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Staff at EMBL

Dr. Jonas Ries

Group Leader
Ries Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Tel: +49 6221 387-8199
E-mail: send a mail


PhD 2008, TU Dresden.
Postdoctoral research research at the ETH Zurich.
Group Leader at EMBL Heidelberg since 2012.


Tracking single serotonin transporter molecules at the endoplasmic reticulum and plasma membrane. Anderluh, A., Klotzsch, E., Ries, J., Reismann, A.W., Weber, S., Folser, M., Koban, F., Freissmuth, M., Sitte, H.H. & Schutz, G.J. Biophys J. 2014 May 6;106(9):L33-5. doi: 10.1016/j.bpj.2014.03.019. Europe PMC

The yeast kinetochore - structural insights from optical microscopy. Cieslinski, K. & Ries, J. Curr Opin Chem Biol. 2014 Apr 21;20C:1-8. doi: 10.1016/j.cbpa.2014.03.020. Europe PMC

Localization microscopy in yeast. Mund, M., Kaplan, C. & Ries, J. Methods Cell Biol. 2014;123C:253-271. doi: 10.1016/B978-0-12-420138-5.00014-8. Europe PMC

A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of beta-amyloid production. Udayar, V., Buggia-Prevot, V., Guerreiro, R.L., Siegel, G., Rambabu, N., Soohoo, A.L., Ponnusamy, M., Siegenthaler, B., Bali, J., Simons, M., Ries, J., Puthenveedu, M.A., Hardy, J., Thinakaran, G. & Rajendran, L. Cell Rep. 2013 Dec 26;5(6):1536-51. doi: 10.1016/j.celrep.2013.12.005. Europe PMC

Superresolution imaging of amyloid fibrils with binding-activated probes. Ries, J., Udayar, V., Soragni, A., Hornemann, S., Nilsson, K.P., Riek, R., Hock, C., Ewers, H., Aguzzi, A.A. & Rajendran, L. ACS Chem Neurosci. 2013 Jul 17;4(7):1057-61. doi: 10.1021/cn400091m. Epub 2013Apr 22. Europe PMC

The bacterial SMC complex displays two distinct modes of interaction with the chromosome. Kleine Borgmann, L.A., Ries, J., Ewers, H., Ulbrich, M.H. & Graumann, P.L. Cell Rep. 2013 May 30;3(5):1483-92. doi: 10.1016/j.celrep.2013.04.005. Epub 2013May 9. Europe PMC

Tuning the "roadblock" effect in Kinesin-based transport. Schmidt, C., Kim, B., Grabner, H., Ries, J., Kulomaa, M. & Vogel, V. Nano Lett. 2012 Jul 11;12(7):3466-71. Epub 2012 Jun 14. Europe PMC

A simple, versatile method for GFP-based super-resolution microscopy via nanobodies. Ries, J., Kaplan, C., Platonova, E., Eghlidi, H. & Ewers, H. Nat Methods. 2012 Jun;9(6):582-4. doi: 10.1038/nmeth.1991. Epub 2012 Apr 29. Europe PMC

Fluorescence correlation spectroscopy. Ries, J. & Schwille, P. Bioessays. 2012 May;34(5):361-8. doi: 10.1002/bies.201100111. Epub 2012 Mar 13. Europe PMC

Fluorescence Correlation Spectroscopy (FCS). Ries, J., Weidemann, T. & Schwille, P. Comprehensive Biophysics 2, Biophysical Techniques for Characterization of Cells, 210–-245 (2012).

Binding-activated localization microscopy of DNA structures. Schoen, I., Ries, J., Klotzsch, E., Ewers, H. & Vogel, V. Nano Lett. 2011 Sep 14;11(9):4008-11. Epub 2011 Aug 18. Europe PMC

Cxcl12 evolution--subfunctionalization of a ligand through altered interaction with the chemokine receptor. Boldajipour, B., Doitsidou, M., Tarbashevich, K., Laguri, C., Yu, S.R., Ries, J., Dumstrei, K., Thelen, S., Dorries, J., Messerschmidt, E.M., Thelen, M., Schwille, P., Brand, M., Lortat-Jacob, H. & Raz Development. 2011 Jul;138(14):2909-14. Europe PMC

Principles and Applications of Fluorescence Correlation Spectroscopy (FCS). Schwille, P. & Ries, J. 63–85 (Biophotonics: Dordrecht, 2010).doi:10.1007/978-90-481-9977-8_4

DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells. Jeyasekharan, A.D., Ayoub, N., Mahen, R., Ries, J., Esposito, A., Rajendra, E., Hattori, H., Kulkarni, R.P. & Venkitaraman, A.R. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21937-42. Epub 2010 Nov 22. Europe PMC

Automated suppression of sample-related artifacts in Fluorescence Correlation Spectroscopy. Ries, J., Bayer, M., Csucs, G., Dirkx, R., Solimena, M., Ewers, H. & Schwille, P. Opt Express. 2010 May 24;18(11):11073-82. doi: 10.1364/OE.18.011073. Europe PMC

Scanning FCS for the characterization of protein dynamics in live cells. Petrasek, Z., Ries, J. & Schwille, P. Methods Enzymol. 2010;472:317-43. Europe PMC

A Comprehensive Framework for Fluorescence Cross-Correlation Spectroscopy. J. Ries, Z. Petrasek, A. Garcia-Saez, and P. Schwille. New Journal of Physics 12, 113009 (2010).

Membrane promotes tBID interaction with BCL(XL). Garcia-Saez, A.J., Ries, J., Orzaez, M., Perez-Paya, E. & Schwille, P. Nat Struct Mol Biol. 2009 Nov;16(11):1178-85. Epub 2009 Oct 11. Europe PMC

Detergent-activated BAX protein is a monomer. Ivashyna, O., Garcia-Saez, A.J., Ries, J., Christenson, E.T., Schwille, P. & Schlesinger, P.H. J Biol Chem. 2009 Sep 4;284(36):23935-46. Epub 2009 Jun 29. Europe PMC

Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules. Yu, S.R., Burkhardt, M., Nowak, M., Ries, J., Petrasek, Z., Scholpp, S., Schwille, P. & Brand, M. Nature. 2009 Sep 24;461(7263):533-6. Epub 2009 Sep 9. Europe PMC

Modular scanning FCS quantifies receptor-ligand interactions in living multicellular organisms. Ries, J., Yu, S.R., Burkhardt, M., Brand, M. & Schwille, P. Nat Methods. 2009 Sep;6(9):643-5. Epub 2009 Aug 2. Europe PMC

Accurate determination of membrane dynamics with line-scan FCS. Ries, J., Chiantia, S. & Schwille, P. Biophys J. 2009 Mar 4;96(5):1999-2008. Europe PMC

Fluorescence correlation spectroscopy in membrane structure elucidation. Chiantia, S., Ries, J. & Schwille, P. Biochim Biophys Acta. 2009 Jan;1788(1):225-33. Epub 2008 Aug 29. Europe PMC

Plasma membranes are poised for activation of raft phase coalescence at physiological temperature. Lingwood, D., Ries, J., Schwille, P. & Simons, K. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10005-10. Epub 2008 Jul 9. Europe PMC

Total internal reflection fluorescence correlation spectroscopy: effects of lateral diffusion and surface-generated fluorescence. Ries, J., Petrov, E.P. & Schwille, P. Biophys J. 2008 Jul;95(1):390-9. Epub 2008 Mar 13. Europe PMC

New concepts for fluorescence correlation spectroscopy on membranes. Ries, J. & Schwille, P. Phys Chem Chem Phys. 2008 Jun 28;10(24):3487-97. Epub 2008 Mar 27. Europe PMC

Spatial regulators for bacterial cell division self-organize into surface waves in vitro. Loose, M., Fischer-Friedrich, E., Ries, J., Kruse, K. & Schwille, P. Science. 2008 May 9;320(5877):789-92. Europe PMC

Role of ceramide in membrane protein organization investigated by combined AFM and FCS. Chiantia, S., Ries, J., Chwastek, G., Carrer, D., Li, Z., Bittman, R. & Schwille, P. Biochim Biophys Acta. 2008 May;1778(5):1356-64. Epub 2008 Feb 29. Europe PMC

Supercritical angle fluorescence correlation spectroscopy. Ries, J., Ruckstuhl, T., Verdes, D. & Schwille, P. Biophys J. 2008 Jan 1;94(1):221-9. Epub 2007 Sep 7. Europe PMC

Rho regulates membrane transport in the endocytic pathway to control plasma membrane specialization in oligodendroglial cells. Kippert, A., Trajkovic, K., Rajendran, L., Ries, J. & Simons, M. J Neurosci. 2007 Mar 28;27(13):3560-70. Europe PMC

Combined AFM and two-focus SFCS study of raft-exhibiting model membranes. Chiantia, S., Ries, J., Kahya, N. & Schwille, P. Chemphyschem. 2006 Nov 13;7(11):2409-18. Europe PMC

Mobility of Min-proteins in Escherichia coli measured by fluorescence correlation spectroscopy. Meacci, G., Ries, J., Fischer-Friedrich, E., Kahya, N., Schwille, P. & Kruse, K. Phys Biol. 2006 Nov 28;3(4):255-63. Europe PMC

Studying slow membrane dynamics with continuous wave scanning fluorescence correlation spectroscopy. Ries, J. & Schwille, P. Biophys J. 2006 Sep 1;91(5):1915-24. Epub 2006 Jun 16. Europe PMC

Effects of ceramide on liquid-ordered domains investigated by simultaneous AFM and FCS. Chiantia, S., Kahya, N., Ries, J. & Schwille, P. Biophys J. 2006 Jun 15;90(12 Europe PMC

Experimental vacuum squeezing in rubidium vapor via self-rotation. Ries, J., Brezger, B. & Lvovsky, A. Phys Rev a 68, – (2003)

Quantum scissors: Teleportation of single-mode optical states by means of a nonlocal single photon Ries, J. & Lvovsky, A. EPL (Europhysics Letters) (2003).