Bioinformatics at EMBLGroups
Bioinformatics activities at EMBL include, but is not limited to: whole genome analyses, metagenomics, analysis of gene, protein, and metabolic networks, structural biology, protein and nucleotide sequence analysis and large scale cell imaging. There are also activities in instrumentation and engineering software development, especially at the Grenoble and Hamburg outstations.
In addition to the groups listed below, EMBL-EBI includes a large number of labs dedicated to bioinformatics research and service provision.
In the list below, the bars at the bottom of each image indicate the proportion of that group's activity taken up by bioinformatics.
Arendt Group
Evolution of the nervous system in Bilateria
By studying and comparing simple marine organisms, the Arendt group looks to understand the origin and evolution of our central nervous system.
Barabas Group
Mechanism of DNA recombination and its applications for research and therapy
The Barabas group investigates how controlled DNA rearrangements - essential for survival at all levels of life, from individual cells to populations - are carried out at the molecular and cellular level.
Beck Group
Structure and function of large macromolecular assemblies
Research in the Beck group combines biochemical approaches, proteomics and cryo-electron microscopy to study large macromolecular assemblies.
Bertone Group
Pluripotency, reprogramming and differentiation
The Bertone Group analyses genetic and biochemical mechanisms underlying cellular differentiation events, particularly in human and mouse embryonic stem (ES) cell lines.
Bork Group
Deciphering function and evolution of biological systems
By analysing and comparing complex molecular data, the Bork group predicts function, gains insights into evolution, and makes connections between genes, organisms and ecosystems.
Briggs Group
Enveloped viruses and coated vesicles – cryo-electron microscopy and tomography
The Briggs group uses cryo-electron microscopy techniques to explore the mechanisms of assembly and budding of enveloped viruses and coated vesicles.
Carlomagno Group
Functional mechanisms of complex enzymes involved in RNA metabolism and methodology development for drug design
The Carlomagno group uses NMR spectroscopy in combination with biochemical and biophysical techniques to study the structure and dynamics of biomolecular complexes.
Ellenberg Group
Systems biology of cell division and nuclear organisation
The Ellenberg group studies how cells divide and organise in mitosis and meiosis, where errors can lead to problems such as cancer and infertility.
Furlong Group
Regulatory networks driving cell fate decisions: dissecting the logic
The Furlong group aims to understand fundamental principles of transcription, focusing on the processes that determine what a cell becomes during embryonic development.
Gavin Group
Biomolecular networks
The Gavin group focuses on detailed and systematic charting of cellular networks and circuitry at molecular levels in time and space.
GeneCore is the in-house genomics service centre at EMBL equipped with state-of-the-art technologies required for functional genomics analyses and operated by highly qualified staff.
Gibson Group
Biological sequence analysis
The Gibson team investigates protein sequence interactions, undertakes computational analyses of macromolecules, and develops tools to enhance sequence analysis research.
Hentze Group
Cytoplasmic gene regulation and molecular medicine
The Hentze group combines biochemical and systems level approaches to investigate the connections between gene expression, cell metabolism, and their role in human disease.
Heppenstall Group
Molecular physiology of somatosensation
The Heppenstall group combines molecular, imaging and electrophysiological techniques to examine how sensory neurons turn information about touch and pain into electrical signals.
Hiiragi Group
Systems-level understanding of early mammalian development
Looking at the molecular, cellular and systems levels, the Hiiragi group studies how, early in mammal development, the embryo is shaped from a spherical mass of cells.
Huber Group
Computational biology and genomics
The Huber Group develops computational and statistical methods to design and analyse novel experimental approaches in genetics and cell biology.
Hufnagel Group
Dynamics of cell growth and tissue architecture
The Hufnagel group studies the role of mechanical constraints on processes such as cell growth, programmed cell death, orientation of division, intra-tissue rearrangements and cell differentiation.
Korbel Group
Origin and function of genomic variation
The Korbel group combines experimental and computational biology to decipher the function and origin of genetic variation with a particular focus on heritable genomic structural variants (SVs) and such occurring in cancer.
Krijgsveld Team
Quantitative proteomics
The Krijgsveld team uses a combination of biochemistry, analytical chemistry, mass spectrometry and bioinformatics to study the role of proteins in cell behaviour.
Lamzin Group
Integrative modelling for structural biology
The Lamzin group applies and develops cutting-edge computational methods and experimental approaches for structural studies of molecules of biological and medical interest.
Lemke Group
Structural light microscopy - single molecule spectroscopy
The Lemke group combines advanced microscopy with modern chemical biology tools to elucidate the nature of naturally unfolded proteins in biological systems and disease mechanisms.
Leptin Group
Visualising complex cell shapes and signalling pathways
The Leptin group studies the mechanisms and forces that determine cell shape in Drosophila and uses the zebrafish to analyse innate immune signalling.
Neveu Group
Systems biology of stem cell differentiation
The Neveu group takes an integrated systems biology approach to investigate the molecular changes that determine what a stem cell becomes.
Panne Group
Integrating signals through complex assembly
The Panne group looks to understand important signalling processing pathways in the cell, which could help in the discovery of anti-viral drugs.
Patil Group
Architecture and regulation of metabolic networks
The Patil group uses a combination of modelling, bioinformatics, and experimental approaches to study metabolic networks and how they are controlled.
Peri Group
Microglia: the guardians of the developing brain
The Peri group combines genetic approaches with quantitative imaging techniques to study interactions between neurons and the microglia that eliminate cellular debris in the brain.
Pillai Group
Regulation of gene expression by non-coding RNAs
The Pillai group seeks to understand molecular mechanisms involved in piRNA biogenesis and its function in protecting the genome from instability.
Sachse Group
Single-particle electron cryo-microscopy of the machinery involved in abnormal protein aggregation
The Sachse group uses electron cryo-microscopy to study protein aggregates, typical of neurodegnerative diseases such as Alzheimer’s, and the mechanisms cells normally use to eliminate them.
Schultz Group
Chemical cell biology
The Schultz group develops tools for imaging and for manipulating cellular enzyme activities, with a particular emphasis on the hereditary disease cystic brosis.
Steinmetz Group
Systems genetics
The Steinmetz group bridges diverse domains of genome science, from deciphering the structure and function of genomes to the application of these insights in understanding diseases.
Svergun Group
Small-angle X-ray scattering from macromolecular solutions
The Svergun group places special emphasis on hybrid methods combining SAXS with X-ray crystallography, NMR spectroscopy, and electron microscopy to improve the resolution and cross-validate structural models.
Typas Group
Dissecting bacterial lifestyle and interspecies interactions with systems approaches
The Typas group develops and utilises high-throughput methods to study the cellular networks of different species of bacteria, and how these bacteria interact with the environment and with each other.
