Seminar Colour Guide:              
EMBL Distinguished Visitor Lecture
Friday, 29 April 2016, 10:00Add to calendarEpigenetics and the determination of phenotypeEmma Whitelaw, College of Science, Health and Engineering, School of Molecular Sciences, La Trobe Institute for Molecular Science, Melbourne (Bundoora), AustraliaHost: Philip AvnerCNR Seminar Room, EMBL Monterotondo
Abstract: Abstract:

I will discuss how the meaning of the word epigenetics has changed over the last ten years and why this has caused confusion. Empirical evidence has altered our view of the importance of DNA methylation in the determination of phenotype. My laboratory has just completed the analysis of a large ENU mutagenesis screen designed to identify proteins involved in epigenetic reprogramming. Around 50 mutant mouse lines were produced and the causative mutations found in most cases. These mutant mice have provided an opportunity to study the importance of these proteins in vivo.

Biography

Professor Emma Whitelaw is a molecular biologist working at the La Trobe Institute of Molecular Sciences, Melbourne. After completing her undergraduate degree at the Australian National University, she obtained a D.Phil at the University of Oxford and remained working in London and Oxford for the next fifteen years. In 1991, she joined the University of Sydney and focused her research on transcription. Her most notable research achievements are in the area of epigenetics. More recently she has extended her studies to include the interaction between the environment and the epigenome. In 2008 she was awarded an Australia Fellowship, the most prestigious fellowship available from the NHMRC, and in 2011 she became a Fellow of the Australian Academy of Science.
External Faculty Speaker
POSTPONED - Monday, 2 May 2016, 11:00Add to calendarTo be announcedClaire Wyart, Institut du Cerveau et de la Moelle Épinière, , FranceHost: Yannick SchwabSmall Operon, EMBL Heidelberg
Tags: Cell Biology
Seminar given by an external postdoc
Tuesday, 3 May 2016, 09:00Add to calendarQuantitative Dissection of Protein Dynamics in the Immune SystemMarko Jovanovic, Broad Institute of MIT and Harvard, USAHost: Anne EphrussiLarge Operon, EMBL Heidelberg
External Faculty Speaker
Tuesday, 3 May 2016, 10:00Add to calendarThe architecture of the redox-driven sodium pump of Vibrio cholerae.Günter Fritz, Universitätsklinikum Freiburg, Institut für Neuropathologie, GermanyHost: Christian HaeringSmall Operon, EMBL Heidelberg
Tags: Cell Biology
Science and Society
Wednesday, 4 May 2016, 15:00Add to calendarExperiments in democracy: why should we care about public engagement in science?James Wilsdon, Sheffield University, United KingdomHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
Abstract: The need for scientists to escape the lab or the seminar room from time to time, and talk to the wider public about the work that they do, and why it matters, is now such an established feature of the research landscape that it s easy to forget how far and fast we ve travelled. From paternalistic talk of public understanding of science in the 1980s, through the bumps and scrapes of battles over GM foods and climate change, we ve reached a point where the diversity, volume and intensity of conversations between researchers and the public at schools, festivals and in pubs; on blogs and twitter; on TV, radio and YouTube is one of the strengths of European science.

Over the past decade, we ve seen a flowering of experiments in public dialogue, and a growing body of expertise in how, when and why to bring public voices into scientific and technological debates. There's still more that could be done to embed such approaches in the everyday practices of science and of policymaking. And ever so often, an issue erupts, where the heat and immediacy of political controversy means that hard-fought lessons are sidestepped or ignored. But this is one area where scientific and policy cultures have made tangible moves in the right direction.

Drawing on a range of European and international examples, James Wilsdon will review the progress we ve seen in public engagement, identify lessons learnt, and highlight obstacles to be overcome if we re to strengthen further the relationship between science, technology and democracy over the next ten years. His talk will be of interest to all those who care about the links between science and society.
EMBL Distinguished Visitor Lecture
Friday, 6 May 2016, 10:00Add to calendarSpinal circuits transmitting and gating mechanical painQiufu Ma, Professor of Neurobiology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USAHost: Philip AvnerCNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Monday, 9 May 2016, 11:00Add to calendarA Workflow for Cryo-TEM Sample Preparation in Structural BiologyAlexander Rigort, Max Planck Institute of Biochemistry, GermanyHost: Martin BeckSmall Operon, EMBL Heidelberg
Tags: Biocomputing, Structural Biology
External Faculty Speaker
Monday, 9 May 2016, 15:00Add to calendarTo be announcedHartmut Luecke, UC Irvine, USAHost: Carsten SchultzSmall Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Thursday, 12 May 2016, 11:00Add to calendarCryo-EM Approaches to Understanding the Eukaryotic ReplisomeAlessandro Costa, Francis Crick Institute, United KingdomHost: Francesco BisiakEMBL Seminar Room, EMBL Grenoble
External Faculty Speaker
Friday, 13 May 2016, 11:00Add to calendarFear in the prey's mindNewton Canteras , Chair of Anatomy at the University of Sao Paulo, Sao Paulo, BrazilHost: Cornelius GrossCNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Monday, 16 May 2016, 11:00Add to calendarTo be announcedMassimiliano Pagani, Professor, of Molecular Biology, Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano; Head of Integrative Biology, INGM, Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi , Milano, ItalyHost: Philip AvnerCNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Friday, 20 May 2016, 13:00Add to calendarTo be announcedSophia Reindl, Bernhard-Nocht Institut fuer Tropenmedizin, GermanyHost: Christian LöwSeminar Room 48e, EMBL Hamburg
External Faculty Speaker
Wednesday, 25 May 2016, 10:00Add to calendarHost-Microbial metabolic complementation modulates the effects of fluoropyrimidines in C. elegans survival and longevityFilipe Gomes Cabreiro, University College London, United KingdomHost: Nassos TypasSmall Operon, EMBL Heidelberg
Hamburg Speaker
Friday, 27 May 2016, 13:00Add to calendarTo be announcedMichele Cianci, EMBL Hamburg, GermanySeminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Monday, 30 May 2016, 10:00Add to calendarTranscriptional and Epigenetic Mechanisms of DepressionEric Nestler, Nash Family Professor and Chair, Department of Neuroscience Director, Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York, NY, USAHost: Philip AvnerCNR Seminar Room, EMBL Monterotondo
Abstract: Depression is a common, chronic, and debilitating disease. Although many patients benefit from antidepressant medications or other therapies, only about half of depressed patients show a complete remission, which underscores the need for more effective agents. The mechanisms that precipitate depression, such as stress, are incompletely understood. One mystery of the disease is its long-lasting nature and delayed response to antidepressant treatment. This persistence is thought to be mediated by slowly developing but stable adaptations in the brain, which might include regulation of gene expression and chromatin structure.
We have used chronic social defeat stress as an animal model of depression that mimics certain symptoms of human depression. Prolonged exposure to an aggressor induces lasting changes in mouse behavior such as social avoidance, which are reversed by chronic (but not acute) treatment with available antidepressants. Importantly, roughly one-third of mice subjected to social defeat stress do not exhibit these deleterious behaviors and appear resilient. We are exploring the molecular basis of defeat-induced behavioral pathology, antidepressant action, and resilience by analyzing genome-wide changes in gene expression and chromatin modifications. Our work to date has focused on the nucleus accumbens, a key brain reward region implicated in aspects of depression, as well as several other limbic brain regions. Parallel work has focused on homologous regions in the brains of depressed humans examined postmortem.
Together, this work is providing novel insight into the molecular mechanisms underlying depression and other stress-related disorders. The findings also suggest novel leads for the development of new antidepressant treatments. For example, our findings on resilience suggest the novel approach of developing medications that promote resilience and not just those that oppose the deleterious effects of stress.

Biography

Dr. Nestler is the Nash Family Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai in New York City, where he serves as Chair of the Department of Neuroscience and Director of the Friedman Brain Institute. He received his B.A., Ph.D., and M.D. degrees, and psychiatry residency training, from Yale University. He served on the Yale faculty from 1987-2000, where he was the Elizabeth Mears and House Jameson Professor of Psychiatry and Neurobiology, and Director of the Division of Molecular Psychiatry. He moved to Dallas in 2000 where he served as the Lou and Ellen McGinley Distinguished Professor and Chair of the Department of Psychiatry at The University of Texas Southwestern Medical Center until moving to New York in 2008. Dr. Nestler is a member of the Institute of Medicine and a Fellow of the American Academy of Arts and Sciences. He is a past President of the American College of Neuropsychopharmacology and President Elect of the Society for Neuroscience. The goal of Dr. Nestler s research is to better understand the molecular mechanisms of addiction and depression based on work in animal models, and to use this information to develop improved treatments of these disorders.
External Faculty Speaker
Monday, 30 May 2016, 11:00Add to calendarTo be announcedJulia Mahamid , MPI Martinsried, GermanyHost: Martin BeckSmall Operon, EMBL Heidelberg
Tags: Structural Biology
EMBL Distinguished Visitor Lecture
Thursday, 2 June 2016, 11:00Add to calendarTo be announcedTimothy J. Mitchison, Harvard University, USAHost: François NédélecLarge Operon, EMBL Heidelberg
External Faculty Speaker
Thursday, 2 June 2016, 15:00Add to calendarTo be announcedAnna Kreshuk, HCI, University of Heidelberg, GermanyHost: Yannick SchwabSmall Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Friday, 3 June 2016, 11:00Add to calendarNeural circuit mechanisms for the initiation and adaptive control of aversive associative learningJoshua Johansen, Laboratory for the Neural Circuitry of Memory, RIKEN Brain Science Institute, Saitama, JapanHost: Cornelius GrossCNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Monday, 6 June 2016, 11:00Add to calendarTo be announcedPhillipp Holliger, MRC-LMB Cambridge, United KingdomHost: Lahari Yeramala EMBL Seminar Room, EMBL Grenoble
EMBL Distinguished Visitor Lecture
Friday, 10 June 2016, 10:00Add to calendarMaking, Breaking and Linking MemoriesSheena Josselyn, Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, CanadaHost: Philip AvnerCNR Seminar Room, EMBL Monterotondo
Abstract: Making, Breaking and Linking Memories .

A fundamental goal of neuroscience is to understand how information is encoded and stored in the brain. The physical or functional representation of a memory (the memory trace or engram ) is thought to be sparsely encoded over a distributed memory network. However, identifying the precise neurons which make up a memory trace has challenged for scientists since Karl Lashley s search for the engram in the 1950 s (Josselyn, 2015; Lashley, 1950; Josselyn, 2010; Josselyn et al., 2015). Moreover, it was not known why one neuron (rather than its neighbour) was involved in a given memory trace. We previously showed that lateral amygdala (LA) neurons with increased levels of the transcription factor CREB (cAMP/Ca++ Responsive Element Binding protein), are preferentially activated by fear memory expression, suggesting they are selectively recruited into the memory trace (Han et al., 2007). We, and others, went on to show that these neurons were critical components of the memory network by selectively ablating (Han et al., 2009) or inactivating them (Zhou et al., 2009). These findings established a causal link between a specific neuronal subpopulation and memory expression, thereby identifying critical neurons within the memory trace. Furthermore, these results suggest that at least within the LA, eligible neurons compete for inclusion in a memory trace, and that the winners of this competition are determined by relative CREB function. Although competition between neurons, axons and synapses is necessary for refining neural circuits in development, little is known about competition between neurons in the adult brain. Our recent results suggest that this neuronal competition during memory formation limits the overall size of the memory trace (number of winning neurons) and is a mechanism that links (or disambiguates) related memories in the LA.
Memory impairments are a hallmark of aging, major mental illnesses (e.g., schizophrenia and depression) as well as neurological disorders (e.g., Alzheimer's and Parkinson's diseases). Therefore, understanding how the brain encodes and stores information is highly relevant to both mental health and mental illness.

Biography

Sheena Josselyn is a Senior Scientist in the Neurosciences & Mental Health program at The Hospital for Sick Children (SickKids) and an Associate Professor in the departments of Psychology and Physiology and the Institute of Medical Sciences at the University of Toronto in Canada. She holds a Canada Research Chair in Molecular and Cellular Cognition and is an EJLB Scholar. Her undergraduate degrees and a Masters degree in Clinical Psychology were granted by Queen s University in Kingston. Sheena received a PhD in Neuroscience/Psychology from the University of Toronto with Dr. Franco Vaccarino as her supervisor. She conducted post-doctoral work with Dr. Mike Davis (Yale University) and Dr. Alcino Silva (UCLA). Her program of research is dedicated to understanding the neural basis of cognitive function and dysfunction. To unravel the molecular, cellular and circuit processes that underlie learning and memory, her lab uses a multidisciplinary approach that focuses on mouse models and attempts to translate these basic findings into humans.

Dr. Josselyn received the Innovations in Psychopharmacology Award from the Canadian College of Neuropsychopharmacology (CCNP) and the Effron Award from the American College of Neurospchycopharmacology (ACNP). She sits on the editorial board for the Neuropsychopharmacology, Journal of Neuroscience and the Neurobiology of Learning and Memory and serves on CIHR and NIH peer review panels

External Faculty Speaker
Friday, 10 June 2016, 13:00Add to calendarTo be announcedNassos Typas, EMBL Heidelberg, GermanyHost: Matthias WilmannsSeminar Room 48e, EMBL Hamburg
Science and Society
Friday, 10 June 2016, 15:00Add to calendarDigitising humanness across genomes, epigenomes and cellsGiuseppe Testa, University of Milan and European Institute of Oncology, ItalyHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
External Faculty Speaker
Wednesday, 15 June 2016, 13:15Add to calendarTo be announcedVirgile Viasnoff, MechanoBiology Institute, SingaporeHost: Francois Nédélec Small Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Friday, 17 June 2016, 13:00Add to calendarTo be announcedCharlotte Uetrecht, European XFEL GmbH, Hamburg, GermanyHost: Rob MeijersSeminar Room 48e, EMBL Hamburg
Hamburg Speaker
Friday, 24 June 2016, 13:00Add to calendarTo be announcedTuhin Bhowmick, EMBL Hamburg, GermanySeminar Room 48e, EMBL Hamburg
Science and Society
Monday, 27 June 2016, 11:00Add to calendarSlow, closed, expensive and ineffective: How science publishing is killing science and how to fix itMichael Eisen, Investigator, Howard Hughes Medical Institute, Professor of Genetics, Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USAHost: Shane MorleyCNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Friday, 1 July 2016, 13:00Add to calendarTo be announcedArdan Patwardhan, EMBL-EBI, United KingdomHost: Matthias WilmannsSeminar Room 48e, EMBL Hamburg
Science and Society
Monday, 4 July 2016, 15:00Add to calendarProposals for climate engineering: potentials, limitations, uncertainties and risksMark Lawrence, Institute for Advanced Sustainability Studies, Potsdam, GermanyHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
Seminar given by an external postdoc
Friday, 8 July 2016, 11:00Add to calendarTo be announcedSara Cuylen, Institute of Molecular Biotechnology, AustriaHost: Jan EllenbergSmall Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Friday, 8 July 2016, 13:00Add to calendarTo be announcedHennig Tidow, University of Hamburg, GermanyHost: Christian LöwSeminar Room 48e, EMBL Hamburg
Company Representative
Monday, 11 July 2016, 11:00Add to calendarOrbitrap technologies and applicationsAlexander Makarov, Thermo Fisher Scientific, GermanyHost: Mikhail SavitskiLarge Operon, EMBL Heidelberg
Science and Society
Tuesday, 12 July 2016, 18:00Add to calendarWhat Neanderthals teach us about Human EvolutionJean-Jacques Hublin, Max Planck Institute for Evolutionary Anthropology, GermanyHost: Halldór StefánssonPrint Media Academy
Hamburg Speaker
Friday, 15 July 2016, 13:00Add to calendarTo be announcedDiana Freire, EMBL Hamburg, GermanyHost: Matthias WilmannsSeminar Room 48e, EMBL Hamburg
External Faculty Speaker
Monday, 18 July 2016, 14:00Add to calendarElectrostatic model of assembly and disintegration of the influenza virus protein scaffoldOleg Batishchev, Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Russian FederationHost: Dmitri SvergunSeminar Room 48e, EMBL Hamburg
Abstract: Influenza A virus is an enveloped negative strand RNA virus. Its outer envelope consists of the lipid membrane with incorporated glycoproteins and proton channel M2. The inner envelope of the virion is a membrane-associated scaffold of matrix protein M1, which contacts both the viral RNP and the lipid envelope. Formation and disintegration of the protein scaffold are essential processes for influenza replication and infection. Both involve interaction of M1 with the lipid membrane; both are controlled by pH. We investigate the physico-chemical mechanism of these processes using the combination of electrochemical and fluorescent measurements with AFM. In neutral media, the adsorption of M1 protein on the lipid bilayer was electrostatic in nature and reversible. Acidification drives conformational changes in M1 molecules and increase of their charge leading to partial desorption due to increased repulsion between M1 monomers still stuck to the membrane. This repulsive force could generate tension for membrane rupture, as it was demonstrated for lipid vesicles coated with M1. Thus, electrostatic forces could explain M1 protein scaffold disintegration at low pH and most likely stretch the lipid membrane, promoting fusion pore widening for RNP release. Performing the measurements of M1 adsorption at different ionic strengths of the solution, we estimated the charge of M1 in the concerned range of pH. Our results show that at pH of late endosome scaffold protein M1 significantly changes its charge meaning that electrostatics could be the main driving force in disassembly of Influenza A virus protein envelope. On the other hand, we demonstrated that assembly of M1 molecules in helices should occur in a pH-independent manner. Modelling these processes using Derjagin-Landau-Verwey-Overbeek theory (DLVO) allows us to estimate the energy of M1-M1 interactions.
Career Day
Thursday, 21 July 2016, 10:00Add to calendarEMBL Career DayVarious speakers, EMBL Heidelberg, GermanyHost: EICAT & EMBLEMATC Auditorium, EMBL Heidelberg
Abstract: Organised by EICAT (PhD and Postdoctoral Programmes) together with EMBLEM, Career Day provides an overview of alternative, non-academic career possibilities for scientists from all EMBL sites and the local scientific community.
Seminar given by an external postdoc
Friday, 5 August 2016, 13:00Add to calendarTo be announcedLisa Oestereich, Bernhard-Nocht-Institut für Tropenmedizin, GermanyHost: Christian Löw / Sophie ZimmermannSeminar Room 48e, EMBL Hamburg
Hamburg Speaker
Friday, 26 August 2016, 13:00Add to calendarTo be announcedAli Flayhan, EMBL Hamburg, GermanySeminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Monday, 5 September 2016, 11:00Add to calendarTo be announcedDoreen Matthies, Subramanian group, NIH, USAHost: Marco MarciaEMBL Seminar Room, EMBL Grenoble
External Faculty Speaker
Friday, 9 September 2016, 13:00Add to calendarTo be announcedElke Dittman, University of Potsdam, GermanyHost: Victor Lamzin / Claudia HackenbergSeminar Room 48e, EMBL Hamburg
External Faculty Speaker
Thursday, 22 September 2016, 11:00Add to calendarTo be announcedDolf Weijers, Wageningen University, NetherlandsHost: Marcus HeislerSmall Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 23 September 2016, 10:00Add to calendarDeciphering the physiology of hematopoiesis by fate mapping and endogenous barcodingHans-Reimer Rodewald, Division of Cellular Immunology, German Cancer Research Center (DKFZ), Heidelberg, GermanyHost: Philip AvnerCNR Seminar Room, EMBL Monterotondo
Abstract: Abstract:

Information on the hematopoietic system has long relied on in vitro in colony assays and in vivo by transplantation of hematopoietic stem cells (HSC) into myeloablated recipients. Given that single cells can rebuild the blood and immune systems upon transplantation, HSC posses huge expansion potential (also coined self-renewal), and under these conditions single HSC are multipotent. Indeed, self-renewal and multipotency are often used as the key HSC-defining hallmarks, and it is commonly assumed that these properties also characterize HSC in situ. High throughput and other single cell technologies are currently being applied to study HSC properties but these approaches, too, may or may not reveal the functions of HSC under physiological conditions. To study the normal functions of HSC in the bone marrow under non-perturbed conditions, we have generated an in vivo experimental fate mapping system that allows tracking of the activity of HSC in situ under steady state conditions and post challenges. We quantified and modeled the cell fluxes through the hematopoietic system during its initial development and maintenance in adult mice, and obtained estimates on the numbers of HSC that contribute to adult hematopoiesis. In parallel, we are developing an endogenous Cre recombinase-dependent barcoding system that, again non-invasively, allows permanent genetic tagging of cells. We are currently characterizing the properties of this versatile tool to study cellular diversity and clonal dynamics in multicellular organs. By linking fate mapping with endogenous barcoding we aim at deciphering the physiology of hematopoiesis in vivo.


Short biography:
Hans-Reimer Rodewald is currently head of the Division for Cellular Immunology at the German Cancer Research Center in Heidelberg. The Rodewald laboratory has a long-standing interest in the development and function of the hematopoietic system. Work from this laboratory included the identification of lineage-committed progenitors, and essential cytokine signals in early T cell development. The Rodewald lab discovered thymus epithelial progenitor activity, leading to medullary epithelial islets, as a developmental mechanism of epithelial organogenesis, and identified the cervical thymus in the mouse. His laboratory developed mouse mutants, including specifically mast cell-deficient mice, to address open questions in mast cell biology, Recently, Rodewald and his colleagues uncovered the inbuilt property of the thymus for progenitor-independent thymus function (thymus autonomy), and noticed the pathological consequences of lack of cell competition in the thymus, i.e. T cell acute lymphoblastic leukemia. Current activities focus on the development of genetic tools to track stem cell output in vivo, aiming at deciphering the physiology of unperturbed hematopoiesis in vivo.
EMBL - Sapienza Lecture
Friday, 7 October 2016, 11:00Add to calendarTo be announcedThalia Eley, Professor of Developmental Behavioural Genetics, Department of Social Genetic & Developmental Psychiatry, King's College London, London, United KingdomHost: Cornelius Gross / Andrea MeleSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Monterotondo
Science and Society
Thursday, 13 October 2016, 15:00Add to calendarLab Coats in Hollywood: Scientists Impact on Cinema, Cinema s Influence on ScienceDavid A. Kirby, Centre for the History of Science, Technology, and Medicine, University of Manchester, United KingdomHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 17 October 2016, 11:00Add to calendarTo be announcedNeil Brockdorff, Department of Biochemistry, University of Oxford, Oxford, United KingdomHost: Philip AvnerCNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Tuesday, 18 October 2016, 11:00Add to calendarTo be announcedCayetano Gonzalez, Barcelona Institute for Science and Technology, SpainHost: Anne EphrussiSmall Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 21 October 2016, 10:00Add to calendarThe First Steps in Vision: Cell types, Circuits and RepairBotond Roska, Friedrich Miescher Institute for Biomedical, Research, Basel, SwitzerlandHost: Philip AvnerCNR Seminar Room, EMBL Monterotondo
EMBL - Sapienza Lecture
Friday, 28 October 2016, 11:00Add to calendarFrom Vision to Decisions and Navigation in Mouse CortexMatteo Carandini, Institute of Ophthalmology, University College London, London, United KingdomHost: Cornelius Gross / Andrea MeleSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Monterotondo
Hamburg Speaker
Friday, 28 October 2016, 13:00Add to calendarTo be announcedMaria Molledo, EMBL Hamburg, GermanyHost: Christian LöwSeminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Monday, 7 November 2016, 11:00Add to calendarTo be announcedPeter Tompa, VIB Department of Structural Biology, Brussels, BelgiumHost: Danielle DesravinesEMBL Seminar Room, EMBL Grenoble
External Faculty Speaker
Monday, 14 November 2016, 15:00Add to calendarTo be announcedEduardo Moreno, University Bern, SwitzerlandHost: Takashi HiiragiSmall Operon, EMBL Heidelberg
External Faculty Speaker
Thursday, 24 November 2016, 11:00Add to calendarTo be announcedJames Sharpe, Centre for Genomic Regulation (CRG), SpainHost: Marcus HeislerSmall Operon, EMBL Heidelberg
EMBL - Sapienza Lecture
Friday, 25 November 2016, 11:00Add to calendarEpigenetics and Rett SyndromeAdrian Bird, Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland, United KingdomHost: Cornelius Gross / Irene BozzoniSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Thursday, 1 December 2016, 11:00Add to calendarTo be announcedXin Liu, The University of Texas Southwestern Medical Center, Dallas, USAHost: Irene Garcia FerrerEMBL Seminar Room, EMBL Grenoble
Science and Society
Friday, 2 December 2016, 14:00Add to calendarGlobal antimicrobial resistance: When two worlds collideTimothy Walsh, Cardiff University, United KingdomHost: Wiebke SchulzeILL Chadwick, EMBL Grenoble
Science and Society
Friday, 2 December 2016, 15:00Add to calendarThe prenatal sex steroid theory of autismSimon Baron-Cohen, Autism Research Centre, Cambridge University, United KingdomHost: Halldór StefánssonLarge Operon, EMBL Heidelberg
Abstract: Autism affects males more often than females. This is likely to be true even after taking into account under-diagnosis of females with Asperger Syndrome. One candidate biological mechanism for this is prenatal sex steroid hormones, that shape brain development, which themselves are under genetic control and have epigenetic properties. In this lecture I summarize work from our lab from 4 lines of evidence: (1) Testing if one sex steroid hormone, testosterone, measured in the womb is associated with individual differences in typical children s language and social development, attention to detail and narrow interests, autistic traits, and brain structure and function. (2) Testing if elevated prenatal sex steroid levels are associated with autism itself. (3) Testing if proxies of prenatal sex steroid levels in people with autism are also atypical. (4) Testing if post-natal sex steroid hormones in autism are elevated. These studies implicate a specific biological pathway (the Δ4 sex steroid pathway) as one important factor in the aetiology of autism. A recent animal model testing this theory is discussed, and the ethics of translating these findings is considered.
EMBL - Sapienza Lecture
Friday, 16 December 2016, 11:00Add to calendarTransgenerational epigenetic inheritance: Evidence in mammals and potential mechanisms involving the germlineIsabelle Mansuy, University of Zürich and ETH Zürich, Zurich, SwitzerlandHost: Cornelius Gross / Andrea MeleSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Thursday, 12 January 2017, 11:00Add to calendarTo be announcedKay Grünewald, Structural Biology & Oxford Particle Imaging Centre, The Wellcome Trust Centre for Human Genetics, Oxford, United KingdomHost: Manikandan KaruppasamyEMBL Seminar Room, EMBL Grenoble
EMBL Distinguished Visitor Lecture
Tuesday, 21 February 2017, 11:00Add to calendarTo be announcedDavid Barford, MRC-LMB (Cambridge, United KingdomHost: Irina CornaciuEMBL Seminar Room, EMBL Grenoble
Science and Society
Friday, 7 April 2017, 14:00Add to calendarTo be announcedBernd Pulverer, EMBO, GermanyHost: Erika Pellegrini ILL Chadwick, EMBL Grenoble
EMBL - Sapienza Lecture
Friday, 19 May 2017, 11:00Add to calendarTo be announcedJennifer Doudna, Li Ka Shing Chancellor's Chair in Biomedical and Health Sciences, Professor, Molecular & Cell Biology; Professor, Chemistry, University of California, Berkeley, CA, USAHost: Cornelius Gross / Irene BozzoniSapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma, EMBL Monterotondo