Staff at EMBL
Dr. François Spitz
Group Leader
Spitz Group
Joint appointment: Genome Biology Unit
Joint appointment: EMBL Monterotondo
EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
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Biography
PhD 1997, Institut Cochin de Génétique Moléculaire, Paris.
Postdoctoral research at the University of Geneva.
Group leader at EMBL since 2006.
Publications
From remote enhancers to gene regulation: charting the genome's regulatory landscapes. Symmons, O. & Spitz, F. Philos Trans R Soc Lond B Biol Sci. 2013 May 6;368(1620):20120358. doi:10.1098/rstb.2012.0358. Print 2013. PubMed
TRACER: a resource to study the regulatory architecture of the mouse genome. Chen, C.K., Symmons, O., Uslu, V.V., Tsujimura, T., Ruf, S., Smedley, D. & Spitz, F. BMC Genomics. 2013 Apr 2;14:215. doi: 10.1186/1471-2164-14-215. PubMed
An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape. Marinic, M., Aktas, T., Ruf, S. & Spitz, F. Dev Cell. 2013 Mar 11;24(5):530-42. doi: 10.1016/j.devcel.2013.01.025. Epub 2013Feb 28. PubMed
Phenotypic impact of genomic structural variation: insights from and for human disease. Weischenfeldt, J., Symmons, O., Spitz, F. & Korbel, J.O. Nat Rev Genet. 2013 Feb;14(2):125-38. doi: 10.1038/nrg3373. PubMed
Transcription factors: from enhancer binding to developmental control. Spitz, F. & Furlong, E.E. Nat Rev Genet. 2012 Sep;13(9):613-26. doi: 10.1038/nrg3207. Epub 2012 Aug 7. PubMed
A regulatory archipelago controls hox genes transcription in digits. Montavon, T., Soshnikova, N., Mascrez, B., Joye, E., Thevenet, L., Splinter, E., de Laat, W., Spitz, F. & Duboule, D. Cell. 2011 Nov 23;147(5):1132-45. PubMed
Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor. Ruf, S., Symmons, O., Uslu, V.V., Dolle, D., Hot, C., Ettwiller, L. & Spitz, F. Nat Genet. 2011 Mar 20;43(4):379-86. PubMed
KAP1 controls endogenous retroviruses in embryonic stem cells. Rowe, H.M., Jakobsson, J., Mesnard, D., Rougemont, J., Reynard, S., Aktas, T., Maillard, P.V., Layard-Liesching, H., Verp, S., Marquis, J., Spitz, F., Constam, D.B. & Trono, D. Nature. 2010 Jan 14;463(7278):237-40. PubMed
Uncoupling time and space in the collinear regulation of Hox genes. Tschopp, P., Tarchini, B., Spitz, F., Zakany, J. & Duboule, D. PLoS Genet. 2009 Mar;5(3):e1000398. Epub 2009 Mar 6. PubMed
Analysis of mammalian gene batteries reveals both stable ancestral cores and highly dynamic regulatory sequences. Ettwiller, L., Budd, A., Spitz, F. & Wittbrodt, J. Genome Biol. 2008 Dec 16;9(12):R172. PubMed
Genotypic features of lentivirus transgenic mice. Sauvain, M.O., Dorr, A.P., Stevenson, B., Quazzola, A., Naef, F., Wiznerowicz, M., Schutz, F., Jongeneel, V., Duboule, D., Spitz, F. & Trono, D. J Virol. 2008 Jul;82(14):7111-9. Epub 2008 May 7. PubMed
Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3. Friedli, M., Nikolaev, S., Lyle, R., Arcangeli, M., Duboule, D., Spitz, F. & Antonarakis, S.E. Mamm Genome. 2008 Apr;19(4):272-8. Epub 2008 Apr 5. PubMed
Global control regions and regulatory landscapes in vertebrate development and evolution. Spitz, F. & Duboule, D. Adv Genet. 2008;61:175-205. PubMed
Transgenic analysis of Hoxd gene regulation during digit development. Gonzalez, F., Duboule, D. & Spitz, F. Dev Biol. 2007 Jun 15;306(2):847-59. Epub 2007 Mar 23. PubMed
Genomics and development: Taking developmental biology to new heights. Spitz, F. & Furlong, E.E. Dev Cell. 2006 Oct;11(4):451-7. PubMed
