Seminar Colour Guide:              
External Faculty Speaker
Friday, 30 January 2015, 11:00 Add to calendar Fly thorax morphogenesis: from cell dynamics to tissue shape Francois Graner, Systèmes Complexes, Université Paris Diderot, France Host: Jean-Léon Maitre
Small Operon, EMBL Heidelberg
Abstract: Fly thorax morphogenesis: from cell dynamics to tissue shape

During animal development, several planar cell polarity pathways control tissue shape by coordinating collective cell behavior. Our model system is the Drosophila dorsal thorax. During the fly metamorphosis, it changes from larval to adult shape within a few days. We image it over several orders of magnitude in space and time. A general set of quantitative tools links the sub-cell scale, the cell dynamics, the level of the group of cells, and the whole tissue. In close interaction between biologists and physicists, we characterize both the Fat/Dachsous/ Four-jointed pathway and its control on the mechanics. Cell tension anisotropy defines the pattern of local tissue contraction that contributes to shaping the epithelium, mainly via oriented cell rearrangements. These results establish how tissue planar polarization coordinates the local changes of cell mechanical properties to control tissue morphogenesis.
External Faculty Speaker
Friday, 30 January 2015, 11:00 Add to calendar GeneCore: are we here yet? Vladimir Benes, Head of Genomics Core Facility, EMBL Heidelberg, Heidelberg, Germany Host: Donal O'Carroll
CNR Seminar Room, EMBL Monterotondo
Company Representative
Monday, 2 February 2015, 09:30 Add to calendar Basics in Light Microscopy Jens Marquardt, Olympus, Germany Host: Stefan Terjung
Room 202, EMBL Heidelberg
Company Representative
Tuesday, 3 February 2015, 09:30 Add to calendar Basics in Fluorescence Microscopy Jens Marquardt, Olympus, Germany Host: Stefan Terjung
Room 202, EMBL Heidelberg
External Faculty Speaker
Tuesday, 3 February 2015, 11:00 Add to calendar Stem cell dynamics in homoeostasis and cancer Edward Morrissey, Cancer Research UK Cambridge Research Institute, United Kingdom Host: Anne Ephrussi
Large Operon, EMBL Heidelberg
Abstract: The intestinal epithelium is characterised by rapid cellular turnover sustained by adult stem cells located at the base of glandular crypts.
Based on expression of specific genes and cell location, several different crypt base sub-populations have been put forward as intestinal
stem cells, making it unclear how this compartment works.

In this talk I will describe how a novel mutationally-activated cell reporter gene in a mouse model combined with mathematical
modelling, allows description of the behaviour of stem cells in homoeostasis and in adenomas. In addition, building on these
quantitative behaviours in homoeostasis we were able to model and quantify the evolutionary advantages of stem cells harbouring
oncogenic mutations, when competing against wild type cells.
Seminar given by an external postdoc
Tuesday, 3 February 2015, 13:00 Add to calendar Integrated on-chip platform for optical trapping, sensing and fluorescence bio-imaging applications Balpreet Singh Ahluwalia, The Arctic University of Norway, Norway Host: Yannick Schwab
Large Operon, EMBL Heidelberg
Abstract: In this talk, I will present the recent developments in our lab on planar trapping of particles and cells using optical waveguides. On-chip approach to trap, transport and levitate micro-particles using the surface evanescent field is proposed. Red blood cells are trapped and deformed on top of optical waveguides and loss of blood deformability with storage is monitored.
I will also present some of the recent work on integrated optical microscopy, super-resolution bio-imaging and discuss the future direction of "integrated optical nanoscopy", the project funded by ERC Starting grant.

External Faculty Speaker
POSTPONED - Friday, 6 February 2015, 11:00 Add to calendar To be announced Binnaz Yalcin, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland, Switzerland Host: Cornelius Gross
CNR Seminar Room, EMBL Monterotondo
Seminar given by an external postdoc
Friday, 6 February 2015, 13:00 Add to calendar Structural and mechanistic insights into function and translocation of bacterial ABC toxins Dominic Meusch, Max Planck Institute for Molecular Physiology,, Department of Structural Biochemistry, Dortmund, Germany Host: Matthias Wilmanns
Seminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Monday, 9 February 2015, 11:00 Add to calendar Metabolic Prostheses Synthetic Biology-Inspired Treatment Strategies For Metabolic Disorders Martin Fussenegger, ETH Zurich, Department of Biosystems Science and Engineering, Switzerland Host: Kiran Patil
Large Operon, EMBL Heidelberg
Abstract: Since Paracelsus (1493-1541) definition that the dosing makes the drug the basic treatment strategies have lagely remained unchanged. We continue to use a precise prescribed dose of a small-molecule drug, a protein therapeutic or a therapeutic transgene to constitutively modulate or complement the activity of a disease-relevant target. However, this treatment concept does neither consider the metabolic dynamics nor the interdependence of the most important pathophysiologies of the 21st century such as obesity, diabetes and cardiovascular disorders. Synthetic biology-inspired prosthetic networks may act as metabolic prostheses that provide the dynamic interventions, the immediate pre-disease action and the multi-target capacity required to meet with the treatment challenges of the future. Prosthetic networks consist of synthetic sensor-effector gene circuits that (i) seamlessly operate in implanted designer cells, (ii) constantly sense, monitor and score metabolic disturbanes in peripheral circulation, (iii) process OFF-level concentrations of pathologic metabolites, and (iv) coordinate an adjusted therapeutic response in an (v) automatic and self-sufficient manner. We will present our latest generation of synthetic mammalian gene circuits and provide a few examples of prosthetic networks operating in animal models of prominent human diseases to highlight the challenges and impact of synthetic biology on future biomedical applications
External Faculty Speaker
Monday, 9 February 2015, 16:30 Add to calendar Human proteomes from basic science to understanding drug action Bernhard Kuster, Technical University Munich, Germany Host: Jeroen Krijgsveld
Small Operon, EMBL Heidelberg
Company Representative
Tuesday, 10 February 2015, 11:00 Add to calendar Open Science publishing: moving beyond Open Access Michaela Torkar, F1000 Research, United Kingdom Host: Wolfgang Huber
Small Operon, EMBL Heidelberg
External Faculty Speaker
Wednesday, 11 February 2015, 14:00 Add to calendar To be announced Samuel Wagner, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Germany Host: Christian Löw
Seminar Room 48e, EMBL Hamburg
External Faculty Speaker
Friday, 13 February 2015, 11:00 Add to calendar To be announced Sebastian Kadener, The Alexander Silberman Institute of Life Sciences, Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel Host: Donal O'Carroll
CNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Friday, 13 February 2015, 13:00 Add to calendar The SPB/SFX instrument at the European XFEL: Overview and scientific possibilities Adrian Mancuso, European XFEL GmbH, Hamburg, Germany Host: Dmitri Svergun
Seminar Room 48e, EMBL Hamburg
Abstract: The presently under-construction European XFEL will produce an unprecedented rate of extremely bright X-ray pulses applicable to a wide variety of research. One potential application envisages using such pulses for structure determination of materials including biological materials through crystallography experiments, imaging experiments, and small angle x-ray scattering experiments, for both static structure determination and time-resolved structure determination.

In this presentation, I will give an overview of the European XFEL, in particular describing the Single Particles, Clusters and Biomolecules/Serial Femtosecond Crystallography (SPB/SFX) instrument, which seeks to enable biological structure determination. The mirror optical systems, detection systems, sample delivery systems and, pending time key, diagnostics will be briefly described.

In the second part of this presentation, scientific opportunities for forward scattering experiments will be presented, including opportunities towards single particle imaging experiments. The relationship between single particle imaging experiments and small angle x-ray scattering (SAXS) experiments will be explored, and the expected experimental parameters for forward scattering experiments at SPB/SFX introduced
Science and Society
Wednesday, 18 February 2015, 15:00 Add to calendar The threat of manufactured disease: The past, present & future of biological weapons Filippa Lentzos, King's College London, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 19 February 2015, 11:00 Add to calendar To be announced Steven Block, Stanford University , Dept. of Biology and Applied Physics, USA Host: Jonas Ries
Large Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Friday, 20 February 2015, 10:00 Add to calendar Controlling the Cell Cycle Sir Paul Nurse , The Royal Society, London, United Kingdom Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
Seminar given by an external postdoc
Friday, 20 February 2015, 13:00 Add to calendar When you can't get high enough: integrative structure modeling from low resolution data Jan Kosinski, EMBL Heidelberg, Germany Host: Arjen Jakobi
Seminar Room 48e, EMBL Hamburg
Company Representative
Monday, 23 February 2015, 09:30 Add to calendar Basics in Confocal Microscopy Florian Eich, Olympus, Germany Host: Stefan Terjung
ATC - Courtyard A+B, EMBL Heidelberg
External Faculty Speaker
Friday, 27 February 2015, 11:00 Add to calendar Preclinical studies to set the ground for early detection of Autism Spectrum Disorders Maria Luisa Scattoni, Neurotoxicology and Neuroendocrinology Section, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy, Italy Host: Cornelius gross
CNR Seminar Room, EMBL Monterotondo
Company Representative
Tuesday, 3 March 2015, 11:00 Add to calendar siPOOLs: complex and defined siRNA pools prevent off-target effects Michael Hannus, siTools, Germany Host: Beate Neumann
Small Operon, EMBL Heidelberg
Abstract: For years, RNAi was considered the magic bullet of functional genomics, promising fast, specific and scalable genetic intervention.

Hype was followed by disappointment when it was shown that off-target effects frequently dominate the phenotypic response in RNAi experiments. Nevertheless, RNAi remains the standard technique for gene inactivation because of its many advantages, such as transient, dose-dependent effects and ease of arrayed screening.

Complex siRNA pools apply a conceptually simple but efficient approach to prevent off-target effects: All siRNAs share the same on-target gene but have different off-target footprints. As a result, off-target effects are efficiently diluted and target gene knockdown becomes very robust.
http://www.sitoolsbiotech.com/

The talk is also open for non-EMBL members.
EMBL-La Sapienza Lecture
Friday, 13 March 2015, 11:00 Add to calendar Local Transcriptomes and Proteomes at Neuronal Synapses Erin Schuman, Max Planck Institute for Brain Research, Frankfurt, Germany Host: Cornelius Gross / Andrea Mele
Sapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma
EMBL Distinguished Visitor Lecture
Tuesday, 17 March 2015, 11:00 Add to calendar To be announced Gilles Trave, Equipe Oncoproteines, IREBS, UMR 7242, Ecole Supérieure de Biotechnologie, Strasbourg, France Host: Esther Ortega
EMBL Seminar Room, EMBL Grenoble
EMBL Distinguished Visitor Lecture
Friday, 20 March 2015, 10:00 Add to calendar Monoallelic gene expression and epigenetics: X-chromosome inactivation and beyond Edith Heard, Directeur de l'Unité Génétique et biologie du développement, Institut Curie, Paris, France Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
Hamburg Speaker
Friday, 20 March 2015, 13:00 Add to calendar Structural insights into substrate binding of the chaperone and prolyl isomerase tSlyD Christian Loew, EMBL Hamburg, Germany Seminar Room 48e, EMBL Hamburg
Science and Society
Monday, 30 March 2015, 15:00 Add to calendar Crafting Stories About Science Ben Lillie, freelance writer and comedian, New York, USA Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 17 April 2015, 11:00 Add to calendar To be announced Stefano Piccolo, University of Padua, Dept. of Molecular Medicine, Italy Host: Darren Gilmour
Large Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Wednesday, 22 April 2015, 14:00 Add to calendar To be announced Andreas Beyer, University of Cologne, Germany Host: Leopold Parts
Small Operon, EMBL Heidelberg
External Faculty Speaker
Thursday, 23 April 2015, 11:00 Add to calendar To be announced Elena Cattaneo, Department of Biosciences, University of Milano, Italy, , Italy Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
Science and Society
Thursday, 23 April 2015, 15:00 Add to calendar The neuroscience of laughter Sophie Scott, University College London, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
Science and Society
Wednesday, 29 April 2015, 18:00 Add to calendar Computer-Gehirn Interface Niels Birbaumer, University of Tuebingen, Germany Host: Halldór Stefánsson
all EMBL HD
EMBL Distinguished Visitor Lecture
Thursday, 30 April 2015, 10:00 Add to calendar Design Principles of Pluripotency Austin Smith, Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Thursday, 30 April 2015, 11:00 Add to calendar To be announced Caroline DEAN, John Innes Centre, Dept. of Cell & Developmental Biology, Norwich, UK, United Kingdom Host: Anne Ephrussi
Large Operon, EMBL Heidelberg
External Faculty Speaker
Tuesday, 5 May 2015, 11:00 Add to calendar Regulating chromosome-wide gene expression by nuclear positioning: dosage compensation in C. elegans Peter Meister, University of Bern, Institute of Cell Biology, Switzerland Host: Christian Haering
Small Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Friday, 8 May 2015, 11:00 Add to calendar To be announced Anne Schaefer, Friedman Brain Institute, Department of Neuroscience , Department of Psychiatry, Mount Sinai School of Medicine, , New York, NY, USA, Host: Donal O'Carroll
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Tuesday, 12 May 2015, 11:00 Add to calendar To be announced Elly Tanaka, Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany Host: Anne Ephrussi
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 22 May 2015, 10:00 Add to calendar Programming blood stem cells during development Roger Patient, Radcliffe Department of Medicine, University of Oxford, Oxford, UK Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Monday, 15 June 2015, 11:00 Add to calendar To be announced James E. Ferrell, Stanford University, Dept. of Chemical and Systems Biology, USA Host: Francois Nedelec
Large Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Thursday, 18 June 2015, 10:00 Add to calendar Engineering the Cancer Genome Tyler Jacks, David H. Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Thursday, 2 July 2015, 11:00 Add to calendar To be announced Adam Arkin, University of California, Berkeley, Dept. of Bioengineering, USA Host: Nassos Typas
ATC Auditorium, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 3 July 2015, 10:00 Add to calendar Development and organization of the sensory neurons of touch David Ginty, Harvard Medical School, Department of Neurobiology, Boston, MA, USA Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
Science and Society
Monday, 13 July 2015, 14:00 Add to calendar Decoding Race Catherine Bliss, University of California, San Francisco, USA Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 16 September 2015, 11:00 Add to calendar To be announced Thomas Pollard, Yale University, New Haven, Dept. of Molecular Cellular & Developmental Biology, USA Host: Peter Lenart
Large Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Friday, 18 September 2015, 10:00 Add to calendar Transplant-mediated repair of spinal cord GABAergic circuitry to treat the disease of neuropathic pain Allan Basbaum, Department of Anatomy, University of California, San Francisco, CA, USA Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Tuesday, 22 September 2015, 11:00 Add to calendar To be announced Christine Holt, University of Cambridge, Dept. of Developmental Neuroscience, United Kingdom Host: Jeroen Krijgsveld
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 30 September 2015, 16:00 Add to calendar To be announced Mary Beckerle, Huntsman Cancer Institute, Salt Lake City, Host: Francois Nedelec
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 2 October 2015, 10:00 Add to calendar Neuronal Plasticity and Genomic Diversity Fred Gage , Laboratory of Genetics LOG-G, The Salk Institute for Biological Studies, La Jolla, CA, USA Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Monday, 5 October 2015, 11:00 Add to calendar To be announced Raymond E. Goldstein, University of Cambridge, Dept. of Applied Mathematics and Theoretical Physics, Center for Mathematical Sciences, United Kingdom Host: Predocs
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 16 October 2015, 10:00 Add to calendar Mechanisms of cell reprogramming Thomas Graf , Centre for Genomic Regulation, Barcelona, Spain Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Tuesday, 27 October 2015, 11:00 Add to calendar To be announced Cynthia Wolberger, John Hopkins University School of Medicine, Dept. of Biophysics and Biophysical Chemistry, Baltimore, USA Host: Christoph Mueller
Large Operon, EMBL Heidelberg
EMBL-La Sapienza Lecture
Friday, 30 October 2015, 11:00 Add to calendar Small RNAs mediate inheritance of memories in C.elegans Oded Rechavi, Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Sagol School of Neuroscience, Tel-Aviv University, Ramat Aviv, Tel Aviv, Israel Host: Cornelius Gross / Andrea Mele
Sapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma
EMBL Distinguished Visitor Lecture
Monday, 16 November 2015, 11:00 Add to calendar To be announced Herwig Baier, Max-Planck-Institute Martinsried, Dept. for Neurology, Germany Host: Francesca Peri
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 10 December 2015, 11:00 Add to calendar To be announced Marianne Bronner, California Institute of Technology, Division of Biology, Pasadena, USA Host: Detlev Arendt
Large Operon, EMBL Heidelberg