Chemistry at EMBL
Structural biology of macromolecular complexes
The Wilmanns Group is interested in structural/functional relations of protein targets of biomedical relevance. For some of our targets, we are interested to identify small molecule inhibitors, either to modulate enzymatic activity or to interfere with assembly processes. Our approach is either by experimental compound screening or by structure-based in silico screening, followed by assay-based refinement of promising compounds using medicinal chemistry. Examples in recent research are on targets from Mycobacterium tuberculosis, protein kinases and a number of transcription factors.
Bimolecular fluorescence complementation in structural biology. Song YH, Wilmanns M. Methods. 2008 Jul;45(3):219-22.
Structure-based approaches to drug discovery against tuberculosis. Holton SJ, Weiss MS, Tucker PA, Wilmanns M. Curr Protein Pept Sci. 2007 Aug;8(4):365-75.
The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase. Ma Q, Zhao X, Nasser Eddine A, Geerlof A, Li X, Cronan JE, Kaufmann SH, Wilmanns M. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8662-7.