Seminar Colour Guide:              
Science and Society
Monday, 27 June 2016, 11:00Add to calendarSlow, closed, expensive and ineffective: How science publishing is killing science and how to fix itMichael Eisen, Investigator, Howard Hughes Medical Institute, Professor of Genetics, Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USAHost: Shane MorleyCNR Seminar Room, EMBL Monterotondo
Abstract: The Internet was invented so that scientists could communicate their research results with each other. Yet twenty years after the birth of the modern Internet most of the the scientific literature one of greatest public works projects of all time remains locked behind expensive pay walls.

Every year universities, governments and other organizations spend in excess of $10 billion dollars to buy back access to papers their researchers gave to journals for free, while most teachers, students, health care providers and members of the public are left out in the cold. Even worse, the stranglehold existing journals have on academic publishing has stifled efforts to improve the ways scholars communicate with each other and the public, slowing scientific progress and increasing the divide between researchers and the public.

In my talk I will describe how we got to this ridiculous place. How twenty years of avarice from publishers, conservatism from researchers, fecklessness from universities and funders, and a basic lack of common sense from everyone has made the research community and public miss the manifest opportunities created by the Internet to transform how scholars communicate their ideas and discoveries. I will also talk about various ongoing efforts to liberate the scholarly literature where we have succeeded and where there is more work to be done. And finally, with these efforts gaining traction, I will describe where I think scholarly communication is headed in the next decade.
EMBL Distinguished Visitor Lecture
Friday, 1 July 2016, 11:00Add to calendarStructural elucidation of innate and adaptive immunityProf. Hao Wu, Harvard University, USAHost: Emiko UchikawaEMBL Seminar Room, EMBL Grenoble
External Faculty Speaker
Friday, 1 July 2016, 13:00Add to calendarEMDB and EMPIAR - status, plans and challengesArdan Patwardhan, EMBL-EBI, United KingdomHost: Matthias WilmannsSeminar Room 48e, EMBL Hamburg
Abstract: The study of the three-dimensional structure of biological macromolecules and assemblies, and their organization in the cellular context is of utmost importance for understanding many biological processes. For example the ribosome synthesizes protein from nucleic acid and its function is intimately related to its structure and changes therein. Multiple ribosomes have been observed in a cellular context processing the same strand of mRNA in order to synthesize protein efficiently.

Cryo-electron microscopy (cryoEM) and electron tomography (ET) have become indispensable tools for molecular and cellular structural biology. In recent years technological advances such as the director electron detector have led to a breakthrough in the level of observable detail. We are now witnessing a period of dramatic expansion in the number of people using cryoEM techniques for structure determination. Moreover the capabilities of the technique are being pushed to the very limits, for example, by using phase plate technology to examine low molecular weight samples and by exploiting image-processing techniques to obtain 3D snapshots of structurally variable samples.

The open and public access to structural data is of utmost importance for validation, development, testing and training. The Electron Microscopy Data Bank (EMDB) archive was established at the European Bioinformatics Institute (EBI) in 2002 and is the authoritative source for 3DEM data. Against the backdrop of technological advances, EMDB has experienced rapid growth and now contains over 3600 structures. In 2014 the Protein Data Bank in Europe (PDBe) started EMPIAR the electron microscopy pilot image archive to store raw image data related to EMDB structures. The challenge here has been in dealing with the storage and transfer of large datasets. EMPIAR now holds circa 50 datasets and approximately 25 TB/month is downloaded on average. In this talk I will present the status of the archives and of on-going initiatives related to the archives such as the EMDataBank Validation Challenges, efforts underway on the topics of validation, data-mining and integration, and future challenges and opportunities.
Science and Society
Monday, 4 July 2016, 15:00Add to calendarClimate Engineering: approaches, uncertainties, and risksMark Lawrence, Institute for Advanced Sustainability Studies, Potsdam, GermanyHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
Abstract: Our climate is changing that much is certain. What can we do about it? Reducing our overall CO2 emissions will take time, and implementing adaptation measures will be difficult and costly. This has raised the question of whether it might somehow be possible to remove CO2 from the atmosphere. Or, if the combination of this and reduced emissions proved insufficient, whether we could cool the Earth by reflecting sunlight back into space. Technical interventions of this kind in the climate system have come to be known under the umbrella terms of Climate Engineering and Geoengineering . But could they actually work? Or would their application lead to new problems? This lecture will review the opportunities, uncertainties and risks associated with these proposals to combat climate change.
External Faculty Speaker
Tuesday, 5 July 2016, 11:00Add to calendarCryo-EM studies of pore forming proteinsChristos Savva, MRC-LMB Cambridge, United KingdomHost: John BriggsSmall Operon, EMBL Heidelberg
Tags: Structural Biology
Seminar given by an external postdoc
Friday, 8 July 2016, 11:00Add to calendarTo be announcedSara Cuylen, Institute of Molecular Biotechnology, AustriaHost: Jan EllenbergSmall Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Friday, 8 July 2016, 13:00Add to calendarTo be announcedHennig Tidow, University of Hamburg, GermanyHost: Christian LöwSeminar Room 48e, EMBL Hamburg
Company Representative
Monday, 11 July 2016, 11:00Add to calendarOrbitrap technologies and applicationsAlexander Makarov, Thermo Fisher Scientific, GermanyHost: Mikhail SavitskiLarge Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 11 July 2016, 11:00Add to calendarNew insight into innate immune antiviral signalingProf. Nathalie Grandvaux, Research Chair in signaling of virus infections and oncogenesis,Faculty of Medicine, Department of Biochemistry and Molecular Medicine, Université de Montréal, CanadaHost: Daniel PanneEMBL Seminar Room, EMBL Grenoble
Science and Society
Tuesday, 12 July 2016, 18:00Add to calendarWhat Neanderthals teach us about Human EvolutionJean-Jacques Hublin, Max Planck Institute for Evolutionary Anthropology, GermanyHost: Halldór StefánssonPrint Media Academy
Hamburg Speaker
Friday, 15 July 2016, 13:00Add to calendarTo be announcedDiana Freire, EMBL Hamburg, GermanyHost: Matthias WilmannsSeminar Room 48e, EMBL Hamburg
External Faculty Speaker
Friday, 15 July 2016, 16:00Add to calendarThe Power of Chemoselectivity: Chemical Phosphorylation and Cellular Delivery of Functional Peptides and ProteinsChristian Hackenberger, Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin, GermanyHost: Carsten Schultz and Gerard DrewesThe Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 18 July 2016, 14:00Add to calendarElectrostatic model of assembly and disintegration of the influenza virus protein scaffoldOleg Batishchev, Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Russian FederationHost: Dmitri SvergunSeminar Room 48e, EMBL Hamburg
Abstract: Influenza A virus is an enveloped negative strand RNA virus. Its outer envelope consists of the lipid membrane with incorporated glycoproteins and proton channel M2. The inner envelope of the virion is a membrane-associated scaffold of matrix protein M1, which contacts both the viral RNP and the lipid envelope. Formation and disintegration of the protein scaffold are essential processes for influenza replication and infection. Both involve interaction of M1 with the lipid membrane; both are controlled by pH. We investigate the physico-chemical mechanism of these processes using the combination of electrochemical and fluorescent measurements with AFM. In neutral media, the adsorption of M1 protein on the lipid bilayer was electrostatic in nature and reversible. Acidification drives conformational changes in M1 molecules and increase of their charge leading to partial desorption due to increased repulsion between M1 monomers still stuck to the membrane. This repulsive force could generate tension for membrane rupture, as it was demonstrated for lipid vesicles coated with M1. Thus, electrostatic forces could explain M1 protein scaffold disintegration at low pH and most likely stretch the lipid membrane, promoting fusion pore widening for RNP release. Performing the measurements of M1 adsorption at different ionic strengths of the solution, we estimated the charge of M1 in the concerned range of pH. Our results show that at pH of late endosome scaffold protein M1 significantly changes its charge meaning that electrostatics could be the main driving force in disassembly of Influenza A virus protein envelope. On the other hand, we demonstrated that assembly of M1 molecules in helices should occur in a pH-independent manner. Modelling these processes using Derjagin-Landau-Verwey-Overbeek theory (DLVO) allows us to estimate the energy of M1-M1 interactions.
Career Day
Thursday, 21 July 2016, 10:00Add to calendarEMBL Career DayVarious speakers, EMBL Heidelberg, GermanyHost: EICAT & EMBLEMATC Auditorium, EMBL Heidelberg
Abstract: Organised by EICAT (PhD and Postdoctoral Programmes) together with EMBLEM, Career Day provides an overview of alternative, non-academic career possibilities for scientists from all EMBL sites and the local scientific community.
Seminar given by an external postdoc
Friday, 5 August 2016, 13:00Add to calendarTo be announcedLisa Oestereich, Bernhard-Nocht-Institut für Tropenmedizin, GermanyHost: Christian Löw / Sophie ZimmermannSeminar Room 48e, EMBL Hamburg
Hamburg Speaker
Friday, 26 August 2016, 13:00Add to calendarTo be announcedAli Flayhan, EMBL Hamburg, GermanySeminar Room 48e, EMBL Hamburg
External Faculty Speaker
Tuesday, 30 August 2016, 14:00Add to calendarTo be announcedKay Schink, Oslo University Hospital, NorwayHost: Carsten SchultzSmall Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Friday, 2 September 2016, 10:00Add to calendarTo be announcedJan Palecek, CEITEC, Czech RepublicHost: Christian HaeringRoom 13-518 a + b, EMBL Heidelberg
Tags: Cell Biology
Hamburg Speaker
Friday, 2 September 2016, 13:00Add to calendarTo be announcedTuhin Bhowmick, EMBL Hamburg, GermanySeminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Monday, 5 September 2016, 11:00Add to calendarTo be announcedDoreen Matthies, Subramanian group, NIH, USAHost: Marco MarciaEMBL Seminar Room, EMBL Grenoble
EMBL Distinguished Visitor Lecture
Wednesday, 7 September 2016, 11:00Add to calendarTo be announcedBenjamin F. Cravatt, Department of Chemical Physiology, The Scripps Research Institute, , USAHost: Maja KöhnThe Operon, EMBL Heidelberg
External Faculty Speaker
Friday, 9 September 2016, 13:00Add to calendarTo be announcedElke Dittman, University of Potsdam, GermanyHost: Victor Lamzin / Claudia HackenbergSeminar Room 48e, EMBL Hamburg
External Faculty Speaker
Tuesday, 13 September 2016, 11:00Add to calendarDNA and RNA processing by pharmaceutically relevant metalloenzymes: insights from multiscale simulationsMarco de Vivo, IIT Genova, ItalyHost: Marco MarciaEMBL Seminar Room, EMBL Grenoble
Seminar given by an external postdoc
Monday, 19 September 2016, 10:00Add to calendarTo be announcedClare Buckley, Centre for Developmental Neurobiology, King's College London, United KingdomHost: Alba Diz-MunozSmall Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Thursday, 22 September 2016, 11:00Add to calendarTo be announcedDolf Weijers, Wageningen University, NetherlandsHost: Marcus HeislerSmall Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 23 September 2016, 10:00Add to calendarDeciphering the physiology of hematopoiesis by fate mapping and endogenous barcodingHans-Reimer Rodewald, Division of Cellular Immunology, German Cancer Research Center (DKFZ), Heidelberg, GermanyHost: Philip AvnerCNR Seminar Room, EMBL Monterotondo
Abstract: Abstract:

Information on the hematopoietic system has long relied on in vitro in colony assays and in vivo by transplantation of hematopoietic stem cells (HSC) into myeloablated recipients. Given that single cells can rebuild the blood and immune systems upon transplantation, HSC posses huge expansion potential (also coined self-renewal), and under these conditions single HSC are multipotent. Indeed, self-renewal and multipotency are often used as the key HSC-defining hallmarks, and it is commonly assumed that these properties also characterize HSC in situ. High throughput and other single cell technologies are currently being applied to study HSC properties but these approaches, too, may or may not reveal the functions of HSC under physiological conditions. To study the normal functions of HSC in the bone marrow under non-perturbed conditions, we have generated an in vivo experimental fate mapping system that allows tracking of the activity of HSC in situ under steady state conditions and post challenges. We quantified and modeled the cell fluxes through the hematopoietic system during its initial development and maintenance in adult mice, and obtained estimates on the numbers of HSC that contribute to adult hematopoiesis. In parallel, we are developing an endogenous Cre recombinase-dependent barcoding system that, again non-invasively, allows permanent genetic tagging of cells. We are currently characterizing the properties of this versatile tool to study cellular diversity and clonal dynamics in multicellular organs. By linking fate mapping with endogenous barcoding we aim at deciphering the physiology of hematopoiesis in vivo.


Short biography:
Hans-Reimer Rodewald is currently head of the Division for Cellular Immunology at the German Cancer Research Center in Heidelberg. The Rodewald laboratory has a long-standing interest in the development and function of the hematopoietic system. Work from this laboratory included the identification of lineage-committed progenitors, and essential cytokine signals in early T cell development. The Rodewald lab discovered thymus epithelial progenitor activity, leading to medullary epithelial islets, as a developmental mechanism of epithelial organogenesis, and identified the cervical thymus in the mouse. His laboratory developed mouse mutants, including specifically mast cell-deficient mice, to address open questions in mast cell biology, Recently, Rodewald and his colleagues uncovered the inbuilt property of the thymus for progenitor-independent thymus function (thymus autonomy), and noticed the pathological consequences of lack of cell competition in the thymus, i.e. T cell acute lymphoblastic leukemia. Current activities focus on the development of genetic tools to track stem cell output in vivo, aiming at deciphering the physiology of unperturbed hematopoiesis in vivo.
External Faculty Speaker
Thursday, 6 October 2016, 11:00Add to calendarPostranscriptional regulation of gene expression in cardiac diseaseNorbert Huebner, MDC Berlin, GermanyHost: Lars SteinmetzSmall Operon, EMBL Heidelberg
EMBL - Sapienza Lecture
Friday, 7 October 2016, 11:00Add to calendarTherapygenetics: Taking GxE interaction into the clinicThalia Eley, Professor of Developmental Behavioural Genetics, Department of Social Genetic & Developmental Psychiatry, King's College London, London, United KingdomHost: Cornelius Gross / Andrea MeleSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Monterotondo
Science and Society
Thursday, 13 October 2016, 15:00Add to calendarLab Coats in Hollywood: Scientists Impact on Cinema, Cinema s Influence on ScienceDavid A. Kirby, Centre for the History of Science, Technology, and Medicine, University of Manchester, United KingdomHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 17 October 2016, 11:00Add to calendarTo be announcedNeil Brockdorff, Department of Biochemistry, University of Oxford, Oxford, United KingdomHost: Philip AvnerCNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Tuesday, 18 October 2016, 11:00Add to calendarTo be announcedCayetano Gonzalez, Barcelona Institute for Science and Technology, SpainHost: Anne EphrussiSmall Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 21 October 2016, 10:00Add to calendarThe First Steps in Vision: Cell types, Circuits and RepairBotond Roska, Friedrich Miescher Institute for Biomedical, Research, Basel, SwitzerlandHost: Philip AvnerCNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Friday, 21 October 2016, 13:00Add to calendarTo be announcedPiotr Neumann , University of Goettingen, GermanyHost: Christian LöwSeminar Room 48e, EMBL Hamburg
External Faculty Speaker
Monday, 24 October 2016, 11:00Add to calendarTo be announcedIlme Schlichting, Max Planck Institute for Medical Research, GermanyHost: Francesco BisiakEMBL Seminar Room, EMBL Grenoble
EMBL - Sapienza Lecture
Friday, 28 October 2016, 11:00Add to calendarFrom Vision to Decisions and Navigation in Mouse CortexMatteo Carandini, Institute of Ophthalmology, University College London, London, United KingdomHost: Cornelius Gross / Andrea MeleSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Monterotondo
Hamburg Speaker
Friday, 28 October 2016, 13:00Add to calendarTo be announcedMaria Molledo, EMBL Hamburg, GermanyHost: Christian LöwSeminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Monday, 7 November 2016, 11:00Add to calendarTo be announcedPeter Tompa, VIB Department of Structural Biology, Brussels, BelgiumHost: Danielle DesravinesEMBL Seminar Room, EMBL Grenoble
External Faculty Speaker
Monday, 14 November 2016, 15:00Add to calendarTo be announcedEduardo Moreno, University Bern, SwitzerlandHost: Takashi HiiragiSmall Operon, EMBL Heidelberg
External Faculty Speaker
Thursday, 24 November 2016, 11:00Add to calendarTo be announcedJames Sharpe, Centre for Genomic Regulation (CRG), SpainHost: Marcus HeislerSmall Operon, EMBL Heidelberg
EMBL - Sapienza Lecture
Friday, 25 November 2016, 11:00Add to calendarEpigenetics and Rett SyndromeAdrian Bird, Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland, United KingdomHost: Cornelius Gross / Irene BozzoniSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Monterotondo
External Faculty Speaker
Wednesday, 30 November 2016, 10:00Add to calendarTo be announcedPascal Bernard, Ecole Normale Superieure Lyon, FranceHost: Christian HaeringRoom 202, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Thursday, 1 December 2016, 11:00Add to calendarTo be announcedXin Liu, The University of Texas Southwestern Medical Center, Dallas, USAHost: Irene Garcia FerrerEMBL Seminar Room, EMBL Grenoble
Science and Society
Friday, 2 December 2016, 14:00Add to calendarGlobal AMR: When two worlds collide Timothy Walsh, Cardiff University, United KingdomHost: Wiebke SchulzeILL Chadwick, EMBL Grenoble
Science and Society
Friday, 2 December 2016, 15:00Add to calendarThe prenatal sex steroid theory of autismSimon Baron-Cohen, Autism Research Centre, Cambridge University, United KingdomHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
Abstract: Autism affects males more often than females. This is likely to be true even after taking into account under-diagnosis of females with Asperger Syndrome. One candidate biological mechanism for this is prenatal sex steroid hormones, that shape brain development, which themselves are under genetic control and have epigenetic properties. In this lecture I summarize work from our lab from 4 lines of evidence: (1) Testing if one sex steroid hormone, testosterone, measured in the womb is associated with individual differences in typical children s language and social development, attention to detail and narrow interests, autistic traits, and brain structure and function. (2) Testing if elevated prenatal sex steroid levels are associated with autism itself. (3) Testing if proxies of prenatal sex steroid levels in people with autism are also atypical. (4) Testing if post-natal sex steroid hormones in autism are elevated. These studies implicate a specific biological pathway (the Δ4 sex steroid pathway) as one important factor in the aetiology of autism. A recent animal model testing this theory is discussed, and the ethics of translating these findings is considered.
External Faculty Speaker
Friday, 16 December 2016, 11:00Add to calendarTo be announcedClaire Wyart, Institut du Cerveau et de la Moelle Épinière, , FranceHost: Yannick SchwabSmall Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL - Sapienza Lecture
Friday, 16 December 2016, 11:00Add to calendarTransgenerational epigenetic inheritance: Evidence in mammals and potential mechanisms involving the germlineIsabelle Mansuy, University of Zürich and ETH Zürich, Zurich, SwitzerlandHost: Cornelius Gross / Andrea MeleSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Thursday, 12 January 2017, 11:00Add to calendarTo be announcedKay Grünewald, Structural Biology & Oxford Particle Imaging Centre, The Wellcome Trust Centre for Human Genetics, Oxford, United KingdomHost: Manikandan KaruppasamyEMBL Seminar Room, EMBL Grenoble
EMBL Distinguished Visitor Lecture
Tuesday, 21 February 2017, 11:00Add to calendarTo be announcedDavid Barford, MRC-LMB (Cambridge, United KingdomHost: Irina CornaciuEMBL Seminar Room, EMBL Grenoble
Science and Society
Friday, 7 April 2017, 14:00Add to calendarTo be announcedBernd Pulverer, EMBO, GermanyHost: Erika Pellegrini ILL Chadwick, EMBL Grenoble
EMBL - Sapienza Lecture
Friday, 19 May 2017, 11:00Add to calendarTo be announcedJennifer Doudna, Li Ka Shing Chancellor's Chair in Biomedical and Health Sciences, Professor, Molecular & Cell Biology; Professor, Chemistry, University of California, Berkeley, CA, USAHost: Cornelius Gross / Irene BozzoniSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Monterotondo