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Staff at EMBL


Dr. Paul Heppenstall

Group Leader
Heppenstall Group Joint appointment: Cell Biology and Biophysics Unit

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail


PhD 1997, University of Edinburgh.
Postdoctoral work at the Max Delbrück Centrum,
Junior Professor at the Charité, Berlin.
Group leader at EMBL Monterotondo since 2008.
Group leader in the Molecular Medicine Partnership Unit.


Total: 34 publication(s)


Yang G, de Castro Reis F, Sundukova M, Pimpinella S, Asaro A, Castaldi L, Batti L, Bilbao D, Reymond L, Johnsson K, Heppenstall PA. (2014)
Genetic targeting of chemical indicators in vivo.
Nat. Methods doi:10.1038/nmeth.3207
Europe PMC | doi

Chen JT, Guo D, Campanelli D, Frattini F, Mayer F, Zhou L, Kuner R, Heppenstall PA, Knipper M, Hu J. (2014)
Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction.
Nat Commun 5 doi:10.1038/ncomms6331
Europe PMC | doi

Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R. (2014)
Wnt-Fzd Signaling Sensitizes Peripheral Sensory Neurons via Distinct Noncanonical Pathways
Neuron 83(1):104-121. doi:10.1016/j.neuron.2014.05.037
Europe PMC | doi


Nockemann D, Rouault M, Labuz D, Hublitz P, McKnelly K, Reis FC, Stein C, Heppenstall PA. (2013)
The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia
EMBO Mol Med 5(8):1263-1277. doi:10.1002/emmm.201201980
Europe PMC | doi

Wildner H, Das Gupta R, Bröhl D, Heppenstall PA, Zeilhofer HU, Birchmeier C. (2013)
Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity
J. Neurosci. 33(17):7299-7307. doi:10.1523/jneurosci.0491-13.2013
Europe PMC | doi

Kalebic N, Martinez C, Perlas E, Hublitz P, Bilbao-Cortes D, Fiedorczuk K, Andolfo A, Heppenstall PA. (2013)
Tubulin acetyltransferase αTAT1 destabilizes microtubules independently of its acetylation activity
Mol. Cell. Biol. 33(6):1114-1123. doi:10.1128/mcb.01044-12
Europe PMC | doi

Lukinavičius G, Umezawa K, Olivier N, Honigmann A, Yang G, Plass T, Mueller V, Reymond L, Corrêa IR Jr, Luo ZG, Schultz C, Lemke EA, Heppenstall P, Eggeling C, Manley S, Johnsson K. (2013)
A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins
Nat Chem 5(2):132-139. doi:10.1038/nchem.1546
Europe PMC | doi

Kress M, Hüttenhofer A, Landry M, Kuner R, Favereaux A, Greenberg D, Bednarik J, Heppenstall P, Kronenberg F, Malcangio M, Rittner H, Uçeyler N, Trajanoski Z, Mouritzen P, Birklein F, Sommer C, Soreq H. (2013)
microRNAs in nociceptive circuits as predictors of future clinical applications
Front Mol Neurosci 6 doi:10.3389/fnmol.2013.00033
Europe PMC | doi

Wang H, Schupp M, Zurborg S, Heppenstall PA. (2013)
Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli
J. Physiol. (Lond.) 591(Pt 1):185-201. doi:10.1113/jphysiol.2012.242842
Europe PMC | doi

Batti L, Mukhtarov M, Audero E, Ivanov A, Paolicelli O, Zurborg S, Gross C, Bregestovski P, Heppenstall PA. (2013)
Transgenic mouse lines for non-invasive ratiometric monitoring of intracellular chloride
Front Mol Neurosci 6:11. doi:10.3389/fnmol.2013.00011
Europe PMC | doi

Kalebic N, Sorrentino S, Perlas E, Bolasco G, Martinez C, Heppenstall PA. (2013)
αTAT1 is the major α-tubulin acetyltransferase in mice
Nat Commun 4:1962. doi:10.1038/ncomms2962
Europe PMC | doi


Topalidou I, Keller C, Kalebic N, Nguyen KC, Somhegyi H, Politi KA, Heppenstall P, Hall DH, Chalfie M. (2012)
Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organization
Curr. Biol. 22(12):1057-1065. doi:10.1016/j.cub.2012.03.066
Europe PMC | doi

Lapatsina L, Jira JA, Smith ES, Poole K, Kozlenkov A, Bilbao D, Lewin GR, Heppenstall PA. (2012)
Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons
Open Biol 2(6):120096. doi:10.1098/rsob.120096
Europe PMC | doi

Schmidt Y, Labuz D, Heppenstall PA, Machelska H. (2012)
Cutaneous nociceptors lack sensitisation, but reveal μ-opioid receptor-mediated reduction in excitability to mechanical stimulation in neuropathy
Mol Pain 8:81. doi:10.1186/1744-8069-8-81
Europe PMC | doi


Zurborg S, Piszczek A, Martínez C, Hublitz P, Al Banchaabouchi M, Moreira P, Perlas E, Heppenstall PA. (2011)
Generation and characterization of an Advillin-Cre driver mouse line
Mol Pain 7:66. doi:10.1186/1744-8069-7-66
Europe PMC | doi


Goswami C, Kuhn J, Heppenstall PA, Hucho T. (2010)
Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells
PLoS ONE 5(7):e11654. doi:10.1371/journal.pone.0011654
Europe PMC | doi


Caspani O, Heppenstall PA. (2009)
TRPA1 and cold transduction: an unresolved issue?
J. Gen. Physiol. 133(3):245-249. doi:10.1085/jgp.200810136
Europe PMC | doi

Caspani O, Zurborg S, Labuz D, Heppenstall PA. (2009)
The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain
PLoS ONE 4(10):e7383. doi:10.1371/journal.pone.0007383
Europe PMC | doi


Park TJ, Lu Y, Jüttner R, Smith ES, Hu J, Brand A, Wetzel C, Milenkovic N, Erdmann B, Heppenstall PA, Laurito CE, Wilson SP, Lewin GR. (2008)
Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber)
PLoS Biol. 6(1):e13. doi:10.1371/journal.pbio.0060013
Europe PMC | doi


Zurborg S, Yurgionas B, Jira JA, Caspani O, Heppenstall PA. (2007)
Direct activation of the ion channel TRPA1 by Ca2+
Nat. Neurosci. 10(3):277-279. doi:10.1038/nn1843
Europe PMC | doi

Wetzel C, Hu J, Riethmacher D, Benckendorff A, Harder L, Eilers A, Moshourab R, Kozlenkov A, Labuz D, Caspani O, Erdmann B, Machelska H, Heppenstall PA, Lewin GR. (2007)
A stomatin-domain protein essential for touch sensation in the mouse
Nature 445(7124):206-209. doi:10.1038/nature05394
Europe PMC | doi

Endres-Becker J, Heppenstall PA, Mousa SA, Labuz D, Oksche A, Schäfer M, Stein C, Zöllner C. (2007)
Mu-opioid receptor activation modulates transient receptor potential vanilloid 1 (TRPV1) currents in sensory neurons in a model of inflammatory pain
Mol. Pharmacol. 71(1):12-18. doi:10.1124/mol.106.026740
Europe PMC | doi


Heppenstall PA, Lewin GR. (2006)
A role for T-type Ca2+ channels in mechanosensation
Cell Calcium 40(2):165-174. doi:10.1016/j.ceca.2006.04.021
Europe PMC | doi


Hartmann B, Ahmadi S, Heppenstall PA, Lewin GR, Schott C, Borchardt T, Seeburg PH, Zeilhofer HU, Sprengel R, Kuner R. (2004)
The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain
Neuron 44(4):637-650. doi:10.1016/j.neuron.2004.10.029
Europe PMC | doi


Machelska H, Heppenstall PA, Stein C. (2003)
Breaking the pain barrier
Nat. Med. 9(11):1353-1354. doi:10.1038/nm1103-1353
Europe PMC | doi

Shin JB, Martinez-Salgado C, Heppenstall PA, Lewin GR. (2003)
A T-type calcium channel required for normal function of a mammalian mechanoreceptor
Nat. Neurosci. 6(7):724-730. doi:10.1038/nn1076
Europe PMC | doi


Schmidt H, Werner M, Heppenstall PA, Henning M, Moré MI, Kühbandner S, Lewin GR, Hofmann F, Feil R, Rathjen FG. (2002)
cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons
J. Cell Biol. 159(3):489-498. doi:10.1083/jcb.200207058
Europe PMC | doi

Müller T, Brohmann H, Pierani A, Heppenstall PA, Lewin GR, Jessell TM, Birchmeier C. (2002)
The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord
Neuron 34(4):551-562. doi:10.1016/s0896-6273(02)00689-x
Europe PMC | doi


Heppenstall PA, Lewin GR. (2001)
BDNF but not NT-4 is required for normal flexion reflex plasticity and function
Proc. Natl. Acad. Sci. U.S.A. 98(14):8107-8112. doi:10.1073/pnas.141015098
Europe PMC | doi


Heppenstall PA, Lewin GR. (2000)
Neurotrophins, nociceptors and pain
Curr Opin Anaesthesiol 13(5):573-576. doi:10.1097/00001503-200010000-00015
Europe PMC | doi

Price MP, Lewin GR, McIlwrath SL, Cheng C, Xie J, Heppenstall PA, Stucky CL, Mannsfeldt AG, Brennan TJ, Drummond HA, Qiao J, Benson CJ, Tarr DE, Hrstka RF, Yang B, Williamson RA, Welsh MJ. (2000)
The mammalian sodium channel BNC1 is required for normal touch sensation
Nature 407(6807):1007-1011. doi:10.1038/35039512
Europe PMC | doi

Pesquero JB, Araujo RC, Heppenstall PA, Stucky CL, Silva JA Jr, Walther T, Oliveira SM, Pesquero JL, Paiva AC, Calixto JB, Lewin GR, Bader M. (2000)
Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors
Proc. Natl. Acad. Sci. U.S.A. 97(14):8140-8145. doi:10.1073/pnas.120035997
Europe PMC | doi


Heppenstall PA, Fleetwood-Walker SM. (1997)
Glycine receptor regulation of neurokinin1 receptor function in rat dorsal horn neurones
Neuroreport 8(14):3109-3112. doi:10.1097/00001756-199709290-00020
Europe PMC | doi

Heppenstall PA, Fleetwood-Walker SM. (1997)
The glycine site of the NMDA receptor contributes to neurokinin1 receptor agonist facilitation of NMDA receptor agonist-evoked activity in rat dorsal horn neurons
Brain Res. 744(2):235-245. doi:10.1016/s0006-8993(96)01065-7
Europe PMC | doi