Seminar Colour Guide:              
Seminar given by an external postdoc
Monday, 7 September 2015, 09:00 Add to calendar Systems proteomics and trans-omic data integration illuminate genetic mechanisms linking mitochondrial function to metabolism Yibo Wu, Swiss Federal Institute of Technology Zürich (ETHZ), Switzerland Host: Eileen Furlong/Rainer Pepperkok
Large Operon, EMBL Heidelberg
Seminar given by an external postdoc
Monday, 7 September 2015, 10:00 Add to calendar Integration of global proteomics with genomics provides new insights into immunology and cancer Philipp Mertins, The Broad Institute of MIT and Harvard, Cambridge, USA Host: Eileen Furlong/Rainer Pepperkok
Large Operon, EMBL Heidelberg
Seminar given by an external postdoc
Monday, 7 September 2015, 11:00 Add to calendar From Technical Development to Translational Research: Enabling Ultrasensitive Proteomics Christopher Hugues, British Columbia Cancer Research Institute, Vancouver, Canada Host: Eileen Furlong/Rainer Pepperkok
Large Operon, EMBL Heidelberg
Seminar given by an external postdoc
Tuesday, 8 September 2015, 09:00 Add to calendar Unbiased assessment of protein state and function in live cells Mikhail Savitski, Cellzome, Heidelberg, Germany Host: Eileen Furlong/Rainer Pepperkok
Large Operon, EMBL Heidelberg
Seminar given by an external postdoc
Tuesday, 8 September 2015, 10:00 Add to calendar Cross-Linking and Mass Spectrometry: Architecture and Mechanism of Chromatin-Associated Complexes and Beyond Franz Herzog, Gene Center of the Ludwig-Maximilians-Universität, Munich, Germany Host: Eileen Furlong/Rainer Pepperkok
Large Operon, EMBL Heidelberg
Seminar given by an external postdoc
Tuesday, 8 September 2015, 11:00 Add to calendar Comprehensive characterization of protein structures, interactions and post-translational modifications Fan Liu, Biomolecular Mass Spectrometry and Proteomics Group, Utrecht University, Utrecht, Netherlands Host: Eileen Furlong/Rainer Pepperkok
Large Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 14 September 2015, 16:00 Add to calendar Living droplets - biomedical discovery at high throughput Christoph Merten, EMBL, Germany Host: Carsten Schultz and Gerard Drewes
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 16 September 2015, 11:00 Add to calendar Mechanism of cytokinesis in fission yeast Thomas Pollard, Yale University, New Haven, Dept. of Molecular Cellular & Developmental Biology, USA Host: Peter Lenart
Large Operon, EMBL Heidelberg
Abstract: Biochemical characterization of the molecules and quantitative measurements in live cells provided the data required to formulate and test mathematical models of all of the major steps in cytokines, interphase preparation, assembly of a contractile ring and constriction of the ring. Tags: Cell Biology
Science and Society
Sunday, 20 September 2015, 14:00 Add to calendar EMBL Heidelberg Science & Society Symposium: What makes us human? Various speakers, MPI for Evolutionary Anthropology, Collège de France, University of Notre Dame Host: Halldór Stefánsson
The Operon, EMBL Heidelberg
Abstract: Humans are distinctly different from all the other animals, in ways both good and bad. But articulating what that difference consists of remains a complex and difficult task, tackled by biologists, anthropologists and brain scientists.

We are, presumably, the only known species with a mind set on unravelling who and what we are. Today, scientists are making use of genomics to realign H. Sapiens with respect to H. neanderthalensis, hominids and apes. But what are the assumptions that are built into these research projects? And what is the nature of the evolved cognitive faculties that allow people to relate and bond to one another in our species-specific way? Are some of our behavioral responses hardwired in neural networks as a result of our evolutionary history, or does the ultimate strength of the human species lie in its apparently unlimited neurological plasticity?

And while humans seem so fabulously well equipped to relate to one another and spin intricate webs of social relations, at the same time they tirelessly invent ways and means of destroying each other in warfare. Is such behaviour to be considered a part of our human nature? Globally speaking, what role do nature, culture and our social environment play in the crafting of humans?
EMBL Distinguished Visitor Lecture
CANCELLED - Tuesday, 22 September 2015, 11:00 Add to calendar To be announced Christine Holt, University of Cambridge, Dept. of Developmental Neuroscience, United Kingdom Host: Jeroen Krijgsveld
Large Operon, EMBL Heidelberg
External Faculty Speaker
Wednesday, 23 September 2015, 11:00 Add to calendar Modulating the gut microbiota to reduce chronic non-communicable disease risk change it, feed it, swap it! Kieran Tuohy, Department of Food Quality and Nutrition, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all Adige, Trento, Italy, Italy Host: Kiran Patil
Small Operon, EMBL Heidelberg
Abstract: The gut microbiome is now recognised as an important player in human health, determining disease risk through interactions with host metabolism, immune system and even brain function. Diet is a major modulator of gut microbiome structure and metabolic activity, and the flow of biologically active metabolites derived from the gut appears to play a regulatory role in many important host physiological processes. This presentation will discuss different strategies for modulating microbiome structure and function using both diet and more radical approaches. It will present data from recent human feeding studies linking gut microbiome modulation with protection for cardio-metabolic disease. It will provide insight into how bariatric surgery, through microbiome modulation, may impact on disease risk in the morbidly obese and finally, it will discuss how the omics technologies, applied in a multidisciplinary manner, are radically changing both our interpretation of diet:microbe:host interactions and our ability to study and model these interactions. The presentation will conclude with a discussion of the therapeutic potential of faecal microbiome transplant (FMT), identifying a clear need for models of gut microbiome structure and function based on ecological principles and high resolution omics data. An obvious target would be the development of statistical models describing microbiome structure and metabolic output capable of predicting which bacteria or metabolite profile may modulate metabolic and immune pathways involved in energy homeostasis, resolution of chronic low-grade systemic inflammation and brain function (e.g. appetite regulation and cognition). The aim is to provide the scientific basis for rational faecal microbiome transplant (RFMT) whereby faecal donors are selected on the basis of their potential to modify microbiome:host cross talk and reduce the risk of chronic diseases like cardiometabolic and autoimmune diseases, rather than simply providing a complex microbial inoculum for pathogen exclusion.
EMBL Distinguished Visitor Lecture
Wednesday, 30 September 2015, 16:00 Add to calendar To be announced Mary Beckerle, Huntsman Cancer Institute, Salt Lake City, Host: Martin Jechlinger
Large Operon, EMBL Heidelberg
Company Representative
Thursday, 1 October 2015, 10:00 Add to calendar Tissue Cytometry and Tissue Sociology A New Technology to
Look at Cells and Cellular Interaction in (Cancer) Tissue and Cell Cultures
Rupert Ecker, CEO, TissueGnostics GmbH, Austria Host: Stefan Terjung
Room 13-518 a + b, EMBL Heidelberg
Abstract: TissueFAXS Cytometry is a high-end
scanning system for slides and well plates
that comes with powerful image analysis
software. It offers a high degree of
automation, paired with user interaction at
relevant points of the analytical
workflow. This platform can be applied as
a means of tissue cytometry for both
immunofluorescence and IHC in
end-point assays as well as live-cell
imaging.
The TissueFAXS Cytometry platform has
been used in more than 500 scientific
publications, including clinical
multi-center studies.
Company Representative
Thursday, 1 October 2015, 16:00 Add to calendar New Tools for Successful CRISPR/CAS9 Genome Editing- Discover how to speed up your workflow with Guide- itTM Cornelia Hampe, Takara Bio Europe SAS, Germany Host: Vladimir Benes
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Monday, 5 October 2015, 11:00 Add to calendar To be announced Raymond E. Goldstein, University of Cambridge, Dept. of Applied Mathematics and Theoretical Physics, Center for Mathematical Sciences, United Kingdom Host: Predocs
Large Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 12 October 2015, 16:00 Add to calendar Controlling Biological Pathways with Photopharmacology Dirk Trauner, University of Munich, Germany Host: Carsten Schultz and Gerard Drewes
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Tuesday, 20 October 2015, 11:00 Add to calendar To be announced Irving Weissman, Stanford University, Institute for Stem Cell Biology and Regenerative Medicine, Standford Ludwig Center for Cancer Stem Cell Research and Medicine, USA Host: Lars Steinmetz
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Tuesday, 27 October 2015, 11:00 Add to calendar To be announced Cynthia Wolberger, John Hopkins University School of Medicine, Dept. of Biophysics and Biophysical Chemistry, Baltimore, USA Host: Christoph Mueller
Large Operon, EMBL Heidelberg
Science and Society
Tuesday, 27 October 2015, 15:00 Add to calendar The Nazi Human Experiments and Post-War Legacies Paul Weindling, Oxford Brookes University, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
Science and Society
Wednesday, 4 November 2015, 18:00 Add to calendar Tomorrow's Table: Organic farming, genetics and the future of food Pamela Ronald, Genome Center, University of California, USA Host: Halldór Stefánsson
Print Media Academy
Abstract: In their book, Tomorrow's Table, Pamela Ronald, a geneticist, and her husband, Raoul Adamchak, an organic farmer, argue that a judicious blend of two important strands of agriculture--genetic engineering and organic farming--is key to helping feed the world's growing population in an ecologically balanced manner. Ronald will describe the challenges that farmers face, as they try to feed the world without further destroying the environment.

The lecture is for technologists, entrepreneurs, consumers, farmers, and policy decision makers who want to make food choices or create policy and businesses that will support ecologically responsible farming practices. It is also for anyone who wants accurate information about organic farming, genetic engineering, and their potential impacts on human health and the environment.
Seminar given by an external postdoc
Monday, 9 November 2015, 11:00 Add to calendar To be announced Reza Farhadifar, Harvard University, USA Host: Peter Lenart
Small Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Tuesday, 10 November 2015, 11:00 Add to calendar To be announced Bjorn Hegemann, ETH Zürich, Institute for Biochemistry, Switzerland Host: Peter Lenart
Small Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Monday, 16 November 2015, 11:00 Add to calendar To be announced Herwig Baier, Max-Planck-Institute Martinsried, Dept. for Neurology, Germany Host: Francesca Peri
Large Operon, EMBL Heidelberg
External Faculty Speaker
Tuesday, 17 November 2015, 11:00 Add to calendar To be announced Marina Ramirez-Alvarado, Mayo Clinic, USA Host: Anne Ephrussi
Small Operon, EMBL Heidelberg
Science and Society
Thursday, 19 November 2015, 15:00 Add to calendar Integrated omic studies for common complex traits & personalised medicine Tim Spector, King's College London, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
Abstract: We are using a large-scale multi-omic study of 5,000 adult twins to explore the potential of omics in personalized medicine. The TwinsUK resource contains the most studied individuals on the planet with all subjects having over 3000 phenotypes and GWAS SNP chips. Over 3000 now have whole genome sequencing at 6-30X depth. The omics being explored includes sub-studies used to explore the basic heritability, QTLs and age relationships as well as disease associations. This includes (EpiTWIN) using whole genome methylation sequencing and 450k for epigenetics, which also uses the discordant twin design using for replication 30,000 twins from the Discotwin European consortium. The same individuals are tested using an integrated omics approach including- the Multiple Human Tissue Expression Resource (MuTHER) and with RNA array and sequencing in three tissues. In addition we have analysed 1000 blood metabolites using metabolomics (Mass Spec and NMR), >100 glycomics markers (IgG and total plasma), immunophenotyping (with 78,000 White cell sub-types) and gut microbiomes (16s and metagenomics) on the same twins. Most subjects are being followed longitudinally to assess prediction of incident disease. Examples of recent integrated Omic analyses include prediction of age, pain sensitivity, renal function, hypertension, cancer, depression, obesity and diabetes. Longitudinal twin studies with global collaborations are the ideal resource to study the potential of personalized medicine.
External Faculty Speaker
Thursday, 26 November 2015, 11:00 Add to calendar To be announced Eirikur Steingrimsson, University of Iceland, Iceland Host: Anne Ephrussi
Small Operon, EMBL Heidelberg
Company Representative
Thursday, 26 November 2015, 15:00 Add to calendar To be announced Jasmin Fisher, Microsoft UK, United Kingdom Host: Francois Nedelec/Karin Sasaki
Small Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Friday, 27 November 2015, 11:00 Add to calendar To be announced Nicholas Proudfoot, University of Oxford, Dept. of Molecular Biology , School of Pathology, United Kingdom Host: Eileen Furlong
Large Operon, EMBL Heidelberg
Seminar given by an external postdoc
Monday, 30 November 2015, 11:00 Add to calendar The role of maternal Nodal signalling in mouse embryos. Katsuyoshi Takaoka, Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University., Japan Host: Jan Ellenberg
Large Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Monday, 7 December 2015, 16:00 Add to calendar Precision tools to custom tailor proteins Edward Lemke, EMBL, Germany Host: Carsten Schultz and Gerard Drewes
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 10 December 2015, 11:00 Add to calendar To be announced Marianne Bronner, California Institute of Technology, Division of Biology, Pasadena, USA Host: Detlev Arendt
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Tuesday, 12 January 2016, 11:00 Add to calendar To be announced Andrej Sali, Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, California Institute for Quantitative Biosciences, University of California, San Francisco, , USA Host: Christoph Mueller
The Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 18 January 2016, 11:00 Add to calendar To be announced Cassandra Extavour, Department of Organismic and Evolutionary Biology, Department of Molecular and Cellular Biology, Harvard University, , USA Host: Anne Ephrussi
Small Operon, EMBL Heidelberg
External Faculty Speaker
Wednesday, 3 February 2016, 11:00 Add to calendar To be announced Ben Lehner, Centre for Genomic Regulation, Pompeu Fabra University, Spain Host: Kiran Paril
Small Operon, EMBL Heidelberg