Seminar Colour Guide:              
EMBL Distinguished Visitor Lecture
Thursday, 2 July 2015, 11:00 Add to calendar Knowledge, Context, and Process: Building a foundational infrastructure for engineering cells for use in an uncertain world Adam Arkin, University of California, Berkeley, Dept. of Bioengineering, USA Host: Nassos Typas
Large Operon, EMBL Heidelberg
Abstract: Both natural and synthetically-augmented organisms like those engineered to produce advanced biofuels ultimately have to operate in an uncertain world. Resources change, contact with other life yield surprising interactions, and in some cases changes in one s own genetic code lead to new (and usually unwanted) behaviors. Predictable behavior and predictable engineering of organisms in the face of these uncertainties is a core challenge in making synthetic biology a true engineering science. To realize this will take a systems engineering view of the problem: invention of tools for rapid manufacture and characterization of biological function in changeable contexts; design and discovery of reliable and flexible sets of biological elements and rules for their composition that reduce variability in their operation; and computer-aided design and manufacturing knowledge systems to make efficient design-build-test-learn cycles feasible. Here I will discuss our approaches to all three issues and how scaling of biomanufacture and characterization is driving the creation of biofoundries to solve problems in energy, health and the environment.
Company Representative
Friday, 3 July 2015, 11:00 Add to calendar CRISPR-based Genome Editing Tools: New Applications and Streamlined Workflows Jon D. Chesnut, Thermo Fisher Scientific, USA Host: Vladimir Benes
Small Operon, EMBL Heidelberg
Abstract: CRISPR-Cas9 is rapidly evolving as the tool
of choice for genome editing in mammalian c cells. However, the delivery of Cas9 and synthesis of guide RNA (gRNA) remain two
steps that limit overall efficiency and
general ease of use. Here we describe novel
methods for rapid synthesis of gRNA and
delivery of Cas9 protein/gRNA complexes into a variety of cells. This workflow enables highly efficient genome editing and biallelic knockout of multiple genes in hard-to-transfect cells in as little as three to four days. The reagent preparation and delivery to cells requires no plasmid manipulation so is amenable for high throughput, multiplexed genome-wide cell engineering.
Further, we will show data using lentivirus-based CRISPR delivery for high-throughput screening of mammalian cell populations. We are creating gene family-specific arrayed libraries of CRISPR-lenti particles that will enable high throughput, arrayed gene knockout screens using various cell types.
These two CRISPR-based gene-editing platforms represent the latest in the rapid evolution of editing tools for mammalian genomes by simplifying cell engineering workflow and providing a pre-designed, ready to use platform for efficient compound screening in mammalian cell lines.
Career Day
Thursday, 9 July 2015, 10:00 Add to calendar EMBL's Career Day 2015 EMBL Career Day, EMBL, Germany Host: EICAT (PhD and Postdoctoral Programmes)
ATC Auditorium, EMBL Heidelberg
Abstract: Organised by EICAT (PhD and Postdoctoral Programmes) together with EMBLEM, Career Day provides an overview of alternative, non-academic career possibilities for scientists from all EMBL sites and the local scientific community.
Seminar given by an external postdoc
Monday, 13 July 2015, 11:00 Add to calendar Enabling Proteomics to Shift from List Building to Robust Quantitative Measurements Mike MacCoss, Professor of Genome Sciences, Department of Genome Sciences, University of Washington, USA Host: Theodore Alexandrov
ATC - Courtyard A+B, EMBL Heidelberg
Science and Society
Monday, 13 July 2015, 14:00 Add to calendar Decoding Race Catherine Bliss, University of California, San Francisco, USA Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
Abstract: This talk will present the move in the genomic sciences toward recasting race as a multifaceted entity worth understanding from a genomic perspective. By the early 2000s, one could say that genomic science had taken a sociogenomic approach to race − a view that race has a genetically determined component and a socially constructed component. Scientists facing scrutiny from editors, social scientists, public health experts, and bioethicists adopted social epidemiological frames for investigating the molecular, and made racial health disparities a focus of their work. As scientists were called on to solve public health dilemmas around race and health, they made the study of social problems, identity, representation, and minority recruitment a mainstay of their race-conscious investigations.
External Faculty Speaker
Tuesday, 21 July 2015, 11:00 Add to calendar To be announced Ralf Jungmann, Max-Planck-Institute of Biochemistry, Martinsried, Germany Host: Jonas Ries
Small Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Monday, 27 July 2015, 16:00 Add to calendar Drug action in the context of the proteome Marcus Bantscheff, Cellzome, Germany Host: Carsten Schultz and Gerard Drewes
Small Operon, EMBL Heidelberg
Seminar given by an external postdoc
Wednesday, 29 July 2015, 11:00 Add to calendar To be announced Bianca Schrul, Stanford University, Biology Department, , USA Host: Jan Ellenberg
Small Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Monday, 14 September 2015, 16:00 Add to calendar Living droplets - biomedical discovery at high throughput Christoph Merten, EMBL, Germany Host: Carsten Schultz and Gerard Drewes
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 16 September 2015, 11:00 Add to calendar To be announced Thomas Pollard, Yale University, New Haven, Dept. of Molecular Cellular & Developmental Biology, USA Host: Peter Lenart
Large Operon, EMBL Heidelberg
Tags: Cell Biology
Science and Society
Sunday, 20 September 2015, 14:00 Add to calendar EMBL Heidelberg Science & Society Symposium: What makes us human? Various speakers, MPI for Evolutionary Anthropology, Collège de France, University of Notre Dame Host: Halldór Stefánsson
The Operon, EMBL Heidelberg
Abstract: Humans are distinctly different from all the other animals, in ways both good and bad. But articulating what that difference consists of remains a complex and difficult task, tackled by biologists, anthropologists and brain scientists.

We are, presumably, the only known species with a mind set on unravelling who and what we are. Today, scientists are making use of genomics to realign H. Sapiens with respect to H. neanderthalensis, hominids and apes. But what are the assumptions that are built into these research projects? And what is the nature of the evolved cognitive faculties that allow people to relate and bond to one another in our species-specific way? Are some of our behavioral responses hardwired in neural networks as a result of our evolutionary history, or does the ultimate strength of the human species lie in its apparently unlimited neurological plasticity?

And while humans seem so fabulously well equipped to relate to one another and spin intricate webs of social relations, at the same time they tirelessly invent ways and means of destroying each other in warfare. Is such behaviour to be considered a part of our human nature? Globally speaking, what role do nature, culture and our social environment play in the crafting of humans?
EMBL Distinguished Visitor Lecture
Tuesday, 22 September 2015, 11:00 Add to calendar To be announced Christine Holt, University of Cambridge, Dept. of Developmental Neuroscience, United Kingdom Host: Jeroen Krijgsveld
Large Operon, EMBL Heidelberg
External Faculty Speaker
Wednesday, 23 September 2015, 11:00 Add to calendar To be announced Kieran Tuohy, Research and Innovation Centre-Fondazione Edmund Mach-IASMA, Italy Host: Kiran Patil
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 30 September 2015, 16:00 Add to calendar To be announced Mary Beckerle, Huntsman Cancer Institute, Salt Lake City, Host: Francois Nedelec
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Monday, 5 October 2015, 11:00 Add to calendar To be announced Raymond E. Goldstein, University of Cambridge, Dept. of Applied Mathematics and Theoretical Physics, Center for Mathematical Sciences, United Kingdom Host: Predocs
Large Operon, EMBL Heidelberg
Company Representative
Thursday, 8 October 2015, 15:00 Add to calendar To be announced Jasmin Fisher, Microsoft UK, United Kingdom Host: Francois Nedelec/Karin Sasaki
Small Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Monday, 12 October 2015, 16:00 Add to calendar Controlling Biological Pathways with Photopharmacology Dirk Trauner, University of Munich, Germany Host: Carsten Schultz and Gerard Drewes
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Tuesday, 20 October 2015, 11:00 Add to calendar To be announced Irving Weissman, Stanford University, Institute for Stem Cell Biology and Regenerative Medicine, Standford Ludwig Center for Cancer Stem Cell Research and Medicine, USA Host: Lars Steinmetz
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Tuesday, 27 October 2015, 11:00 Add to calendar To be announced Cynthia Wolberger, John Hopkins University School of Medicine, Dept. of Biophysics and Biophysical Chemistry, Baltimore, USA Host: Christoph Mueller
Large Operon, EMBL Heidelberg
Science and Society
Tuesday, 27 October 2015, 15:00 Add to calendar The Nazi Human Experiments and Post-War Legacies Paul Weindling, Oxford Brookes University, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
Science and Society
Wednesday, 4 November 2015, 18:00 Add to calendar Tomorrow's Table: Organic farming, genetics and the future of food Pamela Ronald, Genome Center, University of California, USA Host: Halldór Stefánsson
Print Media Academy
Abstract: In their book, Tomorrow's Table, Pamela Ronald, a geneticist, and her husband, Raoul Adamchak, an organic farmer, argue that a judicious blend of two important strands of agriculture--genetic engineering and organic farming--is key to helping feed the world's growing population in an ecologically balanced manner. Ronald will describe the challenges that farmers face, as they try to feed the world without further destroying the environment.

The lecture is for technologists, entrepreneurs, consumers, farmers, and policy decision makers who want to make food choices or create policy and businesses that will support ecologically responsible farming practices. It is also for anyone who wants accurate information about organic farming, genetic engineering, and their potential impacts on human health and the environment.
EMBL Distinguished Visitor Lecture
Monday, 16 November 2015, 11:00 Add to calendar To be announced Herwig Baier, Max-Planck-Institute Martinsried, Dept. for Neurology, Germany Host: Francesca Peri
Large Operon, EMBL Heidelberg
Science and Society
Thursday, 19 November 2015, 15:00 Add to calendar Integrated omic studies for common complex traits & personalised medicine Tim Spector, King's College London, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
Abstract: We are using a large-scale multi-omic study of 5,000 adult twins to explore the potential of omics in personalized medicine. The TwinsUK resource contains the most studied individuals on the planet with all subjects having over 3000 phenotypes and GWAS SNP chips. Over 3000 now have whole genome sequencing at 6-30X depth. The omics being explored includes sub-studies used to explore the basic heritability, QTLs and age relationships as well as disease associations. This includes (EpiTWIN) using whole genome methylation sequencing and 450k for epigenetics, which also uses the discordant twin design using for replication 30,000 twins from the Discotwin European consortium. The same individuals are tested using an integrated omics approach including- the Multiple Human Tissue Expression Resource (MuTHER) and with RNA array and sequencing in three tissues. In addition we have analysed 1000 blood metabolites using metabolomics (Mass Spec and NMR), >100 glycomics markers (IgG and total plasma), immunophenotyping (with 78,000 White cell sub-types) and gut microbiomes (16s and metagenomics) on the same twins. Most subjects are being followed longitudinally to assess prediction of incident disease. Examples of recent integrated Omic analyses include prediction of age, pain sensitivity, renal function, hypertension, cancer, depression, obesity and diabetes. Longitudinal twin studies with global collaborations are the ideal resource to study the potential of personalized medicine.
External Faculty Speaker
Thursday, 26 November 2015, 11:00 Add to calendar To be announced Eirikur Steingrimsson, University of Iceland, Iceland Host: Anne Ephrussi
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 27 November 2015, 11:00 Add to calendar To be announced Nicholas Proudfoot, University of Oxford, Dept. of Molecular Biology , School of Pathology, United Kingdom Host: Eileen Furlong
Large Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 7 December 2015, 16:00 Add to calendar Precision tools to custom tailor proteins Edward Lemke, EMBL, Germany Host: Carsten Schultz and Gerard Drewes
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 10 December 2015, 11:00 Add to calendar To be announced Marianne Bronner, California Institute of Technology, Division of Biology, Pasadena, USA Host: Detlev Arendt
Large Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 18 January 2016, 11:00 Add to calendar To be announced Cassandra Extavour, Department of Organismic and Evolutionary Biology, Department of Molecular and Cellular Biology, Harvard University, , USA Host: Anne Ephrussi
Small Operon, EMBL Heidelberg
External Faculty Speaker
Wednesday, 3 February 2016, 11:00 Add to calendar To be announced Ben Lehner, Centre for Genomic Regulation, Pompeu Fabra University, Spain Host: Kiran Paril
Small Operon, EMBL Heidelberg