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Staff at EMBL

Markus Hassler

Postdoctoral Fellow
Häring Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

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A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Jankevicius, G., Hassler, M., Golia, B., Rybin, V., Zacharias, M., Timinszky, G. & Ladurner, A.G. Nat Struct Mol Biol. 2013 Apr;20(4):508-14. doi: 10.1038/nsmb.2523. Epub 2013 Mar10. Europe PMC

Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation. Oppikofer, M., Kueng, S., Keusch, J.J., Hassler, M., Ladurner, A.G., Gut, H. & Gasser, S.M. EMBO J. 2013 Feb 6;32(3):437-49. doi: 10.1038/emboj.2012.343. Epub 2013 Jan 8. Europe PMC

Structural basis of histone H2A-H2B recognition by the essential chaperone FACT. Hondele, M., Stuwe, T., Hassler, M., Halbach, F., Bowman, A., Zhang, E.T., Nijmeijer, B., Kotthoff, C., Rybin, V., Amlacher, S., Hurt, E. & Ladurner, A.G. Nature. 2013 Jul 4;499(7456):111-4. doi: 10.1038/nature12242. Epub 2013 May 22. Europe PMC

Towards a structural understanding of PARP1 activation and related signalling ADP-ribosyl-transferases. Hassler, M. & Ladurner, A.G. Curr Opin Struct Biol. 2012 Dec;22(6):721-9. doi: 10.1016/ Epub2012 Sep 15. Europe PMC

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks. Ali, A.A., Timinszky, G., Arribas-Bosacoma, R., Kozlowski, M., Hassa, P.O., Hassler, M., Ladurner, A.G., Pearl, L.H. & Oliver, A.W. Nat Struct Mol Biol. 2012 Jun 10;19(7):685-92. doi: 10.1038/nsmb.2335. Europe PMC

PARG: a macrodomain in disguise. Hassler, M., Jankevicius, G. & Ladurner, A.G. Structure. 2011 Oct 12;19(10):1351-3. doi: 10.1016/j.str.2011.09.007. Europe PMC

Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79. Ehrentraut, S., Hassler, M., Oppikofer, M., Kueng, S., Weber, J.M., Mueller, J.W., Gasser, S.M., Ladurner, A.G. & Ehrenhofer-Murray, A.E. Genes Dev. 2011 Sep 1;25(17):1835-46. doi: 10.1101/gad.17175111. Europe PMC

Stress-induced PARP activation mediates recruitment of Drosophila Mi-2 to promote heat shock gene expression. Murawska, M., Hassler, M., Renkawitz-Pohl, R., Ladurner, A. & Brehm, A. PLoS Genet. 2011 Jul;7(7):e1002206. doi: 10.1371/journal.pgen.1002206. Epub 2011Jul 28. Europe PMC

Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture. Hassler, M., Singh, S., Yue, W.W., Luczynski, M., Lakbir, R., Sanchez-Sanchez, F., Bader, T., Pearl, L.H. & Mittnacht, S. Mol Cell. 2007 Nov 9;28(3):371-85. Europe PMC

Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase. Yue, W.W., Hassler, M., Roe, S.M., Thompson-Vale, V. & Pearl, L.H. EMBO J. 2007 Oct 17;26(20):4402-12. Epub 2007 Sep 20. Europe PMC

Direct interaction of Ca2+/calmodulin inhibits histone deacetylase 5 repressor core binding to myocyte enhancer factor 2. Berger, I., Bieniossek, C., Schaffitzel, C., Hassler, M., Santelli, E. & Richmond, T.J. J Biol Chem. 2003 May 16;278(20):17625-35. Epub 2003 Mar 6. Europe PMC

The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex. Hassler, M. & Richmond, T.J. EMBO J. 2001 Jun 15;20(12):3018-28. Europe PMC