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Molecular Medicine Partnership UnitRecent Publications

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Hepcidin binding to ferroportin prevents exocrine pancreatic failure and fatal iron overload.
Altamura, S., R. Kessler, H.-J. Gröne, N. Gretz, M.W. Hentze, B. Galy and M.U. Muckenthaler.
Cell Metab., 2014, in press

Noncoding RNAs: key molecules in understanding and treating pain.
Bali KK, Kuner R.
Trends Mol Med. 2014 Aug;20(8):437-448. doi: 10.1016/j.molmed.2014.05.006. Epub 2014 Jun 28. Review.

Resistance of Ferroportin to Hepcidin Binding causes Exocrine Pancreatic Failure and Fatal Iron Overload.
Altamura S, Kessler R, Gröne HJ, Gretz N, Hentze MW, Galy B, Muckenthaler MU.
Cell Metab. 2014 Aug 5;20(2):359-67. doi: 10.1016/j.cmet.2014.07.007.

A new player in the game: epithelial cathepsin S in early cystic fibrosis lung disease.
Mall MA, Schultz C.
Am J Respir Crit Care Med. 2014 Jul 15;190(2):126-7. doi: 10.1164/rccm.201405-0935ED.

Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical
Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R,
Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R.
Neuron. 2014 Jul 2;83(1):104-21. doi: 10.1016/j.neuron.2014.05.037.

Lack of neutrophil elastase reduces inflammation, mucus hypersecretion and emphysema, but not mucus obstruction, in mice with CF-like lung disease.
Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA.
Am J Respir Crit Care Med. 2014 Mar 28. [Epub ahead of print]

Nitric oxide-mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in salmonella infection.
Nairz M, Schleicher U, Schroll A, Sonnweber T, Theurl I, Ludwiczek S, Talasz H, Brandacher G, Moser PL, Muckenthaler MU, Fang FC, Bogdan C, Weiss G
J Exp Med. 2013 May 6;210(5):855-73. doi: 10.1084/jem.20121946. Epub 2013 Apr 29

Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding
Iskar M, Zeller G, Blattmann P, Campillos M, Kuhn M, Kaminska KH, Runz H, Gavin AC, Pepperkok R, van Noort V, Bork P.
Mol Syst Biol. 2013 Apr 30;9:662. doi: 10.1038/msb.2013.20

RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory functions.
Blattmann P, Schuberth C, Pepperkok R, Runz H.
PLOS Genetics 2013 Feb;9(2):e1003338. doi: 10.1371/journal.pgen.1003338. Epub 2013 Feb 28.

Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain.
Simonetti M, Hagenston AM, Vardeh D, Freitag HE, Mauceri D, Lu J, Satagopam VP, Schneider R, Costigan M, Bading H, Kuner R.
Neuron. 2013 Jan 9;77(1):43-57. doi: 10.1016/j.neuron.2012.10.037

Spatially resolved monitoring of neutrophil elastase activity with ratiometric fluorescent reporters.
Gehrig S, Mall MA, Schultz C.
Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6258-61. doi: 10.1002/anie.201109226. Epub 2012 May 3.

Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by IRPs.
Sanchez, M., B. Galy, B. Schwanhaeusser, J. Blake, T. Bähr-Ivacevic, V. Benes, M. Selbach, M.U. Muckenthaler and M.W. Hentze.
Blood 118: e168-79, Nov 2011

Principles for designing fluorescent sensors and reporters.Lemke, E. A., Schultz, C. Nat Chem Biol. 2011 Jul 18;7(8):480-3. doi: 10.1038/nchembio.620.

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice.
Castoldi M, Vujić Spasić M, Altamura S, Elmén J, Lindow M, Kiss J, Stolte J, Sparla R, D'Alessandro LA, Klingmüller U, Fleming RE, Longerich T, Gröne HJ, Benes V, Kauppinen S, Hentze MW, Muckenthaler MU.
J Clin Invest. 2011 Apr 1;121(4):1386-96

SnapShot: protein-protein interaction networks.
Seebacher J. and Gavin A.C.
Cell 2011 March 18;144, 1000

p38 MAPK controls prothrombin expression by regulated RNA 3' end processing.
Danckwardt S, Gantzert AS, Macher-Goeppinger S, Probst HC, Gentzel M, Wilm M, Gröne HJ, Schirmacher P, Hentze MW, Kulozik AE.
Mol Cell. 2011 Feb 4;41(3):298-310.

Two to tango: regulation of mammalian iron metabolism
Hentze, M.W., M.U. Muckenthaler, B. Galy and C. Camaschella.
Cell 142, 24-38, 2010

Airway surface liquid volume regulation determines different airway phenotypes in liddle's compared to {beta}ENAC-overexpressing mice
Mall MA, Button B, Johannesson B, Zhou Z, Livraghi A, Caldwell RA, Schubert SC, Schultz C, O'Neal WK, Pradervand S, Hummler E, Rossier BC, Grubb BR, Boucher RC
J Biol Chem. 2010 Aug 27;285(35):26945-55. Epub 2010 Jun 21

SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology
Woerner SM, Yuan YP, Benner A, Korff S, von Knebel Doeberitz M, Bork P
Nucleic Acids Res. 2010 Jan; 38 (Database issue)

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression
Mleczko-Sanecka,K., G. Casanovas, A. Ragab, K. Breitkopf, M. Boutros, S. Dooley, M.W. Hentze, M.U. Muckenthaler.
Blood 115, 2657-2665, 2010

Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation
Cobos-Correa A, Trojanek JB, Diemer S, Mall MA, Schultz C.
Nat Chem Biol. 2009 Sep;5(9):628-30. Epub 2009 Aug 2.

Disassembly of exon junction complexes by PYM
Gehring N.H., S. Lamprinaki, A.E. Kulozik, M.W. Hentze.
Cell 2009 May 1;137(3):536-48.

DetecTiff: A novel image analysis routine for high content screening microscopy
Gilbert D, Meinhof T, Pepperkok R, Runz H.,
Journal of Biomolecular Screening 2009 Sep; 14(8):944-55. Epub 2009 Jul 29

Identification of cholesterol-regulating genes by targeted RNAi-screening
Bartz F, Kern L, Erz D, Zhu M, Gilbert D, Meinhof T, Wirkner U, Erfle H, Muckenthaler M, Pepperkok R, Runz H,
Cell Metab. 2009 Jul;10(1):63-75

The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.
Gehring N.H., S. Lamprinaki, M.W. Hentze, A.E. Kulozik.
PLoS Biol. 2009 May 26;7(5):e1000120. Epub 2009 May 26.

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD
Casanovas G, Mleczko-Sanecka K, Altamura S, Hentze MW, Muckenthaler MU.
J Mol Med. 2009 May;87(5):471-80. Epub 2009 Feb 20.

High frequency of LMAN1 abnormalities in colorectal tumors with microsatellite instability
Roeckel N, Woerner SM, Kloor M, Yuan YP, Patsos G, Gromes R, Kopitz J, Gebert, J.
Cancer Res 2009; 69(1):292-9.

For more publications go to Research Groups