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Staff at EMBL

Dr. Marcus Heisler

Group Leader
Heisler Group

EMBL Heidelberg, Meyerhofstra├če 1, 69117 Heidelberg, Germany

E-mail: send a mail


PhD 2000, Monash University, Australia.
Postdoctoral research at the California Institute of Technology.
Senior Research Associate at the California Institute of Technology 2007-2009.
Group leader at EMBL since 2009.
ERC Investigator.


Live-imaging of the Arabidopsis inflorescence meristem. Heisler, M.G. & Ohno, C. Methods Mol Biol. 2014;1110:431-40. doi: 10.1007/978-1-4614-9408-9_25. Europe PMC

Accounting for technical noise in single-cell RNA-seq experiments. Brennecke, P., Anders, S., Kim, J.K., Kolodziejczyk, A.A., Zhang, X., Proserpio, V., Baying, B., Benes, V., Teichmann, S.A., Marioni, J.C. & Heisler, M.G. Nat Methods. 2013 Nov;10(11):1093-5. doi: 10.1038/nmeth.2645. Epub 2013 Sep 22. Europe PMC

Genome-wide identification of KANADI1 target genes. Merelo, P., Xie, Y., Brand, L., Ott, F., Weigel, D., Bowman, J.L., Heisler, M.G. & Wenkel, S. PLoS One. 2013 Oct 14;8(10):e77341. doi: 10.1371/journal.pone.0077341.eCollection 2013. Europe PMC

Live-imaging of plant development: latest approaches. Sappl, P.G. & Heisler, M.G. Curr Opin Plant Biol. 2013 Feb;16(1):33-40. doi: 10.1016/j.pbi.2012.10.006. Epub2012 Nov 26. Europe PMC

Plant stem cell maintenance involves direct transcriptional repression of differentiation program. Yadav, R.K., Perales, M., Gruel, J., Ohno, C., Heisler, M., Girke, T., Jonsson, H. & Reddy, G.V. Mol Syst Biol. 2013;9:654. doi: 10.1038/msb.2013.8. Europe PMC

Integrated genetic and computation methods for in planta cytometry. Federici, F., Dupuy, L., Laplaze, L., Heisler, M. & Haseloff, J. Nat Methods. 2012 Apr 1;9(5):483-5. doi: 10.1038/nmeth.1940. Europe PMC

Cytokinin signaling as a positional cue for patterning the apical-basal axis of the growing Arabidopsis shoot meristem. Chickarmane, V.S., Gordon, S.P., Tarr, P.T., Heisler, M.G. & Meyerowitz, E.M. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):4002-7. Epub 2012 Feb 15. Europe PMC

Alignment between PIN1 polarity and microtubule orientation in the shoot apical meristem reveals a tight coupling between morphogenesis and auxin transport. Heisler, M.G.*, Hamant, O.*, Krupinski, P.*, Uyttewaal, M., Ohno, C., Jonsson, H., Traas, J. & Meyerowitz, E.M. PLoS Biol. 2010 Oct 19;8(10):e1000516.
*equal contribution Europe PMC

Developmental patterning by mechanical signals in Arabidopsis. Hamant*, O., Heisler*, M.G., Jonsson*, H., Krupinski, P., Uyttewaal, M., Bokov, P., Corson, F., Sahlin, P., Boudaoud, A., Meyerowitz, E.M., Couder, Y. & Traas, J. Science. 2008 Dec 12;322(5908):1650-5.
*equal contribution Europe PMC

Pattern formation during de novo assembly of the Arabidopsis shoot meristem. Gordon, S.P., Heisler, M.G., Reddy, G.V., Ohno, C., Das, P. & Meyerowitz, E.M. Development. 2007 Oct;134(19):3539-48. Europe PMC

Antagonistic regulation of PIN phosphorylation by PP2A and PINOID directs auxin flux. Michniewicz, M., Zago, M.K., Abas, L., Weijers, D., Schweighofer, A., Meskiene, I., Heisler, M.G., Ohno, C., Zhang, J., Huang, F., Schwab, R., Weigel, D., Meyerowitz, E.M., Luschnig, C., Offringa, R. & Friml, J. Cell. 2007 Sep 21;130(6):1044-56. Europe PMC

Modelling meristem development in plants. Heisler, M.G. & Jonsson, H. Curr Opin Plant Biol. 2007 Feb;10(1):92-7. Epub 2006 Nov 30. Europe PMC

Apical-basal polarity: why plant cells don't stand on their heads. Friml, J., Benfey, P., Benkova, E., Bennett, M., Berleth, T., Geldner, N., Grebe, M., Heisler, M., Hejatko, J., Jurgens, G., Laux, T., Lindsey, K., Lukowitz, W., Luschnig, C., Offringa, R., Scheres, B., Swarup, R., Torres-Ruiz, R., Weijers, D. & Zazimalova, E. Trends Plant Sci. 2006 Jan;11(1):12-4. Epub 2005 Dec 13. Europe PMC

An auxin-driven polarized transport model for phyllotaxis. Jonsson*, H., Heisler*, M.G., Shapiro, B.E., Meyerowitz, E.M. & Mjolsness, E. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1633-8. Epub 2006 Jan 13. Europe PMC

In situ hybridization for mRNA detection in Arabidopsis tissue sections. Brewer, P.B., Heisler, M.G., Hejatko, J., Friml, J. & Benkova, E. Nat Protoc. 2006;1(3):1462-7. Europe PMC

Patterns of auxin transport and gene expression during primordium development revealed by live imaging of the Arabidopsis inflorescence meristem. Heisler, M.G., Ohno, C., Das, P., Sieber, P., Reddy, G.V., Long, J.A. & Meyerowitz, E.M. Curr Biol. 2005 Nov 8;15(21):1899-911. Europe PMC

Modeling the organization of the WUSCHEL expression domain in the shoot apical meristem. Jonsson, H., Heisler, M., Reddy, G.V., Agrawal, V., Gor, V., Shapiro, B.E., Mjolsness, E. & Meyerowitz, E.M. Bioinformatics. 2005 Jun;21 Suppl 1:i232-40. Europe PMC

Real-time lineage analysis reveals oriented cell divisions associated with morphogenesis at the shoot apex of Arabidopsis thaliana. Reddy, G.V., Heisler, M.G., Ehrhardt, D.W. & Meyerowitz, E.M. Development. 2004 Sep;131(17):4225-37. Epub 2004 Jul 27. Europe PMC

The Arabidopsis JAGGED gene encodes a zinc finger protein that promotes leaf tissue development. Ohno, C.K., Reddy, G.V., Heisler, M.G. & Meyerowitz, E.M. Development. 2004 Mar;131(5):1111-22. Europe PMC

SPATULA, a gene that controls development of carpel margin tissues in Arabidopsis, encodes a bHLH protein. Heisler, M.G., Atkinson, A., Bylstra, Y.H., Walsh, R. & Smyth, D.R. Development. 2001 Apr;128(7):1089-98. Europe PMC

Molecular and evolutionary aspects of self-incompatibility in flowering plants. Mau, S.L., Anderson, M.A., Heisler, M., Haring, V., McClure, B.A. & Clarke, A.E. Symp Soc Exp Biol. 1991;45:245-69. Europe PMC