Schultz GroupPublications
A FlAsH-Based Cross-Linker to Study Protein Interactions in Living Cells.
Rutkowska, A., Haering, C.H. & Schultz, C.
Angew Chem Int Ed Engl. 2011 Dec 23;50(52):12655-8. doi:10.1002/anie.201106404. Epub 2011 Nov 16. PubMed
Switching heterotrimeric G protein subunits with a chemical dimerizer.
Putyrski, M. & Schultz, C.
Chem Biol. 2011 Sep 23;18(9):1126-33. PubMed
Principles for designing fluorescent sensors and reporters.
Lemke, E.A. & Schultz, C.
Nat Chem Biol. 2011 Jul 18;7(8):480-3. doi: 10.1038/nchembio.620. PubMed
Rapid development of genetically encoded FRET reporters.
Piljic, A., de Diego, I., Wilmanns, M. & Schultz, C.
ACS Chem Biol. 2011 Jul 15;6(7):685-91. Epub 2011 Apr 28. PubMed
The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease.
Zhou, Z., Duerr, J., Johannesson, B., Schubert, S.C., Treis, D., Harm, M., Graeber, S.Y., Dalpke, A., Schultz, C. & Mall, M.A.
J Cyst Fibros. 2011 Jun;10 Suppl 2:S172-82. PubMed
Genetically encoded copper-free click chemistry.
Plass, T., Milles, S., Koehler, C., Schultz, C. & Lemke, E.A.
Angew Chem Int Ed Engl. 2011 Apr 18;50(17):3878-81. doi:10.1002/anie.201008178. Epub 2011 Mar 23. PubMed
Photoactivatable and cell-membrane-permeable phosphatidylinositol 3,4,5-trisphosphate.
Mentel, M., Laketa, V., Subramanian, D., Gillandt, H. & Schultz, C.
Angew Chem Int Ed Engl. 2011 Apr 11;50(16):3811-4. doi:10.1002/anie.201007796. Epub 2011 Mar 14. PubMed
Imaging probes--Introduction.
Schultz, C. & Aime, S.
Bioorg Med Chem. 2011 Feb 1;19(3):1022. PubMed
Does cellular hydrogen peroxide diffuse or act locally?
Mishina, N.M., Tyurin-Kuzmin, P.A., Markvicheva, K.N., Vorotnikov, A.V., Tkachuk, V.A., Laketa, V., Schultz, C., Lukyanov, S. & Belousov, V.V.
Antioxid Redox Signal. 2011 Jan 1;14(1):1-7. Epub 2010 Oct 12. PubMed
Covalent Labeling of Biomolecules in Living Cells.
Plass, T. and Schultz, C.
Advanced Fluorescence Reporters in Chemistry and Biology III: Applications to Sensing and Imaging. A. P. Demchenko, (Ed.); Springer Series on Fluorescence, vol. 10. (O. S. Wolfbeis, Series Ed.); ISBN: 978-3-642-18034-7.
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Inositol pentakisphosphate isomers bind PH domains with varying specificity and inhibit phosphoinositide interactions.
Jackson, S.G., Al-Saigh, S., Schultz, C. & Junop, M.S.
BMC Struct Biol. 2011 Feb 10;11:11. PubMed
Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice.
Mall, M.A., Button, B., Johannesson, B., Zhou, Z., Livraghi, A., Caldwell, R.A., Schubert, S.C., Schultz, C., O'Neal, W.K., Pradervand, S., Hummler, E., Rossier, B.C., Grubb, B.R. & Boucher, R.C.
J Biol Chem. 2010 Aug 27;285(35):26945-55. Epub 2010 Jun 21. PubMed
Challenges in studying phospholipid signaling.
Schultz, C.
Nat Chem Biol. 2010 Jul;6(7):473-5. PubMed
Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells.
Subramanian, D.*, Laketa, V.*, Muller, R., Tischer, C., Zarbakhsh, S., Pepperkok, R. & Schultz, C. * - equally contributing first authors.
Nat Chem Biol. 2010 May;6(5):324-6. Epub 2010 Apr 4. PubMed
The ßENaC-overexpressing mouse as a model of cystic fibrosis lung disease.
Zhou, Z., Duerr, J., Johannesson, B., Schubert, S. C., Treis, D., Harm, M., Gräber, S., Dalpke, A., Schultz, C., Mall, M. A.
J. Cystic Fibr. (2010). In press
Imaging lipids in living cells.
Schultz, C., Neef, A., Goedhart, J. & Gadella, T.W.J.
In 'Live Cell Imaging', Spector, D.L., Svedlow, J. & Jaron, B.F (eds), 2010, Cold Spring Harbor Press
Membrane-permeant phosphoinositide derivatives as modulators of growth factor signaling and neurite outgrowth.
Laketa, V., Zarbakhsh, S., Morbier, E., Subramanian, D., Dinkel, C., Brumbaugh, J., Zimmermann, P., Pepperkok, R. & Schultz, C.
Chem Biol. 2009 Nov 25;16(11):1190-6. PubMed
Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation.
Cobos-Correa, A., Trojanek, J.B., Diemer, S., Mall, M.A. & Schultz, C.
Nat Chem Biol. 2009 Sep;5(9):628-30. Epub 2009 Aug 2. PubMed
Fluorescent revelations.
Schultz, C.
Chem Biol. 2009 Feb 27;16(2):107-11. PubMed
Chemical biologists gather in Heidelberg.
Köhn, M. & Schultz, C.
Nat Chem Biol. 2009 Feb;5(2):66-9. PubMed
Selective fluorescence labeling of lipids in living cells.
Neef, A.B. & Schultz, C.
Angew Chem Int Ed Engl. 2009;48(8):1498-500. PubMed
Analysis of protein complex hierarchy in living cells.
Piljic, A. & Schultz, C.
ACS Chem Biol. 2008 Dec 19;3(12):749-55. PubMed
Contribution of fluorophores to protein kinase C FRET probe performance.
Jost, C.A., Reither, G., Hoffmann, C. & Schultz, C.
Chembiochem. 2008 Jun 16;9(9):1379-84. PubMed
Simultaneous recording of multiple cellular events by FRET.
Piljic, A. & Schultz, C.
ACS Chem Biol. 2008 Mar 20;3(3):156-60. PubMed
Heterogeneity and timing of translocation and membrane-mediated assembly of different annexins.
Skrahina, T., Piljic, A. & Schultz, C.
Exp Cell Res. 2008 Mar 10;314(5):1039-47. Epub 2007 Nov 29. PubMed
Fluorescence and bioluminescence procedures for functional proteomics.
Prinz, A., Reither, G., Diskar, M. & Schultz, C.
Proteomics. 2008 Mar;8(6):1179-96. PubMed
Probing lipid- and drug-binding domains with fluorescent dyes.
Black, S.L., Stanley, W.A., Filipp, F.V., Bhairo, M., Verma, A., Wichmann, O., Sattler, M., Wilmanns, M. & Schultz, C.
Bioorg Med Chem. 2008 Feb 1;16(3):1162-73. Epub 2007 Nov 19. PubMed
Simultaneous protein tagging in two colors.
Schultz, C. & Köhn, M.
Chem Biol. 2008 Feb;15(2):91-2. PubMed
Small molecule-based FRET probes.
Cobos Correa, A. & Schultz, C.
In "FLIM and FRET", Gadella, T. (ed.), Elsevier, 2008, pp 225-288
Molecular tools for cell and systems biology
Schultz, C.
Human Frontiers Sci. Progr. J. 2007/11 1(4) 230-248
Probing phospholipase a(2) with fluorescent phospholipid substrates.
Wichmann, O., Gelb, M.H. & Schultz, C.
Chembiochem. 2007 Sep 3;8(13):1555-69. PubMed
Investigation of the ligand spectrum of human sterol carrier protein 2 using a direct mass spectrometry assay.
Stanley, W.A., Versluis, K., Schultz, C., Heck, A.J. & Wilmanns, M.
Arch Biochem Biophys. 2007 May 1;461(1):50-8. Epub 2007 Mar 15. PubMed
Structural analysis of the binding of myo-inositol pentakisphosphates by the C-terminal PH domain of pleckstrin.
Jackson, SG; Zhang, Y; Zhang, K; Bao, XK; Schultz, C.; Haslam, R; Junop, M
FASEB Journal April 2007 21(5)
Live-cell imaging of enzyme-substrate interaction reveals spatial regulation of PTP1B.
Yudushkin, I.A., Schleifenbaum, A., Kinkhabwala, A., Neel, B.G., Schultz, C. & Bastiaens, P.I.
Science. 2007 Jan 5;315(5808):115-9. PubMed
Controlling protein function by caged compounds.
Giordano, A., Zarbahksh, S. & Schultz, C.
In "Chemical Biology" S. Schreiber, T. Kapoor, G. Wess (eds.), Wiley/VCH, 2007, pp140-173
Lipid-induced phenotypes.
Schultz, C.
Nat Chem Biol. 2006 Aug;2(8):396-8. PubMed
Annexin a4 self-association modulates general membrane protein mobility in living cells.
Piljic, A. & Schultz, C.
Mol Biol Cell. 2006 Jul;17(7):3318-28. Epub 2006 May 10. PubMed
Cellular uptake of PNA-terpyridine conjugates and its enhancement by Zn(2+) Ions.
Füssl, A., Schleifenbaum, A., Goritz, M., Riddell, A., Schultz, C. & Kramer, R.
J Am Chem Soc. 2006 May 10;128(18):5986-7. PubMed
Calcium-dependent regulation of NF-(kappa)B activation in cystic fibrosis airway epithelial cells.
Tabary, O., Boncoeur, E., de Martin, R., Pepperkok, R., Clement, A., Schultz, C. & Jacquot, J.
Cell Signal. 2006 May;18(5):652-60. Epub 2005 Aug 9. PubMed
A small-molecule FRET probe to monitor phospholipase A2 activity in cells and organisms.
Wichmann, O., Wittbrodt, J. & Schultz, C.
Angew Chem Int Ed Engl. 2006 Jan 9;45(3):508-12. PubMed
A dual parameter FRET probe for measuring PKC and PKA activity in living cells.
Brumbaugh, J., Schleifenbaum, A., Gasch, A., Sattler, M. & Schultz, C.
J Am Chem Soc. 2006 Jan 11;128(1):24-5. PubMed
An inositol polyphosphate derivative inhibits Na+ flux and improves fluid dynamics in cystic fibrosis airway epithelia.
Moody, M., Pennington, C., Schultz, C., Caldwell, R., Dinkel, C., Rossi, M.W., McNamara, S., Widdicombe, J., Gabriel, S. & Traynor-Kaplan, A.E.
Am J Physiol Cell Physiol 2005 Sep;289(3):C512-20. Epub 2005 Apr 27. PubMed
Multiparameter imaging for the analysis of intracellular signaling.
Schultz, C., Schleifenbaum, A., Goedhart, J. & Gadella TW, J.r
Chembiochem 2005 Aug;6(8):1323-30. PubMed
Closing the gap between chemistry and biology.
Scharer, O. & Schultz, C.
Chembiochem 2005 Jan;6(1):3-5. PubMed
A genetically encoded FRET probe for PKC activity based on pleckstrin.
Schleifenbaum, A., Stier, G., Gasch, A., Sattler, M. & Schultz, C.
J Am Chem Soc 2004 Sep 29;126(38):11786-7. PubMed
Antagonists of myo-inositol 3,4,5,6-tetrakisphosphate allow repeated epithelial chloride secretion.
Rudolf, M.T., Dinkel, C., Traynor-Kaplan, A.E. & Schultz, C.
Bioorg Med Chem 2003 Jul 31;11(15):3315-29. PubMed
Prodrugs of biologically active phosphate esters.
Schultz, C.
Bioorg Med Chem 2003 Mar 20;11(6):885-98. PubMed
Versatile reagents to introduce caged phosphates.
Dinkel, C., Wichmann, O., Schultz, C.
Tetrahedron Lett. 2003 (44) 1153-1155
Synthesis of caged myo-inositol 1,3,4,5-tetrakisphosphate.
Dinkel, C., Schultz, C.
Tetrahedron Lett. 2003 (44) 1157-1159