Top image

Staff at EMBL

Dr. Paul Heppenstall

Group Leader
Heppenstall Group Joint appointment: Cell Biology and Biophysics Unit

EMBL Monterotondo, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy

E-mail: send a mail


PhD 1997, University of Edinburgh.
Postdoctoral work at the Max Delbrück Centrum,
Junior Professor at the Charité, Berlin.
Group leader at EMBL Monterotondo since 2008.
Group leader in the Molecular Medicine Partnership Unit.


Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways. Simonetti, M., Agarwal, N., Stosser, S., Bali, K.K., Karaulanov, E., Kamble, R., Pospisilova, B., Kurejova, M., Birchmeier, W., Niehrs, C., Heppenstall, P. & Kuner, R. Neuron. 2014 Jul 2;83(1):104-21. doi: 10.1016/j.neuron.2014.05.037. Europe PMC

The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia. Nockemann, D., Rouault, M., Labuz, D., Hublitz, P., McKnelly, K., Reis, F.C., Stein, C. & Heppenstall, P.A. EMBO Mol Med. 2013 Aug;5(8):1263-77. doi: 10.1002/emmm.201201980. Epub 2013 Jul1. Europe PMC

Tubulin acetyltransferase alphaTAT1 destabilizes microtubules independently of its acetylation activity. Kalebic, N., Martinez, C., Perlas, E., Hublitz, P., Bilbao-Cortes, D., Fiedorczuk, K., Andolfo, A. & Heppenstall, P.A. Mol Cell Biol. 2013 Mar;33(6):1114-23. doi: 10.1128/MCB.01044-12. Epub 2012 Dec28. Europe PMC

A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins. Lukinavicius, G., Umezawa, K., Olivier, N., Honigmann, A., Yang, G., Plass, T., Mueller, V., Reymond, L., Correa IR, J.r, Luo, Z.G., Schultz, C., Lemke, E.A., Heppenstall, P., Eggeling, C., Manley, S. & Johnsson, K. Nat Chem. 2013 Feb;5(2):132-9. doi: 10.1038/nchem.1546. Epub 2013 Jan 6. Europe PMC

Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli. Wang, H., Schupp, M., Zurborg, S. & Heppenstall, P.A. J Physiol. 2013 Jan 1;591(Pt 1):185-201. doi: 10.1113/jphysiol.2012.242842. Epub2012 Oct 1. Europe PMC

alphaTAT1 is the major alpha-tubulin acetyltransferase in mice. Kalebic, N., Sorrentino, S., Perlas, E., Bolasco, G., Martinez, C. & Heppenstall, P.A. Nat Commun. 2013;4:1962. doi: 10.1038/ncomms2962. Europe PMC

Transgenic mouse lines for non-invasive ratiometric monitoring of intracellular chloride. Batti, L., Mukhtarov, M., Audero, E., Ivanov, A., Paolicelli, O., Zurborg, S., Gross, C., Bregestovski, P. & Heppenstall, P.A. Front Mol Neurosci. 2013;6:11. doi: 10.3389/fnmol.2013.00011. Europe PMC

Cutaneous nociceptors lack sensitisation, but reveal mu-opioid receptor-mediated reduction in excitability to mechanical stimulation in neuropathy. Schmidt, Y., Labuz, D., Heppenstall, P.A. & Machelska, H. Mol Pain. 2012 Nov 2;8:81. doi: 10.1186/1744-8069-8-81. Europe PMC

Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organization. Topalidou, I., Keller, C., Kalebic, N., Nguyen, K.C., Somhegyi, H., Politi, K.A., Heppenstall, P., Hall, D.H. & Chalfie, M. Curr Biol. 2012 Jun 19;22(12):1057-65. doi: 10.1016/j.cub.2012.03.066. Epub 2012May 31. Europe PMC

Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons. Lapatsina, L., Jira, J.A., Smith, E.S., Poole, K., Kozlenkov, A., Bilbao, D., Lewin, G.R. & Heppenstall, P.A. Open Biol. 2012 Jun;2(6):120096. doi: 10.1098/rsob.120096. Europe PMC

Generation and characterization of an Advillin-Cre driver mouse line. Zurborg, S., Piszczek, A., Martinez, C., Hublitz, P., Al Banchaabouchi, M., Moreira, P., Perlas, E. & Heppenstall, P.A. Mol Pain. 2011 Sep 11;7:66. doi: 10.1186/1744-8069-7-66. Europe PMC

Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells. Goswami, C., Kuhn, J., Heppenstall, P.A. & Hucho, T. PLoS One. 2010 Jul 19;5(7):e11654. doi: 10.1371/journal.pone.0011654. Europe PMC

TRPA1 and cold transduction: an unresolved issue? Caspani, O. & Heppenstall, P.A. J Gen Physiol. 2009 Mar;133(3):245-9. Europe PMC

The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain. Caspani, O., Zurborg, S., Labuz, D. & Heppenstall, P.A. PLoS One. 2009 Oct 8;4(10):e7383. Europe PMC

Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber). Park, T.J., Lu, Y., Juttner, R., Smith, E.S., Hu, J., Brand, A., Wetzel, C., Milenkovic, N., Erdmann, B., Heppenstall, P.A., Laurito, C.E., Wilson, S.P. & Lewin, G.R. PLoS Biol. 2008 Jan;6(1):e13. Europe PMC

Direct activation of the ion channel TRPA1 by Ca2+. Zurborg, S., Yurgionas, B., Jira, J.A., Caspani, O. & Heppenstall, P.A. Nat Neurosci. 2007 Mar;10(3):277-9. Epub 2007 Jan 28. Europe PMC

A stomatin-domain protein essential for touch sensation in the mouse. Wetzel, C., Hu, J., Riethmacher, D., Benckendorff, A., Harder, L., Eilers, A., Moshourab, R., Kozlenkov, A., Labuz, D., Caspani, O., Erdmann, B., Machelska, H., Heppenstall, P.A. & Lewin, G.R. Nature. 2007 Jan 11;445(7124):206-9. Epub 2006 Dec 13. Europe PMC

Mu-opioid receptor activation modulates transient receptor potential vanilloid 1 (TRPV1) currents in sensory neurons in a model of inflammatory pain. Endres-Becker, J., Heppenstall, P.A., Mousa, S.A., Labuz, D., Oksche, A., Schafer, M., Stein, C. & Zollner, C. Mol Pharmacol. 2007 Jan;71(1):12-8. Epub 2006 Sep 27. Europe PMC

A role for T-type Ca2+ channels in mechanosensation. Heppenstall, P.A. & Lewin, G.R. Cell Calcium. 2006 Aug;40(2):165-74. Epub 2006 Jun 13. Europe PMC

The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain. Hartmann, B., Ahmadi, S., Heppenstall, P.A., Lewin, G.R., Schott, C., Borchardt, T., Seeburg, P.H., Zeilhofer, H.U., Sprengel, R. & Kuner, R. Neuron. 2004 Nov 18;44(4):637-50. Europe PMC

Breaking the pain barrier. Machelska, H., Heppenstall, P.A. & Stein, C. Nat Med. 2003 Nov;9(11):1353-4. Europe PMC

A T-type calcium channel required for normal function of a mammalian mechanoreceptor. Shin, J.B., Martinez-Salgado, C., Heppenstall, P.A. & Lewin, G.R. Nat Neurosci. 2003 Jul;6(7):724-30. Europe PMC

cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons. Schmidt, H., Werner, M., Heppenstall, P.A., Henning, M., More, M.I., Kuhbandner, S., Lewin, G.R., Hofmann, F., Feil, R. & Rathjen, F.G. J Cell Biol. 2002 Nov 11;159(3):489-98. Epub 2002 Nov 4. Europe PMC

The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord. Muller, T., Brohmann, H., Pierani, A., Heppenstall, P.A., Lewin, G.R., Jessell, T.M. & Birchmeier, C. Neuron. 2002 May 16;34(4):551-62. Europe PMC

BDNF but not NT-4 is required for normal flexion reflex plasticity and function. Heppenstall, P.A. & Lewin, G.R. Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8107-12. Europe PMC

The mammalian sodium channel BNC1 is required for normal touch sensation. Price, M.P., Lewin, G.R., McIlwrath, S.L., Cheng, C., Xie, J., Heppenstall, P.A., Stucky, C.L., Mannsfeldt, A.G., Brennan, T.J., Drummond, H.A., Qiao, J., Benson, C.J., Tarr, D.E., Hrstka, R.F., Yang, B., Williamson, R.A. & Welsh, M.J. Nature. 2000 Oct 26;407(6807):1007-11. Europe PMC

Neurotrophins, nociceptors and pain. Heppenstall, P.A. & Lewin, G.R. Curr Opin Anaesthesiol. 2000 Oct;13(5):573-6. Europe PMC

Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors. Pesquero, J.B., Araujo, R.C., Heppenstall, P.A., Stucky, C.L., Silva JA, J.r, Walther, T., Oliveira, S.M., Pesquero, J.L., Paiva, A.C., Calixto, J.B., Lewin, G.R. & Bader, M. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8140-5. Europe PMC

Glycine receptor regulation of neurokinin1 receptor function in rat dorsal horn neurones. Heppenstall, P.A. & Fleetwood-Walker, S.M. Neuroreport. 1997 Sep 29;8(14):3109-12. Europe PMC

The glycine site of the NMDA receptor contributes to neurokinin1 receptor agonist facilitation of NMDA receptor agonist-evoked activity in rat dorsal horn neurons. Heppenstall, P.A. & Fleetwood-Walker, S.M. Brain Res. 1997 Jan 9;744(2):235-45. Europe PMC