Staff at EMBL

Dr. Eric Karsenti

Group Leader and Senior Scientist
Karsenti Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Biography

Ph.D. 1979 University of Paris, France.
Postdoctoral research at University of California, San Francisco, USA.
Group Leader at EMBL since 1985.

Publications

A holistic approach to marine eco-systems biology. Karsenti, E., Acinas, S.G., Bork, P., Bowler, C., De Vargas, C., Raes, J., Sullivan, M., Arendt, D., Benzoni, F., Claverie, J.M., Follows, M., Gorsky, G., Hingamp, P., Iudicone, D., Jaillon, O., Kandels-Lewis, S., Krzic, U., Not, F., Ogata, H., Pesant, S., Reynaud, E.G., Sardet, C., Sieracki, M.E., Speich, S., Velayoudon, D., Weissenbach, J. & Wincker, P. PLoS Biol. 2011 Oct;9(10):e1001177. doi: 10.1371/journal.pbio.1001177. Epub 2011Oct 18. PubMed

XMAP215-EB1 interaction is required for proper spindle assembly and chromosome segregation in Xenopus egg extract. Kronja, I., Kruljac-Letunic, A., Caudron-Herger, M., Bieling, P. & Karsenti, E. Mol Biol Cell. 2009 Jun;20(11):2684-96. Epub 2009 Apr 15. PubMed

Regulation of microtubule dynamics by reaction cascades around chromosomes. Athale, C.A., Dinarina, A., Mora-Coral, M., Pugieux, C., Nedelec, F. & Karsenti, E. Science. 2008 Nov 21;322(5905):1243-1247. Epub 2008 Oct 23. PubMed

Hepatoma up-regulated protein is required for chromatin-induced microtubule assembly independently of TPX2. Casanova, C.M., Rybina, S., Yokoyama, H., Karsenti, E. & Mattaj, I.W. Mol Biol Cell. 2008 Nov;19(11):4900-8. Epub 2008 Sep 17. PubMed

Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate. Yokoyama, H., Gruss, O.J., Rybina, S., Caudron, M., Schelder, M., Wilm, M., Mattaj, I.W. & Karsenti, E. J Cell Biol. 2008 Mar 10;180(5):867-75. Epub 2008 Mar 3. PubMed

Self-organization in cell biology: a brief history. Karsenti, E. Nat Rev Mol Cell Biol. 2008 Mar;9(3):255-62. PubMed

Tubulin dimers oligomerize before their incorporation into microtubules. Mozziconacci, J., Sandblad, L., Wachsmuth, M., Brunner, D. & Karsenti, E. PLoS ONE. 2008;3(11):e3821. Epub 2008 Nov 27. PubMed

Discrete states of a protein interaction network govern interphase and mitotic microtubule dynamics. Niethammer, P., Kronja, I., Kandels-Lewis, S., Rybina, S., Bastiaens, P. & Karsenti, E. PLoS Biol. 2007 Jan;5(2):e29. PubMed

Self-organisation processes in living matter. Karsenti, E. Interdisciplinary Science Reviews June 2007 32(2) 163-175

Modelling microtubule patterns. Karsenti, E., Nedelec, F. & Surrey, T. Nat Cell Biol. 2006 Nov;8(11):1204-11. PubMed

Gradients in the self-organization of the mitotic spindle. Bastiaens, P., Caudron, M., Niethammer, P. & Karsenti, E. Trends Cell Biol. 2006 Mar;16(3):125-34. Epub 2006 Feb 14. PubMed

Microtubule-dependent transport and organization of sarcomeric myosin during skeletal muscle differentiation. Pizon, V., Gerbal, F., Diaz, C.C. & Karsenti, E. EMBO J 2005 Nov 2;24(21):3781-92. Epub 2005 Oct 20. PubMed

Spatial coordination of spindle assembly by chromosome-mediated signaling gradients. Caudron, M., Bunt, G., Bastiaens, P. & Karsenti, E. Science 2005 Aug 26;309(5739):1373-6. PubMed

TPX or not TPX? Karsenti, E. Mol Cell 2005 Aug 19;19(4):431-2. PubMed

Cytoskeleton: spindle saga. Karsenti, E. Nature 2004 Dec 2;432(7017):563-4. PubMed

Characterization of the TPX2 domains involved in microtubule nucleation and spindle assembly in Xenopus egg extracts. Brunet, S., Sardon, T., Zimmerman, T., Wittmann, T., Pepperkok, R., Karsenti, E. & Vernos, I. Mol Biol Cell 2004 Dec;15(12):5318-28. Epub . PubMed

Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked. Shirasu-Hiza, M., Perlman, Z.E., Wittmann, T., Karsenti, E. & Mitchison, T.J. Curr Biol 2004 Nov 9;14(21):1941-5. PubMed

Homology-based functional proteomics by mass spectrometry: application to the Xenopus microtubule-associated proteome. Liska, A.J., Popov, A.V., Sunyaev, S., Coughlin, P., Habermann, B., Shevchenko, A., Bork, P., Karsenti, E. & Shevchenko, A. Proteomics 2004 Sep;4(9):2707-21. PubMed

The mitotic spindle and actin tails. Karsenti, E. & Nedelec, F. Biol Cell 2004 Apr;96(3):237-40. PubMed

Stathmin-tubulin interaction gradients in motile and mitotic cells. Niethammer, P., Bastiaens, P. & Karsenti, E. Science 2004 Mar 19;303(5665):1862-6. PubMed

Stu2p and XMAP215: turncoat microtubule-associated proteins? Popov, A.V. & Karsenti, E. Trends Cell Biol 2003 Nov;13(11):547-50. PubMed

Long-range communication between chromatin and microtubules in Xenopus egg extracts. Carazo-Salas, R.E. & Karsenti, E. Curr Biol 2003 Sep 30;13(19):1728-33. PubMed

Importin alpha-regulated nucleation of microtubules by TPX2. Schatz, C.A., Santarella, R., Hoenger, A., Karsenti, E., Mattaj, I.W., Gruss, O.J. & Carazo-Salas, R.E. EMBO J 2003 May 1;22(9):2060-70. PubMed

Self-organisation and forces in the microtubule cytoskeleton. Nedelec, F., Surrey, T. & Karsenti, E. Curr Opin Cell Biol. 2003 Feb;15(1):118-24.

Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein. Pizon, V., Iakovenko, A., Van Der Ven, P.F., Kelly, R., Fatu, C., Furst, D.O., Karsenti, E. & Gautel, M. J Cell Sci 2002 Dec 1;115(Pt 23):4469-82. PubMed

Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells. Gruss, O.J., Wittmann, M., Yokoyama, H., Pepperkok, R., Kufer, T., Sillje, H., Karsenti, E., Mattaj, I.W. & Vernos, I. Nat Cell Biol 2002 Nov;4(11):871-9. PubMed

XMAP215 is required for the microtubule-nucleating activity of centrosomes. Popov, A.V., Severin, F. & Karsenti, E. Curr Biol 2002 Aug 6;12(15):1326-30. PubMed

L'auto-organisation au coeur de la division cellulaire. Karsenti, E. La Recherche 2002 (9) 52-55

Des Molécules à la cellule: L'origine de la stabilité dynamique dans les systèmes vivants. Karsenti, E. Médecine Sciences 2002 (12) 1173-1174

The mitotic spindle: a self-made machine. Karsenti, E. & Vernos, I. Science 2001 Oct 19;294(5542):543-7. PubMed

Physical properties determining self-organization of motors and microtubules. Surrey, T., Nédélec, F., Leibler, S. & Karsenti, E. Science 2001 May 11;292(5519):1167-71. PubMed

Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly. Carazo-Salas, R.E., Gruss, O.J., Mattaj, I.W. & Karsenti, E. Nat Cell Biol 2001 Mar;3(3):228-34. PubMed

XMAP215 regulates microtubule dynamics through two distinct domains. Popov, A.V., Pozniakovsky, A., Arnal, I., Antony, C., Ashford, A.J., Kinoshita, K., Tournebize, R., Hyman, A.A. & Karsenti, E. EMBO J 2001 Feb 1;20(3):397-410. PubMed

Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity. Gruss, O.J., Carazo-Salas, R.E., Schatz, C.A., Guarguaglini, G., Kast, J., Wilm, M., Le Bot, N., Vernos, I., Karsenti, E. & Mattaj, I.W. Cell 2001 Jan 12;104(1):83-93. PubMed

Cell form as an essential determinant of cell function. Karsenti, E. Academic Press, San Diego

The use of dominant negative mutants to study the function of mitotic motors in the in vitro spindle assembly assay in Xenopus egg extracts. Boleti, H., Karsenti, E. & Vernos, I. Methods Mol Biol 2001;164:173-89. PubMed

Xkid, a chromokinesin required for chromosome alignment on the metaphase plate. Antonio, C., Ferby, I., Wilhelm, H., Jones, M., Karsenti, E., Nebreda, A.R. & Vernos, I. Cell 2000 Aug 18;102(4):425-35 PubMed

TPX2, A novel xenopus MAP involved in spindle pole organization Wittmann, T., Wilm, M., Karsenti, E. & Vernos, I. J Cell Biol 2000 Jun 26;149(7):1405-18 PubMed

Structural transitions at microtubule ends correlate with their dynamic properties in Xenopus egg extracts. Arnal, I., Karsenti, E. & Hyman, A.A. J Cell Biol 2000 May 15;149(4):767-74 PubMed

Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts. Tournebize, R., Popov, A., Kinoshita, K., Ashford, A.J., Rybina, S., Pozniakovsky, A., Mayer, T.U., Walczak, C.E., Karsenti, E. & Hyman, A.A. Nat Cell Biol 2000 Jan;2(1):13-19 PubMed

Le mouvement: de l'aleatoire au determinisme. Karsenti, E. Medecine Sciences 2000 16 719-721

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Carazo-Salas, R.E., Guarguaglini, G., Gruss, O.J., Segref, A., Karsenti, E. & Mattaj, I.W. Nature 1999 Jul 8;400(6740):178-81 PubMed

Tobacco BY-2 cell-free extracts induce the recovery of microtubule nucleating activity of inactivated mammalian centrosomes. Stoppin-Mellet, V., Peter, C., Buendia, B., Karsenti, E. & Lambert, A.M. Biochim Biophys Acta 1999 Feb 4;1449(1):101-6 PubMed

La forma come fattore determinante della funzione cellulare. Karsenti, E. In "Enciclopedia Italiana ed. Frontiere Della Vita" E. Treccani (ed.). Vol. II. 1999, Roma, pp. 77-98

Role of xklp3, a subunit of the Xenopus kinesin II heterotrimeric complex, in membrane transport between the endoplasmic reticulum and the Golgi apparatus. Le Bot, N., Antony, C., White, J., Karsenti, E. & Vernos, I. J Cell Biol 1998 Dec 14;143(6):1559-73. PubMed

Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein. Wittmann, T., Boleti, H., Antony, C., Karsenti, E. & Vernos, I. J Cell Biol 1998 Nov 2;143(3):673-85. PubMed

The role of nucleation in patterning microtubule networks. Hyman, A.A. & Karsenti, E. J Cell Sci 1998 Aug 111 ( Pt 15) 2077-2083 PubMed

A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity. Walczak, C.E., Vernos, I., Mitchison, T.J., Karsenti, E. & Heald, R. Curr Biol 1998 Jul 30-Aug 13;8(16):903-13. PubMed

Microtubule dynamics, molecular motors and chromosome behavior. Vernos, I. & Karsenti, E. In "Dynamics of Cell Division", Endow, S. & Glover, D. (eds.), 1998, Oxford University Press, New York, pp. 97-123

In vitro assays for mitotic spindle assembly and function. Heald, R., Tournebize, R., Vernos, I., Murray, A., Hyman, A. & Karsenti, E. In "Cell Biology: A laboratory handbook", 2nd Ed., Vol. 2., Celis, J. (ed.), 1998, Academic Press, pp. 326-335

Three-dimensional reconstruction of the mammalian centriole from cryoelectron micrographs: the use of common lines for orientation and alignment. Kenney, J., Karsenti, E., Gowen, B. & Fuller, S.D. J Struct Biol 1997 Dec;120(3):320-8 PubMed

XMAP310: a Xenopus rescue-promoting factor localized to the mitotic spindle. Andersen, S.S. & Karsenti, E. J Cell Biol 1997 Nov 17;139(4):975-83 PubMed

Reconstruction of the centrosome cycle from cryoelectron micrographs. Chretien, D., Buendia, B., Fuller, S.D. & Karsenti, E. J Struct Biol 1997 Nov;120(2):117-33 PubMed

Mitotic chromatin regulates phosphorylation of Stathmin/Op18. Andersen, S.S., Ashford, A.J., Tournebize, R., Gavet, O., Sobel, A., Hyman, A.A. & Karsenti, E. Nature 1997 Oct 9 389(6651) 640-643 PubMed

Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts Heald, R., Tournebize, R., Blank, T., Sandaltzopoulos, R., Becker, P., Hyman, A.A. & Karsenti, E. Nature 1996 Aug 1 382(6590) 420-425 PubMed

Morphogenetic properties of microtubules and mitotic spindle assembly. Hyman, A.A. & Karsenti, E. Cell 1996 Feb 9 84(3) 401-410 PubMed

Motors involved in spindle assembly and chromosome segregation. Vernos, I. & Karsenti, E. Curr Opin Cell Biol 1996 Feb;8(1):4-9 PubMed

Motors involved in spindle assembly and chromosome segregation. Vernos, I. & Karsenti, E. Curr Opin Cell Biol 1996 Feb;8(1):4-9 PubMed

Xklp2, a novel Xenopus centrosomal kinesin-like protein required for centrosome separation during mitosis. Boleti, H., Karsenti, E. & Vernos, I. Cell 1996 Jan 12 84(1) 49-59 PubMed

The role of microtubule dependent motors in centrosome movements and spindle pole organization during mitosis. Karsenti, E., Boleti, H. & Vernos, I. Sem. Cell Biol. 1996 7 367-378

Chromosomes take the lead in spindle assembly. Vernos, I. & Karsenti, E. Trends Cell Biol 1995 Aug;5(8):297-301. PubMed

Structure of growing microtubule ends: two-dimensional sheets close into tubes at variable rates. Chretien, D., Fuller, S.D. & Karsenti, E. J Cell Biol 1995 Jun;129(5):1311-28 PubMed

Xklp1, a chromosomal Xenopus kinesin-like protein essential for spindle organization and chromosome positioning. Vernos, I., Raats, J., Hirano, T., Heasman, J., Karsenti, E. & Wylie, C. Cell 1995 Apr 7 81(1) 117-127 PubMed

Effect on microtubule dynamics of XMAP230, a microtubule-associated protein present in Xenopus laevis eggs and dividing cells [published erratum appears in J Cell Biol 1995 Mar;128(5):following 988] Andersen, S.S., Buendia, B., Dominguez, J.E., Sawyer, A. & Karsenti, E. J Cell Biol 1994 Dec;127(5):1289-99 PubMed

Approaching microtubule structure with the scanning tunneling microscope (STM). Maaloum, M., Chretien, D., Karsenti, E. & Horber, J.K.H. J Cell Sci 1994 Nov 107 ( Pt 11) 3127-3131 PubMed

Lattice defects in microtubules: protofilament numbers vary within individual microtubules. Chretien, D., Metoz, F., Verde, F., Karsenti, E. & Wade, R.H. J Cell Biol 1992 Jun;117(5):1031-40 PubMed

Role of type 1 and type 2A protein phosphatases in the cell cycle. Karsenti, E., Verde, F. & Felix, M.A. Adv. Prot. Phosph. 1991 6 453-482