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Staff at EMBL

Dr. Lars Hufnagel

Group Leader
Hufnagel Group Joint appointment: Developmental Biology Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail


PhD 2001, Max Planck Instutite for Dynamics and Self-Organisation, Göttingen.
Postdoctoral research at the Kavli Institute for Theoretical Physics, Santa Barbara, California.
Group leader at EMBL Heidelberg since 2007.


Quantitative cell polarity imaging defines leader-to-follower transitions during collective migration and the key role of microtubule-dependent adherens junction formation. Revenu, C., Streichan, S., Dona, E., Lecaudey, V., Hufnagel, L. & Gilmour, D. Development. 2014 Mar;141(6):1282-91. doi: 10.1242/dev.101675. Europe PMC

Subtle changes in motif positioning cause tissue-specific effects on robustness of an enhancer's activity. Erceg, J., Saunders, T.E., Girardot, C., Devos, D.P., Hufnagel, L. & Furlong, E.E. PLoS Genet. 2014 Jan;10(1):e1004060. doi: 10.1371/journal.pgen.1004060. Epub 2014Jan 2. Europe PMC

Mechanical stress inference for two dimensional cell arrays. Chiou, K.K., Hufnagel, L. & Shraiman, B.I. PLoS Comput Biol. 2012;8(5):e1002512. doi: 10.1371/journal.pcbi.1002512. Epub2012 May 17. Europe PMC

Collective and single cell behavior in epithelial contact inhibition. Puliafito, A., Hufnagel, L., Neveu, P., Streichan, S., Sigal, A., Fygenson, D.K. & Shraiman, B.I. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):739-44. doi:10.1073/pnas.1007809109. Epub 2012 Jan 6. Europe PMC

Multiview light-sheet microscope for rapid in toto imaging. Krzic, U., Gunther, S., Saunders, T.E., Streichan, S.J. & Hufnagel, L. Nat Methods. 2012 Jun 3;9(7):730-3. doi: 10.1038/nmeth.2064. Europe PMC

Light Sheet Fluorescence Microscopy (SPIM) and laser excitation in orange for imaging of live organisms. Uros Krzic, Stefan Günther, Hufnagel, L., Dag von Gegerfelt, Håkan Karlsson, Elizabeth Illy, and Jonas Hellström. Photonik International, no. 1, pp. 41–43, Nov. 2011

Quantitative fluorescence imaging of protein diffusion and interaction in living cells. Capoulade, J., Wachsmuth, M., Hufnagel, L. & Knop, M. Nat Biotechnol. 2011 Aug 7;29(9):835-9. doi: 10.1038/nbt.1928. Europe PMC

Collective cell migration guided by dynamically maintained gradients. Streichan, S.J., Valentin, G., Gilmour, D. & Hufnagel, L. Phys Biol. 2011 Aug;8(4):045004. doi: 10.1088/1478-3975/8/4/045004. Epub 2011 Jul12. Europe PMC

Lichtscheiben‐Fluoreszenzmikroskopie (SPIM) und Laser‐Anregung in
orange zur Abbildung lebender Organismen.
Uros Krzic, Stefan Günther, Hufnagel, L., Dag von Gegerfelt, Håkan Karlsson, Elizabeth Illy, and Jonas Hellström. BioPhotonik, no. 1, Apr. 2011.

On the mechanism of wing size determination in fly development. Hufnagel, L., Teleman, A.A., Rouault, H., Cohen, S.M. & Shraiman, B.I. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3835-40. Epub 2007 Feb 28. Europe PMC

Front propagation in reaction-superdiffusion dynamics: Taming Levy flights with fluctuations. Brockmann, D. & Hufnagel, L. Physical Review Letters 2007 98(17) 178301

On the role of glypicans in the process of morphogen gradient formation. Hufnagel, L., Kreuger, J., Cohen, S.M. & Shraiman, B.I. Dev Biol. 2006 Dec 15;300(2):512-22. Epub 2006 Sep 19. Europe PMC

The scaling laws of human travel. Brockmann, D., Hufnagel, L. & Geisel, T. Nature. 2006 Jan 26;439(7075):462-5. Europe PMC

Dynamics of Modern Epidemics. Brockmann, D., Hufnagel, L. & Geisel, T. In 'SARS: A Case Study in Emerging Infections', McLean, A., May, R., Pattison, J. & Weiss, R. (eds), 2005, Oxford University Press

Forecast and control of epidemics in a globalized world. Hufnagel, L., Brockmann, D. & Geisel, T. Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15124-9. Epub 2004 Oct 11. Europe PMC