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Staff at EMBL


Dr. François Spitz

Group Leader
Spitz Group Joint appointment: Genome Biology Unit
Joint appointment: EMBL Monterotondo

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail


PhD 1997, Institut Cochin de Génétique Moléculaire, Paris.
Postdoctoral research at the University of Geneva.
Group leader at EMBL since 2006.


Total: 26 publication(s)


Uslu VV, Petretich M, Ruf S, Langenfeld K, Fonseca NA, Marioni JC, Spitz F. (2014)
Long-range enhancers regulating Myc expression are required for normal facial morphogenesis
Nat. Genet. 46(7):753-758. doi:10.1038/ng.2971
Europe PMC | doi

Schwarzer W, Spitz F. (2014)
The architecture of gene expression: integrating dispersed cis-regulatory modules into coherent regulatory domains
Curr. Opin. Genet. Dev. 27C:74-82. doi:10.1016/j.gde.2014.03.014
Europe PMC | doi

Symmons O, Uslu VV, Tsujimura T, Ruf S, Nassari S, Schwarzer W, Ettwiller L, Spitz F. (2014)
Functional and topological characteristics of mammalian regulatory domains
Genome Res. 24(3):390-400. doi:10.1101/gr.163519.113
Europe PMC | doi


Kirchmaier S, Höckendorf B, Möller EK, Bornhorst D, Spitz F, Wittbrodt J. (2013)
Efficient site-specific transgenesis and enhancer activity tests in medaka using PhiC31 integrase
Development 140(20):4287-4295. doi:10.1242/dev.096081
Europe PMC | doi

Andrey G, Montavon T, Mascrez B, Gonzalez F, Noordermeer D, Leleu M, Trono D, Spitz F, Duboule D. (2013)
A switch between topological domains underlies HoxD genes collinearity in mouse limbs
Science 340(6137):1234167. doi:10.1126/science.1234167
Europe PMC | doi

Marinić M, Aktas T, Ruf S, Spitz F. (2013)
An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape
Dev. Cell 24(5):530-542. doi:10.1016/j.devcel.2013.01.025
Europe PMC | doi

Weischenfeldt J, Symmons O, Spitz F, Korbel JO. (2013)
Phenotypic impact of genomic structural variation: insights from and for human disease
Nat. Rev. Genet. 14(2):125-138. doi:10.1038/nrg3373
Europe PMC | doi

Symmons O, Spitz F. (2013)
From remote enhancers to gene regulation: charting the genome's regulatory landscapes
Philos. Trans. R. Soc. Lond., B, Biol. Sci. 368(1620):20120358. doi:10.1098/rstb.2012.0358
Europe PMC | doi

Chen CK, Symmons O, Uslu VV, Tsujimura T, Ruf S, Smedley D, Spitz F. (2013)
TRACER: a resource to study the regulatory architecture of the mouse genome
BMC Genomics 14:215. doi:10.1186/1471-2164-14-215
Europe PMC | doi


Spitz F, Furlong EE. (2012)
Transcription factors: from enhancer binding to developmental control
Nat. Rev. Genet. 13(9):613-626. doi:10.1038/nrg3207
Europe PMC | doi


Montavon T, Soshnikova N, Mascrez B, Joye E, Thevenet L, Splinter E, de Laat W, Spitz F, Duboule D. (2011)
A regulatory archipelago controls Hox genes transcription in digits
Cell 147(5):1132-1145. doi:10.1016/j.cell.2011.10.023
Europe PMC | doi

Ruf S, Symmons O, Uslu VV, Dolle D, Hot C, Ettwiller L, Spitz F. (2011)
Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor
Nat. Genet. 43(4):379-386. doi:10.1038/ng.790
Europe PMC | doi


Rowe HM, Jakobsson J, Mesnard D, Rougemont J, Reynard S, Aktas T, Maillard PV, Layard-Liesching H, Verp S, Marquis J, Spitz F, Constam DB, Trono D. (2010)
KAP1 controls endogenous retroviruses in embryonic stem cells
Nature 463(7278):237-240. doi:10.1038/nature08674
Europe PMC | doi


Tschopp P, Tarchini B, Spitz F, Zakany J, Duboule D. (2009)
Uncoupling time and space in the collinear regulation of Hox genes
PLoS Genet. 5(3):e1000398. doi:10.1371/journal.pgen.1000398
Europe PMC | doi


Sauvain MO, Dorr AP, Stevenson B, Quazzola A, Naef F, Wiznerowicz M, Schütz F, Jongeneel V, Duboule D, Spitz F, Trono D. (2008)
Genotypic features of lentivirus transgenic mice
J. Virol. 82(14):7111-7119. doi:10.1128/jvi.00623-08
Europe PMC | doi

Friedli M, Nikolaev S, Lyle R, Arcangeli M, Duboule D, Spitz F, Antonarakis SE. (2008)
Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3
Mamm. Genome 19(4):272-278. doi:10.1007/s00335-008-9106-0
Europe PMC | doi

Ettwiller L, Budd A, Spitz F, Wittbrodt J. (2008)
Analysis of mammalian gene batteries reveals both stable ancestral cores and highly dynamic regulatory sequences
Genome Biol. 9(12):R172. doi:10.1186/gb-2008-9-12-r172
Europe PMC | doi

Spitz F, Duboule D. (2008)
Global control regions and regulatory landscapes in vertebrate development and evolution
Adv. Genet. 61:175-205. doi:10.1016/s0065-2660(07)00006-5
Europe PMC | doi


Gonzalez F, Duboule D, Spitz F. (2007)
Transgenic analysis of Hoxd gene regulation during digit development
Dev. Biol. 306(2):847-859. doi:10.1016/j.ydbio.2007.03.020
Europe PMC | doi


Spitz F, Furlong EE. (2006)
Genomics and development: Taking developmental biology to new heights
Dev. Cell 11(4):451-457. doi:10.1016/j.devcel.2006.09.013
Europe PMC | doi


Spitz F, Herkenne C, Morris MA, Duboule D. (2005)
Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes
Nat. Genet. 37(8):889-893. doi:10.1038/ng1597
Europe PMC | doi

Spitz F, Duboule D. (2005)
Developmental biology: reproduction in clusters
Nature 434(7034):715-716. doi:10.1038/434715a
Europe PMC | doi


Zuniga A, Michos O, Spitz F, Haramis AP, Panman L, Galli A, Vintersten K, Klasen C, Mansfield W, Kuc S, Duboule D, Dono R, Zeller R. (2004)
Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression
Genes Dev. 18(13):1553-1564. doi:10.1101/gad.299904
Europe PMC | doi

Spitz F. (2004)
[Genes without borders: global control of transcription activity at the level of several genes]
Med Sci (Paris) 20(1):9-10. doi:10.1051/medsci/20042019
Europe PMC | doi


Spitz F, Gonzalez F, Duboule D. (2003)
A global control region defines a chromosomal regulatory landscape containing the HoxD cluster
Cell 113(3):405-417. doi:10.1016/s0092-8674(03)00310-6
Europe PMC | doi


Spitz F, Benbacer L, Sabourin JC, Salminen M, Chen F, Cywiner C, Kahn A, Chatelet F, Maire P, Daegelen D. (2002)
Fiber-type specific and position-dependent expression of a transgene in limb muscles
Differentiation 70(8):457-467. doi:10.1046/j.1432-0436.2002.700808.x
Europe PMC | doi