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Schultz GroupPublications

Caged lipids as tools for investigating cellular signaling.
Hoglinger, D., Nadler, A. & Schultz, C.
Biochim Biophys Acta. 2014 Aug;1841(8):1085-96. doi:10.1016/j.bbalip.2014.03.012. Epub 2014 Apr 5. Europe PMC

T-CrAsH: A Heterologous Chemical Crosslinker.
Rutkowska, A., Plass, T., Hoffmann, J.E., Yushchenko, D.A., Feng, S. & Schultz, C.
Chembiochem. 2014 Jul 10. doi: 10.1002/cbic.201402189. Europe PMC

The European Molecular Biology Laboratory (EMBL)-Its Anniversary and Its Chemistry.
Schultz, C.
Angew Chem Int Ed Engl. 2014 Jul 7. doi: 10.1002/anie.201405106. Europe PMC

In Vivo Imaging of Mouse Tumors by a Lipidated Cathepsin S Substrate.
Hu, H.Y., Vats, D., Vizovisek, M., Kramer, L., Germanier, C., Wendt, K.U., Rudin, M., Turk, B., Plettenburg, O. & Schultz, C.
Angew Chem Int Ed Engl. 2014 May 30. doi: 10.1002/anie.201310979. Europe PMC

A Rapidly Reversible Chemical Dimerizer System to Study Lipid Signaling in Living Cells.
Feng, S., Laketa, V., Stein, F., Rutkowska, A., MacNamara, A., Depner, S., Klingmuller, U., Saez-Rodriguez, J. & Schultz, C.
Angew Chem Int Ed Engl. 2014 May 19. doi: 10.1002/anie.201402294. Europe PMC

Plasma membrane phosphoinositide balance regulates cell shape during Drosophila embryo morphogenesis.
Reversi, A., Loeser, E., Subramanian, D., Schultz, C. & De Renzis, S.
J Cell Biol. 2014 May 12;205(3):395-408. doi: 10.1083/jcb.201309079. Epub 2014May 5. Europe PMC

Lack of neutrophil elastase reduces inflammation, mucus hypersecretion and emphysema, but not mucus obstruction, in mice with CF-like lung disease.
Gehrig, S., Duerr, J., Weitnauer, M., Wagner, C.J., Graeber, S.Y., Schatterny, J., Hirtz, S., Belaaouaj, A., Dalpke, A.H., Schultz, C. & Mall, M.A.
Am J Respir Crit Care Med. 2014 Mar 28. Europe PMC

Genetically encoded fluorescent indicator for imaging NAD(+)/NADH ratio changes in different cellular compartments.
Bilan, D.S., Matlashov, M.E., Gorokhovatsky, A.Y., Schultz, C., Enikolopov, G. & Belousov, V.V.
Biochim Biophys Acta. 2014 Mar;1840(3):951-7. doi: 10.1016/j.bbagen.2013.11.018.Epub 2013 Nov 25. Europe PMC

Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels.
Carta, M., Lanore, F., Rebola, N., Szabo, Z., Da Silva, S.V., Lourenco, J., Verraes, A., Nadler, A., Schultz, C., Blanchet, C. & Mulle, C.
Neuron. 2014 Feb 19;81(4):787-99. doi: 10.1016/j.neuron.2013.12.028. Epub 2014Jan 30. Europe PMC

Minimal Tags for Rapid Dual-Color Live-Cell Labeling and Super-Resolution Microscopy.
Nikic, I., Plass, T., Schraidt, O., Szymanski, J., Briggs, J.A., Schultz, C. & Lemke, E.A.
Angew Chem Int Ed Engl. 2014;53(8):2245?2249. doi: 10.1002/anie.201309847. Europe PMC

FRET-based and other fluorescent proteinase probes.
Hu, H.Y., Gehrig, S., Reither, G., Subramanian, D., Mall, M.A., Plettenburg, O. & Schultz, C.
Biotechnol J. 2014 Feb;9(2):266-81. doi: 10.1002/biot.201300201. Epub 2014 Jan27. Europe PMC

PIP(3) induces the recycling of receptor tyrosine kinases.
Laketa, V., Zarbakhsh, S., Traynor-Kaplan, A., Macnamara, A., Subramanian, D., Putyrski, M., Mueller, R., Nadler, A., Mentel, M., Saez-Rodriguez, J., Pepperkok, R. & Schultz, C.
Sci Signal. 2014 Jan 14;7(308):ra5. doi: 10.1126/scisignal.2004532. Europe PMC

A new player in the game: epithelial cathepsin s in early cystic fibrosis lung disease.
Mall, M.A. & Schultz, C.
Am J Respir Crit Care Med. 2014 Jul 15;190(2):126-7. doi:10.1164/rccm.201405-0935ED. Europe PMC

Tissue clearing for optical anatomy.
Yushchenko, D.A. & Schultz, C.
Angew Chem Int Ed Engl. 2013 Oct 11;52(42):10949-51. doi: 10.1002/anie.201306039.Epub 2013 Sep 3. Europe PMC

FluoQ: a tool for rapid analysis of multiparameter fluorescence imaging data applied to oscillatory events.
Stein, F., Kress, M., Reither, S., Piljic, A. & Schultz, C.
ACS Chem Biol. 2013 Sep 20;8(9):1862-8. doi: 10.1021/cb4003442. Epub 2013 Aug 6. Europe PMC

Chemical activators of protein phosphatase-1 induce calcium release inside intact cells.
Reither, G., Chatterjee, J., Beullens, M., Bollen, M., Schultz, C. & Köhn, M.
Chem Biol. 2013 Sep 19;20(9):1179-86. doi: 10.1016/j.chembiol.2013.07.008. Epub2013 Aug 22. Europe PMC

The fatty acid composition of diacylglycerols determines local signaling patterns.
Nadler, A., Reither, G., Feng, S., Stein, F., Reither, S., Muller, R. & Schultz, C.
Angew Chem Int Ed Engl. 2013 Jun 10;52(24):6330-4. doi: 10.1002/anie.201301716.Epub 2013 May 29. Europe PMC

In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids.
Haberkant, P., Raijmakers, R., Wildwater, M., Sachsenheimer, T., Brugger, B., Maeda, K., Houweling, M., Gavin, A.C., Schultz, C., van Meer, G., Heck, A.J. & Holthuis, J.C.
Angew Chem Int Ed Engl. 2013 Apr 2;52(14):4033-8. doi: 10.1002/anie.201210178.Epub 2013 Feb 28. Europe PMC

HyPer-3: a genetically encoded H(2)O(2) probe with improved performance for ratiometric and fluorescence lifetime imaging.
Bilan, D.S., Pase, L., Joosen, L., Gorokhovatsky, A.Y., Ermakova, Y.G., Gadella, T.W., Grabher, C., Schultz, C., Lukyanov, S. & Belousov, V.V.
ACS Chem Biol. 2013 Mar 15;8(3):535-42. doi: 10.1021/cb300625g. Epub 2013 Jan 7. Europe PMC

The power of fluorogenic probes.
Nadler, A. & Schultz, C.
Angew Chem Int Ed Engl. 2013 Feb 25;52(9):2408-10. doi: 10.1002/anie.201209733.Epub 2013 Jan 21. Europe PMC

A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins.
Lukinavicius, G., Umezawa, K., Olivier, N., Honigmann, A., Yang, G., Plass, T., Mueller, V., Reymond, L., Correa IR, J.r, Luo, Z.G., Schultz, C., Lemke, E.A., Heppenstall, P., Eggeling, C., Manley, S. & Johnsson, K.
Nat Chem. 2013 Feb;5(2):132-9. doi: 10.1038/nchem.1546. Epub 2013 Jan 6. Europe PMC

PLCbeta isoforms differ in their subcellular location and their CT-domain dependent interaction with Galphaq.
Adjobo-Hermans, M.J., Crosby, K.C., Putyrski, M., Bhageloe, A., van Weeren, L., Schultz, C., Goedhart, J. & Gadella TW, J.r
Cell Signal. 2013 Jan;25(1):255-63. doi: 10.1016/j.cellsig.2012.09.022. Epub 2012Sep 21. Europe PMC

Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate.
Posor, Y., Eichhorn-Gruenig, M., Puchkov, D., Schoneberg, J., Ullrich, A., Lampe, A., Muller, R., Zarbakhsh, S., Gulluni, F., Hirsch, E., Krauss, M., Schultz, C., Schmoranzer, J., Noe, F. & Haucke, V.
Nature. 2013 Jul 11;499(7457):233-7. doi: 10.1038/nature12360. Epub 2013 Jul 3. Europe PMC

Imaging H2O2 microdomains in receptor tyrosine kinases signaling.
Mishina, N.M., Markvicheva, K.N., Fradkov, A.F., Zagaynova, E.V., Schultz, C., Lukyanov, S. & Belousov, V.V.
Methods Enzymol. 2013;526:175-87. doi: 10.1016/B978-0-12-405883-5.00011-9. Europe PMC

Visualization of intracellular hydrogen peroxide with HyPer, a genetically encoded fluorescent probe.
Mishina, N.M., Markvicheva, K.N., Bilan, D.S., Matlashov, M.E., Shirmanova, M.V., Liebl, D., Schultz, C., Lukyanov, S. & Belousov, V.V.
Methods Enzymol. 2013;526:45-59. doi: 10.1016/B978-0-12-405883-5.00003-X. Europe PMC

Genetic encoding of a bicyclo[6.1.0]nonyne-charged amino acid enables fast cellular protein imaging by metal-free ligation.
Borrmann, A., Milles, S., Plass, T., Dommerholt, J., Verkade, J.M., Wiessler, M., Schultz, C., van Hest, J.C., van Delft, F.L. & Lemke, E.A.
Chembiochem. 2012 Sep 24;13(14):2094-9. doi: 10.1002/cbic.201200407. Epub 2012Sep 3. Europe PMC

The chemical biology of phosphoinositide 3-kinases.
Wymann, M.P. & Schultz, C.
Chembiochem. 2012 Sep 24;13(14):2022-35. doi: 10.1002/cbic.201200089. Epub 2012Sep 10. Europe PMC

Protein tango: the toolbox to capture interacting partners.
Rutkowska, A. & Schultz, C.
Angew Chem Int Ed Engl. 2012 Aug 13;51(33):8166-76. doi: 10.1002/anie.201201717.Epub 2012 Jun 11. Europe PMC

Target-activated prodrugs for the auto-regulated inhibition of MMP12.
Cobos-Correa, A., Stein, F., Schultz, C.
ACS Med. Chem. Lett., 2012, 3 (8), pp 653-657, doi: 10.1021/ml3001193.

Can We See PIP(3) and Hydrogen Peroxide with a Single Probe?
Mishina, N.M., Bogeski, I., Bolotin, D.A., Hoth, M., Niemeyer, B.A., Schultz, C., Zagaynova, E.V., Lukyanov, S. & Belousov, V.V.
Antioxid Redox Signal. 2012 Aug 1;17(3):505-12. Epub 2012 Apr 10. Europe PMC

Protein translocation as a tool: The current rapamycin story.
Putyrski, M. & Schultz, C.
FEBS Lett. 2012 Jul 16;586(15):2097-105. doi: 10.1016/j.febslet.2012.04.061. Epub2012 May 11. Europe PMC

mCLCA3 does not contribute to calcium-activated chloride conductance in murine airways.
Mundhenk, L., Johannesson, B., Anagnostopoulou, P., Braun, J., Bothe, M.K., Schultz, C., Mall, M.A. & Gruber, A.D.
Am J Respir Cell Mol Biol. 2012 Jul;47(1):87-93. doi: 10.1165/rcmb.2010-0508OC.Epub 2012 Feb 23. Europe PMC

Conformational Analysis of a Genetically Encoded FRET Biosensor by SAXS.
Mertens, H.D., Piljic, A., Schultz, C. & Svergun, D.I.
Biophys J. 2012 Jun 20;102(12):2866-75. Epub 2012 Jun 19. Europe PMC

Spatially resolved monitoring of neutrophil elastase activity with ratiometric fluorescent reporters.
Gehrig, S., Mall, M.A. & Schultz, C.
Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6258-61. doi: 10.1002/anie.201109226.Epub 2012 May 3. Europe PMC

Amino acids for diels-alder reactions in living cells.
Plass, T., Milles, S., Koehler, C., Szymanski, J., Mueller, R., Wiessler, M., Schultz, C. & Lemke, E.A.
Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4166-70. doi: 10.1002/anie.201108231.Epub 2012 Mar 30. Europe PMC

CFTR Regulates Early Pathogenesis of Chronic Obstructive Lung Disease in betaENaC-Overexpressing Mice.
Johannesson, B., Hirtz, S., Schatterny, J., Schultz, C. & Mall, M.A.
PLoS One. 2012;7(8):e44059. Epub 2012 Aug 24. Europe PMC

A FlAsH-Based Cross-Linker to Study Protein Interactions in Living Cells.
Rutkowska, A., Häring, C.H. & Schultz, C.
Angew Chem Int Ed Engl. 2011 Dec 23;50(52):12655-8. doi:10.1002/anie.201106404. Epub 2011 Nov 16. Europe PMC

Switching heterotrimeric G protein subunits with a chemical dimerizer.
Putyrski, M. & Schultz, C.
Chem Biol. 2011 Sep 23;18(9):1126-33. Europe PMC

Principles for designing fluorescent sensors and reporters.
Lemke, E.A. & Schultz, C.
Nat Chem Biol. 2011 Jul 18;7(8):480-3. doi: 10.1038/nchembio.620. Europe PMC

Rapid development of genetically encoded FRET reporters.
Piljic, A., de Diego, I., Wilmanns, M. & Schultz, C.
ACS Chem Biol. 2011 Jul 15;6(7):685-91. Epub 2011 Apr 28. Europe PMC

The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease.
Zhou, Z., Duerr, J., Johannesson, B., Schubert, S.C., Treis, D., Harm, M., Graeber, S.Y., Dalpke, A., Schultz, C. & Mall, M.A.
J Cyst Fibros. 2011 Jun;10 Suppl 2:S172-82. Europe PMC

Genetically encoded copper-free click chemistry.
Plass, T., Milles, S., Koehler, C., Schultz, C. & Lemke, E.A.
Angew Chem Int Ed Engl. 2011 Apr 18;50(17):3878-81. doi:10.1002/anie.201008178. Epub 2011 Mar 23. Europe PMC

Photoactivatable and cell-membrane-permeable phosphatidylinositol 3,4,5-trisphosphate.
Mentel, M., Laketa, V., Subramanian, D., Gillandt, H. & Schultz, C.
Angew Chem Int Ed Engl. 2011 Apr 11;50(16):3811-4. doi:10.1002/anie.201007796. Epub 2011 Mar 14. Europe PMC

Imaging probes--Introduction.
Schultz, C. & Aime, S.
Bioorg Med Chem. 2011 Feb 1;19(3):1022. Europe PMC

Does cellular hydrogen peroxide diffuse or act locally?
Mishina, N.M., Tyurin-Kuzmin, P.A., Markvicheva, K.N., Vorotnikov, A.V., Tkachuk, V.A., Laketa, V., Schultz, C., Lukyanov, S. & Belousov, V.V.
Antioxid Redox Signal. 2011 Jan 1;14(1):1-7. Epub 2010 Oct 12. Europe PMC

Covalent Labeling of Biomolecules in Living Cells.
Plass, T. and Schultz, C.
Advanced Fluorescence Reporters in Chemistry and Biology III: Applications to Sensing and Imaging. A. P. Demchenko, (Ed.); Springer Series on Fluorescence, vol. 10. (O. S. Wolfbeis, Series Ed.); ISBN: 978-3-642-18034-7.

Inositol pentakisphosphate isomers bind PH domains with varying specificity and inhibit phosphoinositide interactions.
Jackson, S.G., Al-Saigh, S., Schultz, C. & Junop, M.S.
BMC Struct Biol. 2011 Feb 10;11:11. doi: 10.1186/1472-6807-11-11. Europe PMC

Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice.
Mall, M.A., Button, B., Johannesson, B., Zhou, Z., Livraghi, A., Caldwell, R.A., Schubert, S.C., Schultz, C., O'Neal, W.K., Pradervand, S., Hummler, E., Rossier, B.C., Grubb, B.R. & Boucher, R.C.
J Biol Chem. 2010 Aug 27;285(35):26945-55. Epub 2010 Jun 21. Europe PMC

Imaging lipids in living cells.
Schultz, C., Neef, A.B., Gadella TW, J.r & Goedhart, J.
Cold Spring Harb Protoc. 2010 Jul 1;2010(7):pdb.top83. doi: 10.1101/pdb.top83. Europe PMC

Challenges in studying phospholipid signaling.
Schultz, C.
Nat Chem Biol. 2010 Jul;6(7):473-5. Europe PMC

Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells.
Subramanian, D.*, Laketa, V.*, Muller, R., Tischer, C., Zarbakhsh, S., Pepperkok, R. & Schultz, C. * - equally contributing first authors.
Nat Chem Biol. 2010 May;6(5):324-6. Epub 2010 Apr 4. Europe PMC

Membrane-permeant phosphoinositide derivatives as modulators of growth factor signaling and neurite outgrowth.
Laketa, V., Zarbakhsh, S., Morbier, E., Subramanian, D., Dinkel, C., Brumbaugh, J., Zimmermann, P., Pepperkok, R. & Schultz, C.
Chem Biol. 2009 Nov 25;16(11):1190-6. Europe PMC

Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation.
Cobos-Correa, A., Trojanek, J.B., Diemer, S., Mall, M.A. & Schultz, C.
Nat Chem Biol. 2009 Sep;5(9):628-30. Epub 2009 Aug 2. Europe PMC

Fluorescent revelations.
Schultz, C.
Chem Biol. 2009 Feb 27;16(2):107-11. Europe PMC

Chemical biologists gather in Heidelberg.
Köhn, M. & Schultz, C.
Nat Chem Biol. 2009 Feb;5(2):66-9. Europe PMC

Selective fluorescence labeling of lipids in living cells.
Neef, A.B. & Schultz, C.
Angew Chem Int Ed Engl. 2009;48(8):1498-500. Europe PMC

Analysis of protein complex hierarchy in living cells.
Piljic, A. & Schultz, C.
ACS Chem Biol. 2008 Dec 19;3(12):749-55. Europe PMC

Contribution of fluorophores to protein kinase C FRET probe performance.
Jost, C.A., Reither, G., Hoffmann, C. & Schultz, C.
Chembiochem. 2008 Jun 16;9(9):1379-84. Europe PMC

Simultaneous recording of multiple cellular events by FRET.
Piljic, A. & Schultz, C.
ACS Chem Biol. 2008 Mar 20;3(3):156-60. Europe PMC

Heterogeneity and timing of translocation and membrane-mediated assembly of different annexins.
Skrahina, T., Piljic, A. & Schultz, C.
Exp Cell Res. 2008 Mar 10;314(5):1039-47. Epub 2007 Nov 29. Europe PMC

Fluorescence and bioluminescence procedures for functional proteomics.
Prinz, A., Reither, G., Diskar, M. & Schultz, C.
Proteomics. 2008 Mar;8(6):1179-96. Europe PMC

Probing lipid- and drug-binding domains with fluorescent dyes.
Black, S.L., Stanley, W.A., Filipp, F.V., Bhairo, M., Verma, A., Wichmann, O., Sattler, M., Wilmanns, M. & Schultz, C.
Bioorg Med Chem. 2008 Feb 1;16(3):1162-73. Epub 2007 Nov 19. Europe PMC

Simultaneous protein tagging in two colors.
Schultz, C. & Köhn, M.
Chem Biol. 2008 Feb;15(2):91-2. Europe PMC

Small molecule-based FRET probes.
Cobos Correa, A. & Schultz, C.
In "FRET and FLIM Techniques", Gadella, T.W.J. (ed.), Elsevier, 2008, pp 225-288

Molecular tools for cell and systems biology.
Schultz, C.
HFSP J. 2007 Nov;1(4):230-48. doi: 10.2976/1.2812442. Epub 2007 Nov 29. Europe PMC

Probing phospholipase a(2) with fluorescent phospholipid substrates.
Wichmann, O., Gelb, M.H. & Schultz, C.
Chembiochem. 2007 Sep 3;8(13):1555-69. Europe PMC

Investigation of the ligand spectrum of human sterol carrier protein 2 using a direct mass spectrometry assay.
Stanley, W.A., Versluis, K., Schultz, C., Heck, A.J. & Wilmanns, M.
Arch Biochem Biophys. 2007 May 1;461(1):50-8. Epub 2007 Mar 15. Europe PMC

Structural analysis of the binding of myo-inositol pentakisphosphates by the C-terminal PH domain of pleckstrin.
Jackson, SG; Zhang, Y; Zhang, K; Bao, XK; Schultz, C.; Haslam, R; Junop, M
FASEB Journal April 2007 21(5)

Live-cell imaging of enzyme-substrate interaction reveals spatial regulation of PTP1B.
Yudushkin, I.A., Schleifenbaum, A., Kinkhabwala, A., Neel, B.G., Schultz, C. & Bastiaens, P.I.
Science. 2007 Jan 5;315(5808):115-9. Europe PMC

Controlling protein function by caged compounds.
Giordano, A., Zarbahksh, S. & Schultz, C.
In "Chemical Biology" S. Schreiber, T. Kapoor, G. Wess (eds.), Wiley/VCH, 2007, pp140-173

Lipid-induced phenotypes.
Schultz, C.
Nat Chem Biol. 2006 Aug;2(8):396-8. Europe PMC

Annexin a4 self-association modulates general membrane protein mobility in living cells.
Piljic, A. & Schultz, C.
Mol Biol Cell. 2006 Jul;17(7):3318-28. Epub 2006 May 10. Europe PMC

Cellular uptake of PNA-terpyridine conjugates and its enhancement by Zn(2+) Ions.
Füssl, A., Schleifenbaum, A., Goritz, M., Riddell, A., Schultz, C. & Kramer, R.
J Am Chem Soc. 2006 May 10;128(18):5986-7. Europe PMC

Calcium-dependent regulation of NF-(kappa)B activation in cystic fibrosis airway epithelial cells.
Tabary, O., Boncoeur, E., de Martin, R., Pepperkok, R., Clement, A., Schultz, C. & Jacquot, J.
Cell Signal. 2006 May;18(5):652-60. Epub 2005 Aug 9. Europe PMC

A small-molecule FRET probe to monitor phospholipase A2 activity in cells and organisms.
Wichmann, O., Wittbrodt, J. & Schultz, C.
Angew Chem Int Ed Engl. 2006 Jan 9;45(3):508-12. Europe PMC

A dual parameter FRET probe for measuring PKC and PKA activity in living cells.
Brumbaugh, J., Schleifenbaum, A., Gasch, A., Sattler, M. & Schultz, C.
J Am Chem Soc. 2006 Jan 11;128(1):24-5. Europe PMC

An inositol polyphosphate derivative inhibits Na+ flux and improves fluid dynamics in cystic fibrosis airway epithelia.
Moody, M., Pennington, C., Schultz, C., Caldwell, R., Dinkel, C., Rossi, M.W., McNamara, S., Widdicombe, J., Gabriel, S. & Traynor-Kaplan, A.E.
Am J Physiol Cell Physiol 2005 Sep;289(3):C512-20. Epub 2005 Apr 27. Europe PMC

Multiparameter imaging for the analysis of intracellular signaling.
Schultz, C., Schleifenbaum, A., Goedhart, J. & Gadella TW, J.r
Chembiochem 2005 Aug;6(8):1323-30. Europe PMC

Closing the gap between chemistry and biology.
Scharer, O. & Schultz, C.
Chembiochem 2005 Jan;6(1):3-5. Europe PMC

A genetically encoded FRET probe for PKC activity based on pleckstrin.
Schleifenbaum, A., Stier, G., Gasch, A., Sattler, M. & Schultz, C.
J Am Chem Soc 2004 Sep 29;126(38):11786-7. Europe PMC

Antagonists of myo-inositol 3,4,5,6-tetrakisphosphate allow repeated epithelial chloride secretion.
Rudolf, M.T., Dinkel, C., Traynor-Kaplan, A.E. & Schultz, C.
Bioorg Med Chem 2003 Jul 31;11(15):3315-29. Europe PMC

Prodrugs of biologically active phosphate esters.
Schultz, C.
Bioorg Med Chem 2003 Mar 20;11(6):885-98. Europe PMC

Versatile reagents to introduce caged phosphates.
Dinkel, C., Wichmann, O., Schultz, C.
Tetrahedron Lett. 2003 (44) 1153-1155

Synthesis of caged myo-inositol 1,3,4,5-tetrakisphosphate.
Dinkel, C. & Schultz, C.
Tetrahedron Lett. 2003 (44) 1157-1159

Biocatalysis and Enzyme-Analogues Processes
Schultz, C., Gröger, H., Dinkel, C., Drauz, K. & Waldmann, H.
In: Applied Homogeneous Catalysis with Organometallic Compounds (B. Cornils, W. A. Herrmann, eds.), pp 872-911, Wiley/VCH, Weinheim 2002

Phosphoinositide: – Informationsträger der anderen Art.
Schultz, C. & Dinkel. C.
Nachrichten aus der Chemie 2002 50(5)

Inositphosphate - das unerkannte Arsenal der intrazellulären Signalübertragung?
Schultz, C.
Nachrichten aus der Chemie, 50(3), 323-326

FRET probes to monitor phospholipase A2 activity.
Wichmann, O. & Schultz, C.
Chem Commun (Camb) 2001 Dec 7;(23):2500-1. Europe PMC

Membrane-Permeant 3-OH-Phosphorylated Phosphoinositide Derivatives.
Dinkel, C., Moody, M., Traynor-Kaplan, A. & Schultz, C.
Angew Chem Int Ed Engl 2001 Aug 17;40(16):3004-3008. Europe PMC

Synthesis of bi- and tricyclic analogues of myo-inositol 3,4,5,6- and 1,4,5,6-tetrakisphosphate with extended carbon backbone.
Schnaars, A. & Schultz, C.
Tetrahedron 2001 (57) 519-524

A membrane-permeant analog of inositol 3,4,5,6-tetrakisphosphate inhibits Na+ absorption in CF nasal epithelia
Moody, M., Duerson, K., Dinkel, C., Pennington, C., Schultz, C., Traynor-Kaplan, A.E.
Ped. Pulmonol. Suppl. 22, 258

myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line.
Carew, M.A., Yang, X., Schultz, C. & Shears, S.B.
J Biol Chem 2000 Sep 1;275(35):26906-13. Europe PMC

Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate.
Yang, X., Rudolf, M., Carew, M.A., Yoshida, M., Nerreter, V., Riley, A.M., Chung, S.K., Bruzik, K.S., Potter, B.V., Schultz, C. & Shears, S.B.
J Biol Chem 1999 Jul 2;274(27):18973-80. Europe PMC

Manipulating intracellular signal transduction.
Schultz, C., Schnaars, A. & Rudolf, M.T.
In "Bioorganic Chemistry: Highlights and New Aspects", Lindhorst, T., Diedrichsen, U., Westermann, B. & Wessjohann, L. (eds.), 1999, Wiley-VCH, Weinheim, pp. 346-355

Membrane-permeant, bioactivatable derivatives of inositol polyphosphates and phosphoinositides.
Schultz, C., Rudolf, M. T., Gillandt, H. H., Traynor-Kaplan, A. E.
In "Phosphoinositides: Chemistry, Biochemistry and Biomedical Applications", Bruzik, K.S. (ed.), Am. Chem. Soc. Symp. Ser., 1999, vol. 718, pp. 232-243

2-Deoxy derivative is a partial agonist of the intracellular messenger inositol 3,4,5,6-tetrakisphosphate in the epithelial cell line T84.
Rudolf, M.T., Li, W.H., Wolfson, N., Traynor-Kaplan, A.E. & Schultz, C.
J Med Chem 1998 Sep 10;41(19):3635-44. Europe PMC