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Staff at EMBL

Dr. Takashi Hiiragi

Group Leader
Hiiragi Group

EMBL Heidelberg, Meyerhofstra├če 1, 69117 Heidelberg, Germany

E-mail: send a mail


PhD 2000, Kyoto University, Japan.
Postdoctoral research at the Max Planck Institute of Immunobiology, Freiburg, Germany.
Group leader at the MPI of Immunobiology 2002-7.
Independent group leader at the MPI for Molecular Biomedicine, M├╝nster, 2007-11.
Group leader at EMBL since 2011.
ERC Investigator.


Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages. Ohnishi, Y., Huber, W., Tsumura, A., Kang, M., Xenopoulos, P., Kurimoto, K., Oles, A.K., Arauzo-Bravo, M.J., Saitou, M., Hadjantonakis, A.K. & Hiiragi, T. Nat Cell Biol. 2014 Jan;16(1):27-37. doi: 10.1038/ncb2881. Epub 2013 Dec 1. Europe PMC

A self-organization framework for symmetry breaking in the mammalian embryo. Wennekamp, S., Mesecke, S., Nedelec, F. & Hiiragi, T. Nat Rev Mol Cell Biol. 2013 Jul;14(7):452-9. doi: 10.1038/nrm3602. Epub 2013 Jun19. Europe PMC

The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development. Courtois, A., Schuh, M., Ellenberg, J. & Hiiragi, T. J Cell Biol. 2012 Aug 6;198(3):357-70. Epub 2012 Jul 30. Europe PMC

The Kruppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo. Groner, A.C., Tschopp, P., Challet, L., Dietrich, J.E., Verp, S., Offner, S., Barde, I., Rodriguez, I., Hiiragi, T. & Trono, D. J Biol Chem. 2012 Jul 20;287(30):25361-9. Epub 2012 May 17. Europe PMC

Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development. Lavial, F., Bessonnard, S., Ohnishi, Y., Tsumura, A., Chandrashekran, A., Fenwick, M.A., Tomaz, R.A., Hosokawa, H., Nakayama, T., Chambers, I., Hiiragi, T., Chazaud, C. & Azuara, V. Genes Dev. 2012 Jul 1;26(13):1445-58. Epub 2012 Jun 19. Europe PMC

Stochastic processes in the development of pluripotency in vivo. Wennekamp, S. & Hiiragi, T. Biotechnol J. 2012 Jun;7(6):737-44. doi: 10.1002/biot.201100357. Epub 2012 Apr27. Europe PMC

Computer simulation of emerging asymmetry in the mouse blastocyst. Honda, H., Motosugi, N., Nagai, T., Tanemura, M. & Hiiragi, T. Development. 2008 Apr;135(8):1407-14. Europe PMC

Dynamic rearrangement of surface proteins is essential for cytokinesis. Bauer, T., Motosugi, N., Miura, K., Sabe, H. & Hiiragi, T. Genesis. 2008 Mar;46(3):152-62. doi: 10.1002/dvg.20377. Europe PMC

Hypomethylation of paternal DNA in the late mouse zygote is not essential for development. Polanski, Z., Motosugi, N., Tsurumi, C., Hiiragi, T. & Hoffmann, S. Int J Dev Biol. 2008;52(2-3):295-8. Europe PMC

Stochastic processes during mouse blastocyst patterning. Dietrich, J.E. & Hiiragi, T. Cells Tissues Organs. 2008;188(1-2):46-51. Epub 2008 Feb 27. Europe PMC

Stochastic patterning in the mouse pre-implantation embryo. Dietrich, J.E. & Hiiragi, T. Development. 2007 Dec;134(23):4219-31. Epub 2007 Oct 31. Europe PMC

Embryology: does prepatterning occur in the mouse egg? Hiiragi, T., Louvet-Vallee, S., Solter, D. & Maro, B. Nature. 2006 Jul 13;442(7099):E3-4; discussion E4. Europe PMC

Space asymmetry directs preferential sperm entry in the absence of polarity in the mouse oocyte. Motosugi, N., Dietrich, J.E., Polanski, Z., Solter, D. & Hiiragi, T. PLoS Biol. 2006 May;4(5):e135. Epub 2006 Apr 25. Europe PMC

Fatal flaws in the case for prepatterning in the mouse egg. Hiiragi, T. & Solter, D. Reprod Biomed Online. 2006 Feb;12(2):150-2. Europe PMC

Polarity of the mouse embryo is established at blastocyst and is not prepatterned. Motosugi, N., Bauer, T., Polanski, Z., Solter, D. & Hiiragi, T. Genes Dev. 2005 May 1;19(9):1081-92. Europe PMC

Mechanism of first cleavage specification in the mouse egg: is our body plan set at day 0? Hiiragi, T. & Solter, D. Cell Cycle. 2005 May;4(5):661-4. Epub 2005 May 22. Europe PMC

First cleavage plane of the mouse egg is not predetermined but defined by the topology of the two apposing pronuclei. Hiiragi, T. & Solter, D. Nature. 2004 Jul 15;430(6997):360-4. Europe PMC