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Staff at EMBL

Dr. Anne Ephrussi

Head of Unit, Head of EICAT and Senior Scientist
Developmental Biology Ephrussi Group EMBL International Centre for Advanced Training (EICAT)

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail


PhD 1985, Massachusetts Institute of Technology.
Postdoctoral research at Harvard University and Whitehead Institute, MIT, Cambridge, Massachusetts.
Group leader at EMBL since 1992.
Head of EICAT since 2005.
Head of Unit since 2007.


Brightness through Local Constraint—LNA-Enhanced FIT Hybridization Probes for In Vivo Ribonucleotide Particle Tracking. Hövelmann, F., Gaspar, I., Loibl, S., Ermilov, E. A., Röder, B., Wengel, J., Ephrussi, A. & Seitz, O. Angew. Chem. Int. Ed. 2014

Considerations when investigating lncRNA function in vivo. Bassett, A.R., Akhtar, A., Barlow, D.P., Bird, A.P., Brockdorff, N., Duboule, D., Ephrussi, A., Ferguson-Smith, A.C., Gingeras, T.R., Haerty, W., Higgs, D.R., Miska, E.A. & Ponting, C.P. Elife. 2014 Aug 14;3:e03058. doi: 10.7554/eLife.03058. Europe PMC

Klar ensures thermal robustness of oskar localization by restraining RNP motility. Gaspar, I., Yu, Y.V., Cotton, S.L., Kim, D.H., Ephrussi, A. & Welte, M.A. J Cell Biol. 2014 Jul 21;206(2):199-215. doi: 10.1083/jcb.201310010. Europe PMC

RNA clamping by Vasa assembles a piRNA amplifier complex on transposon transcripts. Xiol, J., Spinelli, P., Laussmann, M.A., Homolka, D., Yang, Z., Cora, E., Coute, Y., Conn, S., Kadlec, J., Sachidanandam, R., Kaksonen, M., Cusack, S., Ephrussi, A. & Pillai, R.S. Cell. 2014 Jun 19;157(7):1698-711. doi: 10.1016/j.cell.2014.05.018. Epub 2014 Jun5. Europe PMC

The EJC Binding and Dissociating Activity of PYM Is Regulated in Drosophila. Ghosh, S., Obrdlik, A., Marchand, V. & Ephrussi, A. PLoS Genet. 2014 Jun 26;10(6):e1004455. doi: 10.1371/journal.pgen.1004455.eCollection 2014 Jun. Europe PMC

A stem-loop structure directs oskar mRNA to microtubule minus ends. Jambor, H., Mueller, S., Bullock, S.L. & Ephrussi, A. RNA. 2014;20(4):429-39. doi: 10.1261/rna.041566.113. Epub 2014 Feb 26. Europe PMC

Imp promotes axonal remodeling by regulating profilin mRNA during brain development. Medioni, C., Ramialison, M., Ephrussi, A. & Besse, F. Curr Biol. 2014 Mar 31;24(7):793-800. doi: 10.1016/j.cub.2014.02.038. Epub 2014Mar 20. Europe PMC

Brightness Enhanced DNA FIT-Probes for Wash-Free RNA Imaging in Tissue. Hovelmann, F., Gaspar, I., Ephrussi, A. & Seitz, O. J Am Chem Soc. 2013 Dec 18;135(50):19025-32. doi: 10.1021/ja410674h. Epub 2013Dec 10. Europe PMC

A single Drosophila embryo extract for the study of mitosis ex vivo. Telley, I.A., Gaspar, I., Ephrussi, A. & Surrey, T. Nat Protoc. 2013 Jan 17;8(2):310-24. doi: 10.1038/nprot.2013.003. Epub 2013 Jan17. Europe PMC

A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization. Leibfried, A., Muller, S. & Ephrussi, A. Development. 2013 Jan 15;140(2):362-71. doi: 10.1242/dev.089250. Europe PMC

Aster migration determines the length scale of nuclear separation in the Drosophila syncytial embryo. Telley, I.A., Gaspar, I., Ephrussi, A. & Surrey, T. J Cell Biol. 2012 Jun 25;197(7):887-95. Epub 2012 Jun 18. Europe PMC

An intracellular transmission control protocol: assembly and transport of ribonucleoprotein complexes. Marchand, V., Gaspar, I. & Ephrussi, A. Curr Opin Cell Biol. 2012 Apr;24(2):202-10. doi: 10.1016/ Epub2012 Jan 23. Europe PMC

Control of RNP motility and localization by a splicing-dependent structure in oskar mRNA. Ghosh, S., Marchand, V., Gaspar, I. & Ephrussi, A. Nat Struct Mol Biol. 2012 Mar 18;19(4):441-9. doi: 10.1038/nsmb.2257. Europe PMC

Dimerization of oskar 3' UTRs promotes hitchhiking for RNA localization in the Drosophila oocyte. Jambor, H., Brunel, C. & Ephrussi, A. RNA. 2011 Dec;17(12):2049-57. Epub 2011 Oct 25. Europe PMC

Drosophila Ge-1 Promotes P Body Formation and oskar mRNA Localization. Fan, S.J., Marchand, V. & Ephrussi, A. PLoS One. 2011;6(5):e20612. Epub 2011 May 31. Europe PMC

Myosin-V regulates oskar mRNA localization in the Drosophila oocyte. Krauss, J., Lopez de Quinto, S., Nusslein-Volhard, C. & Ephrussi, A. Curr Biol. 2009 Jun 23;19(12):1058-63. Epub 2009 May 28. Europe PMC

mRNA localization: gene expression in the spatial dimension. Martin, K.C. & Ephrussi, A. Cell. 2009 Feb 20;136(4):719-30. Europe PMC

Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation. Besse, F., Lopez de Quinto, S., Marchand, V., Trucco, A. & Ephrussi, A. Genes Dev. 2009 Jan 15;23(2):195-207. Epub 2009 Jan 8. Europe PMC

The actin-binding protein Lasp promotes Oskar accumulation at the posterior pole of the Drosophila embryo. Suyama, R., Jenny, A., Curado, S., Pellis-van Berkel, W. & Ephrussi, A. Development. 2009 Jan;136(1):95-105. Epub 2008 Nov 26. Europe PMC

Drosophila ensconsin promotes productive recruitment of Kinesin-1 to microtubules. Sung, H.H., Telley, I.A., Papadaki, P., Ephrussi, A., Surrey, T. & Rorth, P. Dev Cell. 2008 Dec;15(6):866-76. Europe PMC

Translational control of localized mRNAs: restricting protein synthesis in space and time. Besse, F. & Ephrussi, A. Nat Rev Mol Cell Biol. 2008 Dec;9(12):971-80. Europe PMC

The Ig cell adhesion molecule Basigin controls compartmentalization and vesicle release at Drosophila melanogaster synapses. Besse, F., Mertel, S., Kittel, R.J., Wichmann, C., Rasse, T.M., Sigrist, S.J. & Ephrussi, A. J Cell Biol. 2007 Jun 4;177(5):843-55. Europe PMC

Stimulation of endocytosis and actin dynamics by Oskar polarizes the Drosophila oocyte. Vanzo, N., Oprins, A., Xanthakis, D., Ephrussi, A. & Rabouille, C. Dev Cell. 2007 Apr;12(4):543-55. Europe PMC

Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis. Coutelis, J.B. & Ephrussi, A. Development. 2007 Apr;134(7):1419-30. Epub 2007 Feb 28. Europe PMC

Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila. Anne, J., Ollo, R., Ephrussi, A. & Mechler, B.M. Development. 2007 Jan;134(1):137-46. Europe PMC

A translation-independent role of oskar RNA in early Drosophila oogenesis. Jenny, A., Hachet, O., Zavorszky, P., Cyrklaff, A., Weston, M.D., Johnston, D.S., Erdelyi, M. & Ephrussi, A. Development. 2006 Aug;133(15):2827-33. Europe PMC

Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles. Chekulaeva, M., Hentze, M.W. & Ephrussi, A. Cell. 2006 Feb 10;124(3):521-33. Europe PMC

Gain-of-function screen for genes that affect Drosophila muscle pattern formation. Staudt, N., Molitor, A., Somogyi, K., Mata, J., Curado, S., Eulenberg, K., Meise, M., Siegmund, T., Hader, T., Hilfiker, A., Bronner, G., Ephrussi, A., Rørth, P., Cohen, S.M., Fellert, S., Chung, H.R., Piepenburg, O., Schafer, U., Jackle, H. & Vorbruggen, G. PLoS Genet 2005 Oct;1(4):e55. Epub 2005 Oct 28. Europe PMC

The Drosophila PAR-1 spacer domain is required for lateral membrane association and for polarization of follicular epithelial cells. Vaccari, T., Rabouille, C. & Ephrussi, A. Curr Biol 2005 Feb 8;15(3):255-61. Europe PMC

Par-1 regulates bicoid mRNA localisation by phosphorylating Exuperantia. Riechmann, V. & Ephrussi, A. Development 2004 Dec;131(23):5897-907. Europe PMC

Drosophila development: RNA interference ab ovo. Chekulaeva, M. & Ephrussi, A. Curr Biol 2004 Jun 8;14(11):R428-30. Europe PMC

Hrp48, a Drosophila hnRNPA/B Homolog, Binds and Regulates Translation of oskar mRNA. Yano, T., De Quinto, S.L., Matsui, Y., Shevchenko, A., Shevchenko, A. & Ephrussi, A. Dev Cell 2004 May;6(5):637-48. Europe PMC

Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization. Hachet, O. & Ephrussi, A. Nature 2004 Apr 29;428(6986):959-63. Europe PMC

PKA-R1 spatially restricts Oskar expression for Drosophila embryonic patterning. Yoshida, S., Muller, H.A., Wodarz, A. & Ephrussi, A. Development 2004 Mar;131(6):1401-10. Europe PMC

Seeing is believing: the bicoid morphogen gradient matures. Ephrussi, A. & St Johnston, D. Cell 2004 Jan 23;116(2):143-52. Europe PMC

Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism. Teixeira, L., Rabouille, C., Rorth, P., Ephrussi, A. & Vanzo, N.F. Mech Dev 2003 Sep;120(9):1071-81. Europe PMC

Bruno regulates gurken during Drosophila oogenesis. Filardo, P. & Ephrussi, A. Mech Dev 2003 Mar;120(3):289-97. Europe PMC

Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte. Castagnetti, S. & Ephrussi, A. Development 2003 Mar;130(5):835-43. Europe PMC

The fusome and microtubules enrich Par-1 in the oocyte, Where it effects polarization in conjunction with Par-3, BicD, Egl, and Dynein. Vaccari, T. & Ephrussi, A. Curr Biol 2002 Sep 3;12(17):1524. Europe PMC

Oskar anchoring restricts pole plasm formation to the posterior of the Drosophila oocyte. Vanzo, N.F. & Ephrussi, A. Development 2002 Aug;129(15):3705-14. Europe PMC

A germline-specific gap junction protein required for survival of differentiating early germ cells. Tazuke, S.I., Schulz, C., Gilboa, L., Fogarty, M., Mahowald, A.P., Guichet, A., Ephrussi, A., Wood, C.G., Lehmann, R. & Fuller, M.T. Development 2002 May;129(10):2529-39. Europe PMC

Par-1 regulates stability of the posterior determinant Oskar by phosphorylation. Riechmann, V., Gutierrez, G.J., Filardo, P., Nebreda, A.R. & Ephrussi, A. Nat Cell Biol 2002 May;4(5):337-42. Europe PMC

Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport. Hachet, O. & Ephrussi, A. Curr Biol 2001 Oct 30;11(21):1666-74. Europe PMC

Axis formation during Drosophila oogenesis. Riechmann, V. & Ephrussi, A. Curr Opin Genet Dev 2001 Aug;11(4):374-83. Europe PMC

A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation. Tomancak, P., Piano, F., Riechmann, V., Gunsalus, K.C., Kemphues, K.J. & Ephrussi, A. Nat Cell Biol 2000 Jul;2(7):458-460 Europe PMC

Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis. Mata, J., Curado, S., Ephrussi, A. & Rorth, P. Cell 2000 May 26;101(5):511-22 Europe PMC

Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning. Jimenez, G., Guichet, A., Ephrussi, A. & Casanova, J. Genes Dev 2000 Jan 15;14(2):224-31 Europe PMC

Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries. Castagnetti, S., Hentze, M.W., Ephrussi, A. & Gebauer, F. Development 2000;127(5):1063-1068 Europe PMC

Localization-dependent translation requires a functional interaction between the 5' and 3' ends of oskar mRNA. Gunkel, N., Yano, T., Markussen, F.H., Olsen, L.C. & Ephrussi, A. Genes Dev 1998 Jun 1 12(11) 1652-1664 Europe PMC

Oocyte polarity depends on regulation of gurken by Vasa. Tomancak, P., Guichet, A., Zavorszky, P. & Ephrussi, A. Development 1998 May 125(9) 1723-1732 Europe PMC

Cytoplasmic flows localize injected oskar RNA in Drosophila oocytes. Glotzer, J.B., Saffrich, R., Glotzer, M. & Ephrussi, A. Curr Biol 1997 May 1 7(5) 326-337 Europe PMC

The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors. Guichet, A., Copeland, J.W., Erdelyi, M., Hlousek, D., Zavorszky, P., Ho, J., Brown, S., Percival-Smith, A., Krause, H.M. & Ephrussi, A. Nature 1997 Feb 6;385(6616):548-52. Europe PMC

Ftz-F1 is a cofactor in Ftz activation of the Drosophila engrailed gene. Florence, B., Guichet, A., Ephrussi, A. & Laughon, A. Development 1997 Feb;124(4):839-47. Europe PMC

Efficient translation and phosphorylation of Oskar require Oskar protein and the RNA helicase Vasa. Markussen, F.H., Breitwieser, W. & Ephrussi, A. Cold Spring Harb Symp Quant Biol 1997 62 13-17 Europe PMC

Analysis of RNA distribution during Drosophila oogenesis using fluorescent in situ hybridization. Glotzer, J.B. & Ephrussi, A. In "A Comparative Methods Approach to the Study of Oocytes and Embryos", Richter, J. (ed.), 1997, Oxford University Press, New York

Oskar protein interaction with Vasa represents an essential step in polar granule assembly. Breitwieser, W., Markussen, F.H., Horstmann, H. & Ephrussi, A. Genes Dev 1996 Sep 1 10(17) 2179-2188 Europe PMC

mRNA localization and the cytoskeleton. Glotzer, J.B. & Ephrussi, A. Seminars in Cell and Developmental Biology 1996 7 357-365

Translational control of oskar generates short OSK, the isoform that induces pole plasma assembly. Markussen, F.H., Michon, A.M., Breitwieser, W. & Ephrussi, A. Development 1995 Nov 121(11) 3723-3732 Europe PMC

Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization. Erdelyi, M., Michon, A.M., Guichet, A., Glotzer, J.B. & Ephrussi, A. Nature. 1995 Oct 12;377(6549):524-7. Europe PMC

Germ plasm formation and germ cell determination in Drosophila. Lehmann, R. & Ephrussi, A. Ciba Found Symp 1994;182:282-96; discussion 296-300. Europe PMC

Induction of germ cell formation by oskar. Ephrussi, A. & Lehmann, R. Nature. 1992 Jul 30;358(6385):387-92. Europe PMC

Oskar organizes the germ plasm and directs localization of the posterior determinant nanos. Ephrussi, A., Dickinson, L.K. & Lehmann, R. Cell 1991 Jul 12;66(1):37-50. Europe PMC