Staff at EMBL

Dr. Yannick Schwab

Team Leader and Head of Electron Microscopy Core Facility
Schwab Team Electron Microscopy Core Facility

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Biography

PhD 2001, Louis Pasteur University, Strasbourg.
Postdoctoral research at the University of Calgary, Canada and at the IGBMC, Illkirch, France.
Head of Electron Microscopy at the Imaging Center, IGBMC, Illkirch, France.
Facility head and team leader at EMBL since 2012.

Publications

A pathway for unicellular tube extension depending on the lymphatic vessel determinant Prox1 and on osmoregulation. Kolotuev, I., Hyenne, V., Schwab, Y., Rodriguez, D. & Labouesse, M. Nat Cell Biol. 2013 Feb;15(2):157-68. doi: 10.1038/ncb2662. Epub 2013 Jan 20. PubMed

Selective autophagy degrades DICER and AGO2 and regulates miRNA activity. Gibbings, D., Mostowy, S., Jay, F., Schwab, Y., Cossart, P. & Voinnet, O. Nat Cell Biol. 2012 Dec;14(12):1314-21. PubMed

The BAR Domain Protein Arfaptin-1 Controls Secretory Granule Biogenesis at the trans-Golgi Network. Gehart, H., Goginashvili, A., Beck, R., Morvan, J., Erbs, E., Formentini, I., De Matteis, M.A., Schwab, Y., Wieland, F.T. & Ricci, R. Dev Cell. 2012 Oct 16;23(4):756-68. doi: 10.1016/j.devcel.2012.07.019. Epub 2012Sep 13. PubMed

In vivo visualization of delta opioid receptors upon physiological activation uncovers a distinct internalization profile. Faget, L., Erbs, E., Le Merrer, J., Scherrer, G., Matifas, A., Benturquia, N., Noble, F., Decossas, M., Koch, M., Kessler, P., Vonesch, J.L., Schwab, Y., Kieffer, B.L. & Massotte, D. J Neurosci. 2012 May 23;32(21):7301-10. PubMed

Mouse delta opioid receptors are located on presynaptic afferents to hippocampal pyramidal cells. Rezai, X., Faget, L., Bednarek, E., Schwab, Y., Kieffer, B.L. & Massotte, D. Cell Mol Neurobiol. 2012 May;32(4):509-16. Epub 2012 Jan 18. PubMed

Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes. Gibbings, D., Leblanc, P., Jay, F., Pontier, D., Michel, F., Schwab, Y., Alais, S., Lagrange, T. & Voinnet, O. Nat Struct Mol Biol. 2012 Apr 8;19(5):517-24, S1. doi: 10.1038/nsmb.2273. PubMed

Expression of exocytosis proteins in rat supraoptic nucleus neurones. Tobin, V., Schwab, Y., Lelos, N., Onaka, T., Pittman, Q.J. & Ludwig, M. J Neuroendocrinol. 2012 Apr;24(4):629-41. doi: 10.1111/j.1365-2826.2011.02237.x. PubMed

Targeted ultramicrotomy: a valuable tool for correlated light and electron microscopy of small model organisms. Kolotuev, I., Bumbarger, D.J., Labouesse, M. & Schwab, Y. Methods Cell Biol. 2012;111:203-22. PubMed

The podocyte protein nephrin is required for cardiac vessel formation. Wagner, N., Morrison, H., Pagnotta, S., Michiels, J.F., Schwab, Y., Tryggvason, K., Schedl, A. & Wagner, K.D. Hum Mol Genet. 2011 Jun 1;20(11):2182-94. Epub 2011 Mar 14. PubMed

PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis. Hetherington, S., Gally, C., Fritz, J.A., Polanowska, J., Reboul, J., Schwab, Y., Zahreddine, H., Behm, C. & Labouesse, M. Dev Biol. 2011 Feb 15;350(2):267-78. Epub 2010 Dec 3. PubMed

Defects in amphiphysin 2 (BIN1) and triads in several forms of centronuclear myopathies. Toussaint, A., Cowling, B.S., Hnia, K., Mohr, M., Oldfors, A., Schwab, Y., Yis, U., Maisonobe, T., Stojkovic, T., Wallgren-Pettersson, C., Laugel, V., Echaniz-Laguna, A., Mandel, J.L., Nishino, I. & Laporte, J. Acta Neuropathol. 2011 Feb;121(2):253-66. Epub 2010 Oct 7. PubMed

Mammalian retinal horizontal cells are unconventional GABAergic neurons. Deniz, S., Wersinger, E., Schwab, Y., Mura, C., Erdelyi, F., Szabo, G., Rendon, A., Sahel, J.A., Picaud, S. & Roux, M.J. J Neurochem. 2011 Feb;116(3):350-62. doi: 10.1111/j.1471-4159.2010.07114.x. Epub2010 Dec 13. PubMed

Reevaluation of dystrophin localization in the mouse retina. Wersinger, E., Bordais, A., Schwab, Y., Sene, A., Benard, R., Alunni, V., Sahel, J.A., Rendon, A. & Roux, M.J. Invest Ophthalmol Vis Sci. 2011 Oct 7;52(11):7901-8. doi: 10.1167/iovs.11-7519.Print 2011. PubMed

A precise and rapid mapping protocol for correlative light and electron microscopy of small invertebrate organisms. Kolotuev, I., Schwab, Y. & Labouesse, M. Biol Cell. 2009 Dec 4;102(2):121-32. PubMed

From dynamic live cell imaging to 3D ultrastructure: novel integrated methods for high pressure freezing and correlative light-electron microscopy. Spiegelhalter, C., Tosch, V., Hentsch, D., Koch, M., Kessler, P., Schwab, Y. & Laporte, J. PLoS One. 2010 Feb 3;5(2):e9014. PubMed

AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis. Buj-Bello, A., Fougerousse, F., Schwab, Y., Messaddeq, N., Spehner, D., Pierson, C.R., Durand, M., Kretz, C., Danos, O., Douar, A.M., Beggs, A.H., Schultz, P., Montus, M., Denefle, P. & Mandel, J.L. Hum Mol Genet. 2008 Jul 15;17(14):2132-43. Epub 2008 Apr 22. PubMed

A Caenorhabditis elegans model for epithelial-neuronal transdifferentiation. Jarriault, S., Schwab, Y. & Greenwald, I. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3790-5. Epub 2008 Feb 28. PubMed

DYC-1, a protein functionally linked to dystrophin in Caenorhabditis elegans is associated with the dense body, where it interacts with the muscle LIM domain protein ZYX-1. Lecroisey, C., Martin, E., Mariol, M.C., Granger, L., Schwab, Y., Labouesse, M., Segalat, L. & Gieseler, K. Mol Biol Cell. 2008 Mar;19(3):785-96. Epub 2007 Dec 19. PubMed

Endogenous modulators of synaptic transmission: cannabinoid regulation in the supraoptic nucleus. McDonald, N.A., Kuzmiski, J.B., Naderi, N., Schwab, Y. & Pittman, Q.J. Prog Brain Res. 2008;170:129-36. PubMed

The glutamate transporter EAAT5 works as a presynaptic receptor in mouse rod bipolar cells. Wersinger, E., Schwab, Y., Sahel, J.A., Rendon, A., Pow, D.V., Picaud, S. & Roux, M.J. J Physiol. 2006 Nov 15;577(Pt 1):221-34. Epub 2006 Sep 14. PubMed

The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans. Liegeois, S., Benedetto, A., Garnier, J.M., Schwab, Y. & Labouesse, M. J Cell Biol. 2006 Jun 19;173(6):949-61. PubMed

Physiological maturation of photoreceptors depends on the voltage-gated sodium channel NaV1.6 (Scn8a). Cote, P.D., De Repentigny, Y., Coupland, S.G., Schwab, Y., Roux, M.J., Levinson, S.R. & Kothary, R. J Neurosci. 2005 May 18;25(20):5046-50. PubMed

Dendritically released transmitters cooperate via autocrine and retrograde actions to inhibit afferent excitation in rat brain. Hirasawa, M., Schwab, Y., Natah, S., Hillard, C.J., Mackie, K., Sharkey, K.A. & Pittman, Q.J. J Physiol. 2004 Sep 1;559(Pt 2):611-24. Epub 2004 Jul 14. PubMed

Expression of tetrodotoxin-sensitive and resistant sodium channels by rat melanotrophs. Schwab, Y., Jahke, R. & Jover, E. Neuroreport. 2004 May 19;15(7):1219-23. PubMed

Calcium-dependent translocation of synaptotagmin to the plasma membrane in the dendrites of developing neurones. Schwab, Y., Mouton, J., Chasserot-Golaz, S., Marty, I., Maulet, Y. & Jover, E. Brain Res Mol Brain Res. 2001 Nov 30;96(1-2):1-13. PubMed