EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: Send a mail


Total: 35 publication(s)


Wachsmuth M, Conrad C, Bulkescher J, Koch B, Mahen R, Isokane M, Pepperkok R, Ellenberg J. (2015)

High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells.

Nat. Biotechnol. doi:10.1038/nbt.3146
Europe PMC | doi


Mahen R, Koch B, Wachsmuth M, Politi AZ, Perez-Gonzalez A, Mergenthaler J, Cai Y, Ellenberg J. (2014)

Comparative assessment of fluorescent transgene methods for quantitative imaging in human cells

Mol. Biol. Cell 25(22):3610-3618. doi:10.1091/mbc.e14-06-1091
Europe PMC | doi

Boeke D, Trautmann S, Meurer M, Wachsmuth M, Godlee C, Knop M, Kaksonen M. (2014)

Quantification of cytosolic interactions identifies Ede1 oligomers as key organizers of endocytosis.

Mol. Syst. Biol. 10(11) doi:10.15252/msb.20145422
Europe PMC | doi

Baum M, Erdel F, Wachsmuth M, Rippe K. (2014)

Retrieving the intracellular topology from multi-scale protein mobility mapping in living cells

Nat Commun 5:4494. doi:10.1038/ncomms5494
Europe PMC | doi

Keller D, Orpinell M, Olivier N, Wachsmuth M, Mahen R, Wyss R, Hachet V, Ellenberg J, Manley S, Gönczy P. (2014)

Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells

J. Cell Biol. 204(5):697-712. doi:10.1083/jcb.201307049
Europe PMC | doi

Wachsmuth M. (2014)

Molecular diffusion and binding analyzed with FRAP

Protoplasma 251(2):373-382. doi:10.1007/s00709-013-0604-x
Europe PMC | doi


Capoulade J, Reynaud EG, Wachsmuth M. (2013)

Imaging marine life with a thin light-sheet

In: Reynaud EG (ed.), Imaging Marine Life: Macrophotography and Microscopy Approaches for Marine Biology. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. pp 186-209. doi:10.1002/9783527675418.ch8

Im KB, Schmidt U, Kang MS, Lee JY, Bestvater F, Wachsmuth M. (2013)

Diffusion and binding analyzed with combined point FRAP and FCS

Cytometry A 83(9):876-889. doi:10.1002/cyto.a.22316
Europe PMC | doi


Skruzny M, Brach T, Ciuffa R, Rybina S, Wachsmuth M, Kaksonen M. (2012)

Molecular basis for coupling the plasma membrane to the actin cytoskeleton during clathrin-mediated endocytosis

Proc. Natl. Acad. Sci. U.S.A. 109(38):E2533-42. doi:10.1073/pnas.1207011109
Europe PMC | doi

Khmelinskii A, Keller PJ, Bartosik A, Meurer M, Barry JD, Mardin BR, Kaufmann A, Trautmann S, Wachsmuth M, Pereira G, Huber W, Schiebel E, Knop M. (2012)

Tandem fluorescent protein timers for in vivo analysis of protein dynamics

Nat. Biotechnol. 30(7):708-714. doi:10.1038/nbt.2281
Europe PMC | doi


Capoulade J, Wachsmuth M, Hufnagel L, Knop M. (2011)

Quantitative fluorescence imaging of protein diffusion and interaction in living cells

Nat. Biotechnol. 29(9):835-839. doi:10.1038/nbt.1928
Europe PMC | doi

Erdel F, Müller-Ott K, Baum M, Wachsmuth M, Rippe K. (2011)

Dissecting chromatin interactions in living cells from protein mobility maps

Chromosome Res. 19(1):99-115. doi:10.1007/s10577-010-9155-6
Europe PMC | doi


Im KB, Kang MS, Kim J, Bestvater F, Seghiri Z, Wachsmuth M, Grailhe R. (2010)

Two-photon spectral imaging with high temporal and spectral resolution

Opt Express 18(26):26905-26914. doi:10.1364/oe.18.026905
Europe PMC | doi

Bestvater F, Seghiri Z, Kang MS, Gröner N, Lee JY, Im KB, Wachsmuth M. (2010)

EMCCD-based spectrally resolved fluorescence correlation spectroscopy

Opt Express 18(23):23818-23828. doi:10.1364/oe.18.023818
Europe PMC | doi

Gröner N, Capoulade J, Cremer C, Wachsmuth M. (2010)

Measuring and imaging diffusion with multiple scan speed image correlation spectroscopy

Opt Express 18(20):21225-21237. doi:10.1364/oe.18.021225
Europe PMC | doi


Müller KP, Erdel F, Caudron-Herger M, Marth C, Fodor BD, Richter M, Scaranaro M, Beaudouin J, Wachsmuth M, Rippe K. (2009)

Multiscale analysis of dynamics and interactions of heterochromatin protein 1 by fluorescence fluctuation microscopy

Biophys. J. 97(11):2876-2885. doi:10.1016/j.bpj.2009.08.057
Europe PMC | doi

Heuvelman G, Erdel F, Wachsmuth M, Rippe K. (2009)

Analysis of protein mobilities and interactions in living cells by multifocal fluorescence fluctuation microscopy

Eur. Biophys. J. 38(6):813-828. doi:10.1007/s00249-009-0499-9
Europe PMC | doi

Schmidt U, Im KB, Benzing C, Janjetovic S, Rippe K, Lichter P, Wachsmuth M. (2009)

Assembly and mobility of exon-exon junction complexes in living cells

RNA 15(5):862-876. doi:10.1261/rna.1387009
Europe PMC | doi

Jegou T, Chung I, Heuvelman G, Wachsmuth M, Görisch SM, Greulich-Bode KM, Boukamp P, Lichter P, Rippe K. (2009)

Dynamics of telomeres and promyelocytic leukemia nuclear bodies in a telomerase-negative human cell line

Mol. Biol. Cell 20(7):2070-2082. doi:10.1091/mbc.e08-02-0108
Europe PMC | doi


Wachsmuth M, Caudron-Herger M, Rippe K. (2008)

Genome organization: balancing stability and plasticity

Biochim. Biophys. Acta 1783(11):2061-2079. doi:10.1016/j.bbamcr.2008.07.022
Europe PMC | doi

Mozziconacci J, Sandblad L, Wachsmuth M, Brunner D, Karsenti E. (2008)

Tubulin dimers oligomerize before their incorporation into microtubules

PLoS ONE 3(11):e3821. doi:10.1371/journal.pone.0003821
Europe PMC | doi


Dusch E, Dorval T, Vincent N, Wachsmuth M, Genovesio A. (2007)

Three-dimensional point spread function model for line-scanning confocal microscope with high-aperture objective

J Microsc 228(Pt 2):132-138. doi:10.1111/j.1365-2818.2007.01844.x
Europe PMC | doi

Wachsmuth M, Weisshart K. (2007)

Fluorescence Photobleaching and Fluorescence Correlation Spectroscopy: Two Complementary Technologies To Study Molecular Dynamics in Living Cells

In: Shorte SL, Frischknecht F (eds.), Imaging Cellular and Molecular Biological Functions. Principles and Practice. Springer, Berlin, Heidelberg. pp 183-233. doi:10.1007/978-3-540-71331-9_7
Europe PMC | doi


Görisch SM, Wachsmuth M, Tóth KF, Lichter P, Rippe K. (2005)

Histone acetylation increases chromatin accessibility

J. Cell. Sci. 118(Pt 24):5825-5834. doi:10.1242/jcs.02689
Europe PMC | doi

Strohner R, Wachsmuth M, Dachauer K, Mazurkiewicz J, Hochstatter J, Rippe K, Längst G. (2005)

A 'loop recapture' mechanism for ACF-dependent nucleosome remodeling

Nat. Struct. Mol. Biol. 12(8):683-690. doi:10.1038/nsmb966
Europe PMC | doi


Sommer P, Vartanian JP, Wachsmuth M, Henry M, Guetard D, Wain-Hobson S. (2004)

Anti-termination by SIV Tat requires flexibility of the nascent TAR structure

J. Mol. Biol. 344(1):11-28. doi:10.1016/j.jmb.2004.09.042
Europe PMC | doi

Görisch SM, Wachsmuth M, Ittrich C, Bacher CP, Rippe K, Lichter P. (2004)

Nuclear body movement is determined by chromatin accessibility and dynamics

Proc. Natl. Acad. Sci. U.S.A. 101(36):13221-13226. doi:10.1073/pnas.0402958101
Europe PMC | doi

Tóth KF, Knoch TA, Wachsmuth M, Frank-Stöhr M, Stöhr M, Bacher CP, Müller G, Rippe K. (2004)

Trichostatin A-induced histone acetylation causes decondensation of interphase chromatin

J. Cell. Sci. 117(Pt 18):4277-4287. doi:10.1242/jcs.01293
Europe PMC | doi

Módos K, Galántai R, Bárdos-Nagy I, Wachsmuth M, Tóth K, Fidy J, Langowski J. (2004)

Maximum-entropy decomposition of fluorescence correlation spectroscopy data: application to liposome-human serum albumin association

Eur. Biophys. J. 33(1):59-67. doi:10.1007/s00249-003-0343-6
Europe PMC | doi


Weidemann T, Wachsmuth M, Knoch TA, Müller G, Waldeck W, Langowski J. (2003)

Counting nucleosomes in living cells with a combination of fluorescence correlation spectroscopy and confocal imaging

J. Mol. Biol. 334(2):229-240. doi:10.1016/j.jmb.2003.08.063
Europe PMC | doi

Wachsmuth M, Weidemann T, Müller G, Hoffmann-Rohrer UW, Knoch TA, Waldeck W, Langowski J. (2003)

Analyzing intracellular binding and diffusion with continuous fluorescence photobleaching

Biophys. J. 84(5):3353-3363. doi:10.1016/s0006-3495(03)70059-9
Europe PMC | doi


Braun K, Peschke P, Pipkorn R, Lampel S, Wachsmuth M, Waldeck W, Friedrich E, Debus J. (2002)

A biological transporter for the delivery of peptide nucleic acids (PNAs) to the nuclear compartment of living cells

J. Mol. Biol. 318(2):237-243. doi:10.1016/s0022-2836(02)00031-1
Europe PMC | doi

Weidemann T, Wachsmuth M, Tewes M, Rippe K, Langowski J. (2002)

Analysis of Ligand Binding by Two-Colour Fluorescence Cross-Correlation Spectroscopy

Single Molecules 3(1):49-61.
Europe PMC


Wachsmuth M, Waldeck W, Langowski J. (2000)

Anomalous diffusion of fluorescent probes inside living cell nuclei investigated by spatially-resolved fluorescence correlation spectroscopy

J. Mol. Biol. 298(4):677-689. doi:10.1006/jmbi.2000.3692
Europe PMC | doi

Langowski J, Wachsmuth M, Rippe K, Tewes M. (2000)

Biomolecular shape and interactions determined by fluorescence correlation spectroscopy

In: Frénoy JP (ed.), Energies et forces de l'interaction entre macromolécules biologiques: l'aspect quantitatif. Publications CNRS, Paris.