Uwe Sauer is Professor of Systems Biology in the Department of Biology at the ETH Zurich. He earned his MS and PhD in microbiology from the University of Göttingen. During his postdoc work on metabolic engineering in the chemical engineering lab of Jay Bailey in Zurich, he became interested in computational modelling of cellular behaviour and quantitative analysis of intracellular fluxes in particular. In the late nineties, his research began to focus on quantitative understanding of interactions and regulation within complex microbial metabolic networks by using and developing cutting-edge experimental and computational methods.
For this purpose, research in the Sauer lab takes an interdisciplinary approach that combines quantitative experimentation and modelling to solve fundamental questions of complex metabolic network operation, allowing to engineer general cellular functions such as redox and energy metabolism. In particular, his lab has pioneered methods for 13C-flux analysis and is a key player in quantitative metabolomics, such that he became a well-recognized expert on central metabolism of bacteria and yeast.
Uwe Sauer has over 70 publications in peer-reviewed journals over the last 5 years, and is a member of various international editorial boards, scientific steering and advisory committees of international organisations and companies in systems biology and biotechnology.