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Seminars

Seminar Colour Guide:              
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Science and Society
Monday, 22 September 2014, 14:00 Add to calendar The Long History of Evolution - what can we learn about science and originality? Rebecca Stott University of East Anglia, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 22 September 2014, 16:00 Add to calendar acal and chem: Two new vessels/genes in Drosophila dorsal closure Juan Riesgo-Escovar Neurobiology Institute, , National Autonomous University of Mexico (UNAM), Mexico Host: Daniel Rios
Small Operon, EMBL Heidelberg
Abstract: In Drosophila melanogaster, dorsal closure occurs at mid-embryogenesis and basically is the coordinated stretching of two lateral epithelial sheets, coordinated by the leading edge cells to effect closure of the dorsal aspect of the embryo. Failure to do results in a lethal condition known as dorsal open whereby the embryo fails to form cuticle at the dorsal side, and internal tissues are partially exposed and displaced at the embryo s dorsal aspect. The Jun-N-terminal kinase signaling pathway (JNK pathway) is required for activation and coordination of this process, amongst other signaling pathways, like the dpp pathway, and also ensuing cytoskeletal changes. Mutant conditions in genes for both guises (signaling and cytoskeletal) result in very similar dorsal open phenotypes. We have characterized acal, that codes for a long non-coding RNA, as a regulator of JNK signaling, and chem, that codes for an E3 ubiquitin ligase, as a regulator of the cytoskeleton. Mutations in both genes result in dorsal open embryos.
Seminar given by an external postdoc
Tuesday, 23 September 2014, 09:00 Add to calendar Structural Characterisation of Eukaryotic Translation Initiation at Atomic Resolution by Cryo-EM Israel Sanchez Fernandes Venki Ramakrishnan Lab, MRC Laboratory of Molecular Biology, United Kingdom Host: Christoph Mueller
Large Operon, EMBL Heidelberg
Tags: Imaging and Image Analysis, Structural Biology
External Faculty Speaker
Tuesday, 23 September 2014, 14:00 Add to calendar Design, Synthesis and in vivo Application of Molecular Imaging Probes with
Tunable Chemical Switches
Kazuya Kikuchi Osaka University, Japan Host: Carsten Schultz
Small Operon, EMBL Heidelberg
External Faculty Speaker
Tuesday, 23 September 2014, 15:00 Add to calendar Structural dissection of architecture of caveolar protein coat Oleksiy Kovtun University of Queensland, Australia Host: John Briggs
Small Operon, EMBL Heidelberg
Abstract: Structural dissection of architecture of caveolar protein coat
Coordinated action of membrane embedded caveolins and peripheral cavin proteins results in the formation of membrane invaginations called caveolae. Mammalian caveolae play key roles in variety of cell processes1, and structural information is critically needed to understand the molecular mechanisms underlying their formation and organization. Here we structurally dissect the architecture of the cavin coat from the atomic to the supermolecular scale. The assembly starts from selective trimerisation of cavins via their conservative helical domain. Resultant formation of the supercoil trimer induces helical folding in disordered regions and cavin association into rod-shaped subcomplexes. Then cavin rods assemble through side-to-side and end-to-end interactions into striated lattices characteristic for native caveolar coat. Subcomplexes anchoring to lipid membranes involves basic regions located in helical portions of cavins and this association is sufficient for producing membrane curvature.

1. Parton and del Pozo. Caveolae as plasma membrane sensors, protectors and organizers. Nat Rev Mol Cell Biol, 2013
Tags: Imaging and Image Analysis, Structural Biology
EMBL Distinguished Visitor Lecture
Thursday, 25 September 2014, 16:00 Add to calendar Cell lineage and early mouse development Janet Rossant University of Toronto, Department of Molecular Genetics, Canada Host: Takashi Hiiragi
ATC Auditorium, EMBL Heidelberg
Abstract: By studying the mouse blastocyst and its derived stem cells, we have been able to identify signaling pathways and transcription factors that specify cell fate and are also key to deriving and maintaining blastocyst stem cell lines. These studies provide new understanding of the regulation of the pluripotent state.

Seminar given by an external postdoc
Friday, 26 September 2014, 11:00 Add to calendar Inhibitors of intracellular trafficking active against Shiga toxins and Ricin Neetu Gupta DSV/iBiTec-S/SIMOPRO, Gif sur Yvette, France, France Host: Rainer Pepperkok
Room 13-518 a + b, EMBL Heidelberg
External Faculty Speaker
Monday, 29 September 2014, 11:00 Add to calendar Protein Engineering and Folding with non-natural amino acids Marina Rubini University of Konstanz, Germany, Germany Host: Jonas Ries
Small Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Monday, 29 September 2014, 16:00 Add to calendar Gut microbiota and metabolic diseases: Hunting down the key players Liping Zhao Director Lab. Mol. Microbial Ecology & Ecogenomics, School of Life Sciences, Shanghai Jiao Tong University, China Host: Peer Bork
Small Operon
Abstract: Dr. Liping Zhao is currently a professor for microbiology and the director of Laboratory of Microbial Ecology and Ecogenomics in School of Life Sciences and Biotechnology, Shanghai Jiao Tong University. He is the director of the Laboratory of Nutritional Systems Biology in Shanghai Center for Systems Biomedicine. He is also the director the SJTU-Perfect (China) Joint Research Center on Microbiota and Health. He is a senior editor of the ISME Journal. He was elected the fellow of American Academy of Microbiology in 2014.

His current research focus is the interactions between nutrition and gut microbiota in onset and progression of chronic diseases such as obesity and diabetes, and how traditional Chinese medicine and medicinal foods may modulate this relationship for achieving preventive healthcare. The Science magazine featured a story on how he combines traditional Chinese medicine and gut microbiota study to understand and fight obesity (Science 336: 1248).

1. Xiao S., Fei N., Pang X., Shen J., Wang L., Zhang B., Zhang M., Zhang X., Zhang C., Li M., Sun, L., Xue Z., Wang J., Feng J., Yan F., Zhao N., Liu J., Long W. and Zhao L. A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome. FEMS Microbiol Ecol 2013, DOI 10.1111/1574-6941.12228
2. Zhao L. The gut microbiota and obesity: from correlation to causality. Nat Rev Microbiol 2013, 11(9): 639-647 (Review)
3. Zhang C., Li S., Yang L., Huang P., Li W., Wang S., Zhao G., Zhang M., Pang X., Yan Z., Liu Y. and Zhao L. Structural modulation of gut microbiota in life-long calorie-restricted mice. Nat Commun 2013, 4: 2163
4. Fei N. and Zhao L. An opportunistic pathogen from the gut of an obese human causes obesity in germfree mice. ISME J 2013, 7(4): 880 884
Tags: Biological Networks, Biocomputing, Systems Biology, Molecular Medicine
Seminar given by an external postdoc
Tuesday, 30 September 2014, 11:00 Add to calendar Studying Xenopus Oocytes and Embryos with Quantitative Multiplexed Proteomics Martin Wuehr Harvard Medical School, Department of Systems Biology Host: Peter Lenart
Small Operon, EMBL Heidelberg
Tags: Cell Biology
Seminar given by an external postdoc
Wednesday, 1 October 2014, 11:00 Add to calendar The yeast cyclin dependent kinase routes carbon fluxes to fuel cell cycle progression Jenny Ewald Stanford University, USA Host: Judith Zaugg
Small Operon
Abstract: The yeast cyclin-depedent kinase routes carbon fluxes to fuel cell cycle progression

Jennifer C. Ewald
Skotheimlab, Department of Biology, Stanford University, Stanford CA 94305
jewald@stanford.edu

Metabolic, growth and proliferative signals are coordinated to enhance fitness and ensure survival. During proliferation, the cell cycle control network coordinates many overlapping and sequential processes including DNA replication, mitosis and cytokinesis. The synthesis of specific cellular components within discrete windows of time likely places cell cycle-dependent requirements on the availability of metabolic precursors. However, we currently know little of how metabolic fluxes change throughout the cell cycle and how metabolism is mechanistically linked to proliferation. Here, we show that the major regulator of the cell division cycle, cyclin-dependent kinase (Cdk1), regulates central carbon metabolism in yeast. Cdk1 phosphorylates and activates the enzyme Nth1 at the G1/S transition to funnel trehalose into central carbon metabolism in S/G2/M phases of the cell cycle. Mass spectrometry based metabolomics links cell cycle progression to global changes in central carbon metabolism and downstream biosynthesis pathways. Cdk-regulated trehalose utilization provides a source of carbon precursors and is required to efficiently complete DNA replication and mitosis during acute nutrient deprivation. Taken together, our results show how the cell cycle entrains metabolism to dynamically fuel the coordinated biosynthesis of cellular macromolecules and organelles during proliferation.
Tags: Cell Regulation and Signaling, Biological Networks, Biocomputing, Systems Biology
External Faculty Speaker
Monday, 6 October 2014, 13:00 Add to calendar Human and great apes genome variation and evolution of DNA methylation in the human genome Tomas Marques Bonet Universitat Pompeu Fabra, Barcelona, Spain Host: Jan Korbel
Small Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 13 October 2014, 11:00 Add to calendar Evo-devo in a billion years time scale: using seaweeds to study the evolution and regulation of sexual life cycle Susana Coelho UMR 7139 CNRS--UPMC, France Host: Anne Ephrussi
Small Operon, EMBL Heidelberg
Science and Society
Tuesday, 14 October 2014, 18:00 Add to calendar Das Human Brain Project: Simulation und Realität Karlheinz Meier Universität Heidelberg, Germany Host: Halldór Stefánsson
Print Media Academy
External Faculty Speaker
Wednesday, 15 October 2014, 15:00 Add to calendar To be announced Harald Janovjak Institute of Science and Technology Austria (IST Austria), Austria Host: Stefano De Renzis
Small Operon, EMBL Heidelberg
External Faculty Speaker
Thursday, 16 October 2014, 11:00 Add to calendar To be announced Jan Lohmann Ruprecht-Karls-University Heidelberg Host: Marcus Heisler
Small Operon, EMBL Heidelberg
External Faculty Speaker
Thursday, 23 October 2014, 11:00 Add to calendar Plants, Polarity and Picasso: The Role and Mechanism of Tissue Cell Polarity in Morphogenesis Enrico Coen John Innes Centre, United Kingdom Host: Marcus Heisler
Small Operon, EMBL Heidelberg
Science and Society
Sunday, 26 October 2014, 11:00 Add to calendar Der Sonne entgegen wie unseren Vorfahren aus dem Meer ein Licht aufging Silvia Rohr EMBL, Germany Host: Lena Raditsch
ATC Auditorium, EMBL Heidelberg
Science and Society
Tuesday, 28 October 2014, 15:00 Add to calendar Play and Creativity Patrick Bateson University of Cambridge, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 3 November 2014, 13:00 Add to calendar To be announced Kristian Helin University of Copenhagen, Denmark Host: Eileen Furlong
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 5 November 2014, 16:00 Add to calendar To be announced Clare M. Waterman NIH , Cell Biology and Physiology Center, Bethesda, USA Host: Peter Lenart
Large Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Friday, 7 November 2014, 11:00 Add to calendar To be announced John Lucocq University of St. Andrews, School of Medicine and Biology, United Kingdom Host: Yannick Schwab
Small Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Thursday, 20 November 2014, 11:00 Add to calendar To be announced Jean-Paul Vincent MRC London Host: Stefano De Renzis
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Monday, 19 January 2015, 16:00 Add to calendar To be announced Kenneth S. Zaret University of Pennsylvania, , Perelman School of Medicine, Dept. of Cell and Developmental Biology Host: Eileen Furlong
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Monday, 9 February 2015, 16:00 Add to calendar To be announced Martin Fussenegger ETH Zurich, Department of Biosystems Science and Engineering, Host: Kiran Patil
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 30 April 2015, 16:00 Add to calendar To be announced Caroline DEAN John Innes Centre, Dept. of Cell & Developmental Biology, Norwich, UK, United Kingdom Host: Anne Ephrussi
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 30 September 2015, 16:00 Add to calendar To be announced Mary Beckerle Huntsman Cancer Institute, Salt Lake City, Host: Francois Nedelec
Large Operon, EMBL Heidelberg