Seminar Colour Guide:              
Company Representative
Tuesday, 14 April 2015, 10:00 Add to calendar IN Cell Analyzer 2200 HCA Automated Microscopy System Daniel J. White, GE Healthcare, Life Sciences - Cell Technologies, Germany Host: Beate Neumann
Room 13-518 a + b, EMBL Heidelberg
Abstract: Super-fast, sensitive, and flexible wide-field cell imaging system for a broad range of high-content assays.
Bring your own samples and carry out fixed end-point assays as well as extended live-cell studies.
Perform anything from investigative microscopy to automated high-content screening.
Image organelles, cells, tissues, and whole organisms.
External Faculty Speaker
Tuesday, 14 April 2015, 11:00 Add to calendar Protein-RNA interactions and the origin of the genetic code Bojan Zagrovic, Max F. Perutz Laboratories & University of Vienna, Austria, Austria Host: Judith Zaugg
Small Operon, EMBL Heidelberg
Abstract: Protein-RNA interactions and the origin of the genetic code

In spite of 50 years of effort, the origin of the universal genetic code remains poorly understood. Among different theories, the stereochemical hypothesis proposes that the code evolved as a consequence of direct interactions between amino acids and appropriate bases. If indeed true, such physicochemical foundation of the mRNA-protein relationship could potentially also lead to novel principles of RNA-protein interactions in general. Inspired by this promise, we have recently examined the relationship between the physicochemical properties of mRNAs and their cognate proteins at the proteome level. Using 1) experimentally and computationally derived interaction propensity scales capturing the behavior of amino acids in aqueous solutions of nucleobase analogs, 2) computationally derived binding free energies between individual nucleobases and aminoacid sidechain analogs in different solvents, and 3) knowledge-based interaction preferences of amino acids for different nucleobases, we have revealed a statistically significant matching between the composition of mRNA coding sequences and the base-binding preferences of their cognate protein sequences. Overall, our results redefine the stereo-chemical hypothesis concerning the origin of the genetic code and provide evidence of direct templating of proteins from mRNAs before the development of ribosomal decoding. Moreover, our findings support the possibility of direct complementary interactions between mRNAs and cognate proteins even in present-day cells, especially if both are unstructured, with implications extending to all facets of nucleic acid/protein biology.
Tags: Biocomputing, Evolution, Gene Regulation, RNA, Structural Biology, Systems Biology
EMBL Distinguished Visitor Lecture
Friday, 17 April 2015, 11:00 Add to calendar To be announced Stefano Piccolo, University of Padua, Dept. of Molecular Medicine, Italy Host: Darren Gilmour
Large Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Monday, 20 April 2015, 13:00 Add to calendar To be announced Caren Norden, MPI of Molecular Cell Biology and Genetics, Germany Host: Francesca Peri
Small Operon, EMBL Heidelberg
External Faculty Speaker
Tuesday, 21 April 2015, 11:00 Add to calendar The strength of protein coats deforming cell membranes Aurélien Roux, University of Geneva, Switzerland Host: Marko Kaksonen
Small Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Wednesday, 22 April 2015, 14:00 Add to calendar To be announced Andreas Beyer, University of Cologne, Germany Host: Leopold Parts
Small Operon, EMBL Heidelberg
Science and Society
Thursday, 23 April 2015, 15:00 Add to calendar The neuroscience of laughter Sophie Scott, University College London, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
External Faculty Speaker
Tuesday, 28 April 2015, 13:00 Add to calendar The 15th Public MMPU Research Day The 15th Public MMPU Research Day - MMPU members and invited guest speakers, Molecular Medicine Partnership Unit Heidelberg Host: Matthias Hentze and Andreas Kulozik
ATC - Courtyard A+B, EMBL Heidelberg
Tags: Molecular Medicine
Science and Society
Wednesday, 29 April 2015, 18:00 Add to calendar Computer-Gehirn Interface Niels Birbaumer, University of Tuebingen, Germany Host: Halldór Stefánsson
all EMBL HD
EMBL Distinguished Visitor Lecture
Thursday, 30 April 2015, 11:00 Add to calendar To be announced Caroline DEAN, John Innes Centre, Dept. of Cell & Developmental Biology, Norwich, UK, United Kingdom Host: Anne Ephrussi
Large Operon, EMBL Heidelberg
External Faculty Speaker
Tuesday, 5 May 2015, 11:00 Add to calendar Regulating chromosome-wide gene expression by nuclear positioning: dosage compensation in C. elegans Peter Meister, University of Bern, Institute of Cell Biology, Switzerland Host: Christian Haering
Small Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Tuesday, 12 May 2015, 11:00 Add to calendar To be announced Elly Tanaka, Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany Host: Anne Ephrussi
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Monday, 15 June 2015, 11:00 Add to calendar To be announced James E. Ferrell, Stanford University, Dept. of Chemical and Systems Biology, USA Host: Francois Nedelec
Large Operon, EMBL Heidelberg
Tags: Cell Biology
Science and Society
Friday, 19 June 2015, 15:00 Add to calendar A crisis of trust? Setting guidelines for image processing in scientific journals Emma Frow, Arizona State University, USA Host: Halldór Stefánsson
Small Operon, EMBL Heidelberg
External Faculty Speaker
Wednesday, 1 July 2015, 11:00 Add to calendar To be announced Ilka Bischofs, Bioquant, University of Heidelberg, Germany Host: Kiran Patil
Room 202, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 2 July 2015, 11:00 Add to calendar To be announced Adam Arkin, University of California, Berkeley, Dept. of Bioengineering, USA Host: Nassos Typas
ATC Auditorium, EMBL Heidelberg
Science and Society
Monday, 13 July 2015, 14:00 Add to calendar Decoding Race Catherine Bliss, University of California, San Francisco, USA Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 16 September 2015, 11:00 Add to calendar To be announced Thomas Pollard, Yale University, New Haven, Dept. of Molecular Cellular & Developmental Biology, USA Host: Peter Lenart
Large Operon, EMBL Heidelberg
Tags: Cell Biology
Science and Society
Sunday, 20 September 2015, 14:00 Add to calendar EMBL Heidelberg Science & Society Symposium: What makes us human? Various speakers, MPI for Evolutionary Anthropology, Collège de France, University of Notre Dame Host: Halldór Stefánsson
The Operon, EMBL Heidelberg
Abstract: Humans are distinctly different from all the other animals, in ways both good and bad. But articulating what that difference consists of remains a complex and difficult task, tackled by biologists, anthropologists and brain scientists.

We are, presumably, the only known species with a mind set on unravelling who and what we are. Today, scientists are making use of genomics to realign H. Sapiens with respect to H. neanderthalensis, hominids and apes. But what are the assumptions that are built into these research projects? And what is the nature of the evolved cognitive faculties that allow people to relate and bond to one another in our species-specific way? Are some of our behavioral responses hardwired in neural networks as a result of our evolutionary history, or does the ultimate strength of the human species lie in its apparently unlimited neurological plasticity?

And while humans seem so fabulously well equipped to relate to one another and spin intricate webs of social relations, at the same time they tirelessly invent ways and means of destroying each other in warfare. Is such behaviour to be considered a part of our human nature? Globally speaking, what role do nature, culture and our social environment play in the crafting of humans?
EMBL Distinguished Visitor Lecture
Tuesday, 22 September 2015, 11:00 Add to calendar To be announced Christine Holt, University of Cambridge, Dept. of Developmental Neuroscience, United Kingdom Host: Jeroen Krijgsveld
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 30 September 2015, 16:00 Add to calendar To be announced Mary Beckerle, Huntsman Cancer Institute, Salt Lake City, Host: Francois Nedelec
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Monday, 5 October 2015, 11:00 Add to calendar To be announced Raymond E. Goldstein, University of Cambridge, Dept. of Applied Mathematics and Theoretical Physics, Center for Mathematical Sciences, United Kingdom Host: Predocs
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Tuesday, 20 October 2015, 11:00 Add to calendar To be announced Irving Weissman, Stanford University, Institute for Stem Cell Biology and Regenerative Medicine, Standford Ludwig Center for Cancer Stem Cell Research and Medicine, USA Host: Lars Steinmetz
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Tuesday, 27 October 2015, 11:00 Add to calendar To be announced Cynthia Wolberger, John Hopkins University School of Medicine, Dept. of Biophysics and Biophysical Chemistry, Baltimore, USA Host: Christoph Mueller
Large Operon, EMBL Heidelberg
Science and Society
Tuesday, 27 October 2015, 15:00 Add to calendar The Nazi Human Experiments and Post-War Legacies Paul Weindling, Oxford Brookes University, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Monday, 16 November 2015, 11:00 Add to calendar To be announced Herwig Baier, Max-Planck-Institute Martinsried, Dept. for Neurology, Germany Host: Francesca Peri
Large Operon, EMBL Heidelberg
External Faculty Speaker
Thursday, 26 November 2015, 11:00 Add to calendar To be announced Eirikur Steingrimsson, University of Iceland, Iceland Host: Anne Ephrussi
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 27 November 2015, 11:00 Add to calendar To be announced Nicholas Proudfoot, University of Oxford, Dept. of Molecular Biology , School of Pathology, United Kingdom Host: Eileen Furlong
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 10 December 2015, 11:00 Add to calendar To be announced Marianne Bronner, California Institute of Technology, Division of Biology, Pasadena, USA Host: Detlev Arendt
Large Operon, EMBL Heidelberg
External Faculty Speaker
Wednesday, 3 February 2016, 11:00 Add to calendar To be announced Ben Lehner, Centre for Genomic Regulation, Pompeu Fabra University, Spain Host: Kiran Paril
Small Operon, EMBL Heidelberg