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Staff at EMBL

CP-60003271

Dr. Anne Ephrussi

Head of Unit, Head of EICAT and Senior Scientist
Developmental Biology Ephrussi Group EMBL International Centre for Advanced Training (EICAT)

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Biography

PhD 1985, Massachusetts Institute of Technology.
Postdoctoral research at Harvard University and Whitehead Institute, MIT, Cambridge, Massachusetts.
Group leader at EMBL since 1992.
Head of EICAT since 2005.
Head of Unit since 2007.

Publications

Total: 62 publication(s)

2014

Hövelmann F, Gaspar I, Loibl S, Ermilov EA, Röder B, Wengel J, Ephrussi A, Seitz O. (2014)
Brightness through Local Constraint-LNA-Enhanced FIT Hybridization Probes for In Vivo Ribonucleotide Particle Tracking.
Angew. Chem. Int. Ed. Engl. 53(42):11370-11375. doi:10.1002/anie.201406022
Europe PMC | doi

Bassett AR, Akhtar A, Barlow DP, Bird AP, Brockdorff N, Duboule D, Ephrussi A, Ferguson-Smith AC, Gingeras TR, Haerty W, Higgs DR, Miska EA, Ponting CP. (2014)
Considerations when investigating lncRNA function in vivo
Elife (Cambridge) 3:e03058. doi:10.7554/elife.03058
Europe PMC | doi

Gaspar I, Yu YV, Cotton SL, Kim DH, Ephrussi A, Welte MA. (2014)
Klar ensures thermal robustness of oskar localization by restraining RNP motility
J. Cell Biol. 206(2):199-215. doi:10.1083/jcb.201310010
Europe PMC | doi

Xiol J, Spinelli P, Laussmann MA, Homolka D, Yang Z, Cora E, Couté Y, Conn S, Kadlec J, Sachidanandam R, Kaksonen M, Cusack S, Ephrussi A, Pillai RS. (2014)
RNA Clamping by Vasa Assembles a piRNA Amplifier Complex on Transposon Transcripts
Cell 157(7):1698-1711. doi:10.1016/j.cell.2014.05.018
Europe PMC | doi

Ghosh S, Obrdlik A, Marchand V, Ephrussi A. (2014)
The EJC Binding and Dissociating Activity of PYM Is Regulated in Drosophila.
PLoS Genet. 10(6) doi:10.1371/journal.pgen.1004455
Europe PMC | doi

Jambor H, Mueller S, Bullock SL, Ephrussi A. (2014)
A stem-loop structure directs oskar mRNA to microtubule minus ends
RNA 20(4):429-439. doi:10.1261/rna.041566.113
Europe PMC | doi

Medioni C, Ramialison M, Ephrussi A, Besse F. (2014)
Imp Promotes Axonal Remodeling by Regulating profilin mRNA during Brain Development
Curr. Biol. 24(7):793-800. doi:10.1016/j.cub.2014.02.038
Europe PMC | doi


2013

Hövelmann F, Gaspar I, Ephrussi A, Seitz O. (2013)
Brightness enhanced DNA FIT-probes for wash-free RNA imaging in tissue
J. Am. Chem. Soc. 135(50):19025-19032. doi:10.1021/ja410674h
Europe PMC | doi

Telley IA, Gáspár I, Ephrussi A, Surrey T. (2013)
A single Drosophila embryo extract for the study of mitosis ex vivo
Nat Protoc 8(2):310-324. doi:10.1038/nprot.2013.003
Europe PMC | doi

Leibfried A, Müller S, Ephrussi A. (2013)
A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization
Development 140(2):362-371. doi:10.1242/dev.089250
Europe PMC | doi


2012

Telley IA, Gáspár I, Ephrussi A, Surrey T. (2012)
Aster migration determines the length scale of nuclear separation in the Drosophila syncytial embryo
J. Cell Biol. 197(7):887-895. doi:10.1083/jcb.201204019
Europe PMC | doi

Marchand V, Gaspar I, Ephrussi A. (2012)
An intracellular transmission control protocol: assembly and transport of ribonucleoprotein complexes
Curr. Opin. Cell Biol. 24(2):202-210. doi:10.1016/j.ceb.2011.12.014
Europe PMC | doi

Ghosh S, Marchand V, Gáspár I, Ephrussi A. (2012)
Control of RNP motility and localization by a splicing-dependent structure in oskar mRNA
Nat. Struct. Mol. Biol. 19(4):441-449. doi:10.1038/nsmb.2257
Europe PMC | doi


2011

Jambor H, Brunel C, Ephrussi A. (2011)
Dimerization of oskar 3' UTRs promotes hitchhiking for RNA localization in the Drosophila oocyte
RNA 17(12):2049-2057. doi:10.1261/rna.2686411
Europe PMC | doi

Fan SJ, Marchand V, Ephrussi A. (2011)
Drosophila Ge-1 promotes P body formation and oskar mRNA localization
PLoS ONE 6(5):e20612. doi:10.1371/journal.pone.0020612
Europe PMC | doi


2009

Krauss J, López de Quinto S, Nüsslein-Volhard C, Ephrussi A. (2009)
Myosin-V regulates oskar mRNA localization in the Drosophila oocyte
Curr. Biol. 19(12):1058-1063. doi:10.1016/j.cub.2009.04.062
Europe PMC | doi

Martin KC, Ephrussi A. (2009)
mRNA localization: gene expression in the spatial dimension
Cell 136(4):719-730. doi:10.1016/j.cell.2009.01.044
Europe PMC | doi

Besse F, López de Quinto S, Marchand V, Trucco A, Ephrussi A. (2009)
Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation
Genes Dev. 23(2):195-207. doi:10.1101/gad.505709
Europe PMC | doi

Suyama R, Jenny A, Curado S, Pellis-van Berkel W, Ephrussi A. (2009)
The actin-binding protein Lasp promotes Oskar accumulation at the posterior pole of the Drosophila embryo
Development 136(1):95-105. doi:10.1242/dev.027698
Europe PMC | doi


2008

Sung HH, Telley IA, Papadaki P, Ephrussi A, Surrey T, Rørth P. (2008)
Drosophila ensconsin promotes productive recruitment of Kinesin-1 to microtubules
Dev. Cell 15(6):866-876. doi:10.1016/j.devcel.2008.10.006
Europe PMC | doi

Besse F, Ephrussi A. (2008)
Translational control of localized mRNAs: restricting protein synthesis in space and time
Nat. Rev. Mol. Cell Biol. 9(12):971-980. doi:10.1038/nrm2548
Europe PMC | doi


2007

Besse F, Mertel S, Kittel RJ, Wichmann C, Rasse TM, Sigrist SJ, Ephrussi A. (2007)
The Ig cell adhesion molecule Basigin controls compartmentalization and vesicle release at Drosophila melanogaster synapses
J. Cell Biol. 177(5):843-855. doi:10.1083/jcb.200701111
Europe PMC | doi

Coutelis JB, Ephrussi A. (2007)
Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis
Development 134(7):1419-1430. doi:10.1242/dev.02821
Europe PMC | doi

Vanzo N, Oprins A, Xanthakis D, Ephrussi A, Rabouille C. (2007)
Stimulation of endocytosis and actin dynamics by Oskar polarizes the Drosophila oocyte
Dev. Cell 12(4):543-555. doi:10.1016/j.devcel.2007.03.002
Europe PMC | doi

Anne J, Ollo R, Ephrussi A, Mechler BM. (2007)
Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila
Development 134(1):137-146. doi:10.1242/dev.02687
Europe PMC | doi


2006

Jenny A, Hachet O, Závorszky P, Cyrklaff A, Weston MD, Johnston DS, Erdélyi M, Ephrussi A. (2006)
A translation-independent role of oskar RNA in early Drosophila oogenesis
Development 133(15):2827-2833. doi:10.1242/dev.02456
Europe PMC | doi

Chekulaeva M, Hentze MW, Ephrussi A. (2006)
Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles
Cell 124(3):521-533. doi:10.1016/j.cell.2006.01.031
Europe PMC | doi


2005

Staudt N, Molitor A, Somogyi K, Mata J, Curado S, Eulenberg K, Meise M, Siegmund T, Häder T, Hilfiker A, Brönner G, Ephrussi A, Rørth P, Cohen SM, Fellert S, Chung HR, Piepenburg O, Schäfer U, Jäckle H, Vorbrüggen G. (2005)
Gain-of-function screen for genes that affect Drosophila muscle pattern formation
PLoS Genet. 1(4):e55. doi:10.1371/journal.pgen.0010055
Europe PMC | doi

Vaccari T, Rabouille C, Ephrussi A. (2005)
The Drosophila PAR-1 spacer domain is required for lateral membrane association and for polarization of follicular epithelial cells
Curr. Biol. 15(3):255-261. doi:10.1016/j.cub.2005.01.033
Europe PMC | doi


2004

Riechmann V, Ephrussi A. (2004)
Par-1 regulates bicoid mRNA localisation by phosphorylating Exuperantia
Development 131(23):5897-5907. doi:10.1242/dev.01515
Europe PMC | doi

Chekulaeva M, Ephrussi A. (2004)
Drosophila development: RNA interference ab ovo
Curr. Biol. 14(11):R428-30. doi:10.1016/j.cub.2004.05.036
Europe PMC | doi

Yano T, López de Quinto S, Matsui Y, Shevchenko A, Shevchenko A, Ephrussi A. (2004)
Hrp48, a Drosophila hnRNPA/B homolog, binds and regulates translation of oskar mRNA
Dev. Cell 6(5):637-648. doi:10.1016/s1534-5807(04)00132-7
Europe PMC | doi

Hachet O, Ephrussi A. (2004)
Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization
Nature 428(6986):959-963. doi:10.1038/nature02521
Europe PMC | doi

Yoshida S, Müller HA, Wodarz A, Ephrussi A. (2004)
PKA-R1 spatially restricts Oskar expression for Drosophila embryonic patterning
Development 131(6):1401-1410. doi:10.1242/dev.01034
Europe PMC | doi

Ephrussi A, St Johnston D. (2004)
Seeing is believing: the bicoid morphogen gradient matures
Cell 116(2):143-152. doi:10.1016/s0092-8674(04)00037-6
Europe PMC | doi


2003

Teixeira L, Rabouille C, Rørth P, Ephrussi A, Vanzo NF. (2003)
Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism
Mech. Dev. 120(9):1071-1081. doi:10.1016/s0925-4773(03)00158-8
Europe PMC | doi

Filardo P, Ephrussi A. (2003)
Bruno regulates gurken during Drosophila oogenesis
Mech. Dev. 120(3):289-297. doi:10.1016/s0925-4773(02)00454-9
Europe PMC | doi

Castagnetti S, Ephrussi A. (2003)
Orb and a long poly(A) tail are required for efficient oskar translation at the posterior pole of the Drosophila oocyte
Development 130(5):835-843. doi:10.1242/dev.00309
Europe PMC | doi


2002

Vaccari T, Ephrussi A. (2002)
The fusome and microtubules enrich Par-1 in the oocyte, where it effects polarization in conjunction with Par-3, BicD, Egl, and dynein
Curr. Biol. 12(17):1524-1528. doi:10.1016/s0960-9822(02)01079-5
Europe PMC | doi

Vanzo NF, Ephrussi A. (2002)
Oskar anchoring restricts pole plasm formation to the posterior of the Drosophila oocyte
Development 129(15):3705-3714.
Europe PMC

Tazuke SI, Schulz C, Gilboa L, Fogarty M, Mahowald AP, Guichet A, Ephrussi A, Wood CG, Lehmann R, Fuller MT. (2002)
A germline-specific gap junction protein required for survival of differentiating early germ cells
Development 129(10):2529-2539.
Europe PMC

Riechmann V, Gutierrez GJ, Filardo P, Nebreda AR, Ephrussi A. (2002)
Par-1 regulates stability of the posterior determinant Oskar by phosphorylation
Nat. Cell Biol. 4(5):337-342.
Europe PMC


2001

Hachet O, Ephrussi A. (2001)
Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport
Curr. Biol. 11(21):1666-1674. doi:10.1016/s0960-9822(01)00508-5
Europe PMC | doi

Riechmann V, Ephrussi A. (2001)
Axis formation during Drosophila oogenesis
Curr. Opin. Genet. Dev. 11(4):374-383. doi:10.1016/s0959-437x(00)00207-0
Europe PMC | doi


2000

Tomancak P, Piano F, Riechmann V, Gunsalus KC, Kemphues KJ, Ephrussi A. (2000)
A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation
Nat. Cell Biol. 2(7):458-460. doi:10.1038/35017101
Europe PMC | doi

Mata J, Curado S, Ephrussi A, Rørth P. (2000)
Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis
Cell 101(5):511-522. doi:10.1016/s0092-8674(00)80861-2
Europe PMC | doi

Castagnetti S, Hentze MW, Ephrussi A, Gebauer F. (2000)
Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries
Development 127(5):1063-1068.
Europe PMC

Jiménez G, Guichet A, Ephrussi A, Casanova J. (2000)
Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning
Genes Dev. 14(2):224-231.
Europe PMC


1998

Gunkel N, Yano T, Markussen FH, Olsen LC, Ephrussi A. (1998)
Localization-dependent translation requires a functional interaction between the 5' and 3' ends of oskar mRNA
Genes Dev. 12(11):1652-1664. doi:10.1101/gad.12.11.1652
Europe PMC | doi

Tomancak P, Guichet A, Zavorszky P, Ephrussi A. (1998)
Oocyte polarity depends on regulation of gurken by Vasa
Development 125(9):1723-1732.
Europe PMC


1997

Glotzer JB, Ephrussi A. (1997)
Analysis of RNA distribution during Drosophila oogenesis using fluorescent in situ hybridization
In: Richter JD (ed.), A Comparative Methods Approach to the Study of Oocytes and Embryos. Oxford University Press, New York.

Glotzer JB, Saffrich R, Glotzer M, Ephrussi A. (1997)
Cytoplasmic flows localize injected oskar RNA in Drosophila oocytes
Curr. Biol. 7(5):326-337. doi:10.1016/s0960-9822(06)00156-4
Europe PMC | doi

Florence B, Guichet A, Ephrussi A, Laughon A. (1997)
Ftz-F1 is a cofactor in Ftz activation of the Drosophila engrailed gene
Development 124(4):839-847.
Europe PMC

Guichet A, Copeland JW, Erdélyi M, Hlousek D, Závorszky P, Ho J, Brown S, Percival-Smith A, Krause HM, Ephrussi A. (1997)
The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors
Nature 385(6616):548-552. doi:10.1038/385548a0
Europe PMC | doi

Markussen FH, Breitwieser W, Ephrussi A. (1997)
Efficient translation and phosphorylation of Oskar require Oskar protein and the RNA helicase Vasa
Paper presented at the Cold Spring Harbor Symposium on Quantitative Biology - Pattern Formation During Development, PLAINVIEW, NEW YORK, 1997.Cold Spring Harb. Symp. Quant. Biol. 62:13-17.
Europe PMC


1996

Breitwieser W, Markussen FH, Horstmann H, Ephrussi A. (1996)
Oskar protein interaction with Vasa represents an essential step in polar granule assembly
Genes Dev. 10(17):2179-2188. doi:10.1101/gad.10.17.2179
Europe PMC | doi

Glotzer JB, Ephrussi A. (1996)
mRNA localization and the cytoskeleton
Semin. Cell Dev. Biol. 7(3):357-365.
Europe PMC


1995

Markussen FH, Michon AM, Breitwieser W, Ephrussi A. (1995)
Translational control of oskar generates short OSK, the isoform that induces pole plasma assembly
Development 121(11):3723-3732.
Europe PMC

Erdélyi M, Michon AM, Guichet A, Glotzer JB, Ephrussi A. (1995)
Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization
Nature 377(6549):524-527. doi:10.1038/377524a0
Europe PMC | doi


1994

Lehmann R, Ephrussi A. (1994)
Germ plasm formation and germ cell determination in Drosophila
Paper presented at the Symposium on Germline Development, LONDON, ENGLAND, JUL 20-22, 1993.Ciba Found. Symp. 182:282-96; discussion 296-300.
Europe PMC


1992

Ephrussi A, Lehmann R. (1992)
Induction of germ cell formation by oskar
Nature 358(6385):387-392. doi:10.1038/358387a0
Europe PMC | doi


1991

Ephrussi A, Dickinson LK, Lehmann R. (1991)
Oskar organizes the germ plasm and directs localization of the posterior determinant nanos
Cell 66(1):37-50. doi:10.1016/0092-8674(91)90137-n
Europe PMC | doi