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Staff at EMBL

Dr. François Spitz

Group Leader
Spitz Group Joint appointment: Genome Biology Unit
Joint appointment: EMBL Monterotondo

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail


PhD 1997, Institut Cochin de Génétique Moléculaire, Paris.
Postdoctoral research at the University of Geneva.
Group leader at EMBL since 2006.


Long-range enhancers regulating Myc expression are required for normal facial morphogenesis. Uslu, V.V., Petretich, M., Ruf, S., Langenfeld, K., Fonseca, N.A., Marioni, J.C. & Spitz, F. Nat Genet. 2014 Jul;46(7):753-8. doi: 10.1038/ng.2971. Epub 2014 May 25. Europe PMC

The architecture of gene expression: integrating dispersed cis-regulatory modules into coherent regulatory domains. Schwarzer, W. & Spitz, F. Curr Opin Genet Dev. 2014 Jun 4;27C:74-82. doi: 10.1016/j.gde.2014.03.014. Europe PMC

Functional and topological characteristics of mammalian regulatory domains. Symmons, O., Uslu, V.V., Tsujimura, T., Ruf, S., Nassari, S., Schwarzer, W., Ettwiller, L. & Spitz, F. Genome Res. 2014 Mar;24(3):390-400. doi: 10.1101/gr.163519.113. Epub 2014 Jan 7. Europe PMC

Efficient site-specific transgenesis and enhancer activity tests in medaka using PhiC31 integrase. Kirchmaier, S., Hockendorf, B., Moller, E.K., Bornhorst, D., Spitz, F. & Wittbrodt, J. Development. 2013 Oct;140(20):4287-95. doi: 10.1242/dev.096081. Epub 2013 Sep 18. Europe PMC

A switch between topological domains underlies HoxD genes collinearity in mouse limbs. Andrey, G., Montavon, T., Mascrez, B., Gonzalez, F., Noordermeer, D., Leleu, M., Trono, D., Spitz, F. & Duboule, D. Science. 2013 Jun 7;340(6137):1234167. doi: 10.1126/science.1234167. Europe PMC

From remote enhancers to gene regulation: charting the genome's regulatory landscapes. Symmons, O. & Spitz, F. Philos Trans R Soc Lond B Biol Sci. 2013 May 6;368(1620):20120358. doi:10.1098/rstb.2012.0358. Print 2013. Europe PMC

TRACER: a resource to study the regulatory architecture of the mouse genome. Chen, C.K., Symmons, O., Uslu, V.V., Tsujimura, T., Ruf, S., Smedley, D. & Spitz, F. BMC Genomics. 2013 Apr 2;14:215. doi: 10.1186/1471-2164-14-215. Europe PMC

An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape. Marinic, M., Aktas, T., Ruf, S. & Spitz, F. Dev Cell. 2013 Mar 11;24(5):530-42. doi: 10.1016/j.devcel.2013.01.025. Epub 2013Feb 28. Europe PMC

Phenotypic impact of genomic structural variation: insights from and for human disease. Weischenfeldt, J., Symmons, O., Spitz, F. & Korbel, J.O. Nat Rev Genet. 2013 Feb;14(2):125-38. doi: 10.1038/nrg3373. Europe PMC

Transcription factors: from enhancer binding to developmental control. Spitz, F. & Furlong, E.E. Nat Rev Genet. 2012 Sep;13(9):613-26. doi: 10.1038/nrg3207. Epub 2012 Aug 7. Europe PMC

A regulatory archipelago controls hox genes transcription in digits. Montavon, T., Soshnikova, N., Mascrez, B., Joye, E., Thevenet, L., Splinter, E., de Laat, W., Spitz, F. & Duboule, D. Cell. 2011 Nov 23;147(5):1132-45. Europe PMC

Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor. Ruf, S., Symmons, O., Uslu, V.V., Dolle, D., Hot, C., Ettwiller, L. & Spitz, F. Nat Genet. 2011 Mar 20;43(4):379-86. doi: 10.1038/ng.790. Europe PMC

KAP1 controls endogenous retroviruses in embryonic stem cells. Rowe, H.M., Jakobsson, J., Mesnard, D., Rougemont, J., Reynard, S., Aktas, T., Maillard, P.V., Layard-Liesching, H., Verp, S., Marquis, J., Spitz, F., Constam, D.B. & Trono, D. Nature. 2010 Jan 14;463(7278):237-40. Europe PMC

Uncoupling time and space in the collinear regulation of Hox genes. Tschopp, P., Tarchini, B., Spitz, F., Zakany, J. & Duboule, D. PLoS Genet. 2009 Mar;5(3):e1000398. Epub 2009 Mar 6. Europe PMC

Analysis of mammalian gene batteries reveals both stable ancestral cores and highly dynamic regulatory sequences. Ettwiller, L., Budd, A., Spitz, F. & Wittbrodt, J. Genome Biol. 2008 Dec 16;9(12):R172. Europe PMC

Genotypic features of lentivirus transgenic mice. Sauvain, M.O., Dorr, A.P., Stevenson, B., Quazzola, A., Naef, F., Wiznerowicz, M., Schutz, F., Jongeneel, V., Duboule, D., Spitz, F. & Trono, D. J Virol. 2008 Jul;82(14):7111-9. Epub 2008 May 7. Europe PMC

Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3. Friedli, M., Nikolaev, S., Lyle, R., Arcangeli, M., Duboule, D., Spitz, F. & Antonarakis, S.E. Mamm Genome. 2008 Apr;19(4):272-8. Epub 2008 Apr 5. Europe PMC

Global control regions and regulatory landscapes in vertebrate development and evolution. Spitz, F. & Duboule, D. Adv Genet. 2008;61:175-205. doi: 10.1016/S0065-2660(07)00006-5. Europe PMC

Transgenic analysis of Hoxd gene regulation during digit development. Gonzalez, F., Duboule, D. & Spitz, F. Dev Biol. 2007 Jun 15;306(2):847-59. Epub 2007 Mar 23. Europe PMC

Genomics and development: Taking developmental biology to new heights. Spitz, F. & Furlong, E.E. Dev Cell. 2006 Oct;11(4):451-7. Europe PMC

Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes. Spitz, F., Herkenne, C., Morris, M.A. & Duboule, D. Nat Genet. 2005 Aug;37(8):889-93. Epub 2005 Jul 3. Europe PMC

Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Zuniga, A., Michos, O., Spitz, F., Haramis, A.P., Panman, L., Galli, A., Vintersten, K., Klasen, C., Mansfield, W., Kuc, S., Duboule, D., Dono, R. & Zeller, R. Genes Dev. 2004 Jul 1;18(13):1553-64. Epub 2004 Jun 15. Europe PMC

A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Spitz, F., Gonzalez, F. & Duboule, D. Cell. 2003 May 2;113(3):405-17. Europe PMC