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Staff at EMBL

CP-60003440

Dr. François Nédélec

Group Leader
Nédélec Group Joint appointment: Structural and Computational Biology Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Biography

PhD 1998, Université Paris-Sud II.
Postdoctoral Research at EMBL.
Group Leader since 2005.
Joint Appointment with the Stuctural and Computational Biology Unit.

Publications

Total: 35 publication(s)

2014

Mori M, Somogyi K, Kondo H, Monnier N, Falk HJ, Machado P, Bathe M, Nédélec F, Lénárt P. (2014)
An arp2/3 nucleated f-actin shell fragments nuclear membranes at nuclear envelope breakdown in starfish oocytes.
Curr. Biol. 24(12):1421-1428. doi:10.1016/j.cub.2014.05.019
Europe PMC | doi

Athale CA, Dinarina A, Nedelec F, Karsenti E. (2014)
Collective behavior of minus-ended motors in mitotic microtubule asters gliding toward DNA
Phys Biol 11(1):016008. doi:10.1088/1478-3975/11/1/016008
Europe PMC | doi

Tarnawska K, Pugieux C, Nédélec F. (2014)
Mitotic spindle assembly on chromatin patterns made with deep UV photochemistry
Methods Cell Biol. 120:3-17. doi:10.1016/b978-0-12-417136-7.00001-x
Europe PMC | doi

Pugieux C, Dmitrieff S, Tarnawska K, Nédélec F. (2014)
Spindle assembly on immobilized chromatin micropatterns
Meth. Enzymol. 540:435-448. doi:10.1016/b978-0-12-397924-7.00024-8
Europe PMC | doi


2013

Wennekamp S, Mesecke S, Nédélec F, Hiiragi T. (2013)
A self-organization framework for symmetry breaking in the mammalian embryo
Nat. Rev. Mol. Cell Biol. 14(7):452-459. doi:10.1038/nrm3602
Europe PMC | doi

Gibeaux R, Politi AZ, Nédélec F, Antony C, Knop M. (2013)
Spindle pole body-anchored Kar3 drives the nucleus along microtubules from another nucleus in preparation for nuclear fusion during yeast karyogamy
Genes Dev. 27(3):335-349. doi:10.1101/gad.206318.112
Europe PMC | doi


2012

Rupp B, Nédélec F. (2012)
Patterns of molecular motors that guide and sort filaments
Lab Chip 12(22):4903-4910. doi:10.1039/c2lc40250e
Europe PMC | doi


2011

Loughlin R, Wilbur JD, McNally FJ, Nédélec FJ, Heald R. (2011)
Katanin contributes to interspecies spindle length scaling in Xenopus
Cell 147(6):1397-1407. doi:10.1016/j.cell.2011.11.014
Europe PMC | doi

Petry S, Pugieux C, Nédélec FJ, Vale RD. (2011)
Augmin promotes meiotic spindle formation and bipolarity in Xenopus egg extracts
Proc. Natl. Acad. Sci. U.S.A. 108(35):14473-14478. doi:10.1073/pnas.1110412108
Europe PMC | doi


2010

Loughlin R, Heald R, Nédélec F. (2010)
A computational model predicts Xenopus meiotic spindle organization
J. Cell Biol. 191(7):1239-1249. doi:10.1083/jcb.201006076
Europe PMC | doi

Renshaw MJ, Ward JJ, Kanemaki M, Natsume K, Nédélec FJ, Tanaka TU. (2010)
Condensins promote chromosome recoiling during early anaphase to complete sister chromatid separation
Dev. Cell 19(2):232-244. doi:10.1016/j.devcel.2010.07.013
Europe PMC | doi

Ward JJ, Nédélec FJ. (2010)
Computational cell biology at the home of the helix
EMBO Rep. 11(6):413-415. doi:10.1038/embor.2010.77
Europe PMC | doi

Pugieux C, Nedelec F. (2010)
La chromatine façonne le fuseau mitotique [Mitotic spindle assembly depends on chromatin geometry]
vol 26. Med Sci, Paris.doi:10.1051/medsci/2010262139
Europe PMC | doi


2009

Brun L, Rupp B, Ward JJ, Nédélec F. (2009)
A theory of microtubule catastrophes and their regulation
Proc. Natl. Acad. Sci. U.S.A. 106(50):21173-21178. doi:10.1073/pnas.0910774106
Europe PMC | doi

Dinarina A, Pugieux C, Corral MM, Loose M, Spatz J, Karsenti E, Nédélec F. (2009)
Chromatin shapes the mitotic spindle
Cell 138(3):502-513. doi:10.1016/j.cell.2009.05.027
Europe PMC | doi

Fu C, Ward JJ, Loiodice I, Velve-Casquillas G, Nedelec FJ, Tran PT. (2009)
Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation
Dev. Cell 17(2):257-267. doi:10.1016/j.devcel.2009.06.012
Europe PMC | doi

Pinot M, Chesnel F, Kubiak JZ, Arnal I, Nedelec FJ, Gueroui Z. (2009)
Effects of confinement on the self-organization of microtubules and motors
Curr. Biol. 19(11):954-960. doi:10.1016/j.cub.2009.04.027
Europe PMC | doi

Foethke D, Makushok T, Brunner D, Nédélec F. (2009)
Force- and length-dependent catastrophe activities explain interphase microtubule organization in fission yeast
Mol. Syst. Biol. 5:241. doi:10.1038/msb.2008.76
Europe PMC | doi


2008

Jékely G, Colombelli J, Hausen H, Guy K, Stelzer E, Nédélec F, Arendt D. (2008)
Mechanism of phototaxis in marine zooplankton
Nature 456(7220):395-399. doi:10.1038/nature07590
Europe PMC | doi

Athale CA, Dinarina A, Mora-Coral M, Pugieux C, Nedelec F, Karsenti E. (2008)
Regulation of microtubule dynamics by reaction cascades around chromosomes
Science 322(5905):1243-1247. doi:10.1126/science.1161820
Europe PMC | doi

Channels WE, Nédélec FJ, Zheng Y, Iglesias PA. (2008)
Spatial regulation improves antiparallel microtubule overlap during mitotic spindle assembly
Biophys. J. 94(7):2598-2609. doi:10.1529/biophysj.107.117671
Europe PMC | doi


2007

Kozlowski C, Srayko M, Nedelec F. (2007)
Cortical microtubule contacts position the spindle in C. elegans embryos
Cell 129(3):499-510. doi:10.1016/j.cell.2007.03.027
Europe PMC | doi

Janson ME, Loughlin R, Loïodice I, Fu C, Brunner D, Nédélec FJ, Tran PT. (2007)
Crosslinkers and motors organize dynamic microtubules to form stable bipolar arrays in fission yeast
Cell 128(2):357-368. doi:10.1016/j.cell.2006.12.030
Europe PMC | doi


2006

Karsenti E, Nédélec F, Surrey T. (2006)
Modelling microtubule patterns
Nat. Cell Biol. 8(11):1204-1211. doi:10.1038/ncb1498
Europe PMC | doi


2005

Goshima G, Nédélec F, Vale RD. (2005)
Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins
J. Cell Biol. 171(2):229-240. doi:10.1083/jcb.200505107
Europe PMC | doi


2004

Karsenti E, Nédélec F. (2004)
The mitotic spindle and actin tails
Biol. Cell 96(3):237-240. doi:10.1016/j.biolcel.2003.12.008
Europe PMC | doi


2003

Nédélec F, Surrey T, Karsenti E. (2003)
Self-organisation and forces in the microtubule cytoskeleton
Curr. Opin. Cell Biol. 15(1):118-124. doi:10.1016/s0955-0674(02)00014-5
Europe PMC | doi


2002

Nédélec F. (2002)
Computer simulations reveal motor properties generating stable antiparallel microtubule interactions
J. Cell Biol. 158(6):1005-1015. doi:10.1083/jcb.200202051
Europe PMC | doi


2001

Surrey T, Nedelec F, Leibler S, Karsenti E. (2001)
Physical properties determining self-organization of motors and microtubules
Science 292(5519):1167-1171. doi:10.1126/science.1059758
Europe PMC | doi

Nédélec F, Surrey T, Maggs AC. (2001)
Dynamic concentration of motors in microtubule arrays
Phys. Rev. Lett. 86(14):3192-3195. doi:10.1103/physrevlett.86.3192
Europe PMC | doi

Nédélec F, Surrey T. (2001)
Assaying spatial organization of microtubules by kinesin motors
Methods Mol. Biol. 164:213-222. doi:10.1385/1-59259-069-1:213
Europe PMC | doi

Nédélec F, Surrey T. (2001)
Dynamics of microtubule aster formation by motor complexes
C. R. Acad. Sci. IV-Phys. 2(6):841-847. doi:10.1016/s1296-2147(01)01227-6
Europe PMC | doi


2000

Nédélec F, Surrey T. (2000)
De l'action collective des moteurs à l'ordre cellulaire
médecine/sciences 16(6-7):739-744. doi:10.4267/10608/1725
doi


1998

Surrey T, Elowitz MB, Wolf PE, Yang F, Nédélec F, Shokat K, Leibler S. (1998)
Chromophore-assisted light inactivation and self-organization of microtubules and motors
Proc. Natl. Acad. Sci. U.S.A. 95(8):4293-4298. doi:10.1073/pnas.95.8.4293
Europe PMC | doi


1997

Nédélec FJ, Surrey T, Maggs AC, Leibler S. (1997)
Self-organization of microtubules and motors
Nature 389(6648):305-308. doi:10.1038/38532
Europe PMC | doi