Seminar Colour Guide:              
External Faculty Speaker
Monday, 20 April 2015, 11:00 Add to calendar Molecular Mechanisms in Cardiovascular Disease Antje Ebert, Stanford University, School of Medicine, Radiology, USA Host: Jan Ellenberg
Small Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Monday, 20 April 2015, 16:00 Add to calendar Cell Biology and Mechanics that drive Proliferation in the Retinal Neuroepithelium Caren Norden, MPI of Molecular Cell Biology and Genetics, Germany Host: Francesca Peri
Small Operon, EMBL Heidelberg
External Faculty Speaker
Tuesday, 21 April 2015, 11:00 Add to calendar The strength of protein coats deforming cell membranes Aurélien Roux, University of Geneva, Switzerland Host: Marko Kaksonen
Small Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
Wednesday, 22 April 2015, 14:00 Add to calendar Importance of rare copy number alterations for personalized tumor characterization Andreas Beyer, University of Cologne, Germany Host: Leopold Parts
Small Operon, EMBL Heidelberg
Abstract: Copy number alterations (CNAs) of large genomic regions are frequent in many tumor types, but only few of them are assumed to be relevant for the cancerous phenotype. It has proven exceedingly difficult to ascertain rare mutations that might have strong effects in individual patients. Here, we show that a genome-wide transcriptional regulatory
network inferred from gene expression and gene copy number data of 768 human cancer cell lines can be used to quantify the impact of individual patient-specific gene CNAs on cancer-specific survival signatures. The model was highly predictive for gene expression in 4,548 clinical samples originating from 13 different tissues. Focused analysis of
tumors from six tissues revealed that in an individual patient a combination of up to 100 gene CNAs directly or indirectly affect the expression of clinically relevant survival signature genes. Importantly, rare patient-specific mutations (< 1% in a given cohort) often have
stronger effects on signature genes than frequent mutations. Subsequent integration with genomic data suggests that frequency variation among high-impact genes is mainly driven by gene location rather than gene
function. Our framework contributes to the individualized quantification of cancer risk, along with determining individual key risk factors and their downstream targets.

External Faculty Speaker
Thursday, 23 April 2015, 10:00 Add to calendar Huntington's Disease and the story of its 800 million-year-old gene Elena Cattaneo, Department of Biosciences, University of Milano, Italy, Italy Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
Science and Society
Thursday, 23 April 2015, 15:00 Add to calendar The neuroscience of laughter Sophie Scott, University College London, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
Abstract: In this talk I will discuss laughter, a universal human vocal expression of emotion, which we associate with humour but which is more closely associated with social bonding and affiliation. I'll discuss the evolution of laughter and the ways we use it in everyday conversation. I'll also address the brain bases of laughter, and what sensorimotor systems roles are in laughter processing. I will also address the ways that laughter can vary across individuals.
External Faculty Speaker
Friday, 24 April 2015, 10:15 Add to calendar Adaptive Evolution of Metallo-beta-Lactamases Grants Organismal Fitness by Improving Catalysis and Flexibility Alejandro J. Vila, Director of IBR Rosario, Member of the National Scientific Committee advising MINCYT on the implementation of Argentina s associate membership to EMBL, Argentina Host: Christoph Mueller
Small Operon, EMBL Heidelberg
Tags: Structural Biology, Biocomputing
Hamburg Speaker
Friday, 24 April 2015, 13:00 Add to calendar Using a hybrid structural biology approach to solve a puzzle in axon guidance Rob Meijers, EMBL Hamburg, Germany Seminar Room 48e, EMBL Hamburg
External Faculty Speaker
Tuesday, 28 April 2015, 13:00 Add to calendar The 15th Public MMPU Research Day The 15th Public MMPU Research Day - MMPU members and invited guest speakers, Molecular Medicine Partnership Unit Heidelberg Host: Matthias Hentze and Andreas Kulozik
ATC - Courtyard A+B, EMBL Heidelberg
Tags: Molecular Medicine
Science and Society
Wednesday, 29 April 2015, 18:00 Add to calendar Computer-Gehirn Interface Niels Birbaumer, University of Tuebingen, Germany Host: Halldór Stefánsson
all EMBL HD
EMBL Distinguished Visitor Lecture
Thursday, 30 April 2015, 10:00 Add to calendar Design Principles of Pluripotency Austin Smith, Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Thursday, 30 April 2015, 11:00 Add to calendar To be announced Caroline DEAN, John Innes Centre, Dept. of Cell & Developmental Biology, Norwich, UK, United Kingdom Host: Anne Ephrussi
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 30 April 2015, 11:00 Add to calendar siRNA-mediated assembly of heterochromatin - a kiss to remember March Buehler , Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland Host: Ramesh Pillai
EMBL Seminar Room, EMBL Grenoble
External Faculty Speaker
Tuesday, 5 May 2015, 11:00 Add to calendar Regulating chromosome-wide gene expression by nuclear positioning: dosage compensation in C. elegans Peter Meister, University of Bern, Institute of Cell Biology, Switzerland Host: Christian Haering
Small Operon, EMBL Heidelberg
Tags: Cell Biology
External Faculty Speaker
CANCELLED - Friday, 8 May 2015, 11:00 Add to calendar To be announced Anne Schaefer, Friedman Brain Institute, Department of Neuroscience , Department of Psychiatry, Mount Sinai School of Medicine, , New York, NY, USA, Host: Donal O'Carroll
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Tuesday, 12 May 2015, 11:00 Add to calendar To be announced Elly Tanaka, Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany Host: Anne Ephrussi
Large Operon, EMBL Heidelberg
External Faculty Speaker
Wednesday, 13 May 2015, 11:00 Add to calendar To be announced Thomas Schalch, Professeur boursier FNS, Department of Molecular Biology,, University of Geneva, Switzerland Host: Ramesh Pillai
EMBL Seminar Room, EMBL Grenoble
External Faculty Speaker
Friday, 15 May 2015, 11:00 Add to calendar Molecular mechanisms of respiratory circuit assembly Polyxeni Philippidou, NYU Neuroscience Institute, Department of Neuroscience & Physiology, NYU School of Medicine, New York, NY, USA Host: Cornelius Gross
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Friday, 22 May 2015, 10:00 Add to calendar Programming blood stem cells during development Roger Patient, Radcliffe Department of Medicine, University of Oxford, Oxford, UK Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Friday, 22 May 2015, 11:00 Add to calendar Dissecting the mechanisms of miRNA function Marina Chekulaeva Marina Chekulaeva, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany Host: Ramesh Pillai
EMBL Seminar Room, EMBL Grenoble
External Faculty Speaker
Friday, 29 May 2015, 11:00 Add to calendar Genetic basis of brain disorders using mouse models Binnaz Yalcin, Faculty of Biology and Medicine, Centre for Integrative Genomics, University of Lausanne, Lausanne, Switzerland Host: Cornelius Gross
CNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Wednesday, 3 June 2015, 15:00 Add to calendar How to cope with always being wrong in systems biology? Michael Stumpf, Imperial College London, United Kingdom Host: Francois Nédélec/ Karin Sasaki
Small Operon, EMBL Heidelberg
Tags: Systems Biology, Cell Biology
Science and Society
Thursday, 4 June 2015, 11:00 Add to calendar Artificial Life and Origins of Life Martin M. Hanczyc, Centre for Integrative Biology (CIBIO), Università degli Studi di Trento, Italy Host: Halldór Stefánsson
CNR Seminar Room, EMBL Monterotondo
Abstract: My work is focused on understanding the fundamental principles of living and evolving systems through experimental science. To this end, I build synthetic systems where dynamic life-like properties emerge when self-assembled systems are pushed away from equilibrium. I will present several experimental models based on oil droplets and vesicles. These systems are of interest due to their ability to sense, metabolize and their potential to evolve. In the oil droplet system, I will present how sensory-motor coupling can produce chemotactic motile droplets in a prebiotic context. In the vesicle system I will present how clays can organize organic material into protocell architectures.
Science and Society
Thursday, 4 June 2015, 11:00 Add to calendar To be announced Martin Hanczyc, CIBIO, Università degli Studi di Trento, Povo, Italy Host: Shane Morley
CNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Friday, 5 June 2015, 13:00 Add to calendar To be announced Jochen Hub, Computational Molecular Biophysics Group, Institute for Microbiology and Genetics, University of Göttingen, Germany Host: Dmitri Svergun
Seminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Monday, 15 June 2015, 11:00 Add to calendar To be announced James E. Ferrell, Stanford University, Dept. of Chemical and Systems Biology, USA Host: Francois Nedelec
Large Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Wednesday, 17 June 2015, 10:00 Add to calendar Engineering the Cancer Genome Tyler Jacks, David H. Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA, USA Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Thursday, 18 June 2015, 11:00 Add to calendar ESCHERICHIA COLI AS HOST FOR MEMBRANE PROTEIN STRUCTURE
DETERMINATION: A GLOBAL ANALYSIS
Dr. Bruno Miroux, Laboratoire de Biologie Physico-Chimique des Protéines Membranaires,UMR 7099 (CNRS - Université Paris Diderot), Institut de Biologie Physico-Chimique, France Host: Christiane Schaffitzel
EMBL Seminar Room, EMBL Grenoble
Science and Society
Friday, 19 June 2015, 15:00 Add to calendar A crisis of trust? Setting guidelines for image processing in scientific journals Emma Frow, Arizona State University, USA Host: Halldór Stefánsson
Small Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 22 June 2015, 11:00 Add to calendar To be announced Jim Hughes, University of Oxford, United Kingdom Host: Francois Spitz
Small Operon, EMBL Heidelberg
External Faculty Speaker
Monday, 29 June 2015, 11:00 Add to calendar To be announced Fuchou Tang, Peking University, China Host: Takashi Hiiragi
Room 13-518 a + b, EMBL Heidelberg
External Faculty Speaker
Wednesday, 1 July 2015, 11:00 Add to calendar To be announced Ilka Bischofs, Bioquant, University of Heidelberg, Germany Host: Kiran Patil
Room 202, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Thursday, 2 July 2015, 11:00 Add to calendar To be announced Adam Arkin, University of California, Berkeley, Dept. of Bioengineering, USA Host: Nassos Typas
ATC Auditorium, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 3 July 2015, 10:00 Add to calendar Development and organization of the sensory neurons of touch David Ginty, Harvard Medical School, Department of Neurobiology, Boston, MA, USA Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
Science and Society
Monday, 13 July 2015, 14:00 Add to calendar Decoding Race Catherine Bliss, University of California, San Francisco, USA Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
Hamburg Speaker
Friday, 14 August 2015, 13:00 Add to calendar To be announced Bertrand Simon, EMBL Hamburg, Germany Host: Matthias Wilmanns
Seminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Wednesday, 16 September 2015, 11:00 Add to calendar To be announced Thomas Pollard, Yale University, New Haven, Dept. of Molecular Cellular & Developmental Biology, USA Host: Peter Lenart
Large Operon, EMBL Heidelberg
Tags: Cell Biology
EMBL Distinguished Visitor Lecture
Friday, 18 September 2015, 10:00 Add to calendar Transplant-mediated repair of spinal cord GABAergic circuitry to treat the disease of neuropathic pain Allan Basbaum, Department of Anatomy, University of California, San Francisco, CA, USA Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
External Faculty Speaker
Friday, 18 September 2015, 13:00 Add to calendar To be announced Yimin Zou, Neurobiology Section, Division of Biological Sciences, University of California, San Diego, USA Host: Rob Meijers
Seminar Room 48e, EMBL Hamburg
Science and Society
Sunday, 20 September 2015, 14:00 Add to calendar EMBL Heidelberg Science & Society Symposium: What makes us human? Various speakers, MPI for Evolutionary Anthropology, Collège de France, University of Notre Dame Host: Halldór Stefánsson
The Operon, EMBL Heidelberg
Abstract: Humans are distinctly different from all the other animals, in ways both good and bad. But articulating what that difference consists of remains a complex and difficult task, tackled by biologists, anthropologists and brain scientists.

We are, presumably, the only known species with a mind set on unravelling who and what we are. Today, scientists are making use of genomics to realign H. Sapiens with respect to H. neanderthalensis, hominids and apes. But what are the assumptions that are built into these research projects? And what is the nature of the evolved cognitive faculties that allow people to relate and bond to one another in our species-specific way? Are some of our behavioral responses hardwired in neural networks as a result of our evolutionary history, or does the ultimate strength of the human species lie in its apparently unlimited neurological plasticity?

And while humans seem so fabulously well equipped to relate to one another and spin intricate webs of social relations, at the same time they tirelessly invent ways and means of destroying each other in warfare. Is such behaviour to be considered a part of our human nature? Globally speaking, what role do nature, culture and our social environment play in the crafting of humans?
EMBL Distinguished Visitor Lecture
Tuesday, 22 September 2015, 11:00 Add to calendar To be announced Christine Holt, University of Cambridge, Dept. of Developmental Neuroscience, United Kingdom Host: Jeroen Krijgsveld
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Wednesday, 30 September 2015, 16:00 Add to calendar To be announced Mary Beckerle, Huntsman Cancer Institute, Salt Lake City, Host: Francois Nedelec
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 2 October 2015, 10:00 Add to calendar Neuronal Plasticity and Genomic Diversity Fred Gage , Laboratory of Genetics LOG-G, The Salk Institute for Biological Studies, La Jolla, CA, USA Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Monday, 5 October 2015, 11:00 Add to calendar To be announced Raymond E. Goldstein, University of Cambridge, Dept. of Applied Mathematics and Theoretical Physics, Center for Mathematical Sciences, United Kingdom Host: Predocs
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 16 October 2015, 10:00 Add to calendar Mechanisms of cell reprogramming Thomas Graf , Centre for Genomic Regulation, Barcelona, Spain Host: Philip Avner
CNR Seminar Room, EMBL Monterotondo
EMBL Distinguished Visitor Lecture
Tuesday, 20 October 2015, 11:00 Add to calendar To be announced Irving Weissman, Stanford University, Institute for Stem Cell Biology and Regenerative Medicine, Standford Ludwig Center for Cancer Stem Cell Research and Medicine, USA Host: Lars Steinmetz
Large Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Tuesday, 27 October 2015, 11:00 Add to calendar To be announced Cynthia Wolberger, John Hopkins University School of Medicine, Dept. of Biophysics and Biophysical Chemistry, Baltimore, USA Host: Christoph Mueller
Large Operon, EMBL Heidelberg
Science and Society
Tuesday, 27 October 2015, 15:00 Add to calendar The Nazi Human Experiments and Post-War Legacies Paul Weindling, Oxford Brookes University, United Kingdom Host: Halldór Stefánsson
Large Operon, EMBL Heidelberg
EMBL-La Sapienza Lecture
Friday, 30 October 2015, 11:00 Add to calendar Small RNAs mediate inheritance of memories in C.elegans Oded Rechavi, Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Sagol School of Neuroscience, Tel-Aviv University, Ramat Aviv, Tel Aviv, Israel Host: Cornelius Gross / Andrea Mele
Sapienza Università di Roma - Aula Odeion - Museo dell'Arte Classica - P.le Aldo Moro, 5 - Roma
EMBL Distinguished Visitor Lecture
Monday, 16 November 2015, 11:00 Add to calendar To be announced Herwig Baier, Max-Planck-Institute Martinsried, Dept. for Neurology, Germany Host: Francesca Peri
Large Operon, EMBL Heidelberg
External Faculty Speaker
Thursday, 26 November 2015, 11:00 Add to calendar To be announced Eirikur Steingrimsson, University of Iceland, Iceland Host: Anne Ephrussi
Small Operon, EMBL Heidelberg
EMBL Distinguished Visitor Lecture
Friday, 27 November 2015, 11:00 Add to calendar To be announced Nicholas Proudfoot, University of Oxford, Dept. of Molecular Biology , School of Pathology, United Kingdom Host: Eileen Furlong
Large Operon, EMBL Heidelberg
Hamburg Speaker
Friday, 27 November 2015, 13:00 Add to calendar To be announced Eike Schulz, EMBL Hamburg, Germany Seminar Room 48e, EMBL Hamburg
Hamburg Speaker
Friday, 4 December 2015, 13:00 Add to calendar To be announced Anne-Sophie Huart, EMBL Hamburg, Germany Seminar Room 48e, EMBL Hamburg
EMBL Distinguished Visitor Lecture
Thursday, 10 December 2015, 11:00 Add to calendar To be announced Marianne Bronner, California Institute of Technology, Division of Biology, Pasadena, USA Host: Detlev Arendt
Large Operon, EMBL Heidelberg
External Faculty Speaker
Wednesday, 3 February 2016, 11:00 Add to calendar To be announced Ben Lehner, Centre for Genomic Regulation, Pompeu Fabra University, Spain Host: Kiran Paril
Small Operon, EMBL Heidelberg
Science and Society
Monday, 5 September 2016, 11:00 Add to calendar To be announced Gail Davies, College of Life and Environmental Sciences, University of Exeter, United Kingdom Host: Shane Morley
CNR Seminar Room, EMBL Monterotondo