Biochemical and chemical approaches to biomolecular networks

Biological or cellular functions emerge from networks of interacting molecules. We develop and apply (bio)chemical strategies to chart interactions between biomolecules on a large-scale. One of our recent focus concerns the development of metabolite arrays and the integration of biochemical protein purification and mass spectrometry to study interactions between proteins and small molecule metabolites.

Gavin Group

Selected publications

A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae.
Gallego, O., Betts, M.J., Gvozdenovic-Jeremic, J., Maeda, K., Matetzki, C., Aguilar-Gurrieri, C., Beltran-Alvarez, P., Bonn, S., Fernandez-Tornero, C., Jensen, L.J., Kuhn, M., Trott, J., Rybin, V., Muller, C.W., Bork, P., Kaksonen, M., Russell, R.B. & Gavin, A.C.
Mol Syst Biol. 2010 Nov 30;6:430.

Impact of genome reduction on bacterial metabolism and its regulation.

Yus, E., Maier, T., Michalodimitrakis, K., van Noort, V., Yamada, T., Chen, W.H., Wodke, J.A., Guell, M., Martinez, S., Bourgeois, R., Kuhner, S., Raineri, E., Letunic, I., Kalinina, O.V., Rode, M., Herrmann, R., Gutierrez-Gallego, R., Russell, R.B., Gavin, A.C., Bork, P. & Serrano, L.
Science. 2009 Nov 27;326(5957):1263-8.

Transcriptome complexity in a genome-reduced bacterium.
Guell, M., van Noort, V., Yus, E., Chen, W.H., Leigh-Bell, J., Michalodimitrakis, K., Yamada, T., Arumugam, M., Doerks, T., Kuhner, S., Rode, M., Suyama, M., Schmidt, S., Gavin, A.C., Bork, P. & Serrano, L.
Science. 2009 Nov 27;326(5957):1268-71.

Proteome organization in a genome-reduced bacterium.
Kühner S., van Noort V., Betts M.J., Leo-Macias A., Batisse C., Rode M., Yamada T., Maier T., Bader S., Beltran-Alvarez P., Castaño-Diez D., Chen W.H., Devos D., Güell Cargol M., Norambuena T., Racke I., Rybin V., Schmidt A., Yus E., Aebersold R., Herrmann R., Böttcher B., Frangakis A.S., Russell R.B., Serrano L., Bork, P. and Gavin, A.C.
Science, 2009, 326, 1235-1240