10(12):1039-47. Epub 2003 Nov 9. Europe PMC

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Ohnishi, T., Yamashita, A., Kashima, I., Schell, T., Anders, K.R., Grimson, A., Hachiya, T., Hentze, M.W., Anderson, P. & Ohno, S. Mol Cell 2003 Nov;12(5):1187-200. Europe PMC

A co-repressor assembly nucleated by Sex-lethal in the 3'UTR mediates translational control of Drosophila msl-2 mRNA. Grskovic, M., Hentze, M.W. & Gebauer, F. EMBO J 2003 Oct 15;22(20):5571-81. Europe PMC

Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. Schell, T., Kocher, T., Wilm, M., Seraphin, B., Kulozik, A.E. & Hentze, M.W. Biochem J 2003 Aug 1;373(Pt 3):775-83. Europe PMC

The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast. Baron-Benhamou, J., Fortes, P., Inada, T., Preiss, T. & Hentze, M.W. RNA 2003 Jun;9(6):654-62. Europe PMC

Relationships and distinctions in iron-regulatory networks responding to interrelated signals. Muckenthaler, M., Richter, A., Gunkel, N., Riedel, D., Polycarpou-Schwarz, M., Hentze, S., Falkenhahn, M., Stremmel, W., Ansorge, W. & Hentze, M.W. Blood 2003 May 1;101(9):3690-8. Epub 2002 Sep 26. Europe PMC

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Muckenthaler, M., Roy, C.N., Custodio, A.O., Minana, B., deGraaf, J., Montross, L.K., Andrews, N.C. & Hentze, M.W. Nat Genet 2003 May;34(1):102-7. Europe PMC

Drosophila sex-lethal inhibits the stable association of the 40S ribosomal subunit with msl-2 mRNA. Gebauer, F., Grskovic, M. & Hentze, M.W. Mol Cell 2003 May;11(5):1397-404. Europe PMC

Y14 and hUpf3b form an NMD-activating complex. Gehring, N.H., Neu-Yilik, G., Schell, T., Hentze, M.W. & Kulozik, A.E. Mol Cell 2003 Apr;11(4):939-49. Europe PMC

Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress. Thompson, K., Menzies, S., Muckenthaler, M., Torti, F.M., Wood, T., Torti, S.V., Hentze, M.W., Beard, J. & Connor, J. J Neurosci Res 2003 Jan 1;71(1):46-63. Europe PMC

Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Hubert, N. & Hentze, M.W. Proc Natl Acad Sci U S A 2002 Sep 17;99(19):12345-50. Europe PMC

Tolerable upper intakes for dietary iron set by the US Food and Nutrition Board. Schumann, K., Borch-Iohnsen, B., Hentze, M.W. & Marx, J.J. Am J Clin Nutr 2002 Sep;76(3):499-500. Europe PMC

Comparison of fluorescent tag DNA labeling methods used for expression analysis by DNA microarrays. Richter, A., Schwager, C., Hentze, S., Ansorge, W., Hentze, M.W. & Muckenthaler, M. Biotechniques 2002 Sep;33(3):620-8, 630. Europe PMC

c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs. Ostareck-Lederer, A., Ostareck, D.H., Cans, C., Neubauer, G., Bomsztyk, K., Superti-Furga, G. & Hentze, M.W. Mol Cell Biol 2002 Jul;22(13):4535-43. Europe PMC

Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay. Danckwardt, S., Neu-Yilik, G., Thermann, R., Frede, U., Hentze, M.W. & Kulozik, A.E. Blood 2002 Mar 1;99(5):1811-6. Europe PMC

The human intronless melanocortin 4-receptor gene is NMD insensitive. Brocke, K.S., Neu-Yilik, G., Gehring, N.H., Hentze, M.W. & Kulozik, A.E. Hum Mol Genet 2002 Feb 1;11(3):331-335. Europe PMC

Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway. Schell, T., Kulozik, A.E. & Hentze, M.W. Genome Biol 2002;3(3):REVIEWS1006. Europe PMC

Iron-dependent regulation of the divalent metal ion transporter. Gunshin, H., Allerson, C.R., Polycarpou-Schwarz, M., Rofts, A., Rogers, J.T., Kishi, F., Hentze, M.W., Rouault, T.A., Andrews, N.C. & Hediger, M.A. FEBS Lett 2001 Dec 7;509(2):309-16. Europe PMC

Generation of stable mRNA fragments and translation of N-truncated proteins induced by antisense oligodeoxynucleotides. Thoma, C., Hasselblatt, P., Kock, J., Chang, S.F., Hockenjos, B., Will, H., Hentze, M.W., Blum, H.E., von Weizsacker, F. & Offensperger, W.B. Mol Cell 2001 Oct;8(4):865-72. Europe PMC

Protein synthesis. Believe it or not-translation in the nucleus. Hentze, M.W. Science. 2001 Aug 10;293(5532):1058-9. Europe PMC

Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia. Gehring, N.H., Frede, U., Neu-Yilik, G., Hundsdoerfer, P., Vetter, B., Hentze, M.W. & Kulozik, A.E. Nat Genet 2001 Aug;28(4):389-92. Europe PMC

Fertility facts: male and female germ cell development requires translational control by CPEB. Gebauer, F. & Hentze, M.W. Mol Cell 2001 Aug;8(2):247-9. Europe PMC

IRP1 activation by extracellular oxidative stress in the perfused rat liver. Mueller, S., Pantopoulos, K., Hubner, C.A., Stremmel, W. & Hentze, M.W. J Biol Chem 2001 Jun 22;276(25):23192-6. Europe PMC

Construction of regulatable picornavirus IRESes as a test of current models of the mechanism of internal translation initiation. Poyry, T.A., Hentze, M.W. & Jackson, R.J. RNA 2001 May;7(5):647-60. Europe PMC

ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. Habelhah, H., Shah, K., Huang, L., Ostareck-Lederer, A., Burlingame, A.L., Shokat, K.M., Hentze, M.W. & Ronai, Z. Nat Cell Biol 2001 Mar;3(3):325-30. Europe PMC

Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs. Neu-Yilik, G., Gehring, N.H., Thermann, R., Frede, U., Hentze, M.W. & Kulozik, A.E. EMBO J 2001 Feb 1;20(3):532-40. Europe PMC

Lipoxygenase mRNA silencing in erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining. Ostareck, D.H., Ostareck-Lederer, A., Shatsky, I.N. & Hentze, M.W. Cell 2001 Jan 26;104(2):281-90. Europe PMC

Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure. De Gregorio, E., Baron, J., Preiss, T. & Hentze, M.W. RNA 2001 Jan;7(1):106-13. Europe PMC

Translational control of 15-lipoxygenase and msl-2 mRNAs: single regulators or corepressor assemblies? Gebauer, F., Ostareck, D.H., Ostareck-Lederer, A., Grskovic, M. & Hentze, M.W. Cold Spring Harb Symp Quant Biol 2001;66:329-36. Europe PMC

Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system. Bergamini, G., Preiss, T. & Hentze, M.W. RNA 2000 Dec;6(12):1781-90. Europe PMC

A new era for the RNA world. Conference: RNA 2000. Hentze, M.W., Izaurralde, E. & Seraphin, B. EMBO Rep. 2000 Nov;1(5):394-8. Europe PMC

The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation. Fortes, P., Inada, T., Preiss, T., Hentze, M.W., Mattaj, I.W. & Sachs, A.B. Mol Cell 2000 Jul;6(1):191-6 Europe PMC

[Pair of siblings of Italian ethnicity with hyperferritinemia and cataract] Volkmann, M., Schiff, J.H., Hor, M., Hentze, M.W., Fiehn, W. & Merkt, J. Internist (Berl) 2000 Apr;41(4):381-4 Europe PMC

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. McKie, A.T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T.J., Farzaneh, F., Hediger, M.A., Hentze, M.W. & Simpson, R.J. Mol Cell 2000 Feb;5(2):299-309 Europe PMC

Translational control of developmental decisions. Wickens, M., E.B. Goodwin, J. Kimble, S. Strickland & Hentze, M.W. In "Translational Control of Gene Expression" Sonenberg, N., Hershey, J.W.B. & Mathews, M.B. (eds.) Cold Spring Harbor Press, pp. 295-370

Translational repression assay procedure: a method to study RNA-protein interactions in yeast. Paraskeva, E. & Hentze, M.W. Methods Enzymol. 2000;318:374-84. Europe PMC

Nitric oxide, oxygen radicals and iron metabolism. Pantopoulos, K. & Hentze, M.W. In "Nitric Oxide: Biology and Pathobiology", L. Ignarro (ed.). Academic Press, 293-313

Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries. Castagnetti, S., Hentze, M.W., Ephrussi, A. & Gebauer, F. Development 2000;127(5):1063-1068 Europe PMC

HFE downregulates iron uptake from transferrin and induces iron- regulatory protein activity in stably transfected cells. Riedel, H.D., Muckenthaler, M.U., Gehrke, S.G., Mohr, I., Brennan, K., Herrmann, T., Fitscher, B.A., Hentze, M.W. & Stremmel, W. Blood 1999 Dec 1;94(11):3915-21 Europe PMC

Translational control of dosage compensation in Drosophila by Sex- lethal: cooperative silencing via the 5' and 3' UTRs of msl-2 mRNA is independent of the poly(A) tail. Gebauer, F., Corona, D.F., Preiss, T., Becker, P.B. & Hentze, M.W. EMBO J 1999 Nov 1;18(21):6146-54 Europe PMC

Human cytoplasmic aconitase (Iron regulatory protein 1) is converted into its [3Fe-4S] form by hydrogen peroxide in vitro but is not activated for iron-responsive element binding. Brazzolotto, X., Gaillard, J., Pantopoulos, K., Hentze, M.W. & Moulis, J.M. J Biol Chem 1999 Jul 30;274(31):21625-30 Europe PMC

Ligand-induced structural alterations in human iron regulatory protein- 1 revealed by protein footprinting. Gegout, V., Schlegl, J., Schlager, B., Hentze, M.W., Reinbolt, J., Ehresmann, B., Ehresmann, C. & Romby, P. J Biol Chem 1999 May 21;274(21):15052-8 Europe PMC

Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress. Gehring, N.H., Hentze, M.W. & Pantopoulos, K. J Biol Chem 1999 Mar 5;274(10):6219-25 Europe PMC

A perfect message: RNA surveillance and nonsense-mediated decay. Hentze, M.W. & Kulozik, A.E. Cell 1999 Feb 5;96(3):307-10. Europe PMC

Ribosomal pausing and scanning arrest as mechanisms of translational regulation from cap-distal iron-responsive elements. Paraskeva, E., Gray, N.K., Schlager, B., Wehr, K. & Hentze, M.W. Mol Cell Biol 1999 Jan 19(1) 807-816 Europe PMC

Regulation of iron metabolism in higher eukaryotes: iron-sulfur centers as genetic switches. Pantopoulos, K. & Hentze, M.W. In "Inorganic biochemistry and regulatory mechanisms of iron metabolism", Ferreira, G. C., Moura, J. J. G. & Franco, R. (eds.), Wiley-VCH, Weinheim, pp. 131-152

Poly(A)-tail-promoted translation in yeast: implications for translational control. Preiss, T., Muckenthaler, M. & Hentze, M.W. RNA 1998 Nov 4(11) 1321-1331 Europe PMC

Cytoplasmic regulatory functions of the KH-domain proteins hnRNPs K and E1/E2. Ostareck-Lederer, A., Ostareck, D.H. & Hentze, M.W. Trends Biochem Sci 1998 Nov 23(11) 409-411 Europe PMC

Activation of iron regulatory protein-1 by oxidative stress in vitro. Pantopoulos, K. & Hentze, M.W. Proc Natl Acad Sci U S A 1998 Sep 1 95(18) 10559-10563 Europe PMC

IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F. Muckenthaler, M., Gray, N.K. & Hentze, M.W. Mol Cell 1998 Sep 2(3) 383-388 Europe PMC

Molecular cloning and characterisation of a novel duodenal-specific gene implicated in iron absorption. McKie, A.T., Wehr, K., Simpson, R.J., Peters, T.J., Hentze, M.W. & Farzaneh, F. Biochem Soc Trans 1998 Aug;26(3):S264 Europe PMC

Translational activation of uncapped mRNAs by the central part of human eIF4G is 5' end-dependent. De Gregorio, E., Preiss, T. & Hentze, M.W. RNA 1998 Jul 4(7) 828-836 Europe PMC

Binary specification of nonsense codons by splicing and cytoplasmic translation. Thermann, R., Neu-Yilik, G., Deters, A., Frede, U., Wehr, K., Hagemeier, C., Hentze, M.W. & Kulozik, A.E. EMBO J 1998 Jun 15 17(12) 3484-3494 Europe PMC

Dual function of the messenger RNA cap structure in poly(A)-tail- promoted translation in yeast. Preiss, T. & Hentze, M.W. Nature 1998 Apr 2 392(6675) 516-520 Europe PMC

A translational repression assay procedure (TRAP) for RNA-protein interactions in vivo. Paraskeva, E., Atzberger, A. & Hentze, M.W. Proc Natl Acad Sci U S A 1998 Feb 3 95(3) 951-956 Europe PMC

The Drosophila splicing regulator sex-lethal directly inhibits translation of male-specific-lethal 2 mRNA. Gebauer, F., Merendino, L., Hentze, M.W. & Valcarcel, J. RNA 1998 Feb 4(2) 142-150 Europe PMC

Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans. Muckenthaler, M., Gunkel, N., Frishman, D., Cyrklaff, A., Tomancak, P. & Hentze, M.W. Eur J Biochem. 1998 Jun 1;254(2):230-7. Europe PMC

Systematic genomic screening and analysis of mRNA in untranslated regions and mRNA precursors: combining experimental and computational approaches. Dandekar, T., Beyer, K., Bork, P., Kenealy, M.R., Pantopoulos, K., Hentze, M., Sonntag-Buck, V., Flouriot, G., Gannon, F. & Schreiber, S. Bioinformatics 1998;14(3):271-8 Europe PMC

Novel functions for 'nuclear factors' in the cytoplasm: the Sex-lethal paradigm. Gebauer, F., Merendino, L., Hentze, M.W. & Valcarcel, J. Semin Cell Dev Biol 1997 Dec 8(6) 561-566 Europe PMC

Probing the structure of the regulatory region of human transferrin receptor messenger RNA and its interaction with iron regulatory protein- 1. Schlegl, J., Gegout, V., Schlager, B., Hentze, M.W., Westhof, E., Ehresmann, C., Ehresmann, B. & Romby, P. RNA 1997 Oct;3(10):1159-72 Europe PMC

Regulated poly(A) tail shortening in somatic cells mediated by cap- proximal translational repressor proteins and ribosome association. Muckenthaler, M., Gunkel, N., Stripecke, R. & Hentze, M.W. RNA 1997 Sep;3(9):983-95 Europe PMC

Starting at the beginning, middle, and end: translation initiation in eukaryotes. Sachs, A.B., Sarnow, P. & Hentze, M.W. Cell 1997 Jun 13 89(6) 831-838 Europe PMC

mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end. Ostareck, D.H., Ostareck-Lederer, A., Wilm, M., Thiele, B.J., Mann, M. & Hentze, M.W. Cell 1997 May 16;89(4):597-606 Europe PMC

Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress. Pantopoulos, K., Mueller, S., Atzberger, A., Ansorge, W., Stremmel, W. & Hentze, M.W. J Biol Chem 1997 Apr 11;272(15):9802-8 Europe PMC

eIF4G: a multipurpose ribosome adapter? Hentze, M.W. Science 1997 Jan 24 275(5299) 500-501 Europe PMC

Pathways for the regulation of macrophage iron metabolism by the anti- inflammatory cytokines IL-4 and IL-13. Weiss, G., Bogdan, C. & Hentze, M.W. J Immunol 1997 Jan 1;158(1):420-5 Europe PMC

Iron regulatory protein-1 (IRP-1) is differentially regulated by extracellular and intracellular hydrogen-peroxide. Muller, S, Pantopoulas, K., Atzberger, A., Ansorge, W., Hentze, M.W. & Stremmel, W. Gastroenterology 1997 112(4) 419

Mechanisms for posttranscriptional regulation by iron-responsive elements and iron regulatory proteins. Muckenthaler, M. & Hentze, M.W. Prog Mol Subcell Biol 1997;18:93-115 Europe PMC

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Hentze, M.W. & Kuhn, L.C. Proc Natl Acad Sci U S A 1996 Aug 6;93(16):8175-82 Europe PMC

Iron-sulfur clusters and oxidant stress responses Hentze, M.W. Trends Biochem Sci 1996 Aug;21(8):282-3 Europe PMC

Conservation of aconitase residues revealed by multiple sequence analysis. Implications for structure/function relationships. Frishman, D. & Hentze, M.W. Eur J Biochem 1996 Jul 1;239(1):197-200 Europe PMC

Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways. Pantopoulos, K., Weiss, G. & Hentze, M.W. Mol Cell Biol 1996 Jul;16(7):3781-8 Europe PMC

Iron-sulphur clusters as genetic regulatory switches: the bifunctional iron regulatory protein-1. Paraskeva, E. & Hentze, M.W. FEBS Lett 1996 Jun 24;389(1):40-3 Europe PMC

Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements. Gray, N.K., Pantopoulous, K., Dandekar, T., Ackrell, B.A. & Hentze, M.W. Proc Natl Acad Sci U S A 1996 May 14;93(10):4925-30 Europe PMC

Regulated ribosomal frameshifting by an RNA-protein interaction. Kollmus, H., Hentze, M.W. & Hauser, H. RNA 1996 Apr;2(4):316-23 Europe PMC

Overexpression of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution. Picard, V., Renaudie, F., Porcher, C., Hentze, M.W., Grandchamp, B. & Beaumont, C. Blood 1996 Mar 1;87(5):2057-64 Europe PMC

Rapid responses to oxidative stress mediated by iron regulatory protein. Pantopoulos, K. & Hentze, M.W. EMBO J 1995 Jun 15;14(12):2917-24 Europe PMC