Research GroupsCancer Early Detection, Diagnosis and Prevention (CED-DAP)
Research Focus 2: Pathogenetic mechanisms of MSI tumors
Preliminary evidence from our and other labs suggest that MSI tumor cells display altered pattern of cell surface glycosylation. Biochemical and molecular analyses are directed towards identifying these glycostructures in a cell culture models that allow inducible and regulated expression of specific MSI target genes. Resulting glycostructures are further evaluated in MSI tumor tissues. Differential Glycochip analyses will be used to identify alterations in components of the cellular glycosylation/deglycosylation machinery.