Staff at EMBL

Dr. Detlev Arendt

Group Leader, Senior Scientist and Academic Mentor Postdoctoral Training
Arendt Group EMBL International Centre for Advanced Training (EICAT)

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Biography

PhD 1999, Albert-Ludwigs-Universität, Freiburg.
Team leader at EMBL since 2002.
Group leader and senior scientist since 2007.
Academic mentor, postdoctoral training since 2007.
ERC Advanced Investigator since 2012.

Publications

Mesoteloblast-Like Mesodermal Stem Cells in the Polychaete Annelid Platynereis dumerilii (Nereididae). Fischer, A.H. & Arendt, D. J Exp Zool B Mol Dev Evol. 2013 Mar;320(2):94-104. doi: 10.1002/jez.b.22486. Epub2013 Feb 13. PubMed

Extensive chordate and annelid macrosynteny reveals ancestral homeobox gene organization. Hui, J.H., McDougall, C., Monteiro, A.S., Holland, P.W., Arendt, D., Balavoine, G. & Ferrier, D.E. Mol Biol Evol. 2012 Jan;29(1):157-65. doi: 10.1093/molbev/msr175. Epub 2011 Jul4. PubMed

A holistic approach to marine eco-systems biology. Karsenti, E., Acinas, S.G., Bork, P., Bowler, C., De Vargas, C., Raes, J., Sullivan, M., Arendt, D., Benzoni, F., Claverie, J.M., Follows, M., Gorsky, G., Hingamp, P., Iudicone, D., Jaillon, O., Kandels-Lewis, S., Krzic, U., Not, F., Ogata, H., Pesant, S., Reynaud, E.G., Sardet, C., Sieracki, M.E., Speich, S., Velayoudon, D., Weissenbach, J. & Wincker, P. PLoS Biol. 2011 Oct;9(10):e1001177. doi: 10.1371/journal.pbio.1001177. Epub 2011Oct 18. PubMed

The segmental pattern of otx, gbx, and Hox genes in the annelid Platynereis dumerilii. Steinmetz, P.R., Kostyuchenko, R.P., Fischer, A. & Arendt, D. Evol Dev. 2011 Jan-Feb;13(1):72-9. doi: 10.1111/j.1525-142X.2010.00457.x. PubMed

Profiling by image registration reveals common origin of annelid mushroom bodies and vertebrate pallium. Tomer, R., Denes, A.S., Tessmar-Raible, K. & Arendt, D. Cell. 2010 Sep 3;142(5):800-9. PubMed

Hedgehog signaling regulates segment formation in the annelid Platynereis. Dray, N., Tessmar-Raible, K., Le Gouar, M., Vibert, L., Christodoulou, F., Schipany, K., Guillou, A., Zantke, J., Snyman, H., Behague, J., Vervoort, M., Arendt, D. & Balavoine, G. Science. 2010 Jul 16;329(5989):339-42. PubMed

Three consecutive generations of nephridia occur during development of Platynereis dumerilii (Annelida, Polychaeta). Hasse, C., Rebscher, N., Reiher, W., Sobjinski, K., Moerschel, E., Beck, L., Tessmar-Raible, K., Arendt, D. & Hassel, M. Dev Dyn. 2010Jul;239(7):1967-76. PubMed

Ancient animal microRNAs and the evolution of tissue identity. Christodoulou, F., Raible, F., Tomer, R., Simakov, O., Trachana, K., Klaus, S., Snyman, H., Hannon, G.J., Bork, P. & Arendt, D. Nature. 2010 Feb 25;463(7284):1084-8. Epub 2010 Jan 31. PubMed

Six3 demarcates the anterior-most developing brain region in bilaterian animals. Steinmetz, P.R., Urbach, R., Posnien, N., Eriksson, J., Kostyuchenko, R.P., Brena, C., Guy, K., Akam, M., Bucher, G. & Arendt, D. Evodevo. 2010 Dec 29;1(1):14. PubMed

The normal development of Platynereis dumerilii (Nereididae, Annelida). Fischer, A.H., Henrich, T. & Arendt, D. Front Zool. 2010 Dec 30;7:31. PubMed

The evolution of phototransduction and eyes. Lamb, T.D., Arendt, D. & Collin, S.P. Philos Trans R Soc Lond B Biol Sci. 2009 Oct 12;364(1531):2791-3. PubMed

The 'division of labour' model of eye evolution. Arendt, D., Hausen, H. & Purschke, G. Philos Trans R Soc Lond B Biol Sci. 2009 Oct 12;364(1531):2809-17. PubMed

CNS evolution: new insight from the mud. Benito-Gutierrez, E. & Arendt, D. Curr Biol. 2009 Aug 11;19(15):R640-2. PubMed

Features of the ancestral bilaterian inferred from Platynereis dumerilii ParaHox genes. Hui, J.H., Raible, F., Korchagina, N., Dray, N., Samain, S., Magdelenat, G., Jubin, C., Segurens, B., Balavoine, G., Arendt, D. & Ferrier, D.E. BMC Biol. 2009 Jul 23;7:43. PubMed

To be or not to be a flatworm: the acoel controversy. Egger, B., Steinke, D., Tarui, H., De Mulder, K., Arendt, D., Borgonie, G., Funayama, N., Gschwentner, R., Hartenstein, V., Hobmayer, B., Hooge, M., Hrouda, M., Ishida, S., Kobayashi, C., Kuales, G., Nishimura, O., Pfister, D., Rieger, R., Salvenmoser, W., Smith, J., Technau, U., Tyler, S., Agata, K., Salzburger, W. & Ladurner, P. PLoS One. 2009;4(5):e5502. Epub 2009 May 11. PubMed

Eye evolution: the blurry beginning. Nilsson, D.E. & Arendt, D. Curr Biol. 2008 Dec 9;18(23):R1096-8. PubMed

Mechanism of phototaxis in marine zooplankton. Jekely, G., Colombelli, J., Hausen, H., Guy, K., Stelzer, E.H.K., Nedelec, F. & Arendt, D. Nature. 2008 Nov 20;456(7220):395-9. PubMed

The evolution of cell types in animals: emerging principles from molecular studies. Arendt, D. Nat Rev Genet. 2008 Nov;9(11):868-82. PubMed

The evolution of nervous system centralization. Arendt, D., Denes, A.S., Jekely, G. & Tessmar-Raible, K. Philos Trans R Soc Lond B Biol Sci. 2008 Apr 27;363(1496):1523-8. PubMed

atonal- and achaete-scute-related genes in the annelid Platynereis dumerilii: insights into the evolution of neural basic-Helix-Loop-Helix genes. Simionato, E., Kerner, P., Dray, N., Le Gouar, M., Ledent, V., Arendt, D. & Vervoort, M. BMC Evol Biol. 2008 Jun 9;8:170. PubMed

4DXpress: a database for cross-species expression pattern comparisons. Haudry, Y., Berube, H., Letunic, I., Weeber, P.D., Gagneur, J., Girardot, C., Kapushesky, M., Arendt, D., Bork, P., Brazma, A., Furlong, E., Wittbrodt, J. & Henrich, T. Nucleic Acids Res. 2007 Oct 4;. PubMed

Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution. Tessmar-Raible, K., Raible, F., Christodoulou, F., Guy, K., Rembold, M., Hausen, H. & Arendt, D. Cell. 2007 Jun 29;129(7):1389-400. PubMed

Vasa unveils a common origin of germ cells and of somatic stem cells from the posterior growth zone in the polychaete Platynereis dumerilii. Rebscher, N., Zelada-Gonzalez, F., Banisch, T.U., Raible, F. & Arendt, D. Dev Biol. 2007 Jun 15;306(2):599-611. Epub 2007 Apr 1. PubMed

Cellular resolution expression profiling using confocal detection of NBT/BCIP precipitate by reflection microscopy. Jekely, G. & Arendt, D. Biotechniques. 2007 Jun;42(6):751-5. PubMed

Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria. Denes, A.S., Jekely, G., Steinmetz, P.R., Raible, F., Snyman, H., Prud'homme, B., Ferrier, D.E., Balavoine, G. & Arendt, D. Cell. 2007 Apr 20;129(2):277-88. PubMed

Duplication of the ribosomal gene cluster in the marine polychaete Platynereis dumerilii correlates with ITS polymorphism. Hui, JHL; Kortchagina, N; Arendt, D.; Balavoine, G; Ferrier, DEK Journal of the Marine Biological Association of the United Kingdom 2007/04 87(2)

Polychaete trunk neuroectoderm converges and extends by mediolateral cell intercalation. Steinmetz, P.R., Zelada-Gonzales, F., Burgtorf, C., Wittbrodt, J. & Arendt, D. Proc Natl Acad Sci U S A. 2007 Feb 14;. PubMed

Hox gene expression in larval development of the polychaetes Nereis virens and Platynereis dumerilii (Annelida, Lophotrochozoa). Kulakova, M., Bakalenko, N., Novikova, E., Cook, C.E., Eliseeva, E., Steinmetz, P.R., Kostyuchenko, R.P., Dondua, A., Arendt, D., Akam, M. & Andreeva, T. Dev Genes Evol. 2007 Jan;217(1):39-54. Epub 2006 Dec 19. PubMed

Evolution of the vertebrate hypothalamus: An ancient set of sensory-neurosecretory cell types in the polychaete and vertebrate medial forebrain Tessmar-Raible, K., Raible, F., Guy, K., Rembold, M., Hausen, H. and Arendt, D. (2007) Cell, 129:1389-400.

The expression of a hunchback ortholog in the polychaete annelid Platynereis dumerilii suggests an ancestral role in mesoderm development and neurogenesis. Kerner, P., Zelada Gonzalez, F., Le Gouar, M., Ledent, V., Arendt, D. & Vervoort, M. Dev Genes Evol. 2006 Dec;216(12):821-8. Epub 2006 Sep 16. PubMed

The regulatory genome - Gene regulatory networks in development and evolution. Arendt, D. Science 2006/11 314(5802)

Opsins and clusters of sensory G-protein-coupled receptors in the sea urchin genome. Raible, F., Tessmar-Raible, K., Arboleda, E., Kaller, T., Bork, P., Arendt, D. & Arnone, M.I. Dev Biol. 2006 Sep 5;. PubMed

Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium. Jekely, G. & Arendt, D. Bioessays. 2006 Feb;28(2):191-8. PubMed

Photoreceptor cells and eyes in Annelida. Purschke, G., Arendt, D., Hausen, H. & Müller, M.C.M. Arthropod Structure & Development 2006 35 211-230

Vertebrate-type intron-rich genes in the marine annelid Platynereis dumerilii. Raible, F., Tessmar-Raible, K., Osoegawa, K., Wincker, P., Jubin, C., Balavoine, G., Ferrier, D., Benes, V., de Jong, P., Weissenbach, J., Bork, P. & Arendt, D. Science 2005 Nov 25;310(5752):1325-6. PubMed

Fluorescent two-color whole mount in situ hybridization in Platynereis dumerilii (Polychaeta, Annelida), an emerging marine molecular model for evolution and development. Tessmar-Raible, K., Steinmetz, P.R., Snyman, H., Hassel, M. & Arendt, D. Biotechniques 2005 Oct;39(4):460, 462, 464. PubMed

Ancestry of photic and mechanic sensation? Fritzsch, B., Piatigorsky, J., Tessmar-Raible, K., Jekely, G., Guy, K., Raible, F., Wittbrodt, J. & Arendt, D. Science 2005 May 20;308(5725):1113-1114. PubMed

New animal models for evolution and development. Tessmar-Raible, K. & Arendt, D. Genome Biol 2005;6(1):303. Epub 2004 Dec 21. PubMed

Genes and homology in nervous system evolution: Comparing gene functions, expression patterns, and cell type molecular fingerprints. Arendt, D. Theory in Biosciences 2005 Nov;124(2):185-197.

Ciliary photoreceptors with a vertebrate-type opsin in an invertebrate brain. Arendt, D., Tessmar-Raible, K., Snyman, H., Dorresteijn, A.W. & Wittbrodt, J. Science 2004 Oct 29;306(5697):869-71. PubMed

Metazoan evolution: some animals are more equal than others. Raible, F. & Arendt, D. Curr Biol 2004 Feb 3;14(3):R106-8. PubMed

Comparative aspects of gastrulation. Arendt, D. In "Gastrulation", Stern, C. (ed.), Cold Spring Harbor Press, New York

Arthropod-like expression patterns of engrailed and wingless in the annelid Platynereis dumerilii suggest a role in segment formation. Prud'homme, B., de Rosa, R., Arendt, D., Julien, J.F., Pajaziti, R., Dorresteijn, A.W., Adoutte, A., Wittbrodt, J. & Balavoine, G. Curr Biol 2003 Oct 28;13(21):1876-81. PubMed

Emerging systems: between vertebrates and arthropods, the Lophotrochozoa. Tessmar-Raible, K. & Arendt, D. Curr Opin Genet Dev 2003 Aug;13(4):331-40. PubMed

Evolution of eyes and photoreceptor cell types. Arendt, D. Int J Dev Biol 2003;47(7-8):563-71. PubMed

Spiralians in the limelight. Arendt, D. Genome Biol 2003;5(1):303. PubMed

Development of pigment-cup eyes in the polychaete Platynereis dumerilii and evolutionary conservation of larval eyes in Bilateria. Arendt, D., Tessmar, K., de Campos-Baptista, M.I., Dorresteijn, A. & Wittbrodt, J. Development 2002 Mar;129(5):1143-54. PubMed

Reconstructing the eyes of Urbilateria. Arendt, D. & Wittbrodt, J. Philos Trans R Soc Lond B Biol Sci 2001 Oct 29;356(1414):1545-63. PubMed

Medaka eyeless is the key factor linking retinal determination and eye growth. Loosli, F., Winkler, S., Burgtorf, C., Wurmbach, E., Ansorge, W., Henrich, T., Grabher, C., Arendt, D., Carl, M., Krone, A., Grzebisz, E. & Wittbrodt, J. Development 2001 Oct;128(20):4035-44. PubMed

Evolution of the bilaterian larval foregut. Arendt, D., Technau, U. & Wittbrodt, J. Nature 2001 Jan 4;409(6816):81-5. PubMed

Comparison of early nerve cord development in insects and vertebrates. Arendt, D. & Nubler-Jung, K. Development 1999 Jun;126(11):2309-25. PubMed

Rearranging gastrulation in the name of yolk: evolution of gastrulation in yolk-rich amniote eggs. Arendt, D. & Nubler-Jung, K. Mech Dev. 1999 Mar;81(1-2):3-22. PubMed

Dorsal or ventral: similarities in fate maps and gastrulation patterns in annelids, arthropods and chordates. Arendt, D. and Nübler-Jung, K. (1997). Mech. Dev. 61, 7-21.

Dorsal or ventral: similarities in fate maps and gastrulation patterns in annelids, arthropods and chordates. Arendt, D. and Nübler-Jung, K. (1997). Mech. Dev. 61, 7-21.

Common ground plans in early brain development in mice and flies. Arendt, D. & Nubler-Jung, K. Bioessays. 1996 Mar;18(3):255-9. PubMed

Enteropneusts and chordate evolution Nübler-Jung, K. and Arendt, D. (1996). Curr. Biol. 6, 352-3.

Inversion of dorsoventral axis? Arendt, D. & Nubler-Jung, K. Nature 1994 Sep 1;371(6492):26. PubMed

Blocked endocytotic uptake by the oocyte causes accumulation of vitellogenins in the haemolymph of the female-sterile mutants quitPX61 and stand stillPS34 of Drosophila. Gutzeit, H.O. & Arendt, D. Cell Tissue Res. 1994 Feb;275(2):291-8. PubMed

Is ventral in insects dorsal in vertebrates? A history of embryological arguments favouring axis inversion in chordate ancestors. Roux's Arch Nübler-Jung, K. and Arendt, D. (1994). Roux's Arch. Dev. Biol. 203, 357-366