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Staff at EMBL

Dr. Marko Kaksonen

Group Leader
Kaksonen Group Joint appointment: Structural and Computational Biology Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail


PhD 2002, University of Helsinki, Finland.
Postdoctoral research at the University of California, Berkeley, USA.
Group leader at EMBL since 2006.


RNA clamping by Vasa assembles a piRNA amplifier complex on transposon transcripts. Xiol, J., Spinelli, P., Laussmann, M.A., Homolka, D., Yang, Z., Cora, E., Coute, Y., Conn, S., Kadlec, J., Sachidanandam, R., Kaksonen, M., Cusack, S., Ephrussi, A. & Pillai, R.S. Cell. 2014 Jun 19;157(7):1698-711. doi: 10.1016/j.cell.2014.05.018. Epub 2014 Jun5. Europe PMC

The initiation of clathrin-mediated endocytosis is mechanistically highly flexible. Brach, T., Godlee, C., Moeller-Hansen, I., Boeke, D. & Kaksonen, M. Curr Biol. 2014 Mar 3;24(5):548-54. doi: 10.1016/j.cub.2014.01.048. Epub 2014 Feb13. Europe PMC

Review series: From uncertain beginnings: initiation mechanisms of clathrin-mediated endocytosis. Godlee, C. & Kaksonen, M. J Cell Biol. 2013 Dec 9;203(5):717-25. doi: 10.1083/jcb.201307100. Europe PMC

Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins. Maeda, K., Anand, K., Chiapparino, A., Kumar, A., Poletto, M., Kaksonen, M. & Gavin, A.C. Nature. 2013 Sep 12;501(7466):257-61. doi: 10.1038/nature12430. Epub 2013 Aug 11. Europe PMC

Detection and characterization of protein interactions in vivo by a simple live-cell imaging method. Gallego, O., Specht, T., Brach, T., Kumar, A., Gavin, A.C. & Kaksonen, M. PLoS One. 2013 May 1;8(5):e62195. doi: 10.1371/journal.pone.0062195. Print 2013. Europe PMC

Molecular basis for coupling the plasma membrane to the actin cytoskeleton during clathrin-mediated endocytosis. Skruzny, M., Brach, T., Ciuffa, R., Rybina, S., Wachsmuth, M. & Kaksonen, M. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):E2533-42. Epub 2012 Aug 27. Europe PMC

Plasma membrane reshaping during endocytosis is revealed by time-resolved electron tomography. Kukulski, W., Schorb, M., Kaksonen, M. & Briggs, J.A. Cell. 2012 Aug 3;150(3):508-20. doi: 10.1016/j.cell.2012.05.046. Europe PMC

Precise, correlated fluorescence microscopy and electron tomography of lowicryl sections using fluorescent fiducial markers. Kukulski, W., Schorb, M., Welsch, S., Picco, A., Kaksonen, M. & Briggs, J.A. Methods Cell Biol. 2012;111:235-57. doi: 10.1016/B978-0-12-416026-2.00013-3. Europe PMC

Reassessment of the role of plasma membrane domains in the regulation of vesicular traffic in yeast. Brach, T., Specht, T. & Kaksonen, M. J Cell Sci. 2011 Feb 1;124(Pt 3):328-37. Epub 2011 Jan 11. Europe PMC

Correlated fluorescence and 3D electron microscopy with high sensitivity and spatial precision. Kukulski, W., Schorb, M., Welsch, S., Picco, A., Kaksonen, M. & Briggs, J.A. J Cell Biol. 2011 Jan 10;192(1):111-9. doi: 10.1083/jcb.201009037. Epub 2011 Jan3. Europe PMC

A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Gallego, O., Betts, M.J., Gvozdenovic-Jeremic, J., Maeda, K., Matetzki, C., Aguilar-Gurrieri, C., Beltran-Alvarez, P., Bonn, S., Fernandez-Tornero, C., Jensen, L.J., Kuhn, M., Trott, J., Rybin, V., Muller, C.W., Bork, P., Kaksonen, M., Russell, R.B. & Gavin, A.C. Mol Syst Biol. 2010 Nov 30;6:430. doi: 10.1038/msb.2010.87. Europe PMC

Taking apart the endocytic machinery. Kaksonen, M. J Cell Biol. 2008 Mar 24;180(6):1059-60. Europe PMC

Endocytic vesicle scission by lipid phase boundary forces. Liu, J., Kaksonen, M., Drubin, D.G. & Oster, G. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10277-82. Epub 2006 Jun 26. Europe PMC

Harnessing actin dynamics for clathrin-mediated endocytosis. Kaksonen, M., Toret, C.P. & Drubin, D.G. Nat Rev Mol Cell Biol. 2006 Jun;7(6):404-14. Europe PMC

A modular design for the clathrin- and actin-mediated endocytosis machinery. Kaksonen, M., Toret, C.P. & Drubin, D.G. Cell. 2005 Oct 21;123(2):305-20. Europe PMC

A pathway for association of receptors, adaptors, and actin during endocytic internalization. Kaksonen, M., Sun, Y. & Drubin, D.G. Cell. 2003 Nov 14;115(4):475-87. Europe PMC