Staff at EMBL

Malte Wachsmuth

Staff Scientist
Cell Biology and Biophysics

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Publications

Molecular basis for coupling the plasma membrane to the actin cytoskeleton during clathrin-mediated endocytosis. Skruzny, M., Brach, T., Ciuffa, R., Rybina, S., Wachsmuth, M. & Kaksonen, M. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):E2533-42. Epub 2012 Aug 27. PubMed

Quantitative fluorescence imaging of protein diffusion and interaction in living cells. Capoulade, J., Wachsmuth, M., Hufnagel, L. & Knop, M. Nat Biotechnol. 2011 Aug 7;29(9):835-9. doi: 10.1038/nbt.1928. PubMed

Dissecting chromatin interactions in living cells from protein mobility maps. Erdel, F., Muller-Ott, K., Baum, M., Wachsmuth, M. & Rippe, K. Chromosome Res. 2011 Jan;19(1):99-115. PubMed

Quantitative imaging of fluorescent protein diffusion and interaction inside cells Capoulade J, Wachsmuth M, Hufnagel L, and Knop, M. (2011). Nat. Biotechnol., advanced online publication.

Two-photon spectral imaging with high temporal and spectral resolution Im K-B, Kang M-S, Kim J, Bestvater F, Seghiri Z, Wachsmuth M, and Grailhe R (2010). Optics Express 18, 26905-26914.

Measuring and imaging diffusion with multiple scan speed image correlation spectroscopy. Gröner N, Capoulade J, Cremer C, and Wachsmuth M (2010). Optics Express 18, 21225-21237. PubMed

EMCCD-based spectrally resolved fluorescence correlation spectroscopy. Bestvater F, Seghiri Z, Kang MS, Gröner N, Lee JY, Im K-B, and Wachsmuth M (2010). Optics Express 18, 23818-23828.

Multiscale analysis of dynamics and interactions of heterochromatin protein 1 by fluorescence fluctuation microscopy. Muller, K.P., Erdel, F., Caudron-Herger, M., Marth, C., Fodor, B.D., Richter, M., Scaranaro, M., Beaudouin, J., Wachsmuth, M. & Rippe, K. Biophys J. 2009 Dec 2;97(11):2876-85. PubMed

Analysis of protein mobilities and interactions in living cells by multifocal fluorescence fluctuation microscopy. Heuvelman, G., Erdel, F., Wachsmuth, M. & Rippe, K. Eur Biophys J. 2009 Jul;38(6):813-28. Epub 2009 Jun 19. PubMed

Assembly and mobility of exon-exon junction complexes in living cells. Schmidt, U., Im, K.B., Benzing, C., Janjetovic, S., Rippe, K., Lichter, P. & Wachsmuth, M. RNA. 2009 May;15(5):862-76. Epub 2009 Mar 26. PubMed

Dynamics of telomeres and promyelocytic leukemia nuclear bodies in a telomerase-negative human cell line. Jegou, T., Chung, I., Heuvelman, G., Wachsmuth, M., Gorisch, S.M., Greulich-Bode, K.M., Boukamp, P., Lichter, P. & Rippe, K. Mol Biol Cell. 2009 Apr;20(7):2070-82. Epub 2009 Feb 11. PubMed

Genome organization: balancing stability and plasticity. Wachsmuth, M., Caudron-Herger, M. & Rippe, K. Biochim Biophys Acta. 2008 Nov;1783(11):2061-79. Epub 2008 Aug 3. PubMed

Tubulin dimers oligomerize before their incorporation into microtubules. Mozziconacci, J., Sandblad, L., Wachsmuth, M., Brunner, D. & Karsenti, E. PLoS ONE. 2008;3(11):e3821. Epub 2008 Nov 27. PubMed

Three-dimensional point spread function model for line-scanning confocal microscope with high-aperture objective. Dusch, E., Dorval, T., Vincent, N., Wachsmuth, M. & Genovesio, A. J Microsc. 2007 Nov;228(Pt 2):132-8. PubMed

Fluorescence photobleaching and fluorescence correlation spectroscopy: two complementary technologies to study molecular dynamics in living cells. Wachsmuth, M., and Weisshart, K. In Imaging Cellular and Molecular Biological Functions (eds. S. Shorte and F. Frischknecht)

Histone acetylation increases chromatin accessibility. Gorisch, S.M., Wachsmuth, M., Toth, K.F., Lichter, P. & Rippe, K. J Cell Sci. 2005 Dec 15;118(Pt 24):5825-34. Epub 2005 Nov 29. PubMed

A 'loop recapture' mechanism for ACF-dependent nucleosome remodeling. Strohner, R., Wachsmuth, M., Dachauer, K., Mazurkiewicz, J., Hochstatter, J., Rippe, K. & Langst, G. Nat Struct Mol Biol. 2005 Aug;12(8):683-90. Epub 2005 Jul 17. PubMed

Anti-termination by SIV Tat requires flexibility of the nascent TAR structure. Sommer, P., Vartanian, J.P., Wachsmuth, M., Henry, M., Guetard, D. & Wain-Hobson, S. J Mol Biol. 2004 Nov 12;344(1):11-28. PubMed

Nuclear body movement is determined by chromatin accessibility and dynamics. Gorisch, S.M., Wachsmuth, M., Ittrich, C., Bacher, C.P., Rippe, K. & Lichter, P. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13221-6. Epub 2004 Aug 26. PubMed

Trichostatin A-induced histone acetylation causes decondensation of interphase chromatin. Toth, K.F., Knoch, T.A., Wachsmuth, M., Frank-Stohr, M., Stohr, M., Bacher, C.P., Muller, G. & Rippe, K. J Cell Sci. 2004 Aug 15;117(Pt 18):4277-87. Epub 2004 Aug 3. PubMed

Maximum-entropy decomposition of fluorescence correlation spectroscopy data: application to liposome-human serum albumin association. Modos, K., Galantai, R., Bardos-Nagy, I., Wachsmuth, M., Toth, K., Fidy, J. & Langowski, J. Eur Biophys J. 2004 Feb;33(1):59-67. Epub 2003 Aug 30. PubMed

Counting nucleosomes in living cells with a combination of fluorescence correlation spectroscopy and confocal imaging. Weidemann, T., Wachsmuth, M., Knoch, T.A., Muller, G., Waldeck, W. & Langowski, J. J Mol Biol. 2003 Nov 21;334(2):229-40. PubMed

Analyzing intracellular binding and diffusion with continuous fluorescence photobleaching. Wachsmuth, M., Weidemann, T., Muller, G., Hoffmann-Rohrer, U.W., Knoch, T.A., Waldeck, W. & Langowski, J. Biophys J. 2003 May;84(5):3353-63. PubMed

Analysis of ligand binding by two-colour fluorescence cross-correlation spectroscopy. Weidemann, T., Wachsmuth, M., Tewes, M., Rippe, K., and Langowski, J. Single Molecules 3, 49-61 2003

A biological transporter for the delivery of peptide nucleic acids (PNAs) to the nuclear compartment of living cells. Braun, K., Peschke, P., Pipkorn, R., Lampel, S., Wachsmuth, M., Waldeck, W., Friedrich, E. & Debus, J. J Mol Biol. 2002 Apr 26;318(2):237-43. PubMed

Anomalous diffusion of fluorescent probes inside living cell nuclei investigated by spatially-resolved fluorescence correlation spectroscopy. Wachsmuth, M., Waldeck, W. & Langowski, J. J Mol Biol. 2000 May 12;298(4):677-89. PubMed

Biomolecular shape and interactions determined by fluorescence correlation spectroscopy. Langowski, J., Wachsmuth, M., Rippe, K., and Tewes, M. Energies et forces de l'interaction entre macromolécules biologiques: l'aspect quantitatif. J.-P. Frénoy, editor.