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Staff at EMBL

Dr. Marko Kaksonen

Group Leader
Kaksonen Group Joint appointment: Structural and Computational Biology Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail


PhD 2002, University of Helsinki, Finland.
Postdoctoral research at the University of California, Berkeley, USA.
Group leader at EMBL since 2006.


The initiation of clathrin-mediated endocytosis is mechanistically highly flexible. Brach, T., Godlee, C., Moeller-Hansen, I., Boeke, D. & Kaksonen, M. Curr Biol. 2014 Mar 3;24(5):548-54. doi: 10.1016/j.cub.2014.01.048. Epub 2014 Feb13. Europe PMC

Review series: From uncertain beginnings: initiation mechanisms of clathrin-mediated endocytosis. Godlee, C. & Kaksonen, M. J Cell Biol. 2013 Dec 9;203(5):717-25. doi: 10.1083/jcb.201307100. Europe PMC

Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins. Maeda, K., Anand, K., Chiapparino, A., Kumar, A., Poletto, M., Kaksonen, M. & Gavin, A.C. Nature. 2013 Sep 12;501(7466):257-61. doi: 10.1038/nature12430. Epub 2013 Aug 11. Europe PMC

Detection and characterization of protein interactions in vivo by a simple live-cell imaging method. Gallego, O., Specht, T., Brach, T., Kumar, A., Gavin, A.C. & Kaksonen, M. PLoS One. 2013 May 1;8(5):e62195. doi: 10.1371/journal.pone.0062195. Print 2013. Europe PMC

Molecular basis for coupling the plasma membrane to the actin cytoskeleton during clathrin-mediated endocytosis. Skruzny, M., Brach, T., Ciuffa, R., Rybina, S., Wachsmuth, M. & Kaksonen, M. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):E2533-42. Epub 2012 Aug 27. Europe PMC

Plasma membrane reshaping during endocytosis is revealed by time-resolved electron tomography. Kukulski, W., Schorb, M., Kaksonen, M. & Briggs, J.A. Cell. 2012 Aug 3;150(3):508-20. doi: 10.1016/j.cell.2012.05.046. Europe PMC

Precise, correlated fluorescence microscopy and electron tomography of lowicryl sections using fluorescent fiducial markers. Kukulski, W., Schorb, M., Welsch, S., Picco, A., Kaksonen, M. & Briggs, J.A. Methods Cell Biol. 2012;111:235-57. doi: 10.1016/B978-0-12-416026-2.00013-3. Europe PMC

Reassessment of the role of plasma membrane domains in the regulation of vesicular traffic in yeast. Brach, T., Specht, T. & Kaksonen, M. J Cell Sci. 2011 Feb 1;124(Pt 3):328-37. Epub 2011 Jan 11. Europe PMC

Correlated fluorescence and 3D electron microscopy with high sensitivity and spatial precision. Kukulski, W., Schorb, M., Welsch, S., Picco, A., Kaksonen, M. & Briggs, J.A. J Cell Biol. 2011 Jan 10;192(1):111-9. doi: 10.1083/jcb.201009037. Epub 2011 Jan3. Europe PMC

A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Gallego, O., Betts, M.J., Gvozdenovic-Jeremic, J., Maeda, K., Matetzki, C., Aguilar-Gurrieri, C., Beltran-Alvarez, P., Bonn, S., Fernandez-Tornero, C., Jensen, L.J., Kuhn, M., Trott, J., Rybin, V., Muller, C.W., Bork, P., Kaksonen, M., Russell, R.B. & Gavin, A.C. Mol Syst Biol. 2010 Nov 30;6:430. doi: 10.1038/msb.2010.87. Europe PMC

Taking apart the endocytic machinery. Kaksonen, M. J Cell Biol. 2008 Mar 24;180(6):1059-60. Europe PMC

Endocytic vesicle scission by lipid phase boundary forces. Liu, J., Kaksonen, M., Drubin, D.G. & Oster, G. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10277-82. Epub 2006 Jun 26. Europe PMC

Harnessing actin dynamics for clathrin-mediated endocytosis. Kaksonen, M., Toret, C.P. & Drubin, D.G. Nat Rev Mol Cell Biol. 2006 Jun;7(6):404-14. Europe PMC

A modular design for the clathrin- and actin-mediated endocytosis machinery. Kaksonen, M., Toret, C.P. & Drubin, D.G. Cell. 2005 Oct 21;123(2):305-20. Europe PMC

A pathway for association of receptors, adaptors, and actin during endocytic internalization. Kaksonen, M., Sun, Y. & Drubin, D.G. Cell. 2003 Nov 14;115(4):475-87. Europe PMC