EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

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  • PhD 1999, Albert-Ludwigs-Universität, Freiburg.
    Team leader at EMBL since 2002.
    Group leader and senior scientist since 2007.
    Academic mentor, postdoctoral training since 2007.
    ERC Advanced Investigator since 2012.


Total: 76 publication(s)


Brunet T, Lauri A, Arendt D. (2015)

Did the notochord evolve from an ancient axial muscle? The axochord hypothesis.

Bioessays doi:10.1002/bies.201500027
Europe PMC | doi

Achim K, Pettit JB, Saraiva LR, Gavriouchkina D, Larsson T, Arendt D, Marioni JC. (2015)

High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin.

Nat. Biotechnol.
Europe PMC

Wäge J, Hardege JD, Larsson TA, Simakov O, Chapman EC, Arendt D, Rotchell JM. (2015)

Effects of low seawater pH on the marine polychaete Platynereis dumerilii.

Mar. Pollut. Bull. doi:10.1016/j.marpolbul.2015.04.027
Europe PMC | doi


Tosches MA, Bucher D, Vopalensky P, Arendt D. (2014)

Melatonin signaling controls circadian swimming behavior in marine zooplankton

Cell 159(1):46-57. doi:10.1016/j.cell.2014.07.042
Europe PMC | doi

Lauri A, Brunet T, Handberg-Thorsager M, Fischer AH, Simakov O, Steinmetz PR, Tomer R, Keller PJ, Arendt D. (2014)

Development of the annelid axochord: insights into notochord evolution.

Science 345(6202):1365-1368. doi:10.1126/science.1253396
Europe PMC | doi

Marlow H, Arendt D. (2014)

Evolution: ctenophore genomes and the origin of neurons

Curr. Biol. 24(16):R757-R761. doi:10.1016/j.cub.2014.06.057
Europe PMC | doi

Achim K, Arendt D. (2014)

Structural evolution of cell types by step-wise assembly of cellular modules

Curr. Opin. Genet. Dev. 27C:102-108. doi:10.1016/j.gde.2014.05.001
Europe PMC | doi

Weigert A, Helm C, Meyer M, Nickel B, Arendt D, Hausdorf B, Santos SR, Halanych KM, Purschke G, Bleidorn C, Struck TH. (2014)

Illuminating the base of the annelid tree using transcriptomics

Mol. Biol. Evol. 31(6):1391-1401. doi:10.1093/molbev/msu080
Europe PMC | doi

Marlow H, Tosches MA, Tomer R, Steinmetz PR, Lauri A, Larsson T, Arendt D. (2014)

Larval body patterning and apical organs are conserved in animal evolution.

BMC Biol. 12:7. doi:10.1186/1741-7007-12-7
Europe PMC | doi


Tosches MA, Arendt D. (2013)

The bilaterian forebrain: an evolutionary chimaera

Curr. Opin. Neurobiol. 23(6):1080-1089. doi:10.1016/j.conb.2013.09.005
Europe PMC | doi

Simakov O, Larsson TA, Arendt D. (2013)

Linking micro- and macro-evolution at the cell type level: a view from the lophotrochozoan Platynereis dumerilii

Brief Funct Genomics 12(5):430-439. doi:10.1093/bfgp/els049
Europe PMC | doi

Fischer AH, Arendt D. (2013)

Mesoteloblast-like mesodermal stem cells in the polychaete annelid Platynereis dumerilii (Nereididae)

J. Exp. Zool. B Mol. Dev. Evol. 320(2):94-104. doi:10.1002/jez.b.22486
Europe PMC | doi

Benito-Gutiérrez E, Weber H, Bryant DV, Arendt D. (2013)

Methods for generating year-round access to amphioxus in the laboratory

PLoS ONE 8(8):e71599. doi:10.1371/journal.pone.0071599
Europe PMC | doi

Bertucci P, Arendt D. (2013)

Somatic and visceral nervous systems - an ancient duality

BMC Biol. 11(1):54. doi:10.1186/1741-7007-11-54
Europe PMC | doi

Döring C, Gosda J, Tessmar-Raible K, Hausen H, Arendt D, Purschke G. (2013)

Evolution of clitellate phaosomes from rhabdomeric photoreceptor cells of polychaetes - a study in the leech Helobdella robusta (Annelida, Sedentaria, Clitellata)

Front. Zool. 10(1):52. doi:10.1186/1742-9994-10-52
Europe PMC | doi

Simakov O, Marletaz F, Cho SJ, Edsinger-Gonzales E, Havlak P, Hellsten U, Kuo DH, Larsson T, Lv J, Arendt D, Savage R, Osoegawa K, de Jong P, Grimwood J, Chapman JA, Shapiro H, Aerts A, Otillar RP, Terry AY, Boore JL, Grigoriev IV, Lindberg DR, Seaver EC, Weisblat DA, Putnam NH, Rokhsar DS. (2013)

Insights into bilaterian evolution from three spiralian genomes

Nature 493(7433):526-531. doi:10.1038/nature11696
Europe PMC | doi


Vopalensky P, Pergner J, Liegertova M, Benito-Gutierrez E, Arendt D, Kozmik Z. (2012)

Molecular analysis of the amphioxus frontal eye unravels the evolutionary origin of the retina and pigment cells of the vertebrate eye

Proc. Natl. Acad. Sci. U.S.A. 109(38):15383-15388. doi:10.1073/pnas.1207580109
Europe PMC | doi

Hui JH, McDougall C, Monteiro AS, Holland PW, Arendt D, Balavoine G, Ferrier DE. (2012)

Extensive chordate and annelid macrosynteny reveals ancestral homeobox gene organization

Mol. Biol. Evol. 29(1):157-165. doi:10.1093/molbev/msr175
Europe PMC | doi


Creevey CJ, Muller J, Doerks T, Thompson JD, Arendt D, Bork P. (2011)

Identifying single copy orthologs in Metazoa

PLoS Comput. Biol. 7(12):e1002269. doi:10.1371/journal.pcbi.1002269
Europe PMC | doi

Karsenti E, Acinas SG, Bork P, Bowler C, De Vargas C, Raes J, Sullivan M, Arendt D, Benzoni F, Claverie JM, Follows M, Gorsky G, Hingamp P, Iudicone D, Jaillon O, Kandels-Lewis S, Krzic U, Not F, Ogata H, Pesant S, Reynaud EG, Sardet C, Sieracki ME, Speich S, Velayoudon D, Weissenbach J, Wincker P, Tara Oceans Consortium. (2011)

A holistic approach to marine eco-systems biology

PLoS Biol. 9(10):e1001177. doi:10.1371/journal.pbio.1001177
Europe PMC | doi

Arendt D. (2011)

Evolutionary biology: Annelid who's who

Nature 471(7336):44-45. doi:10.1038/471044a
Europe PMC | doi

Steinmetz PR, Kostyuchenko RP, Fischer A, Arendt D. (2011)

The segmental pattern of otx, gbx, and Hox genes in the annelid Platynereis dumerilii

Evol. Dev. 13(1):72-79. doi:10.1111/j.1525-142x.2010.00457.x
Europe PMC | doi


Tomer R, Denes AS, Tessmar-Raible K, Arendt D. (2010)

Profiling by image registration reveals common origin of annelid mushroom bodies and vertebrate pallium

Cell 142(5):800-809. doi:10.1016/j.cell.2010.07.043
Europe PMC | doi

Dray N, Tessmar-Raible K, Le Gouar M, Vibert L, Christodoulou F, Schipany K, Guillou A, Zantke J, Snyman H, Béhague J, Vervoort M, Arendt D, Balavoine G. (2010)

Hedgehog signaling regulates segment formation in the annelid Platynereis

Science 329(5989):339-342. doi:10.1126/science.1188913
Europe PMC | doi

Hasse C, Rebscher N, Reiher W, Sobjinski K, Moerschel E, Beck L, Tessmar-Raible K, Arendt D, Hassel M. (2010)

Three consecutive generations of nephridia occur during development of Platynereis dumerilii (Annelida, Polychaeta)

Dev. Dyn. 239(7):1967-1976. doi:10.1002/dvdy.22331
Europe PMC | doi

Reuner A, Hengherr S, Mali B, Förster F, Arndt D, Reinhardt R, Dandekar T, Frohme M, Brümmer F, Schill RO. (2010)

Stress response in tardigrades: differential gene expression of molecular chaperones

Cell Stress Chaperones 15(4):423-430. doi:10.1007/s12192-009-0158-1
Europe PMC | doi

Christodoulou F, Raible F, Tomer R, Simakov O, Trachana K, Klaus S, Snyman H, Hannon GJ, Bork P, Arendt D. (2010)

Ancient animal microRNAs and the evolution of tissue identity

Nature 463(7284):1084-1088. doi:10.1038/nature08744
Europe PMC | doi

Fischer AH, Henrich T, Arendt D. (2010)

The normal development of Platynereis dumerilii (Nereididae, Annelida)

Front. Zool. 7:31. doi:10.1186/1742-9994-7-31
Europe PMC | doi

Muller J, Creevey CJ, Thompson JD, Arendt D, Bork P. (2010)

AQUA: automated quality improvement for multiple sequence alignments

Bioinformatics 26(2):263-265. doi:10.1093/bioinformatics/btp651
Europe PMC | doi

Steinmetz PR, Urbach R, Posnien N, Eriksson J, Kostyuchenko RP, Brena C, Guy K, Akam M, Bucher G, Arendt D. (2010)

Six3 demarcates the anterior-most developing brain region in bilaterian animals

Evodevo 1(1):14. doi:10.1186/2041-9139-1-14
Europe PMC | doi


Arendt D, Hausen H, Purschke G. (2009)

The 'division of labour' model of eye evolution

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 364(1531):2809-2817. doi:10.1098/rstb.2009.0104
Europe PMC | doi

Lamb TD, Arendt D, Collin SP. (2009)

The evolution of phototransduction and eyes

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 364(1531):2791-2793. doi:10.1098/rstb.2009.0106
Europe PMC | doi

Benito-Gutiérrez E, Arendt D. (2009)

CNS evolution: new insight from the mud

Curr. Biol. 19(15):R640-2. doi:10.1016/j.cub.2009.06.020
Europe PMC | doi

Egger B, Steinke D, Tarui H, De Mulder K, Arendt D, Borgonie G, Funayama N, Gschwentner R, Hartenstein V, Hobmayer B, Hooge M, Hrouda M, Ishida S, Kobayashi C, Kuales G, Nishimura O, Pfister D, Rieger R, Salvenmoser W, Smith J, Technau U, Tyler S, Agata K, Salzburger W, Ladurner P. (2009)

To be or not to be a flatworm: the acoel controversy

PLoS ONE 4(5):e5502. doi:10.1371/journal.pone.0005502
Europe PMC | doi

Hui JH, Raible F, Korchagina N, Dray N, Samain S, Magdelenat G, Jubin C, Segurens B, Balavoine G, Arendt D, Ferrier DE. (2009)

Features of the ancestral bilaterian inferred from Platynereis dumerilii ParaHox genes

BMC Biol. 7:43. doi:10.1186/1741-7007-7-43
Europe PMC | doi


Nilsson DE, Arendt D. (2008)

Eye evolution: the blurry beginning

Curr. Biol. 18(23):R1096-8. doi:10.1016/j.cub.2008.10.025
Europe PMC | doi

Arendt D. (2008)

The evolution of cell types in animals: emerging principles from molecular studies

Nat. Rev. Genet. 9(11):868-882. doi:10.1038/nrg2416
Europe PMC | doi

Jékely G, Colombelli J, Hausen H, Guy K, Stelzer E, Nédélec F, Arendt D. (2008)

Mechanism of phototaxis in marine zooplankton

Nature 456(7220):395-399. doi:10.1038/nature07590
Europe PMC | doi

Arendt D, Denes AS, Jékely G, Tessmar-Raible K. (2008)

The evolution of nervous system centralization

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 363(1496):1523-1528. doi:10.1098/rstb.2007.2242
Europe PMC | doi

Haudry Y, Berube H, Letunic I, Weeber PD, Gagneur J, Girardot C, Kapushesky M, Arendt D, Bork P, Brazma A, Furlong EE, Wittbrodt J, Henrich T. (2008)

4DXpress: a database for cross-species expression pattern comparisons

Nucleic Acids Res. 36(Database issue):D847-53. doi:10.1093/nar/gkm797
Europe PMC | doi

Simionato E, Kerner P, Dray N, Le Gouar M, Ledent V, Arendt D, Vervoort M. (2008)

atonal- and achaete-scute-related genes in the annelid Platynereis dumerilii: insights into the evolution of neural basic-Helix-Loop-Helix genes

BMC Evol. Biol. 8:170. doi:10.1186/1471-2148-8-170
Europe PMC | doi


Jékely G, Arendt D. (2007)

Cellular resolution expression profiling using confocal detection of NBT/BCIP precipitate by reflection microscopy

BioTechniques 42(6):751-755.
Europe PMC

Rebscher N, Zelada-González F, Banisch TU, Raible F, Arendt D. (2007)

Vasa unveils a common origin of germ cells and of somatic stem cells from the posterior growth zone in the polychaete Platynereis dumerilii

Dev. Biol. 306(2):599-611. doi:10.1016/j.ydbio.2007.03.521
Europe PMC | doi

Tessmar-Raible K, Raible F, Christodoulou F, Guy K, Rembold M, Hausen H, Arendt D. (2007)

Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution

Cell 129(7):1389-1400. doi:10.1016/j.cell.2007.04.041
Europe PMC | doi

Denes AS, Jékely G, Steinmetz PR, Raible F, Snyman H, Prud'homme B, Ferrier DE, Balavoine G, Arendt D. (2007)

Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria

Cell 129(2):277-288. doi:10.1016/j.cell.2007.02.040
Europe PMC | doi

Steinmetz PR, Zelada-Gonzáles F, Burgtorf C, Wittbrodt J, Arendt D. (2007)

Polychaete trunk neuroectoderm converges and extends by mediolateral cell intercalation

Proc. Natl. Acad. Sci. U.S.A. 104(8):2727-2732. doi:10.1073/pnas.0606589104
Europe PMC | doi

Hui JHL, Kortchagina N, Arendt D, Balavoine G, Ferrier DEK. (2007)

Duplication of the ribosomal gene cluster in the marine polychaete Platynereis dumerilii correlates with ITS polymorphism

J. Mar. Biolog. Assoc. U.K. 87(2):443-449.
Europe PMC

Kulakova M, Bakalenko N, Novikova E, Cook CE, Eliseeva E, Steinmetz PR, Kostyuchenko RP, Dondua A, Arendt D, Akam M, Andreeva T. (2007)

Hox gene expression in larval development of the polychaetes Nereis virens and Platynereis dumerilii (Annelida, Lophotrochozoa)

Dev. Genes Evol. 217(1):39-54. doi:10.1007/s00427-006-0119-y
Europe PMC | doi


Kerner P, Zelada González F, Le Gouar M, Ledent V, Arendt D, Vervoort M. (2006)

The expression of a hunchback ortholog in the polychaete annelid Platynereis dumerilii suggests an ancestral role in mesoderm development and neurogenesis

Dev. Genes Evol. 216(12):821-828. doi:10.1007/s00427-006-0100-9
Europe PMC | doi

Purschke G, Arendt D, Hausen H, Müller MC. (2006)

Photoreceptor cells and eyes in Annelida

Arthropod Struct Dev 35(4):211-230. doi:10.1016/j.asd.2006.07.005
Europe PMC | doi

Raible F, Tessmar-Raible K, Arboleda E, Kaller T, Bork P, Arendt D, Arnone MI. (2006)

Opsins and clusters of sensory G-protein-coupled receptors in the sea urchin genome

Dev. Biol. 300(1):461-475. doi:10.1016/j.ydbio.2006.08.070
Europe PMC | doi

Jékely G, Arendt D. (2006)

Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium

Bioessays 28(2):191-198. doi:10.1002/bies.20369
Europe PMC | doi

Arendt D. (2006)

A Kernel Bears Fruit

Science 314(5802):1085-1086. doi:10.1126/science.1134545
Europe PMC | doi


Arendt D. (2005)

Genes and homology in nervous system evolution: comparing gene functions, expression patterns, and cell type molecular fingerprints

Paper presented at the 46th Phylogenetisches Symposium, Jena, GERMANY, NOV 20-21, 2004. Theory Biosci. 124(2):185-197. doi:10.1016/j.thbio.2005.08.002
Europe PMC | doi

Raible F, Tessmar-Raible K, Osoegawa K, Wincker P, Jubin C, Balavoine G, Ferrier D, Benes V, de Jong P, Weissenbach J, Bork P, Arendt D. (2005)

Vertebrate-type intron-rich genes in the marine annelid Platynereis dumerilii

Science 310(5752):1325-1326. doi:10.1126/science.1119089
Europe PMC | doi

Tessmar-Raible K, Steinmetz PR, Snyman H, Hassel M, Arendt D. (2005)

Fluorescent two-color whole mount in situ hybridization in Platynereis dumerilii (Polychaeta, Annelida), an emerging marine molecular model for evolution and development

BioTechniques 39(4):460, 462, 464.
Europe PMC

Fritzsch B, Piatigorsky J, Tessmar-Raible K, Jékely G, Guy K, Raible F, Wittbrodt J, Arendt D. (2005)

Ancestry of Photic and Mechanic Sensation?

Science 308(5725):1113-1114. doi:10.1126/science.308.5725.1113
Europe PMC | doi

Tessmar-Raible K, Arendt D. (2005)

New animal models for evolution and development

Genome Biol. 6(1):303. doi:10.1186/gb-2004-6-1-303
Europe PMC | doi


Arendt D, Tessmar-Raible K, Snyman H, Dorresteijn AW, Wittbrodt J. (2004)

Ciliary photoreceptors with a vertebrate-type opsin in an invertebrate brain

Science 306(5697):869-871. doi:10.1126/science.1099955
Europe PMC | doi

Raible F, Arendt D. (2004)

Metazoan evolution: some animals are more equal than others

Curr. Biol. 14(3):R106-8. doi:10.1016/s0960-9822(04)00030-2
Europe PMC | doi

Arendt D. (2004)

Comparative aspects of gastrulation

In: Stern CD (ed.), Gastrulation: From Cells to Embryo. Cold Spring Harbor Laboratory Press, New York.


Prud'homme B, de Rosa R, Arendt D, Julien JF, Pajaziti R, Dorresteijn AW, Adoutte A, Wittbrodt J, Balavoine G. (2003)

Arthropod-like expression patterns of engrailed and wingless in the annelid Platynereis dumerilii suggest a role in segment formation

Curr. Biol. 13(21):1876-1881. doi:10.1016/j.cub.2003.10.006
Europe PMC | doi

Tessmar-Raible K, Arendt D. (2003)

Emerging systems: between vertebrates and arthropods, the Lophotrochozoa

Curr. Opin. Genet. Dev. 13(4):331-340. doi:10.1016/s0959-437x(03)00086-8
Europe PMC | doi

Arendt D. (2003)

Evolution of eyes and photoreceptor cell types

Int. J. Dev. Biol. 47(7-8):563-571.
Europe PMC

Arendt D. (2003)

Spiralians in the limelight

Genome Biol. 5(1):303. doi:10.1186/gb-2003-5-1-303
Europe PMC | doi


Arendt D, Tessmar K, de Campos-Baptista MI, Dorresteijn A, Wittbrodt J. (2002)

Development of pigment-cup eyes in the polychaete Platynereis dumerilii and evolutionary conservation of larval eyes in Bilateria

Development 129(5):1143-1154.
Europe PMC


Arendt D, Wittbrodt J. (2001)

Reconstructing the eyes of Urbilateria

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 356(1414):1545-1563. doi:10.1098/rstb.2001.0971
Europe PMC | doi

Loosli F, Winkler S, Burgtorf C, Wurmbach E, Ansorge W, Henrich T, Grabher C, Arendt D, Carl M, Krone A, Grzebisz E, Wittbrodt J. (2001)

Medaka eyeless is the key factor linking retinal determination and eye growth

Development 128(20):4035-4044.
Europe PMC

Arendt D, Technau U, Wittbrodt J. (2001)

Evolution of the bilaterian larval foregut

Nature 409(6816):81-85. doi:10.1038/35051075
Europe PMC | doi


Arendt D, Nübler-Jung K. (1999)

Comparison of early nerve cord development in insects and vertebrates

Development 126(11):2309-2325.
Europe PMC

Nubler-Jung K, Arendt D. (1999)

Dorsoventral axis inversion: Enteropneust anatomy links invertebrates to chordates turned upside down

J ZOOL SYST EVOL RES 37(2):93-100. doi:10.1046/j.1439-0469.1999.372106.x

Arendt D, Nübler-Jung K. (1999)

Rearranging gastrulation in the name of yolk: evolution of gastrulation in yolk-rich amniote eggs

Mech. Dev. 81(1-2):3-22. doi:10.1016/s0925-4773(98)00226-3
Europe PMC | doi


Arendt D, Nübler-Jung K. (1997)

Dorsal or ventral: similarities in fate maps and gastrulation patterns in annelids, arthropods and chordates

Mech. Dev. 61(1-2):7-21. doi:10.1016/s0925-4773(96)00620-x
Europe PMC | doi


Arendt D, Nübler-Jung K. (1996)

Common ground plans in early brain development in mice and flies

Bioessays 18(3):255-259. doi:10.1002/bies.950180314
Europe PMC | doi


Nübler-Jung K, Arendt D. (1994)

Is ventral in insects dorsal in vertebrates? A history of embryological arguments favouring axis inversion in chordate ancestors

Roux Arch Dev Biol 203(7-8):357-366. doi:10.1007/BF00188683

Gutzeit HO, Arendt D. (1994)

Blocked endocytotic uptake by the oocyte causes accumulation of vitellogenins in the haemolymph of the female-sterile mutants quitPX61 and stand stillPS34 of Drosophila

Cell Tissue Res. 275(2):291-298. doi:10.1007/bf00319427
Europe PMC | doi