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Staff at EMBL

CP-60002438

Dr. Carsten Schultz

Interdisciplinary Group Leader and Senior Scientist
Schultz Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Biography

PhD 1989, University of Bremen, Germany.
Postdoctoral research at the University of California, San Diego, USA.
Habilitation 1997, Organic Chemistry, University of Bremen, Germany.
Group leader, MPI for Molecular Physiology, Dortmund, Germany.
Group leader at EMBL since 2001. Senior Scientist since 2008.
Group leader in the Molecular Medicine Partnership Unit.

Publications

Total: 96 publication(s)

2014

Mall MA, Schultz C. (2014)
A New Player in the Game: Epithelial Cathepsin S in Early Cystic Fibrosis Lung Disease
AM J RESP CRIT CARE 190(2):126-127. doi:10.1164/rccm.201405-0935ED
Europe PMC | doi

Rutkowska A, Plass T, Hoffmann JE, Yushchenko DA, Feng S, Schultz C. (2014)
T-CrAsH: A Heterologous Chemical Crosslinker
Chembiochem doi:10.1002/cbic.201402189
Europe PMC | doi

Schultz C. (2014)
The European Molecular Biology Laboratory (EMBL) - Its Anniversary and Its Chemistry
Angew. Chem. Int. Ed. Engl. doi:10.1002/anie.201405106
Europe PMC | doi

Feng S, Laketa V, Stein F, Rutkowska A, MacNamara A, Depner S, Klingmüller U, Saez-Rodriguez J, Schultz C. (2014)
A rapidly reversible chemical dimerizer system to study lipid signaling in living cells
Angew. Chem. Int. Ed. Engl. 53(26):6720-6723. doi:10.1002/anie.201402294
Europe PMC | doi

Reversi A, Loeser E, Subramanian D, Schultz C, De Renzis S. (2014)
Plasma membrane phosphoinositide balance regulates cell shape during Drosophila embryo morphogenesis
J CELL BIOL 205(3):395-408. doi:10.1083/jcb.201309079
Europe PMC | doi

Hu HY, Vats D, Vizovisek M, Kramer L, Germanier C, Wendt KU, Rudin M, Turk B, Plettenburg O, Schultz C. (2014)
In Vivo Imaging of Mouse Tumors by a Lipidated Cathepsin S Substrate
Angew. Chem. Int. Ed. Engl. 1841(8):1085-1096. doi:10.1002/anie.201310979
Europe PMC | doi

Höglinger D, Nadler A, Schultz C. (2014)
Caged lipids as tools for investigating cellular signaling
Biochim. Biophys. Acta 1841(8):1085-1096. doi:10.1016/j.bbalip.2014.03.012
Europe PMC | doi

Bilan DS, Matlashov ME, Gorokhovatsky AY, Schultz C, Enikolopov G, Belousov VV. (2014)
Genetically encoded fluorescent indicator for imaging NAD(+)/NADH ratio changes in different cellular compartments
Biochim. Biophys. Acta 1840(3):951-957. doi:10.1016/j.bbagen.2013.11.018
Europe PMC | doi

Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA. (2014)
Lack of neutrophil elastase reduces inflammation, mucus hypersecretion and emphysema, but not mucus obstruction, in mice with CF-like lung disease
Am. J. Respir. Crit. Care Med. doi:10.1164/rccm.201311-1932oc
Europe PMC | doi

Hu HY, Gehrig S, Reither G, Subramanian D, Mall MA, Plettenburg O, Schultz C. (2014)
FRET-based and other fluorescent proteinase probes
Biotechnol J 9(2):266-281. doi:10.1002/biot.201300201
Europe PMC | doi

Carta M, Lanore F, Rebola N, Szabo Z, Da Silva SV, Lourenço J, Verraes A, Nadler A, Schultz C, Blanchet C, Mulle C. (2014)
Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels
Neuron 81(4):787-799. doi:10.1016/j.neuron.2013.12.028
Europe PMC | doi

Laketa V, Zarbakhsh S, Traynor-Kaplan A, Macnamara A, Subramanian D, Putyrski M, Mueller R, Nadler A, Mentel M, Saez-Rodriguez J, Pepperkok R, Schultz C. (2014)
PIP₃ induces the recycling of receptor tyrosine kinases
Sci Signal 7(308):ra5. doi:10.1126/scisignal.2004532
Europe PMC | doi

Nikić I, Plass T, Schraidt O, Szymański J, Briggs JA, Schultz C, Lemke EA. (2014)
Minimal Tags for Rapid Dual-Color Live-Cell Labeling and Super-Resolution Microscopy
Angew. Chem. Int. Ed. Engl. doi:10.1002/anie.201309847
Europe PMC | doi


2013

Yushchenko DA, Schultz C. (2013)
Tissue clearing for optical anatomy
Angew. Chem. Int. Ed. Engl. 52(42):10949-10951. doi:10.1002/anie.201306039
Europe PMC | doi

Reither G, Chatterjee J, Beullens M, Bollen M, Schultz C, Köhn M. (2013)
Chemical activators of protein phosphatase-1 induce calcium release inside intact cells
Chem. Biol. 20(9):1179-1186. doi:10.1016/j.chembiol.2013.07.008
Europe PMC | doi

Stein F, Kress M, Reither S, Piljić A, Schultz C. (2013)
FluoQ: a tool for rapid analysis of multiparameter fluorescence imaging data applied to oscillatory events
ACS Chem. Biol. 8(9):1862-1868. doi:10.1021/cb4003442
Europe PMC | doi

Posor Y, Eichhorn-Gruenig M, Puchkov D, Schöneberg J, Ullrich A, Lampe A, Müller R, Zarbakhsh S, Gulluni F, Hirsch E, Krauss M, Schultz C, Schmoranzer J, Noé F, Haucke V. (2013)
Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate
Nature 499(7457):233-237. doi:10.1038/nature12360
Europe PMC | doi

Nadler A, Reither G, Feng S, Stein F, Reither S, Müller R, Schultz C. (2013)
The fatty acid composition of diacylglycerols determines local signaling patterns
Angew. Chem. Int. Ed. Engl. 52(24):6330-6334. doi:10.1002/anie.201301716
Europe PMC | doi

Haberkant P, Raijmakers R, Wildwater M, Sachsenheimer T, Brügger B, Maeda K, Houweling M, Gavin AC, Schultz C, van Meer G, Heck AJ, Holthuis JC. (2013)
In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids
Angew. Chem. Int. Ed. Engl. 52(14):4033-4038. doi:10.1002/anie.201210178
Europe PMC | doi

Bilan DS, Pase L, Joosen L, Gorokhovatsky AY, Ermakova YG, Gadella TW, Grabher C, Schultz C, Lukyanov S, Belousov VV. (2013)
HyPer-3: a genetically encoded H(2)O(2) probe with improved performance for ratiometric and fluorescence lifetime imaging
ACS Chem. Biol. 8(3):535-542. doi:10.1021/cb300625g
Europe PMC | doi

Lukinavičius G, Umezawa K, Olivier N, Honigmann A, Yang G, Plass T, Mueller V, Reymond L, Corrêa IR Jr, Luo ZG, Schultz C, Lemke EA, Heppenstall P, Eggeling C, Manley S, Johnsson K. (2013)
A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins
Nat Chem 5(2):132-139. doi:10.1038/nchem.1546
Europe PMC | doi

Nadler A, Schultz C. (2013)
The power of fluorogenic probes
Angew. Chem. Int. Ed. Engl. 52(9):2408-2410. doi:10.1002/anie.201209733
Europe PMC | doi

Mishina NM, Markvicheva KN, Fradkov AF, Zagaynova EV, Schultz C, Lukyanov S, Belousov VV. (2013)
Imaging H2O2 microdomains in receptor tyrosine kinases signaling
Meth. Enzymol. 526:175-187. doi:10.1016/b978-0-12-405883-5.00011-9
Europe PMC | doi

Adjobo-Hermans MJ, Crosby KC, Putyrski M, Bhageloe A, van Weeren L, Schultz C, Goedhart J, Gadella TW Jr. (2013)
PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq
Cell. Signal. 25(1):255-263. doi:10.1016/j.cellsig.2012.09.022
Europe PMC | doi

Mishina NM, Markvicheva KN, Bilan DS, Matlashov ME, Shirmanova MV, Liebl D, Schultz C, Lukyanov S, Belousov VV. (2013)
Visualization of intracellular hydrogen peroxide with HyPer, a genetically encoded fluorescent probe
Meth. Enzymol. 526:45-59. doi:10.1016/b978-0-12-405883-5.00003-x
Europe PMC | doi


2012

Borrmann A, Milles S, Plass T, Dommerholt J, Verkade JM, Wiessler M, Schultz C, van Hest JC, van Delft FL, Lemke EA. (2012)
Genetic encoding of a bicyclo[6.1.0]nonyne-charged amino acid enables fast cellular protein imaging by metal-free ligation
Chembiochem 13(14):2094-2099. doi:10.1002/cbic.201200407
Europe PMC | doi

Wymann MP, Schultz C. (2012)
The chemical biology of phosphoinositide 3-kinases
Chembiochem 13(14):2022-2035. doi:10.1002/cbic.201200089
Europe PMC | doi

Mishina NM, Bogeski I, Bolotin DA, Hoth M, Niemeyer BA, Schultz C, Zagaynova EV, Lukyanov S, Belousov VV. (2012)
Can we see PIP(3) and hydrogen peroxide with a single probe?
Antioxid. Redox Signal. 17(3):505-512. doi:10.1089/ars.2012.4574
Europe PMC | doi

Rutkowska A, Schultz C. (2012)
Protein tango: the toolbox to capture interacting partners
Angew. Chem. Int. Ed. Engl. 51(33):8166-8176. doi:10.1002/anie.201201717
Europe PMC | doi

Mundhenk L, Johannesson B, Anagnostopoulou P, Braun J, Bothe MK, Schultz C, Mall MA, Gruber AD. (2012)
mCLCA3 does not contribute to calcium-activated chloride conductance in murine airways
Am. J. Respir. Cell Mol. Biol. 47(1):87-93. doi:10.1165/rcmb.2010-0508oc
Europe PMC | doi

Putyrski M, Schultz C. (2012)
Protein translocation as a tool: The current rapamycin story
FEBS Lett. 586(15):2097-2105. doi:10.1016/j.febslet.2012.04.061
Europe PMC | doi

Mertens HD, Piljić A, Schultz C, Svergun DI. (2012)
Conformational analysis of a genetically encoded FRET biosensor by SAXS
Biophys. J. 102(12):2866-2875. doi:10.1016/j.bpj.2012.05.009
Europe PMC | doi

Gehrig S, Mall MA, Schultz C. (2012)
Spatially resolved monitoring of neutrophil elastase activity with ratiometric fluorescent reporters
Angew. Chem. Int. Ed. Engl. 51(25):6258-6261. doi:10.1002/anie.201109226
Europe PMC | doi

Plass T, Milles S, Koehler C, Szymański J, Mueller R, Wiessler M, Schultz C, Lemke EA. (2012)
Amino acids for Diels-Alder reactions in living cells
Angew. Chem. Int. Ed. Engl. 51(17):4166-4170. doi:10.1002/anie.201108231
Europe PMC | doi

Johannesson B, Hirtz S, Schatterny J, Schultz C, Mall MA. (2012)
CFTR regulates early pathogenesis of chronic obstructive lung disease in βENaC-overexpressing mice
PLoS ONE 7(8):e44059. doi:10.1371/journal.pone.0044059
Europe PMC | doi

Cobos-Correa A, Stein F, Schultz C. (2012)
Target-Activated Prodrugs (TAPs) for the autoregulated inhibition of MMP12
ACS Med Chem Lett 3(8):653-657. doi:10.1021/ml3001193
Europe PMC | doi


2011

Rutkowska A, Haering CH, Schultz C. (2011)
A FlAsH-based cross-linker to study protein interactions in living cells
Angew. Chem. Int. Ed. Engl. 50(52):12655-12658. doi:10.1002/anie.201106404
Europe PMC | doi

Putyrski M, Schultz C. (2011)
Switching heterotrimeric G protein subunits with a chemical dimerizer
Chem. Biol. 18(9):1126-1133. doi:10.1016/j.chembiol.2011.07.013
Europe PMC | doi

Lemke EA, Schultz C. (2011)
Principles for designing fluorescent sensors and reporters
Nat. Chem. Biol. 7(8):480-483. doi:10.1038/nchembio.620
Europe PMC | doi

Piljić A, de Diego I, Wilmanns M, Schultz C. (2011)
Rapid development of genetically encoded FRET reporters
ACS Chem. Biol. 6(7):685-691. doi:10.1021/cb100402n
Europe PMC | doi

Zhou Z, Duerr J, Johannesson B, Schubert SC, Treis D, Harm M, Graeber SY, Dalpke A, Schultz C, Mall MA. (2011)
The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease
J. Cyst. Fibros. 10 Suppl 2:S172-82. doi:10.1016/s1569-1993(11)60021-0
Europe PMC | doi

Plass T, Milles S, Koehler C, Schultz C, Lemke EA. (2011)
Genetically encoded copper-free click chemistry
Angew. Chem. Int. Ed. Engl. 50(17):3878-3881. doi:10.1002/anie.201008178
Europe PMC | doi

Mentel M, Laketa V, Subramanian D, Gillandt H, Schultz C. (2011)
Photoactivatable and cell-membrane-permeable phosphatidylinositol 3,4,5-trisphosphate
Angew. Chem. Int. Ed. Engl. 50(16):3811-3814. doi:10.1002/anie.201007796
Europe PMC | doi

Schultz C, Aime S. (2011)
Imaging probes--Introduction
Bioorg. Med. Chem. 19(3):1022. doi:10.1016/j.bmc.2011.01.040
Europe PMC | doi

Plass T, Schultz C. (2011)
Covalent labeling of biomolecules in living cells
In: Demchenko AP (ed.), Advanced Fluorescence Reporters in Chemistry and Biology III. Springer Series on Fluorescence. Springer Berlin Heidelberg. pp 225-261.doi:10.1007/978-3-642-18035-4_7
Europe PMC | doi

Mishina NM, Tyurin-Kuzmin PA, Markvicheva KN, Vorotnikov AV, Tkachuk VA, Laketa V, Schultz C, Lukyanov S, Belousov VV. (2011)
Does cellular hydrogen peroxide diffuse or act locally?
Antioxid. Redox Signal. 14(1):1-7. doi:10.1089/ars.2010.3539
Europe PMC | doi

Jackson SG, Al-Saigh S, Schultz C, Junop MS. (2011)
Inositol pentakisphosphate isomers bind PH domains with varying specificity and inhibit phosphoinositide interactions
BMC Struct. Biol. 11:11. doi:10.1186/1472-6807-11-11
Europe PMC | doi


2010

Mall MA, Button B, Johannesson B, Zhou Z, Livraghi A, Caldwell RA, Schubert SC, Schultz C, O'Neal WK, Pradervand S, Hummler E, Rossier BC, Grubb BR, Boucher RC. (2010)
Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice
J. Biol. Chem. 285(35):26945-26955. doi:10.1074/jbc.m110.151803
Europe PMC | doi

Schultz C. (2010)
Challenges in studying phospholipid signaling
Nat. Chem. Biol. 6(7):473-475. doi:10.1038/nchembio.389
Europe PMC | doi

Schultz C, Neef AB, Gadella TW Jr, Goedhart J. (2010)
Imaging lipids in living cells
Cold Spring Harb Protoc 2010(7):pdb.top83. doi:10.1101/pdb.top83
Europe PMC | doi

Subramanian D, Laketa V, Müller R, Tischer C, Zarbakhsh S, Pepperkok R, Schultz C. (2010)
Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells
Nat. Chem. Biol. 6(5):324-326. doi:10.1038/nchembio.348
Europe PMC | doi

Schultz C. (2010)
Climbing to the next step: photosensitive protein labels
ACS Chem. Biol. 5(5):447-448. doi:10.1021/cb1001125
Europe PMC | doi


2009

Laketa V, Zarbakhsh S, Morbier E, Subramanian D, Dinkel C, Brumbaugh J, Zimmermann P, Pepperkok R, Schultz C. (2009)
Membrane-permeant phosphoinositide derivatives as modulators of growth factor signaling and neurite outgrowth
Chem. Biol. 16(11):1190-1196. doi:10.1016/j.chembiol.2009.10.005
Europe PMC | doi

Cobos-Correa A, Trojanek JB, Diemer S, Mall MA, Schultz C. (2009)
Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation
Nat. Chem. Biol. 5(9):628-630. doi:10.1038/nchembio.196
Europe PMC | doi

Köhn M, Schultz C. (2009)
Chemical biologists gather in Heidelberg
Nat. Chem. Biol. 5(2):66-69. doi:10.1038/nchembio0209-66
Europe PMC | doi

Schultz C. (2009)
Fluorescent revelations
Chem. Biol. 16(2):107-111. doi:10.1016/j.chembiol.2009.02.001
Europe PMC | doi

Neef AB, Schultz C. (2009)
Selective fluorescence labeling of lipids in living cells
Angew. Chem. Int. Ed. Engl. 48(8):1498-1500. doi:10.1002/anie.200805507
Europe PMC | doi


2008

Piljić A, Schultz C. (2008)
Analysis of protein complex hierarchy in living cells
ACS Chem. Biol. 3(12):749-755. doi:10.1021/cb8002539
Europe PMC | doi

Jost CA, Reither G, Hoffmann C, Schultz C. (2008)
Contribution of fluorophores to protein kinase C FRET probe performance
Chembiochem 9(9):1379-1384. doi:10.1002/cbic.200700728
Europe PMC | doi

Prinz A, Reither G, Diskar M, Schultz C. (2008)
Fluorescence and bioluminescence procedures for functional proteomics
Proteomics 8(6):1179-1196. doi:10.1002/pmic.200700802
Europe PMC | doi

Skrahina T, Piljić A, Schultz C. (2008)
Heterogeneity and timing of translocation and membrane-mediated assembly of different annexins
Exp. Cell Res. 314(5):1039-1047. doi:10.1016/j.yexcr.2007.11.015
Europe PMC | doi

Piljic A, Schultz C. (2008)
Simultaneous recording of multiple cellular events by FRET
ACS Chem. Biol. 3(3):156-160. doi:10.1021/cb700247q
Europe PMC | doi

Black SL, Stanley WA, Filipp FV, Bhairo M, Verma A, Wichmann O, Sattler M, Wilmanns M, Schultz C. (2008)
Probing lipid- and drug-binding domains with fluorescent dyes
Bioorg. Med. Chem. 16(3):1162-1173. doi:10.1016/j.bmc.2007.10.080
Europe PMC | doi

Schultz C, Köhn M. (2008)
Simultaneous protein tagging in two colors
Chem. Biol. 15(2):91-92. doi:10.1016/j.chembiol.2008.02.004
Europe PMC | doi

Cobos Correa A, Schultz C. (2008)
Small molecule-based FRET probes
In: Gadella TWJ (ed.), Fret and Flim Techniques, vol 33. Laboratory Techniques in Biochemistry and Molecular Biology. Elsevier. pp 225-288.doi:10.1016/S0075-7535(08)00006-5
doi


2007

Schultz C. (2007)
Molecular tools for cell and systems biology
HFSP J 1(4):230-248. doi:10.2976/1.2812442
Europe PMC | doi

Wichmann O, Gelb MH, Schultz C. (2007)
Probing phospholipase a(2) with fluorescent phospholipid substrates
Chembiochem 8(13):1555-1569. doi:10.1002/cbic.200600462
Europe PMC | doi

Stanley WA, Versluis K, Schultz C, Heck AJ, Wilmanns M. (2007)
Investigation of the ligand spectrum of human sterol carrier protein 2 using a direct mass spectrometry assay
Arch. Biochem. Biophys. 461(1):50-58. doi:10.1016/j.abb.2007.02.026
Europe PMC | doi

Giordano A, Zarbakhsh S, Schultz C. (2007)
Controlling protein function by caged compounds
In: Schreiber SL, Kapoor TM, Wess G (eds.), Chemical Biology: From Small Molecules to Systems Biology and Drug Design, vol 1-3. Wiley-VCH Verlag GmbH, Weinheim. pp 140-173.doi:10.1002/9783527619375.ch3b
doi

Yudushkin IA, Schleifenbaum A, Kinkhabwala A, Neel BG, Schultz C, Bastiaens PI. (2007)
Live-cell imaging of enzyme-substrate interaction reveals spatial regulation of PTP1B
Science 315(5808):115-119. doi:10.1126/science.1134966
Europe PMC | doi


2006

Schultz C. (2006)
Lipid-induced phenotypes
Nat. Chem. Biol. 2(8):396-398. doi:10.1038/nchembio0806-396
Europe PMC | doi

Piljic A, Schultz C. (2006)
Annexin A4 self-association modulates general membrane protein mobility in living cells
Mol. Biol. Cell 17(7):3318-3328. doi:10.1091/mbc.e06-01-0041
Europe PMC | doi

Tabary O, Boncoeur E, de Martin R, Pepperkok R, Clément A, Schultz C, Jacquot J. (2006)
Calcium-dependent regulation of NF-(kappa)B activation in cystic fibrosis airway epithelial cells
Cell. Signal. 18(5):652-660. doi:10.1016/j.cellsig.2005.06.004
Europe PMC | doi

Füssl A, Schleifenbaum A, Göritz M, Riddell A, Schultz C, Krämer R. (2006)
Cellular uptake of PNA--terpyridine conjugates and its enhancement by Zn2+ ions
J. Am. Chem. Soc. 128(18):5986-5987. doi:10.1021/ja0571139
Europe PMC | doi

Brumbaugh J, Schleifenbaum A, Gasch A, Sattler M, Schultz C. (2006)
A dual parameter FRET probe for measuring PKC and PKA activity in living cells
J. Am. Chem. Soc. 128(1):24-25. doi:10.1021/ja0562200
Europe PMC | doi

Wichmann O, Wittbrodt J, Schultz C. (2006)
A small-molecule FRET probe to monitor phospholipase A2 activity in cells and organisms
Angew. Chem. Int. Ed. Engl. 45(3):508-512. doi:10.1002/anie.200500751
Europe PMC | doi


2005

Moody M, Pennington C, Schultz C, Caldwell R, Dinkel C, Rossi MW, McNamara S, Widdicombe J, Gabriel S, Traynor-Kaplan AE. (2005)
Inositol polyphosphate derivative inhibits Na+ transport and improves fluid dynamics in cystic fibrosis airway epithelia
Am. J. Physiol., Cell Physiol. 289(3):C512-20. doi:10.1152/ajpcell.00591.2004
Europe PMC | doi

Schultz C, Schleifenbaum A, Goedhart J, Gadella TW Jr. (2005)
Multiparameter imaging for the analysis of intracellular signaling
Chembiochem 6(8):1323-1330. doi:10.1002/cbic.200500012
Europe PMC | doi

Schärer O, Schultz C. (2005)
Closing the gap between chemistry and biology
Chembiochem 6(1):3-5. doi:10.1002/cbic.200400405
Europe PMC | doi


2004

Schleifenbaum A, Stier G, Gasch A, Sattler M, Schultz C. (2004)
Genetically encoded FRET probe for PKC activity based on pleckstrin
J. Am. Chem. Soc. 126(38):11786-11787. doi:10.1021/ja0460155
Europe PMC | doi


2003

Rudolf MT, Dinkel C, Traynor-Kaplan AE, Schultz C. (2003)
Antagonists of myo-inositol 3,4,5,6-tetrakisphosphate allow repeated epithelial chloride secretion
Bioorg. Med. Chem. 11(15):3315-3329. doi:10.1016/s0968-0896(03)00188-3
Europe PMC | doi

Schultz C. (2003)
Prodrugs of biologically active phosphate esters
Bioorg. Med. Chem. 11(6):885-898. doi:10.1016/s0968-0896(02)00552-7
Europe PMC | doi

Dinkel C, Wichmann O, Schultz C. (2003)
Versatile reagents to introduce caged phosphates
TETRAHEDRON LETT 44(6):1153-1155. doi:10.1016/S0040-4039(02)02832-0
doi

Dinkel C, Schultz C. (2003)
Synthesis of caged myo-inositol 1,3,4,5-tetrakisphosphate
Tetrahedron Lett. 44(6):1157-1159. doi:10.1016/S0040-4039(02)02834-4
Europe PMC | doi


2002

Schultz C. (2002)
Inositphosphate - das unerkannte Arsenal der intrazellulären Signalübertragung?
Nachr. Chem. 50(3):323-326.

Schultz C, Dinkel C. (2002)
Phosphatidylinosite: Informationsträger der anderen Art
Nachr. Chem. 50(5):590-595. doi:10.1002/nadc.20020500507
doi

Schultz C, Gröger H, Dinkel C, Drauz K, Waldmann H. (2002)
Special Catalysts and Processes: Section 3.2.1–3.2.6.6
In: Cornils B, Herrmann WA (eds.), Applied Homogeneous Catalysis with Organometallic Compounds. Wiley-VCH Verlag GmbH, Weinheim. pp 972-1033.doi:10.1002/9783527618231.ch3c
doi

Schultz C, Gröger H, Dinkel C, Drauz K, Waldmann H. (2002)
Special Catalysts and Processes: Section 3.2.7–3.2.14.7
In: Cornils B, Herrmann WA (eds.), Applied Homogeneous Catalysis with Organometallic Compounds. Wiley-VCH Verlag GmbH, Weinheim. pp 1034-1130.doi:10.1002/9783527618231.ch3d
doi


2001

Wichmann O, Schultz C. (2001)
FRET probes to monitor phospholipase A2 activity
Chem. Commun. (Camb.) (23):2500-2501. doi:10.1039/b107670c
Europe PMC | doi

Dinkel C, Moody M, Traynor-Kaplan A, Schultz C. (2001)
Membrane-Permeant 3-OH-Phosphorylated Phosphoinositide Derivatives
Angew. Chem. Int. Ed. Engl. 40(16):3004-3008. doi:10.1002/1521-3773(20010817)40:163.0.co;2-o
Europe PMC | doi

Schnaars A, Schultz C. (2001)
Synthesis of bi- and tricyclic analogues of myo-inositol 3,4,5,6- and 1,4,5,6-tetrakisphosphate with extended carbon backbone
Tetrahedron 57(3):519-524. doi:10.1016/S0040-4020(00)01021-8
Europe PMC | doi


2000

Carew MA, Yang X, Schultz C, Shears SB. (2000)
myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line
J. Biol. Chem. 275(35):26906-26913. doi:10.1074/jbc.M002316200
Europe PMC | doi


1999

Yang X, Rudolf M, Carew MA, Yoshida M, Nerreter V, Riley AM, Chung SK, Bruzik KS, Potter BV, Schultz C, Shears SB. (1999)
Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate
J. Biol. Chem. 274(27):18973-18980. doi:10.1074/jbc.274.27.18973
Europe PMC | doi

Schultz C, Schnaars A, Rudolf MT. (1999)
Manipulating intracellular signal transduction
In: Lindhorst T, Diedrichsen U, Westermann B, Wessjohann L (eds.), Bioorganic chemistry highlights and new aspects. Wiley-VCH Verlag GmbH, Weinheim. pp 346-355.


1998

Rudolf MT, Li WH, Wolfson N, Traynor-Kaplan AE, Schultz C. (1998)
2-Deoxy derivative is a partial agonist of the intracellular messenger inositol 3,4,5,6-tetrakisphosphate in the epithelial cell line T84
J. Med. Chem. 41(19):3635-3644. doi:10.1021/jm970781n
Europe PMC | doi

Schultz C, Rudolf MT, Gillandt HH, Traynor-Kaplan AE. (1998)
Membrane-permeant, bioactivatable derivatives of inositol polyphosphates and phosphoinositides
In: Bruzik KS (ed.), Phosphoinositides, vol 718. ACS Symposium Series. American Chemical Society. pp 232-243.doi:10.1021/bk-1999-0718.ch015
Europe PMC | doi