Top image

Staff at EMBL

CP-60002173

Malte Wachsmuth

Staff Scientist
Cell Biology and Biophysics

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail
Web page: http://www.embl.de/~wachsmut/

Publications

Total: 33 publication(s)

2014

Mahen R, Koch B, Wachsmuth M, Politi AZ, Perez-Gonzalez A, Mergenthaler J, Cai Y, Ellenberg J. (2014)
Comparative assessment of fluorescent transgene methods for quantitative imaging in human cells
Mol. Biol. Cell doi:10.1091/mbc.E14-06-1091
Europe PMC | doi

Baum M, Erdel F, Wachsmuth M, Rippe K. (2014)
Retrieving the intracellular topology from multi-scale protein mobility mapping in living cells
Nat Commun 5:4494. doi:10.1038/ncomms5494
Europe PMC | doi

Keller D, Orpinell M, Olivier N, Wachsmuth M, Mahen R, Wyss R, Hachet V, Ellenberg J, Manley S, Gönczy P. (2014)
Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells
J. Cell Biol. 204(5):697-712. doi:10.1083/jcb.201307049
Europe PMC | doi

Wachsmuth M. (2014)
Molecular diffusion and binding analyzed with FRAP
Protoplasma 251(2):373-382. doi:10.1007/s00709-013-0604-x
Europe PMC | doi


2013

Capoulade J, Reynaud EG, Wachsmuth M. (2013)
Imaging marine life with a thin light-sheet
In: Reynaud EG (ed.), Imaging Marine Life: Macrophotography and Microscopy Approaches for Marine Biology. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. pp 186-209.doi:10.1002/9783527675418.ch8
doi

Im KB, Schmidt U, Kang MS, Lee JY, Bestvater F, Wachsmuth M. (2013)
Diffusion and binding analyzed with combined point FRAP and FCS
Cytometry A 83(9):876-889. doi:10.1002/cyto.a.22316
Europe PMC | doi


2012

Skruzny M, Brach T, Ciuffa R, Rybina S, Wachsmuth M, Kaksonen M. (2012)
Molecular basis for coupling the plasma membrane to the actin cytoskeleton during clathrin-mediated endocytosis
Proc. Natl. Acad. Sci. U.S.A. 109(38):E2533-42. doi:10.1073/pnas.1207011109
Europe PMC | doi

Khmelinskii A, Keller PJ, Bartosik A, Meurer M, Barry JD, Mardin BR, Kaufmann A, Trautmann S, Wachsmuth M, Pereira G, Huber W, Schiebel E, Knop M. (2012)
Tandem fluorescent protein timers for in vivo analysis of protein dynamics
Nat. Biotechnol. 30(7):708-714. doi:10.1038/nbt.2281
Europe PMC | doi


2011

Capoulade J, Wachsmuth M, Hufnagel L, Knop M. (2011)
Quantitative fluorescence imaging of protein diffusion and interaction in living cells
Nat. Biotechnol. 29(9):835-839. doi:10.1038/nbt.1928
Europe PMC | doi

Erdel F, Müller-Ott K, Baum M, Wachsmuth M, Rippe K. (2011)
Dissecting chromatin interactions in living cells from protein mobility maps
Chromosome Res. 19(1):99-115. doi:10.1007/s10577-010-9155-6
Europe PMC | doi


2010

Im KB, Kang MS, Kim J, Bestvater F, Seghiri Z, Wachsmuth M, Grailhe R. (2010)
Two-photon spectral imaging with high temporal and spectral resolution
Opt Express 18(26):26905-26914. doi:10.1364/oe.18.026905
Europe PMC | doi

Bestvater F, Seghiri Z, Kang MS, Gröner N, Lee JY, Im KB, Wachsmuth M. (2010)
EMCCD-based spectrally resolved fluorescence correlation spectroscopy
Opt Express 18(23):23818-23828. doi:10.1364/oe.18.023818
Europe PMC | doi

Gröner N, Capoulade J, Cremer C, Wachsmuth M. (2010)
Measuring and imaging diffusion with multiple scan speed image correlation spectroscopy
Opt Express 18(20):21225-21237. doi:10.1364/oe.18.021225
Europe PMC | doi


2009

Müller KP, Erdel F, Caudron-Herger M, Marth C, Fodor BD, Richter M, Scaranaro M, Beaudouin J, Wachsmuth M, Rippe K. (2009)
Multiscale analysis of dynamics and interactions of heterochromatin protein 1 by fluorescence fluctuation microscopy
Biophys. J. 97(11):2876-2885. doi:10.1016/j.bpj.2009.08.057
Europe PMC | doi

Heuvelman G, Erdel F, Wachsmuth M, Rippe K. (2009)
Analysis of protein mobilities and interactions in living cells by multifocal fluorescence fluctuation microscopy
Eur. Biophys. J. 38(6):813-828. doi:10.1007/s00249-009-0499-9
Europe PMC | doi

Schmidt U, Im KB, Benzing C, Janjetovic S, Rippe K, Lichter P, Wachsmuth M. (2009)
Assembly and mobility of exon-exon junction complexes in living cells
RNA 15(5):862-876. doi:10.1261/rna.1387009
Europe PMC | doi

Jegou T, Chung I, Heuvelman G, Wachsmuth M, Görisch SM, Greulich-Bode KM, Boukamp P, Lichter P, Rippe K. (2009)
Dynamics of telomeres and promyelocytic leukemia nuclear bodies in a telomerase-negative human cell line
Mol. Biol. Cell 20(7):2070-2082. doi:10.1091/mbc.e08-02-0108
Europe PMC | doi


2008

Wachsmuth M, Caudron-Herger M, Rippe K. (2008)
Genome organization: balancing stability and plasticity
Biochim. Biophys. Acta 1783(11):2061-2079. doi:10.1016/j.bbamcr.2008.07.022
Europe PMC | doi

Mozziconacci J, Sandblad L, Wachsmuth M, Brunner D, Karsenti E. (2008)
Tubulin dimers oligomerize before their incorporation into microtubules
PLoS ONE 3(11):e3821. doi:10.1371/journal.pone.0003821
Europe PMC | doi


2007

Dusch E, Dorval T, Vincent N, Wachsmuth M, Genovesio A. (2007)
Three-dimensional point spread function model for line-scanning confocal microscope with high-aperture objective
J Microsc 228(Pt 2):132-138. doi:10.1111/j.1365-2818.2007.01844.x
Europe PMC | doi

Wachsmuth M, Weisshart K. (2007)
Fluorescence Photobleaching and Fluorescence Correlation Spectroscopy: Two Complementary Technologies To Study Molecular Dynamics in Living Cells
In: Shorte SL, Frischknecht F (eds.), Imaging Cellular and Molecular Biological Functions. Principles and Practice. Springer, Berlin, Heidelberg. pp 183-233.doi:10.1007/978-3-540-71331-9_7
doi


2005

Görisch SM, Wachsmuth M, Tóth KF, Lichter P, Rippe K. (2005)
Histone acetylation increases chromatin accessibility
J. Cell. Sci. 118(Pt 24):5825-5834. doi:10.1242/jcs.02689
Europe PMC | doi

Strohner R, Wachsmuth M, Dachauer K, Mazurkiewicz J, Hochstatter J, Rippe K, Längst G. (2005)
A 'loop recapture' mechanism for ACF-dependent nucleosome remodeling
Nat. Struct. Mol. Biol. 12(8):683-690. doi:10.1038/nsmb966
Europe PMC | doi


2004

Sommer P, Vartanian JP, Wachsmuth M, Henry M, Guetard D, Wain-Hobson S. (2004)
Anti-termination by SIV Tat requires flexibility of the nascent TAR structure
J. Mol. Biol. 344(1):11-28. doi:10.1016/j.jmb.2004.09.042
Europe PMC | doi

Görisch SM, Wachsmuth M, Ittrich C, Bacher CP, Rippe K, Lichter P. (2004)
Nuclear body movement is determined by chromatin accessibility and dynamics
Proc. Natl. Acad. Sci. U.S.A. 101(36):13221-13226. doi:10.1073/pnas.0402958101
Europe PMC | doi

Tóth KF, Knoch TA, Wachsmuth M, Frank-Stöhr M, Stöhr M, Bacher CP, Müller G, Rippe K. (2004)
Trichostatin A-induced histone acetylation causes decondensation of interphase chromatin
J. Cell. Sci. 117(Pt 18):4277-4287. doi:10.1242/jcs.01293
Europe PMC | doi

Módos K, Galántai R, Bárdos-Nagy I, Wachsmuth M, Tóth K, Fidy J, Langowski J. (2004)
Maximum-entropy decomposition of fluorescence correlation spectroscopy data: application to liposome-human serum albumin association
Eur. Biophys. J. 33(1):59-67. doi:10.1007/s00249-003-0343-6
Europe PMC | doi


2003

Weidemann T, Wachsmuth M, Knoch TA, Müller G, Waldeck W, Langowski J. (2003)
Counting nucleosomes in living cells with a combination of fluorescence correlation spectroscopy and confocal imaging
J. Mol. Biol. 334(2):229-240. doi:10.1016/j.jmb.2003.08.063
Europe PMC | doi

Wachsmuth M, Weidemann T, Müller G, Hoffmann-Rohrer UW, Knoch TA, Waldeck W, Langowski J. (2003)
Analyzing intracellular binding and diffusion with continuous fluorescence photobleaching
Biophys. J. 84(5):3353-3363. doi:10.1016/s0006-3495(03)70059-9
Europe PMC | doi


2002

Braun K, Peschke P, Pipkorn R, Lampel S, Wachsmuth M, Waldeck W, Friedrich E, Debus J. (2002)
A biological transporter for the delivery of peptide nucleic acids (PNAs) to the nuclear compartment of living cells
J. Mol. Biol. 318(2):237-243. doi:10.1016/s0022-2836(02)00031-1
Europe PMC | doi

Weidemann T, Wachsmuth M, Tewes M, Rippe K, Langowski J. (2002)
Analysis of Ligand Binding by Two-Colour Fluorescence Cross-Correlation Spectroscopy
Single Molecules 3(1):49-61. doi:10.1002/1438-5171(200204)3:13.3.CO;2-K
Europe PMC | doi


2000

Wachsmuth M, Waldeck W, Langowski J. (2000)
Anomalous diffusion of fluorescent probes inside living cell nuclei investigated by spatially-resolved fluorescence correlation spectroscopy
J. Mol. Biol. 298(4):677-689. doi:10.1006/jmbi.2000.3692
Europe PMC | doi

Langowski J, Wachsmuth M, Rippe K, Tewes M. (2000)
Biomolecular shape and interactions determined by fluorescence correlation spectroscopy
In: Frénoy JP (ed.), Energies et forces de l'interaction entre macromolécules biologiques: l'aspect quantitatif. Publications CNRS, Paris.