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2015

A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain.
Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R.
Cancer Cell. 2015 Jun 8;27(6):780-96. doi: 10.1016/j.ccell.2015.04.017.
PMID:26058077

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R.
Nat Med. 2015 May;21(5):518-23. doi: 10.1038/nm.3852. Epub 2015 Apr 27.
PMID:25915831

A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.
Lu J, Luo C, Bali KK, Xie RG, Mains RE, Eipper BA, Kuner R.
Nat Commun. 2015 Apr 13;6:6820. doi: 10.1038/ncomms7820.
PMID:25865668

A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia.
Guida C, Altamura S, Klein FA, Galy B, Boutros M, Ulmer AJ, Hentze MW, Muckenthaler MU.
Blood. 2015 Apr 2;125(14):2265-75. doi: 10.1182/blood-2014-08-595256. Epub 2015 Feb 6.
PMID:25662334

Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency.
Martelli A, Schmucker S, Reutenauer L, Mathieu JR, Peyssonnaux C, Karim Z, Puy H, Galy B, Hentze MW, Puccio H.
Cell Metab. 2015 Feb 3;21(2):311-22. doi: 10.1016/j.cmet.2015.01.010.
PMID:25651183

Genetic targeting of chemical indicators in vivo.
Yang G, de Castro Reis F, Sundukova M, Pimpinella S, Asaro A, Castaldi L, Batti L, Bilbao D, Reymond L, Johnsson K, Heppenstall PA.
Nat Methods. 2015 Feb;12(2):137-9. doi: 10.1038/nmeth.3207. Epub 2014 Dec 8.

Systematic Cell-Based Phenotyping of Missense Alleles Empowers Rare Variant Association Studies: A Case for LDLR and Myocardial Infarction.
Thormaehlen AS, Schuberth C, Won HH, Blattmann P, Joggerst-Thomalla B, Theiss S, Asselta R, Duga S, Merlini PA, Ardissino D, Lander ES, Gabriel S, Rader DJ, Peloso GM, Pepperkok R, Kathiresan S, Runz H.
PLoS Genet. 2015 Feb 3;11(2):e1004855. doi: 10.1371/journal.pgen.1004855. eCollection 2015 Feb.PMID:25647241

2014

Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice.
Gritsch S, Lu J, Thilemann S, Wörtge S, Möbius W, Bruttger J, Karram K, Ruhwedel T, Blanfeld M, Vardeh D, Waisman A, Nave KA, Kuner R
Nature Communications 2014 Dec 1;5:5472.

Potential of fecal microbiota for early-stage detection of colorectal cancer.
Zeller G, Tap J, Voigt AY, Sunagawa S, Kultima JR, Costea PI, Amiot A, Böhm J, Brunetti F, Habermann N, Hercog R, Koch M, Luciani A, Mende DR, Schneider MA, Schrotz-King P, Tournigand C, Tran Van Nhieu J, Yamada T, Zimmermann J, Benes V, Kloor M, Ulrich CM, von Knebel Doeberitz M, Sobhani I, Bork P.
Mol Syst Biol. 2014 Nov 28;10:766.doi:10.15252/msb.20145645.PMID:25432777

Airway Mucus Obstruction Triggers Macrophage Activation and MMP12-dependent Emphysema.
Trojanek JB, Cobos-Correa A, Diemer S, Kormann M, Schubert SC, Zhou-Suckow Z, Agrawal R, Duerr J, Wagner CJ, Schatterny J, Hirtz S, Sommerburg O, Hartl D, Schultz C, Mall MA.
Am J Respir Cell Mol Biol. 2014 Nov;51(5):709-20.

5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.
Bhuvanagiri M, Lewis J, Putzker K, Becker JP, Leicht S, Krijgsveld J, Batra R, Turnwald B, Jovanovic B, Hauer C, Sieber J, Hentze MW, Kulozik AE.
EMBO Mol Med. 2014 Oct 15. pii: e201404461. doi: 10.15252/emmm.201404461.

Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors.
Woerner SM, Tosti E, Yuan YP, Kloor M, Bork P, Edelmann W, Gebert J.
Mol Carcinog. 2014 Sep 11. doi: 10.1002/mc.22213.

Transmembrane Protein 55B Is a Novel Regulator of Cellular Cholesterol Metabolism.
Medina MW, Bauzon F, Naidoo D, Theusch E, Stevens K, Schilde J, Schubert C, Mangravite LM, Rudel LL, Temel RE, Runz H, Krauss RM.
Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1917-23. doi: 10.1161/ATVBAHA.113.302806. Epub 2014 Jul 17. PMID:25035345

Noncoding RNAs: key molecules in understanding and treating pain.
Bali KK, Kuner R.
Trends Mol Med. 2014 Aug;20(8):437-448. doi: 10.1016/j.molmed.2014.05.006. Epub 2014 Jun 28. Review.

Resistance of Ferroportin to Hepcidin Binding causes Exocrine Pancreatic Failure and Fatal Iron Overload.
Altamura S, Kessler R, Gröne HJ, Gretz N, Hentze MW, Galy B, Muckenthaler MU.Cell Metab. 2014 Aug 5;20(2):359-67. doi: 10.1016/j.cmet.2014.07.007.

A new player in the game: epithelial cathepsin S in early cystic fibrosis lung disease
Mall MA, Schultz C.
Am J Respir Crit Care Med. 2014 Jul 15;190(2):126-7. doi: 10.1164/rccm.201405-0935ED.

Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical
pathways
.
Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R.
Neuron. 2014 Jul 2;83(1):104-21. doi: 10.1016/j.neuron.2014.05.037.

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia.
Shochat C1, Tal N, Gryshkova V, Birger Y, Bandapalli OR, Cazzaniga G, Gershman N, Kulozik AE, Biondi A, Mansour MR, Twizere JC, Muckenthaler MU, Ben-Tal N, Constantinescu SN, Bercovich D, Izraeli S.
Blood. 2014 Jul 3;124(1):106-10.   

Studying ongoing and spontaneous pain in rodents--challenges and opportunities.
Tappe-Theodor A, Kuner R.
Eur J Neurosci. 2014 Jun;39(11):1881-90. doi: 10.1111/ejn.12643. Epub 2014 May 29.

Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly.
Bharat, T.A., Castillo Menendez, L.R., Hagen, W.J., Lux, V., Igonet, S., Schorb, M., Schur, F.K., Krausslich, H.G. & Briggs, J.A.
Proc Natl Acad Sci U S A. 2014 May 19. pii: 201401455. Europe PMC

Atherogenesis and iron: from epidemiology to cellular level.
Vinchi F, Muckenthaler MU, Da Silva MC, Balla G, Balla J, Jeney V.
Front Pharmacol. 2014 May 5;5:94. doi: 10.3389/fphar.2014.00094. eCollection 2014. Review

The NC domain of Gag is dispensable for actin incorporation into HIV-1 and for association of viral budding sites with cortical F-actin.
Stauffer S1, Rahman SA, de Marco A, Carlson LA, Glass B, Oberwinkler H, Herold N, Briggs JA, Müller B, Grünewald K, Kräusslich HG.
J Virol. 2014 Apr 30. [Epub ahead of print]

Lack of neutrophil elastase reduces inflammation, mucus hypersecretion and emphysema, but not mucus obstruction, in mice with CF-like lung disease.
Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA.
Am J Respir Crit Care Med. 2014 Mar 28. [Epub ahead of print]

Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria
Chung J, Anderson SA, Gwynn B, Deck KM, Chen MJ, Langer NB, Shaw GC, Huston NC, Boyer LF, Datta S, Paradkar PN, Li L, Wei Z, Lambert AJ, Sahr K, Wittig JG, Chen W, Lu W, Galy B, Schlaeger TM, Hentze MW, Ward DM, Kaplan J, Eisenstein RS, Peters LL, Paw BH.
J Biol Chem. 2014 Mar 14;289(11):7835-43. doi: 10.1074/jbc.M114.547778. Epub 2014 Feb 7. Erratum in: J Biol Chem. 2014 May 16;289(20):13707. PMID:24509859

Sequencing of a patient with balanced chromosome abnormalities and neurodevelopmental disease identifies disruption of multiple high risk loci by structural variation
Blake J, Riddell A, Theiss S, Gonzalez AP, Haase B, Jauch A, Janssen JW, Ibberson D, Pavlinic D, Moog U, Benes V, Runz H.
PLoS One. 2014 Mar 13;9(3):e90894. doi: 10.1371/journal.pone.0090894. eCollection 2014. PMID:24625750

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to the proliferative Ras/RAF and the nutrient-dependent mTOR signaling pathways.
Mleczko-Sanecka, K., F. Roche, A.R. da Silva, D. Call, F. D’Allesio, A. Ragab, P.E. Lapinski, R. Ummanni, U. Korf, C. Oakes, G. Damm, L.A. D’Alessandro, U. Klingmüller, P.D. King, M. Boutros, M.W. Hentze and M.U. Muckenthaler. 
Blood. 2014 Mar 6;123(10):1574-85. doi: 10.1182/blood-2013-07-515957. Epub 2014 Jan 2. 

FRET-based and other fluorescent proteinase probes.
Hu HY, Gehrig S, Reither G, Subramanian D, Mall MA, Plettenburg O, Schultz C.
Biotechnol J. 2014 Feb;9(2):266-81. doi: 10.1002/biot.201300201. Epub 2014 Jan 27.

Clinical significance of microsatellite instability in colorectal cancer.
Kloor M, Staffa L, Ahadova A, von Knebel Doeberitz M.
Langenbecks Arch Surg. 2014 Jan;399(1):23-31. doi: 10.1007/s00423-013-1112-3. Epub 2013 Sep 19.

Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations.
Sommerburg O, Krulisova V, Hammermann J, Lindner M, Stahl M, Muckenthaler M, Kohlmueller D, Happich M, Kulozik AE, Votava F, Balascakova M, Skalicka V, Stopsack M, Gahr M, Macek M Jr, Mall MA, Hoffmann GF.
J Cyst Fibros. 2014 Jan;13(1):15-23. doi: 10.1016/j.jcf.2013.06.003. Epub 2013 Jul 25.  

A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis.
Casanovas G, Banerji A, d'Alessio F, Muckenthaler MU, Legewie S.
PLoS Comput Biol. 2014 Jan;10(1):e1003421.doi:10.1371/journal.pcbi.1003421. Epub 2014 Jan2.

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse.
Bandapalli OR, Schuessele S, Kunz JB, Rausch T, Stütz AM, Tal N, Geron I, Gershman N, Izraeli S, Eilers J, Vaezipour N, Kirschner-Schwabe R, Hof J, von Stackelberg A, Schrappe M, Stanulla M, Zimmermann M, Koehler R, Avigad S, Handgretinger R, Frismantas V, Bourquin JP, Bornhauser B, Korbel JO, Muckenthaler MU, Kulozik AE.
Haematologica. 2014 Jun 27. pii: haematol.2014.104992. [Epub ahead of print]

High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol.
Cario G1, Rhein P, Mitlöhner R, Zimmermann M, Bandapalli OR, Romey R, Moericke A, Ludwig WD, Ratei R, Muckenthaler MU, Kulozik AE, Schrappe M, Stanulla M, Karawajew L.
Haematologica. 2014 Jan;99(1):103-10. doi: 10.3324/haematol.2013.090225. Epub 2013 Aug 2.

mRNA 3'end processing: A tale of the tail reaches the clinic
Ina Hollerer, Kerstin Grund, Matthias W. Hentze, Andreas E. Kulozik
EMBO Mol Med. 2014 Jan 1;6(1):16-26. doi: 10.1002/emmm.201303300.

For more publications go to Research Groups