Seminar Colour Guide:              
External Faculty Speaker
Friday, 30 January 2015, 11:00 Add to calendar Fly thorax morphogenesis: from cell dynamics to tissue shape Francois Graner, Systèmes Complexes, Université Paris Diderot, France Host: Jean-Léon Maitre
Small Operon, EMBL Heidelberg
Abstract: Fly thorax morphogenesis: from cell dynamics to tissue shape

During animal development, several planar cell polarity pathways control tissue shape by coordinating collective cell behavior. Our model system is the Drosophila dorsal thorax. During the fly metamorphosis, it changes from larval to adult shape within a few days. We image it over several orders of magnitude in space and time. A general set of quantitative tools links the sub-cell scale, the cell dynamics, the level of the group of cells, and the whole tissue. In close interaction between biologists and physicists, we characterize both the Fat/Dachsous/ Four-jointed pathway and its control on the mechanics. Cell tension anisotropy defines the pattern of local tissue contraction that contributes to shaping the epithelium, mainly via oriented cell rearrangements. These results establish how tissue planar polarization coordinates the local changes of cell mechanical properties to control tissue morphogenesis.
Company Representative
Monday, 2 February 2015, 09:30 Add to calendar Basics in Light Microscopy Jens Marquardt, Olympus, Germany Host: Stefan Terjung
Room 202, EMBL Heidelberg
Company Representative
Tuesday, 3 February 2015, 09:30 Add to calendar Basics in Fluorescence Microscopy Jens Marquardt, Olympus, Germany Host: Stefan Terjung
Room 202, EMBL Heidelberg
External Faculty Speaker
Tuesday, 3 February 2015, 11:00 Add to calendar Stem cell dynamics in homoeostasis and cancer Edward Morrissey, Cancer Research UK Cambridge Research Institute, United Kingdom Host: Anne Ephrussi
Large Operon, EMBL Heidelberg
Abstract: The intestinal epithelium is characterised by rapid cellular turnover sustained by adult stem cells located at the base of glandular crypts.
Based on expression of specific genes and cell location, several different crypt base sub-populations have been put forward as intestinal
stem cells, making it unclear how this compartment works.

In this talk I will describe how a novel mutationally-activated cell reporter gene in a mouse model combined with mathematical
modelling, allows description of the behaviour of stem cells in homoeostasis and in adenomas. In addition, building on these
quantitative behaviours in homoeostasis we were able to model and quantify the evolutionary advantages of stem cells harbouring
oncogenic mutations, when competing against wild type cells.
Seminar given by an external postdoc
Tuesday, 3 February 2015, 14:30 Add to calendar Integrated on-chip platform for optical trapping, sensing and fluorescence bio-imaging applications Balpreet Singh Ahluwalia, The Arctic University of Norway, Norway Host: Yannick Schwab
Large Operon, EMBL Heidelberg
Abstract: In this talk, I will present the recent developments in our lab on planar trapping of particles and cells using optical waveguides. On-chip approach to trap, transport and levitate micro-particles using the surface evanescent field is proposed. Red blood cells are trapped and deformed on top of optical waveguides and loss of blood deformability with storage is monitored.
I will also present some of the recent work on integrated optical microscopy, super-resolution bio-imaging and discuss the future direction of "integrated optical nanoscopy", the project funded by ERC Starting grant.

EMBL Distinguished Visitor Lecture
Monday, 9 February 2015, 11:00 Add to calendar Metabolic Prostheses Synthetic Biology-Inspired Treatment Strategies For Metabolic Disorders Martin Fussenegger, ETH Zurich, Department of Biosystems Science and Engineering, Switzerland Host: Kiran Patil
Large Operon, EMBL Heidelberg
Abstract: Since Paracelsus (1493-1541) definition that the dosing makes the drug the basic treatment strategies have lagely remained unchanged. We continue to use a precise prescribed dose of a small-molecule drug, a protein therapeutic or a therapeutic transgene to constitutively modulate or complement the activity of a disease-relevant target. However, this treatment concept does neither consider the metabolic dynamics nor the interdependence of the most important pathophysiologies of the 21st century such as obesity, diabetes and cardiovascular disorders. Synthetic biology-inspired prosthetic networks may act as metabolic prostheses that provide the dynamic interventions, the immediate pre-disease action and the multi-target capacity required to meet with the treatment challenges of the future. Prosthetic networks consist of synthetic sensor-effector gene circuits that (i) seamlessly operate in implanted designer cells, (ii) constantly sense, monitor and score metabolic disturbanes in peripheral circulation, (iii) process OFF-level concentrations of pathologic metabolites, and (iv) coordinate an adjusted therapeutic response in an (v) automatic and self-sufficient manner. We will present our latest generation of synthetic mammalian gene circuits and provide a few examples of prosthetic networks operating in animal models of prominent human diseases to highlight the challenges and impact of synthetic biology on future biomedical applications
External Faculty Speaker
Monday, 9 February 2015, 16:30 Add to calendar Human proteomes from basic science to understanding drug action Bernhard Kuster, Technical University Munich, Germany Host: Jeroen Krijgsveld
Small Operon, EMBL Heidelberg
Company Representative
Tuesday, 10 February 2015, 11:00 Add to calendar Open Science publishing: moving beyond Open Access Michaela Torkar, F1000 Research, United Kingdom Host: Wolfgang Huber
Small Operon, EMBL Heidelberg
Science and Society
Wednesday, 18 February 2015, 15:00 Add to calendar The threat of manufactured disease: The past, present & future of biological weapons Filippa Lentzos, King's College London, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 19 February 2015, 11:00 Add to calendar To be announced Steven Block, Stanford University , Dept. of Biology and Applied Physics, USA Host: Jonas Ries
Large Operon, EMBL Heidelberg
Tags: Cell Biology
Company Representative
Monday, 23 February 2015, 09:30 Add to calendar Basics in Confocal Microscopy Florian Eich, Olympus, Germany Host: Stefan Terjung
ATC - Courtyard A+B, EMBL Heidelberg
Company Representative
Tuesday, 3 March 2015, 11:00 Add to calendar siPOOLs: complex and defined siRNA pools prevent off-target effects Michael Hannus, siTools, Germany Host: Beate Neumann
Small Operon, EMBL Heidelberg
Abstract: For years, RNAi was considered the magic bullet of functional genomics, promising fast, specific and scalable genetic intervention.

Hype was followed by disappointment when it was shown that off-target effects frequently dominate the phenotypic response in RNAi experiments. Nevertheless, RNAi remains the standard technique for gene inactivation because of its many advantages, such as transient, dose-dependent effects and ease of arrayed screening.

Complex siRNA pools apply a conceptually simple but efficient approach to prevent off-target effects: All siRNAs share the same on-target gene but have different off-target footprints. As a result, off-target effects are efficiently diluted and target gene knockdown becomes very robust.
http://www.sitoolsbiotech.com/

The talk is also open for non-EMBL members.
Science and Society
Monday, 30 March 2015, 15:00 Add to calendar Crafting Stories About Science Ben Lillie, freelance writer and comedian, New York, USA Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 17 April 2015, 11:00 Add to calendar To be announced Stefano Piccolo, University of Padua, Dept. of Molecular Medicine, Italy Host: Darren Gilmour
Large Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Wednesday, 22 April 2015, 14:00 Add to calendar To be announced Andreas Beyer, University of Cologne, Germany Host: Leopold Parts
Small Operon, EMBL Heidelberg
Science and Society
Thursday, 23 April 2015, 15:00 Add to calendar The neuroscience of laughter Sophie Scott, University College London, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
Science and Society
Wednesday, 29 April 2015, 18:00 Add to calendar Computer-Gehirn Interface Niels Birbaumer, University of Tuebingen, Germany Host: Halldór Stefánsson
all EMBL HD
EMBL Distinguished Visitor Lecture
Thursday, 30 April 2015, 11:00 Add to calendar To be announced Caroline DEAN, John Innes Centre, Dept. of Cell & Developmental Biology, Norwich, UK, United Kingdom Host: Anne Ephrussi
Large Operon, EMBL Heidelberg
External Faculty Speaker
Tuesday, 5 May 2015, 11:00 Add to calendar Regulating chromosome-wide gene expression by nuclear positioning: dosage compensation in C. elegans Peter Meister, University of Bern, Institute of Cell Biology, Switzerland Host: Christian Haering
Small Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Tuesday, 12 May 2015, 11:00 Add to calendar To be announced Elly Tanaka, Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany Host: Anne Ephrussi
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Monday, 15 June 2015, 11:00 Add to calendar To be announced James E. Ferrell, Stanford University, Dept. of Chemical and Systems Biology, USA Host: Francois Nedelec
Large Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Thursday, 2 July 2015, 11:00 Add to calendar To be announced Adam Arkin, University of California, Berkeley, Dept. of Bioengineering, USA Host: Nassos Typas
ATC Auditorium, EMBL Heidelberg
Science and Society
Monday, 13 July 2015, 14:00 Add to calendar Decoding Race Catherine Bliss, University of California, San Francisco, USA Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 16 September 2015, 11:00 Add to calendar To be announced Thomas Pollard, Yale University, New Haven, Dept. of Molecular Cellular & Developmental Biology, USA Host: Peter Lenart
Large Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Tuesday, 22 September 2015, 11:00 Add to calendar To be announced Christine Holt, University of Cambridge, Dept. of Developmental Neuroscience, United Kingdom Host: Jeroen Krijgsveld
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 30 September 2015, 16:00 Add to calendar To be announced Mary Beckerle, Huntsman Cancer Institute, Salt Lake City, Host: Francois Nedelec
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Monday, 5 October 2015, 11:00 Add to calendar To be announced Raymond E. Goldstein, University of Cambridge, Dept. of Applied Mathematics and Theoretical Physics, Center for Mathematical Sciences, United Kingdom Host: Predocs
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Tuesday, 27 October 2015, 11:00 Add to calendar To be announced Cynthia Wolberger, John Hopkins University School of Medicine, Dept. of Biophysics and Biophysical Chemistry, Baltimore, USA Host: Christoph Mueller
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Monday, 16 November 2015, 11:00 Add to calendar To be announced Herwig Baier, Max-Planck-Institute Martinsried, Dept. for Neurology, Germany Host: Francesca Peri
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 10 December 2015, 11:00 Add to calendar To be announced Marianne Bronner, California Institute of Technology, Division of Biology, Pasadena, USA Host: Detlev Arendt
Large Operon, EMBL Heidelberg