Staff at EMBL

Dr. Christian Häring

Group Leader
Häring Group Joint appointment: Structural and Computational Biology Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Biography

PhD 2003, Institute of Molecular Pathology, Vienna.
Postdoctoral research at the University of Oxford.
Group Leader at EMBL Heidelberg since 2007

Publications

Condensin: crafting the chromosome landscape. Piazza, I., Haering, C.H. & Rutkowska, A. Chromosoma. 2013 Apr 2. PubMed

Quantitative analysis of chromosome condensation in fission yeast. Petrova, B., Dehler, S., Kruitwagen, T., Heriche, J.K., Miura, K. & Haering, C.H. Mol Cell Biol. 2013 Mar;33(5):984-98. doi: 10.1128/MCB.01400-12. Epub 2012 Dec21. PubMed

Understanding chromatin and chromosomes: from static views to dynamic thinking. Haering, C.H. & Losada, A. EMBO Rep. 2013 Feb;14(2):109-11. doi: 10.1038/embor.2012.221. Epub 2013 Jan 15. PubMed

Cohesin in determining chromosome architecture. Haering, C.H. & Jessberger, R. Exp Cell Res. 2012 Jul 15;318(12):1386-93. Epub 2012 Mar 24. PubMed

A FlAsH-Based Cross-Linker to Study Protein Interactions in Living Cells. Rutkowska, A., Häring, C.H. & Schultz, C. Angew Chem Int Ed Engl. 2011 Dec 23;50(52):12655-8. doi:10.1002/anie.201106404. Epub 2011 Nov 16. PubMed

Condensin engages chromatin. Petrova, B. & Haering, C.H. Chembiochem. 2011 Nov 4;12(16):2399-401. doi: 10.1002/cbic.201100531. Epub 2011Sep 23. PubMed

Deciphering condensin action during chromosome segregation. Cuylen, S. & Haering, C.H. Trends Cell Biol. 2011 Sep;21(9):552-9. doi: 10.1016/j.tcb.2011.06.003. Epub 2011Jul 15. PubMed

Condensin structures chromosomal DNA through topological links. Cuylen, S., Metz, J. & Häring, C.H. Nat Struct Mol Biol. 2011 Jul 17;18(8):894-901. doi: 10.1038/nsmb.2087. PubMed

A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion. Kurze, A., Michie, K.A., Dixon, S.E., Mishra, A., Itoh, T., Khalid, S., Strmecki, L., Shirahige, K., Haering, C.H., Lowe, J. & Nasmyth, K. EMBO J. 2011 Jan 19;30(2):364-78. doi: 10.1038/emboj.2010.315. Epub 2010 Dec 7. PubMed

A new cohesive team to mediate DNA looping. Cuylen, S. & Häring, C.H. Cell Stem Cell. 2010 Oct 8;7(4):424-6. PubMed

Cohesin: its roles and mechanisms. Nasmyth, K. & Häring, C.H. Annu Rev Genet. 2009;43:525-58. PubMed

The cohesin ring concatenates sister DNA molecules. Häring, C.H., Farcas, A.M., Arumugam, P., Metson, J. & Nasmyth, K. Nature. 2008 Jul 17;454(7202):297-301. Epub 2008 Jul 2. PubMed

Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit. Arumugam, P., Nishino, T., Häring, C.H., Gruber, S. & Nasmyth, K. Curr Biol. 2006 Oct 24;16(20):1998-2008. PubMed

The structure and function of SMC and kleisin complexes. Nasmyth, K. & Häring, C.H. Annu Rev Biochem. 2005;74:595-648. PubMed

Structure and stability of cohesin's Smc1-kleisin interaction. Häring, C.H., Schoffnegger, D., Nishino, T., Helmhart, W., Nasmyth, K. & Lowe, J. Mol Cell. 2004 Sep 24;15(6):951-64. PubMed

Building and breaking bridges between sister chromatids. Häring, C.H. & Nasmyth, K. Bioessays. 2003 Dec;25(12):1178-91. PubMed

ATP hydrolysis is required for cohesin's association with chromosomes. Arumugam, P., Gruber, S., Tanaka, K., Häring, C.H., Mechtler, K. & Nasmyth, K. Curr Biol. 2003 Nov 11;13(22):1941-53. PubMed

Chromosomal cohesin forms a ring. Gruber, S., Häring, C.H. & Nasmyth, K. Cell. 2003 Mar 21;112(6):765-77. PubMed

Molecular architecture of SMC proteins and the yeast cohesin complex. Häring, C.H., Lowe, J., Hochwagen, A. & Nasmyth, K. Mol Cell. 2002 Apr;9(4):773-88. PubMed

Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion. Ivanov, D., Schleiffer, A., Eisenhaber, F., Mechtler, K., Häring, C.H. & Nasmyth, K. Curr Biol. 2002 Feb 19;12(4):323-8. PubMed

Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe. Häring, C.H., Nakamura, T.M., Baumann, P. & Cech, T.R. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6367-72. PubMed