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Staff at EMBL

Malte Wachsmuth

Staff Scientist
Cell Biology and Biophysics

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail
Web page: http://www.embl.de/~wachsmut/

Publications

Retrieving the intracellular topology from multi-scale protein mobility mapping in living cells. Baum, M., Erdel, F., Wachsmuth, M. & Rippe, K. Nat Commun. 2014 Jul 24;5:4494. doi: 10.1038/ncomms5494. Europe PMC

Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells. Keller, D., Orpinell, M., Olivier, N., Wachsmuth, M., Mahen, R., Wyss, R., Hachet, V., Ellenberg, J., Manley, S. & Gonczy, P. J Cell Biol. 2014 Mar 3;204(5):697-712. doi: 10.1083/jcb.201307049. Europe PMC

Molecular diffusion and binding analyzed with FRAP. Wachsmuth, M. Protoplasma. 2014 Jan 4. Europe PMC

Diffusion and binding analyzed with combined point FRAP and FCS. Im, K.B., Schmidt, U., Kang, M.S., Lee, J.Y., Bestvater, F. & Wachsmuth, M. Cytometry A. 2013 Sep;83(9):876-89. doi: 10.1002/cyto.a.22316. Epub 2013 Jul 11. Europe PMC

Molecular basis for coupling the plasma membrane to the actin cytoskeleton during clathrin-mediated endocytosis. Skruzny, M., Brach, T., Ciuffa, R., Rybina, S., Wachsmuth, M. & Kaksonen, M. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):E2533-42. Epub 2012 Aug 27. Europe PMC

Tandem fluorescent protein timers for in vivo analysis of protein dynamics. Khmelinskii, A., Keller, P.J., Bartosik, A., Meurer, M., Barry, J.D., Mardin, B.R., Kaufmann, A., Trautmann, S., Wachsmuth, M., Pereira, G., Huber, W., Schiebel, E. & Knop, M. Nat Biotechnol. 2012 Jun 24;30(7):708-14. doi: 10.1038/nbt.2281. Europe PMC

Quantitative fluorescence imaging of protein diffusion and interaction in living cells. Capoulade, J., Wachsmuth, M., Hufnagel, L. & Knop, M. Nat Biotechnol. 2011 Aug 7;29(9):835-9. doi: 10.1038/nbt.1928. Europe PMC

Dissecting chromatin interactions in living cells from protein mobility maps. Erdel, F., Muller-Ott, K., Baum, M., Wachsmuth, M. & Rippe, K. Chromosome Res. 2011 Jan;19(1):99-115. Europe PMC

Two-photon spectral imaging with high temporal and spectral resolution. Im, K.B., Kang, M.S., Kim, J., Bestvater, F., Seghiri, Z., Wachsmuth, M. & Grailhe, R. Opt Express. 2010 Dec 20;18(26):26905-14. doi: 10.1364/OE.18.026905. Europe PMC

EMCCD-based spectrally resolved fluorescence correlation spectroscopy. Bestvater, F., Seghiri, Z., Kang, M.S., Groner, N., Lee, J.Y., Im, K.B. & Wachsmuth, M. Opt Express. 2010 Nov 8;18(23):23818-28. doi: 10.1364/OE.18.023818. Europe PMC

Measuring and imaging diffusion with multiple scan speed image correlation spectroscopy. Groner, N., Capoulade, J., Cremer, C. & Wachsmuth, M. Opt Express. 2010 Sep 27;18(20):21225-37. doi: 10.1364/OE.18.021225. Europe PMC

Multiscale analysis of dynamics and interactions of heterochromatin protein 1 by fluorescence fluctuation microscopy. Muller, K.P., Erdel, F., Caudron-Herger, M., Marth, C., Fodor, B.D., Richter, M., Scaranaro, M., Beaudouin, J., Wachsmuth, M. & Rippe, K. Biophys J. 2009 Dec 2;97(11):2876-85. Europe PMC

Analysis of protein mobilities and interactions in living cells by multifocal fluorescence fluctuation microscopy. Heuvelman, G., Erdel, F., Wachsmuth, M. & Rippe, K. Eur Biophys J. 2009 Jul;38(6):813-28. Epub 2009 Jun 19. Europe PMC

Assembly and mobility of exon-exon junction complexes in living cells. Schmidt, U., Im, K.B., Benzing, C., Janjetovic, S., Rippe, K., Lichter, P. & Wachsmuth, M. RNA. 2009 May;15(5):862-76. Epub 2009 Mar 26. Europe PMC

Dynamics of telomeres and promyelocytic leukemia nuclear bodies in a telomerase-negative human cell line. Jegou, T., Chung, I., Heuvelman, G., Wachsmuth, M., Gorisch, S.M., Greulich-Bode, K.M., Boukamp, P., Lichter, P. & Rippe, K. Mol Biol Cell. 2009 Apr;20(7):2070-82. Epub 2009 Feb 11. Europe PMC

Genome organization: balancing stability and plasticity. Wachsmuth, M., Caudron-Herger, M. & Rippe, K. Biochim Biophys Acta. 2008 Nov;1783(11):2061-79. Epub 2008 Aug 3. Europe PMC

Tubulin dimers oligomerize before their incorporation into microtubules. Mozziconacci, J., Sandblad, L., Wachsmuth, M., Brunner, D. & Karsenti, E. PLoS ONE. 2008;3(11):e3821. Epub 2008 Nov 27. Europe PMC

Three-dimensional point spread function model for line-scanning confocal microscope with high-aperture objective. Dusch, E., Dorval, T., Vincent, N., Wachsmuth, M. & Genovesio, A. J Microsc. 2007 Nov;228(Pt 2):132-8. Europe PMC

Fluorescence photobleaching and fluorescence correlation spectroscopy: two complementary technologies to study molecular dynamics in living cells. Wachsmuth, M., and Weisshart, K. In Imaging Cellular and Molecular Biological Functions (eds. S. Shorte and F. Frischknecht)

Histone acetylation increases chromatin accessibility. Gorisch, S.M., Wachsmuth, M., Toth, K.F., Lichter, P. & Rippe, K. J Cell Sci. 2005 Dec 15;118(Pt 24):5825-34. Epub 2005 Nov 29. Europe PMC

A 'loop recapture' mechanism for ACF-dependent nucleosome remodeling. Strohner, R., Wachsmuth, M., Dachauer, K., Mazurkiewicz, J., Hochstatter, J., Rippe, K. & Langst, G. Nat Struct Mol Biol. 2005 Aug;12(8):683-90. Epub 2005 Jul 17. Europe PMC

Anti-termination by SIV Tat requires flexibility of the nascent TAR structure. Sommer, P., Vartanian, J.P., Wachsmuth, M., Henry, M., Guetard, D. & Wain-Hobson, S. J Mol Biol. 2004 Nov 12;344(1):11-28. Europe PMC

Nuclear body movement is determined by chromatin accessibility and dynamics. Gorisch, S.M., Wachsmuth, M., Ittrich, C., Bacher, C.P., Rippe, K. & Lichter, P. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13221-6. Epub 2004 Aug 26. Europe PMC

Trichostatin A-induced histone acetylation causes decondensation of interphase chromatin. Toth, K.F., Knoch, T.A., Wachsmuth, M., Frank-Stohr, M., Stohr, M., Bacher, C.P., Muller, G. & Rippe, K. J Cell Sci. 2004 Aug 15;117(Pt 18):4277-87. Epub 2004 Aug 3. Europe PMC

Maximum-entropy decomposition of fluorescence correlation spectroscopy data: application to liposome-human serum albumin association. Modos, K., Galantai, R., Bardos-Nagy, I., Wachsmuth, M., Toth, K., Fidy, J. & Langowski, J. Eur Biophys J. 2004 Feb;33(1):59-67. Epub 2003 Aug 30. Europe PMC

Counting nucleosomes in living cells with a combination of fluorescence correlation spectroscopy and confocal imaging. Weidemann, T., Wachsmuth, M., Knoch, T.A., Muller, G., Waldeck, W. & Langowski, J. J Mol Biol. 2003 Nov 21;334(2):229-40. Europe PMC

Analyzing intracellular binding and diffusion with continuous fluorescence photobleaching. Wachsmuth, M., Weidemann, T., Muller, G., Hoffmann-Rohrer, U.W., Knoch, T.A., Waldeck, W. & Langowski, J. Biophys J. 2003 May;84(5):3353-63. Europe PMC

Analysis of ligand binding by two-colour fluorescence cross-correlation spectroscopy. Weidemann, T., Wachsmuth, M., Tewes, M., Rippe, K., and Langowski, J. Single Molecules 3, 49-61 2003

A biological transporter for the delivery of peptide nucleic acids (PNAs) to the nuclear compartment of living cells. Braun, K., Peschke, P., Pipkorn, R., Lampel, S., Wachsmuth, M., Waldeck, W., Friedrich, E. & Debus, J. J Mol Biol. 2002 Apr 26;318(2):237-43. Europe PMC

Anomalous diffusion of fluorescent probes inside living cell nuclei investigated by spatially-resolved fluorescence correlation spectroscopy. Wachsmuth, M., Waldeck, W. & Langowski, J. J Mol Biol. 2000 May 12;298(4):677-89. Europe PMC

Biomolecular shape and interactions determined by fluorescence correlation spectroscopy. Langowski, J., Wachsmuth, M., Rippe, K., and Tewes, M. Energies et forces de l'interaction entre macromolécules biologiques: l'aspect quantitatif. J.-P. Frénoy, editor.