Seminar Colour Guide:              
Seminar given by an external postdoc
Wednesday, 27 May 2015, 11:00 Add to calendar Coupled folding and binding of intrinsically disordered proteins Sarah Shammas, University of Cambridge, UK, Chemistry Department, United Kingdom Host: Edward Lemke
Small Operon, EMBL Heidelberg
Tags: Biocomputing, Structural Biology
External Faculty Speaker
Friday, 29 May 2015, 11:00 Add to calendar Genetic basis of brain disorders using mouse models Binnaz Yalcin, Faculty of Biology and Medicine, Centre for Integrative Genomics, University of Lausanne, Lausanne, Switzerland Host: Cornelius Gross
CNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Wednesday, 3 June 2015, 15:00 Add to calendar How to cope with always being wrong in systems biology? Michael Stumpf, Imperial College London, United Kingdom Host: Francois Nédélec/ Karin Sasaki
Small Operon, EMBL Heidelberg
Tags: Systems Biology, Cell Biology
Science and Society
Thursday, 4 June 2015, 14:00 Add to calendar Artificial Life and Origins of Life Martin M. Hanczyc, Centre for Integrative Biology (CIBIO), Università degli Studi di Trento, Italy Host: Halldór Stefánsson
CNR Seminar Room, EMBL Monterotondo
Abstract: My work is focused on understanding the fundamental principles of living and evolving systems through experimental science. To this end, I build synthetic systems where dynamic life-like properties emerge when self-assembled systems are pushed away from equilibrium. I will present several experimental models based on oil droplets and vesicles. These systems are of interest due to their ability to sense, metabolize and their potential to evolve. In the oil droplet system, I will present how sensory-motor coupling can produce chemotactic motile droplets in a prebiotic context. In the vesicle system I will present how clays can organize organic material into protocell architectures.
External Faculty Speaker
Friday, 5 June 2015, 11:00 Add to calendar Molecular diversification of neuronal surface receptors: mechanisms and functions Dietmar Schreiner, Scheiffele Lab, Biozentrum, University of Basel, Basel, Switzerland Host: Cornelius Gross
CNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Friday, 5 June 2015, 13:00 Add to calendar Interpretation of SWAXS data by explicit-solvent molecular dynamics Jochen Hub, Computational Molecular Biophysics Group, Institute for Microbiology and Genetics, University of Göttingen, Germany Host: Dmitri Svergun
Seminar Room 48e, EMBL Hamburg
Abstract: Small and wide angle X-ray scattering (SWAXS) and molecular dynamics
(MD) simulations are complementary approaches that probe conformational
transitions of biomolecules in solution, even in a time-resolved manner.
However, the structural interpretation of the scattering signals is
challenging, while MD simulations frequently suffer from incomplete
sampling or from a force field bias.

To combine the advantages of both techniques, we present a method that
incorporates solution scattering data as a differentiable energetic
restraint into explicit-solvent MD simulations, termed SWAXS-driven MD,
with the aim to direct the simulation into conformations satisfying the
experimental data. Because the calculations fully rely on explicit
solvent, no fitting parameters associated with the solvation layer or
excluded solvent are required, and the calculations remain valid at wide
angles [1]. Notably, the calculation of SWAXS curves based on
explicit-solvent MD is now available via the web server WAXSiS [2].

The complementarity of SWAXS and MD is illustrated using three
biological examples, namely a periplasmic binding protein, aspartate
carbamoyltransferase, and a nuclear exportin [3]. The examples suggest
that SWAXS-driven MD is capable of refining structures against SWAXS
data without foreknowledge of possible reaction paths. In turn, the
SWAXS data accelerates conformational transitions in MD simulations and
reduces the force field bias.

Recent extensions of these methods are discussed. First, towards the
interpretation time-resolved anisotropic scattering, and, if time
remains, towards Bayesian interpretation of SAXS data.

[1] Chen and Hub, Validating solution ensembles from molecular dynamics
simulation by wide-angle X-ray scattering data, Biophys. J. 2014, 107,
435-447
[2] Knight and Hub, WAXSiS: a web server for the calculation of
SAXS/WAXS curves based on explicit-solvent molecular dynamics, Nucleic
Acids Res (2015), doi: 10.1093/nar/gkv309; http://waxsis.uni-goettingen.de/
[3] Chen and Hub, Interpretation of solution X-ray scattering data by
explicit-solvent molecular dynamics, Biophys. J., in press
Hamburg Speaker
Friday, 12 June 2015, 13:00 Add to calendar To be announced Erica Valentini, EMBL Hamburg, Germany Host: Dmitri Svergun
Seminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Monday, 15 June 2015, 11:00 Add to calendar To be announced James E. Ferrell, Stanford University, Dept. of Chemical and Systems Biology, USA Host: Francois Nedelec
Large Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Wednesday, 17 June 2015, 10:00 Add to calendar Engineering the Cancer Genome Tyler Jacks, David H. Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Thursday, 18 June 2015, 11:00 Add to calendar ESCHERICHIA COLI AS HOST FOR MEMBRANE PROTEIN STRUCTURE
DETERMINATION: A GLOBAL ANALYSIS
Dr. Bruno Miroux, Laboratoire de Biologie Physico-Chimique des Protéines Membranaires,UMR 7099 (CNRS - Université Paris Diderot), Institut de Biologie Physico-Chimique, France Host: Christiane Schaffitzel
EMBL Seminar Room, EMBL Grenoble
Science and Society
Friday, 19 June 2015, 15:00 Add to calendar A crisis of trust? Setting guidelines for image processing in scientific journals Emma Frow, Arizona State University, USA Host: Halldór Stefánsson
Small Operon, EMBL Heidelberg
Abstract: In this talk I will address a contemporary debate in scientific publishing. Journal editors are increasingly concerned about how scientists use digital image-processing software to prepare images for publication. The growing availability of software like Photoshop means that images can easily be adjusted to emphasize key aspects of experimental results, or to create a more aesthetically pleasing image. To some, these practices threaten the credibility of images in research papers. In response, several journals are developing guidelines for authors to follow when preparing images, and are hiring forensic experts to screen for inappropriate practice. I will offer some examples of image manipulation and journal responses, and use these to explore the crisis of trust being triggered by digital technologies.
External Faculty Speaker
Monday, 22 June 2015, 11:00 Add to calendar To be announced Jim Hughes, University of Oxford, United Kingdom Host: Francois Spitz
Small Operon, EMBL Heidelberg
External Faculty Speaker
Tuesday, 23 June 2015, 10:00 Add to calendar Organization and biochemistry in strained bacterial membranes Doug Weibel, University of Wisconsin-Madison, USA Host: Nassos Typas
Small Operon, EMBL Heidelberg
Abstract: We are exploring an evolutionarily conserved mechanism for the localization and regulation of biochemistry at strained membranes in bacteria and mitochondria. In this talk, I describe how this mechanism plays a role in regulating the universal and widely conserved DNA-repair protein, RecA. Our picture of bacterial organization is that membrane curvature causes strain in the bilayer that leads to the accumulation of intrinsically curved, anionic phospholipids at the bacterial poles to dissipate elastic strain.

We have discovered that the interaction of RecA with these anionic-rich regions of membranes stabilizes RecA filament bundles, which plays a fundamental role in homology pairing during DNA recombination. Our data further indicates that the interaction of RecA with the membrane enables it to sense phospholipid composition and can trigger the biosynthesis of anionic phospholipids as needed.

Early studies in this field demonstrated that large amounts of RecA associate with membrane fractions during DNA damage (Garvey et al. 1985, J. Biol. Chem. 285, 18984). A fundamental unanswered question is why does RecA bind the membrane? We have pursued this question using an approach that fuses biophysics, biochemistry, and engineering and have found that this interaction is important in regulating the stability of RecA filament bundles, which play a fundamental role in DNA repair. This and other studies in our lab are enabling us to decode the spatial and temporal control of biochemistry in bacteria and mitochondria at curved membranes.
External Faculty Speaker
Wednesday, 24 June 2015, 11:00 Add to calendar The apical membrane domain and tube morphogenesis Amin S. Ghabrial, Dept of Cell and Developmental Biology , University of Pennsylvania School of Medicine, USA Host: Daniel Rios
Small Operon, EMBL Heidelberg
External Faculty Speaker
Thursday, 25 June 2015, 11:30 Add to calendar From Down's syndrome to cancer: consequences of aneuploidy in human cells Zuzana Storchova, MPI for Biochemistry, Munich, Germany Host: Jan Korbel
Small Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 29 June 2015, 11:00 Add to calendar To be announced Fuchou Tang, Peking University, China Host: Takashi Hiiragi
Room 13-518 a + b, EMBL Heidelberg
External Faculty Speaker
Wednesday, 1 July 2015, 11:00 Add to calendar To be announced Ilka Bischofs, Bioquant, University of Heidelberg, Germany Host: Kiran Patil
Room 202, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 2 July 2015, 11:00 Add to calendar To be announced Adam Arkin, University of California, Berkeley, Dept. of Bioengineering, USA Host: Nassos Typas
ATC Auditorium, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 3 July 2015, 10:00 Add to calendar Development and organization of the sensory neurons of touch David Ginty, Harvard Medical School, Department of Neurobiology, Boston, MA, USA Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
Career Day
Thursday, 9 July 2015, 10:00 Add to calendar EMBL's Career Day 2015 EMBL Career Day, EMBL, Germany Host: EICAT (PhD and Postdoctoral Programmes)
ATC Auditorium, EMBL Heidelberg
Abstract: Organised by EICAT (PhD and Postdoctoral Programmes) together with EMBLEM, Career Day provides an overview of alternative, non-academic career possibilities for scientists from all EMBL sites and the local scientific community.
Science and Society
Monday, 13 July 2015, 14:00 Add to calendar Decoding Race Catherine Bliss, University of California, San Francisco, USA Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 27 July 2015, 16:00 Add to calendar Drug action in the context of the proteome Marcus Bantscheff, Cellzome, Germany Host: Carsten Schultz and Gerard Drewes
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Monday, 3 August 2015, 11:00 Add to calendar Functional implications of long noncoding RNAs Dr. ULITSKY Igor, Weizmann Institute of Science, Israel, Israel Host: Ramesh Pillai
EMBL Seminar Room, EMBL Grenoble
Hamburg Speaker
Friday, 14 August 2015, 13:00 Add to calendar To be announced Bertrand Simon, EMBL Hamburg, Germany Host: Matthias Wilmanns
Seminar Room 48e, EMBL Hamburg
Hamburg Speaker
Friday, 4 September 2015, 13:00 Add to calendar To be announced Maria Marta Garcia Alai, EMBL Hamburg, Germany Seminar Room 48e, EMBL Hamburg
External Faculty Speaker
Monday, 14 September 2015, 16:00 Add to calendar Living droplets - biomedical discovery at high throughput Christoph Merten, EMBL, Germany Host: Carsten Schultz and Gerard Drewes
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 16 September 2015, 11:00 Add to calendar To be announced Thomas Pollard, Yale University, New Haven, Dept. of Molecular Cellular & Developmental Biology, USA Host: Peter Lenart
Large Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Friday, 18 September 2015, 10:00 Add to calendar Transplant-mediated repair of spinal cord GABAergic circuitry to treat the disease of neuropathic pain Allan Basbaum, Department of Anatomy, University of California, San Francisco, CA, USA Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Friday, 18 September 2015, 13:00 Add to calendar To be announced Yimin Zou, Neurobiology Section, Division of Biological Sciences, University of California, San Diego, USA Host: Rob Meijers
Seminar Room 48e, EMBL Hamburg
Science and Society
Sunday, 20 September 2015, 14:00 Add to calendar EMBL Heidelberg Science & Society Symposium: What makes us human? Various speakers, MPI for Evolutionary Anthropology, Collège de France, University of Notre Dame Host: Halldór Stefánsson
The Operon, EMBL Heidelberg
Abstract: Humans are distinctly different from all the other animals, in ways both good and bad. But articulating what that difference consists of remains a complex and difficult task, tackled by biologists, anthropologists and brain scientists.

We are, presumably, the only known species with a mind set on unravelling who and what we are. Today, scientists are making use of genomics to realign H. Sapiens with respect to H. neanderthalensis, hominids and apes. But what are the assumptions that are built into these research projects? And what is the nature of the evolved cognitive faculties that allow people to relate and bond to one another in our species-specific way? Are some of our behavioral responses hardwired in neural networks as a result of our evolutionary history, or does the ultimate strength of the human species lie in its apparently unlimited neurological plasticity?

And while humans seem so fabulously well equipped to relate to one another and spin intricate webs of social relations, at the same time they tirelessly invent ways and means of destroying each other in warfare. Is such behaviour to be considered a part of our human nature? Globally speaking, what role do nature, culture and our social environment play in the crafting of humans?
EMBL Distinguished Visitor Lecture
Tuesday, 22 September 2015, 11:00 Add to calendar To be announced Christine Holt, University of Cambridge, Dept. of Developmental Neuroscience, United Kingdom Host: Jeroen Krijgsveld
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 30 September 2015, 16:00 Add to calendar To be announced Mary Beckerle, Huntsman Cancer Institute, Salt Lake City, Host: Francois Nedelec
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 2 October 2015, 10:00 Add to calendar Neuronal Plasticity and Genomic Diversity Fred Gage , Laboratory of Genetics LOG-G, The Salk Institute for Biological Studies, La Jolla, CA, USA Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Monday, 5 October 2015, 11:00 Add to calendar To be announced Raymond E. Goldstein, University of Cambridge, Dept. of Applied Mathematics and Theoretical Physics, Center for Mathematical Sciences, United Kingdom Host: Predocs
Large Operon, EMBL Heidelberg
Company Representative
Thursday, 8 October 2015, 15:00 Add to calendar To be announced Jasmin Fisher, Microsoft UK, United Kingdom Host: Francois Nedelec/Karin Sasaki
Small Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Monday, 12 October 2015, 16:00 Add to calendar Controlling Biological Pathways with Photopharmacology Dirk Trauner, University of Munich, Germany Host: Carsten Schultz and Gerard Drewes
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 16 October 2015, 10:00 Add to calendar Mechanisms of cell reprogramming Thomas Graf , Centre for Genomic Regulation, Barcelona, Spain Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Tuesday, 20 October 2015, 11:00 Add to calendar To be announced Irving Weissman, Stanford University, Institute for Stem Cell Biology and Regenerative Medicine, Standford Ludwig Center for Cancer Stem Cell Research and Medicine, USA Host: Lars Steinmetz
Large Operon, EMBL Heidelberg
Hamburg Speaker
Friday, 23 October 2015, 13:00 Add to calendar To be announced Anne Tuukkanen, EMBL Hamburg, Germany Seminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Friday, 23 October 2015, 14:00 Add to calendar To be announced Jennifer A. Doudna, Howard Hughes Medical Institute Investigator, USA Host: Ramesh Pillai
ILL Chadwick, EMBL Grenoble
EMBL Distinguished Visitor Lecture
Tuesday, 27 October 2015, 11:00 Add to calendar To be announced Cynthia Wolberger, John Hopkins University School of Medicine, Dept. of Biophysics and Biophysical Chemistry, Baltimore, USA Host: Christoph Mueller
Large Operon, EMBL Heidelberg
Science and Society
Tuesday, 27 October 2015, 15:00 Add to calendar The Nazi Human Experiments and Post-War Legacies Paul Weindling, Oxford Brookes University, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
EMBL-La Sapienza Lecture
Friday, 30 October 2015, 11:00 Add to calendar Small RNAs mediate inheritance of memories in C.elegans Oded Rechavi, Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Sagol School of Neuroscience, Tel-Aviv University, Ramat Aviv, Tel Aviv, Israel Host: Cornelius Gross / Andrea Mele
Sapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma
Science and Society
Wednesday, 4 November 2015, 18:00 Add to calendar Tomorrow s Table: Organic farming, genetics and the future of food Pamela Ronald, Genome Center, University of California, USA Host: Halldór Stefánsson
Alte Aula of Ruprecht-Karls-Universität, Grabengasse 1, Heidelberg
Abstract: In their book, Tomorrow's Table, Pamela Ronald, a geneticist, and her husband, Raoul Adamchak, an organic farmer, argue that a judicious blend of two important strands of agriculture--genetic engineering and organic farming--is key to helping feed the world's growing population in an ecologically balanced manner. Ronald will describe the challenges that farmers face, as they try to feed the world without further destroying the environment.

The lecture is for technologists, entrepreneurs, consumers, farmers, and policy decision makers who want to make food choices or create policy and businesses that will support ecologically responsible farming practices. It is also for anyone who wants accurate information about organic farming, genetic engineering, and their potential impacts on human health and the environment.
Science and Society
Thursday, 5 November 2015, 11:00 Add to calendar To be announced Gail Davies, College of Life and Environmental Sciences, University of Exeter, United Kingdom Host: Shane Morley
CNR Seminar Room, EMBL Monterotondo
Hamburg Speaker
Friday, 13 November 2015, 13:00 Add to calendar To be announced Nabil Hanna, EMBL Hamburg, Germany Seminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Monday, 16 November 2015, 11:00 Add to calendar To be announced Herwig Baier, Max-Planck-Institute Martinsried, Dept. for Neurology, Germany Host: Francesca Peri
Large Operon, EMBL Heidelberg
Science and Society
Thursday, 19 November 2015, 15:00 Add to calendar Integrated omic studies for common complex traits & personalised medicine Tim Spector, King's College London, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
Abstract: We are using a large-scale multi-omic study of 5,000 adult twins to explore the potential of omics in personalized medicine. The TwinsUK resource contains the most studied individuals on the planet with all subjects having over 3000 phenotypes and GWAS SNP chips. Over 3000 now have whole genome sequencing at 6-30X depth. The omics being explored includes sub-studies used to explore the basic heritability, QTLs and age relationships as well as disease associations. This includes (EpiTWIN) using whole genome methylation sequencing and 450k for epigenetics, which also uses the discordant twin design using for replication 30,000 twins from the Discotwin European consortium. The same individuals are tested using an integrated omics approach including- the Multiple Human Tissue Expression Resource (MuTHER) and with RNA array and sequencing in three tissues. In addition we have analysed 1000 blood metabolites using metabolomics (Mass Spec and NMR), >100 glycomics markers (IgG and total plasma), immunophenotyping (with 78,000 White cell sub-types) and gut microbiomes (16s and metagenomics) on the same twins. Most subjects are being followed longitudinally to assess prediction of incident disease. Examples of recent integrated Omic analyses include prediction of age, pain sensitivity, renal function, hypertension, cancer, depression, obesity and diabetes. Longitudinal twin studies with global collaborations are the ideal resource to study the potential of personalized medicine.
Hamburg Speaker
Friday, 20 November 2015, 13:00 Add to calendar To be announced Alexey Kikhney, EMBL Hamburg, Germany Seminar Room 48e, EMBL Hamburg
External Faculty Speaker
Thursday, 26 November 2015, 11:00 Add to calendar To be announced Eirikur Steingrimsson, University of Iceland, Iceland Host: Anne Ephrussi
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 27 November 2015, 11:00 Add to calendar To be announced Nicholas Proudfoot, University of Oxford, Dept. of Molecular Biology , School of Pathology, United Kingdom Host: Eileen Furlong
Large Operon, EMBL Heidelberg
Hamburg Speaker
Friday, 27 November 2015, 13:00 Add to calendar To be announced Eike Schulz, EMBL Hamburg, Germany Seminar Room 48e, EMBL Hamburg
Hamburg Speaker
Friday, 4 December 2015, 13:00 Add to calendar To be announced Anne-Sophie Huart, EMBL Hamburg, Germany Seminar Room 48e, EMBL Hamburg
External Faculty Speaker
Monday, 7 December 2015, 16:00 Add to calendar Precision tools to custom tailor proteins Edward Lemke, EMBL, Germany Host: Carsten Schultz and Gerard Drewes
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 10 December 2015, 11:00 Add to calendar To be announced Marianne Bronner, California Institute of Technology, Division of Biology, Pasadena, USA Host: Detlev Arendt
Large Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 18 January 2016, 11:00 Add to calendar To be announced Cassandra Extavour, Department of Organismic and Evolutionary Biology, Department of Molecular and Cellular Biology, Harvard University, , USA Host: Anne Ephrussi
Small Operon, EMBL Heidelberg
External Faculty Speaker
Wednesday, 3 February 2016, 11:00 Add to calendar To be announced Ben Lehner, Centre for Genomic Regulation, Pompeu Fabra University, Spain Host: Kiran Paril
Small Operon, EMBL Heidelberg