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Staff at EMBL

CP-60003181

Prof. Matthias Hentze

Director, Co-Director of MMPU
Director Hentze Group Molecular Medicine Partnership Unit Resource Development Alumni Relations Joint appointment: Genome Biology Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Personal Assistant
Nina Papritz
Room: ATC B2402
Tel: +49 6221 387-8909
Fax: +49 6221 387-8144
E-mail: director@embl.org
Administrative Assistant, Director's Office
Esther Liebig
Room: ATC B2402
Tel: +49 6221 387-8914
Fax: +49 6221 387-8144
E-mail: director@embl.org

Biography

MD 1984, University of Münster.
Postdoctoral training at the NIH, Bethesda.
Group Leader at EMBL since 1989.
Senior Scientist since 1998.
Co-Director of the EMBL/University of Heidelberg Molecular Medicine Partnership Unit since 2002.
Associate Director of EMBL since 2005.
ERC Advanced Investigator since 2011.
Director of EMBL since 2013.

Publications

Total: 231 publication(s)

2014

Bhuvanagiri M, Lewis J, Putzker K, Becker JP, Leicht S, Krijgsveld J, Batra R, Turnwald B, Jovanovic B, Hauer C, Sieber J, Hentze MW, Kulozik AE. (2014)
5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.
EMBO Mol Med doi:10.15252/emmm.201404461
Europe PMC | doi

Kramer K, Sachsenberg T, Beckmann BM, Qamar S, Boon KL, Hentze MW, Kohlbacher O, Urlaub H. (2014)
Photo-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins
Nat. Methods 11(10):1064-1070. doi:10.1038/nmeth.3092
Europe PMC | doi

Altamura S, Kessler R, Gröne HJ, Gretz N, Hentze MW, Galy B, Muckenthaler MU. (2014)
Resistance of Ferroportin to Hepcidin Binding causes Exocrine Pancreatic Failure and Fatal Iron Overload
Cell Metab. 20(2):359-367. doi:10.1016/j.cmet.2014.07.007
Europe PMC | doi

Strein C, Alleaume AM, Rothbauer U, Hentze MW, Castello A. (2014)
A versatile assay for RNA-binding proteins in living cells
RNA 20(5):721-731. doi:10.1261/rna.043562.113
Europe PMC | doi

Chung J, Anderson SA, Gwynn B, Deck KM, Chen MJ, Langer NB, Shaw GC, Huston NC, Boyer LF, Datta S, Paradkar PN, Li L, Wei Z, Lambert AJ, Sahr K, Wittig JG, Chen W, Lu W, Galy B, Schlaeger TM, Hentze MW, Ward DM, Kaplan J, Eisenstein RS, Peters LL, Paw BH. (2014)
Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria
J. Biol. Chem. 289(11):7835-7843. doi:10.1074/jbc.m114.547778
Europe PMC | doi

Mleczko-Sanecka K, Roche F, da Silva AR, Call D, D'Alessio F, Ragab A, Lapinski PE, Ummanni R, Korf U, Oakes C, Damm G, D'Alessandro LA, Klingmüller U, King PD, Boutros M, Hentze MW, Muckenthaler MU. (2014)
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling
Blood 123(10):1574-1585. doi:10.1182/blood-2013-07-515957
Europe PMC | doi

Hollerer I, Grund K, Hentze MW, Kulozik AE. (2014)
mRNA 3'end processing: A tale of the tail reaches the clinic
EMBO Mol Med 6(1):16-26. doi:10.1002/emmm.201303300
Europe PMC | doi


2013

Danckwardt S, Hentze MW, Kulozik AE. (2013)
Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond
J. Mol. Med. 91(11):1257-1271. doi:10.1007/s00109-013-1074-5
Europe PMC | doi

Kwon SC, Yi H, Eichelbaum K, Föhr S, Fischer B, You KT, Castello A, Krijgsveld J, Hentze MW, Kim VN. (2013)
The RNA-binding protein repertoire of embryonic stem cells
Nat. Struct. Mol. Biol. 20(9):1122-1130. doi:10.1038/nsmb.2638
Europe PMC | doi

Casarrubea D, Viatte L, Hallas T, Vasanthakumar A, Eisenstein RS, Schümann K, Hentze MW, Galy B. (2013)
Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function
J. Mol. Med. 91(7):871-881. doi:10.1007/s00109-013-1008-2
Europe PMC | doi

Hentze MW, Izaurralde E. (2013)
Making sense of nonsense
Nat. Struct. Mol. Biol. 20(6):651-653. doi:10.1038/nsmb.2601
Europe PMC | doi

Castello A, Fischer B, Hentze MW, Preiss T. (2013)
RNA-binding proteins in Mendelian disease
Trends Genet. 29(5):318-327. doi:10.1016/j.tig.2013.01.004
Europe PMC | doi

Hentze MW, Preiss T. (2013)
Circular RNAs: splicing's enigma variations
EMBO J. 32(7):923-925. doi:10.1038/emboj.2013.53
Europe PMC | doi

Galy B, Ferring-Appel D, Becker C, Gretz N, Gröne HJ, Schümann K, Hentze MW. (2013)
Iron regulatory proteins control a mucosal block to intestinal iron absorption
Cell Rep 3(3):844-857. doi:10.1016/j.celrep.2013.02.026
Europe PMC | doi

Castello A, Horos R, Strein C, Fischer B, Eichelbaum K, Steinmetz LM, Krijgsveld J, Hentze MW. (2013)
System-wide identification of RNA-binding proteins by interactome capture
Nat Protoc 8(3):491-500. doi:10.1038/nprot.2013.020
Europe PMC | doi

Anderson SA, Nizzi CP, Chang YI, Deck KM, Schmidt PJ, Galy B, Damnernsawad A, Broman AT, Kendziorski C, Hentze MW, Fleming MD, Zhang J, Eisenstein RS. (2013)
The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption
Cell Metab. 17(2):282-290. doi:10.1016/j.cmet.2013.01.007
Europe PMC | doi


2012

D'Alessio F, Hentze MW, Muckenthaler MU. (2012)
The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation
J. Hepatol. 57(5):1052-1060. doi:10.1016/j.jhep.2012.06.015
Europe PMC | doi

Gebauer F, Preiss T, Hentze MW. (2012)
From cis-regulatory elements to complex RNPs and back
Cold Spring Harb Perspect Biol 4(7):a012245. doi:10.1101/cshperspect.a012245
Europe PMC | doi

Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW. (2012)
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
Cell 149(6):1393-1406. doi:10.1016/j.cell.2012.04.031
Europe PMC | doi

Moretti F, Kaiser C, Zdanowicz-Specht A, Hentze MW. (2012)
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding
Nat. Struct. Mol. Biol. 19(6):603-608. doi:10.1038/nsmb.2309
Europe PMC | doi

Casanova CM, Sehr P, Putzker K, Hentze MW, Neumann B, Duncan KE, Thoma C. (2012)
Automated high-throughput RNAi screening in human cells combined with reporter mRNA transfection to identify novel regulators of translation
PLoS ONE 7(9):e45943. doi:10.1371/journal.pone.0045943
Europe PMC | doi


2011

Sanchez M, Galy B, Schwanhaeusser B, Blake J, Bähr-Ivacevic T, Benes V, Selbach M, Muckenthaler MU, Hentze MW. (2011)
Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins
Blood 118(22):e168-79. doi:10.1182/blood-2011-04-343541
Europe PMC | doi

Medenbach J, Seiler M, Hentze MW. (2011)
Translational control via protein-regulated upstream open reading frames
Cell 145(6):902-913. doi:10.1016/j.cell.2011.05.005
Europe PMC | doi

Rakotondrafara AM, Hentze MW. (2011)
An efficient factor-depleted mammalian in vitro translation system
Nat Protoc 6(5):563-571. doi:10.1038/nprot.2011.314
Europe PMC | doi

Neu-Yilik G, Amthor B, Gehring NH, Bahri S, Paidassi H, Hentze MW, Kulozik AE. (2011)
Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon
RNA 17(5):843-854. doi:10.1261/rna.2401811
Europe PMC | doi

Castoldi M, Vujic Spasic M, Altamura S, Elmén J, Lindow M, Kiss J, Stolte J, Sparla R, D'Alessandro LA, Klingmüller U, Fleming RE, Longerich T, Gröne HJ, Benes V, Kauppinen S, Hentze MW, Muckenthaler MU. (2011)
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice
J. Clin. Invest. 121(4):1386-1396. doi:10.1172/jci44883
Europe PMC | doi

Danckwardt S, Gantzert AS, Macher-Goeppinger S, Probst HC, Gentzel M, Wilm M, Gröne HJ, Schirmacher P, Hentze MW, Kulozik AE. (2011)
p38 MAPK controls prothrombin expression by regulated RNA 3' end processing
Mol. Cell 41(3):298-310. doi:10.1016/j.molcel.2010.12.032
Europe PMC | doi


2010

Moretti F, Thermann R, Hentze MW. (2010)
Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame
RNA 16(12):2493-2502. doi:10.1261/rna.2384610
Europe PMC | doi

Bhuvanagiri M, Schlitter AM, Hentze MW, Kulozik AE. (2010)
NMD: RNA biology meets human genetic medicine
Biochem. J. 430(3):365-377. doi:10.1042/bj20100699
Europe PMC | doi

Cohen LA, Gutierrez L, Weiss A, Leichtmann-Bardoogo Y, Zhang DL, Crooks DR, Sougrat R, Morgenstern A, Galy B, Hentze MW, Lazaro FJ, Rouault TA, Meyron-Holtz EG. (2010)
Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway
Blood 116(9):1574-1584. doi:10.1182/blood-2009-11-253815
Europe PMC | doi

Galy B, Ferring-Appel D, Sauer SW, Kaden S, Lyoumi S, Puy H, Kölker S, Gröne HJ, Hentze MW. (2010)
Iron regulatory proteins secure mitochondrial iron sufficiency and function
Cell Metab. 12(2):194-201. doi:10.1016/j.cmet.2010.06.007
Europe PMC | doi

Hentze MW, Preiss T. (2010)
The REM phase of gene regulation
Trends Biochem. Sci. 35(8):423-426. doi:10.1016/j.tibs.2010.05.009
Europe PMC | doi

Campillos M, Cases I, Hentze MW, Sanchez M. (2010)
SIREs: searching for iron-responsive elements
Nucleic Acids Res. 38(Web Server issue):W360-7. doi:10.1093/nar/gkq371
Europe PMC | doi

Hentze MW, Muckenthaler MU, Galy B, Camaschella C. (2010)
Two to tango: regulation of Mammalian iron metabolism
Cell 142(1):24-38. doi:10.1016/j.cell.2010.06.028
Europe PMC | doi

Mleczko-Sanecka K, Casanovas G, Ragab A, Breitkopf K, Müller A, Boutros M, Dooley S, Hentze MW, Muckenthaler MU. (2010)
SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression
Blood 115(13):2657-2665. doi:10.1182/blood-2009-09-238105
Europe PMC | doi

Lopes TJ, Luganskaja T, Vujić Spasić M, Hentze MW, Muckenthaler MU, Schümann K, Reich JG. (2010)
Systems analysis of iron metabolism: the network of iron pools and fluxes
BMC Syst Biol 4:112. doi:10.1186/1752-0509-4-112
Europe PMC | doi

Vainshtein Y, Sanchez M, Brazma A, Hentze MW, Dandekar T, Muckenthaler MU. (2010)
The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays
BMC Bioinformatics 11:112. doi:10.1186/1471-2105-11-112
Europe PMC | doi

Pisarev AV, Skabkin MA, Pisareva VP, Skabkina OV, Rakotondrafara AM, Hentze MW, Hellen CU, Pestova TV. (2010)
The role of ABCE1 in eukaryotic posttermination ribosomal recycling
Mol. Cell 37(2):196-210. doi:10.1016/j.molcel.2009.12.034
Europe PMC | doi


2009

Duncan KE, Strein C, Hentze MW. (2009)
The SXL-UNR corepressor complex uses a PABP-mediated mechanism to inhibit ribosome recruitment to msl-2 mRNA
Mol. Cell 36(4):571-582. doi:10.1016/j.molcel.2009.09.042
Europe PMC | doi

Zdanowicz A, Thermann R, Kowalska J, Jemielity J, Duncan K, Preiss T, Darzynkiewicz E, Hentze MW. (2009)
Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression
Mol. Cell 35(6):881-888. doi:10.1016/j.molcel.2009.09.009
Europe PMC | doi

Viatte L, Gröne HJ, Hentze MW, Galy B. (2009)
In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation
J. Mol. Med. 87(9):913-921. doi:10.1007/s00109-009-0494-8
Europe PMC | doi

Clerici M, Mourão A, Gutsche I, Gehring NH, Hentze MW, Kulozik A, Kadlec J, Sattler M, Cusack S. (2009)
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2
EMBO J. 28(15):2293-2306. doi:10.1038/emboj.2009.175
Europe PMC | doi

Casanovas G, Mleczko-Sanecka K, Altamura S, Hentze MW, Muckenthaler MU. (2009)
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD
J. Mol. Med. 87(5):471-480. doi:10.1007/s00109-009-0447-2
Europe PMC | doi

Gehring NH, Lamprinaki S, Kulozik AE, Hentze MW. (2009)
Disassembly of exon junction complexes by PYM
Cell 137(3):536-548. doi:10.1016/j.cell.2009.02.042
Europe PMC | doi

Gehring NH, Lamprinaki S, Hentze MW, Kulozik AE. (2009)
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay
PLoS Biol. 7(5):e1000120. doi:10.1371/journal.pbio.1000120
Europe PMC | doi

Hentze MW. (2009)
EMBO Molecular Medicine: Conquering new frontiers
EMBO Mol Med 1(1):5. doi:10.1002/emmm.200900011
Europe PMC | doi

Beilharz TH, Humphreys DT, Clancy JL, Thermann R, Martin DI, Hentze MW, Preiss T. (2009)
microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells
PLoS ONE 4(8) doi:10.1371/journal.pone.0006783
Europe PMC | doi


2008

Thoma C, Fraterman S, Gentzel M, Wilm M, Hentze MW. (2008)
Translation initiation by the c-myc mRNA internal ribosome entry sequence and the poly(A) tail
RNA 14(8):1579-1589. doi:10.1261/rna.1043908
Europe PMC | doi

Verga Falzacappa MV, Casanovas G, Hentze MW, Muckenthaler MU. (2008)
A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells
J. Mol. Med. 86(5):531-540. doi:10.1007/s00109-008-0313-7
Europe PMC | doi

Ivanov PV, Gehring NH, Kunz JB, Hentze MW, Kulozik AE. (2008)
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways
EMBO J. 27(5):736-747. doi:10.1038/emboj.2008.17
Europe PMC | doi

Danckwardt S, Hentze MW, Kulozik AE. (2008)
3' end mRNA processing: molecular mechanisms and implications for health and disease
EMBO J. 27(3):482-498. doi:10.1038/sj.emboj.7601932
Europe PMC | doi

Vujić Spasić M, Kiss J, Herrmann T, Galy B, Martinache S, Stolte J, Gröne HJ, Stremmel W, Hentze MW, Muckenthaler MU. (2008)
Hfe acts in hepatocytes to prevent hemochromatosis
Cell Metab. 7(2):173-178. doi:10.1016/j.cmet.2007.11.014
Europe PMC | doi

Galy B, Ferring-Appel D, Kaden S, Gröne HJ, Hentze MW. (2008)
Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum
Cell Metab. 7(1):79-85. doi:10.1016/j.cmet.2007.10.006
Europe PMC | doi

Castoldi M, Schmidt S, Benes V, Hentze MW, Muckenthaler MU. (2008)
miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes
Nat Protoc 3(2):321-329. doi:10.1038/nprot.2008.4
Europe PMC | doi

Pantopoulos K, Hentze MW. (2008)
Regulation of iron metabolism in higher eukaryotes: iron-sulfur centers as genetic switches
In: Ferreira GC, Moura JJG, Franco R (eds.), Inorganic biochemistry and regulatory mechanisms of iron metabolism. Wiley-VCH Verlag GmbH. pp 131-152.doi:10.1002/9783527613700.ch08
Europe PMC | doi

Muckenthaler MU, Galy B, Hentze MW. (2008)
Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network
Annu. Rev. Nutr. 28:197-213. doi:10.1146/annurev.nutr.28.061807.155521
Europe PMC | doi

Gehring NH, Hentze MW, Kulozik AE. (2008)
Tethering assays to investigate nonsense-mediated mRNA decay activating proteins
Meth. Enzymol. 448:467-482. doi:10.1016/s0076-6879(08)02623-2
Europe PMC | doi


2007

Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG. (2007)
A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain
Nat. Struct. Mol. Biol. 14(10):897-903. doi:10.1038/nsmb1302
Europe PMC | doi

Percy MJ, Sanchez M, Swierczek S, McMullin MF, Mojica-Henshaw MP, Muckenthaler MU, Prchal JT, Hentze MW. (2007)
Is congenital secondary erythrocytosis/polycythemia caused by activating mutations within the HIF-2 alpha iron-responsive element?
Blood 110(7):2776-2777. doi:10.1182/blood-2007-03-082503
Europe PMC | doi

Castoldi M, Benes V, Hentze MW, Muckenthaler MU. (2007)
miChip: a microarray platform for expression profiling of microRNAs based on locked nucleic acid (LNA) oligonucleotide capture probes
Methods 43(2):146-152. doi:10.1016/j.ymeth.2007.04.009
Europe PMC | doi

Fillebeen C, Muckenthaler M, Andriopoulos B, Bisaillon M, Mounir Z, Hentze MW, Koromilas AE, Pantopoulos K. (2007)
Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells
J. Hepatol. 47(1):12-22. doi:10.1016/j.jhep.2007.01.035
Europe PMC | doi

Thermann R, Hentze MW. (2007)
Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation
Nature 447(7146):875-878. doi:10.1038/nature05878
Europe PMC | doi

Danckwardt S, Kaufmann I, Gentzel M, Foerstner KU, Gantzert AS, Gehring NH, Neu-Yilik G, Bork P, Keller W, Wilm M, Hentze MW, Kulozik AE. (2007)
Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals
EMBO J. 26(11):2658-2669. doi:10.1038/sj.emboj.7601699
Europe PMC | doi

Sanchez M, Galy B, Muckenthaler MU, Hentze MW. (2007)
Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency
Nat. Struct. Mol. Biol. 14(5):420-426. doi:10.1038/nsmb1222
Europe PMC | doi

Vujic Spasic M, Kiss J, Herrmann T, Kessler R, Stolte J, Galy B, Rathkolb B, Wolf E, Stremmel W, Hentze MW, Muckenthaler MU. (2007)
Physiologic systemic iron metabolism in mice deficient for duodenal Hfe
Blood 109(10):4511-4517. doi:10.1182/blood-2006-07-036186
Europe PMC | doi

Ludwiczek S, Theurl I, Muckenthaler MU, Jakab M, Mair SM, Theurl M, Kiss J, Paulmichl M, Hentze MW, Ritter M, Weiss G. (2007)
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1
Nat. Med. 13(4):448-454. doi:10.1038/nm1542
Europe PMC | doi

Mihailovich M, Thermann R, Grohovaz F, Hentze MW, Zacchetti D. (2007)
Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region
Nucleic Acids Res. 35(9):2975-2985. doi:10.1093/nar/gkm191
Europe PMC | doi

Sanchez M, Galy B, Hentze MW, Muckenthaler MU. (2007)
Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays
Nat Protoc 2(8):2033-2042. doi:10.1038/nprot.2007.293
Europe PMC | doi

Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU. (2007)
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
Blood 109(1):353-358. doi:10.1182/blood-2006-07-033969
Europe PMC | doi

Gebauer F, Hentze MW. (2007)
Studying translational control in Drosophila cell-free systems
Meth. Enzymol. 429:23-33. doi:10.1016/s0076-6879(07)29002-0
Europe PMC | doi

Viegas MH, Gehring NH, Breit S, Hentze MW, Kulozik AE. (2007)
The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway
Nucleic Acids Res. 35(13):4542-4551. doi:10.1093/nar/gkm461
Europe PMC | doi


2006

Boelz S, Neu-Yilik G, Gehring NH, Hentze MW, Kulozik AE. (2006)
A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay
Biochem. Biophys. Res. Commun. 349(1):186-191. doi:10.1016/j.bbrc.2006.08.017
Europe PMC | doi

Galy B, Hölter SM, Klopstock T, Ferring D, Becker L, Kaden S, Wurst W, Gröne HJ, Hentze MW. (2006)
Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse
Nat. Genet. 38(9):967-9; discussion 969-70. doi:10.1038/ng0906-967
Europe PMC | doi

Sanchez M, Galy B, Dandekar T, Bengert P, Vainshtein Y, Stolte J, Muckenthaler MU, Hentze MW. (2006)
Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy
J. Biol. Chem. 281(32):22865-22874. doi:10.1074/jbc.m603876200
Europe PMC | doi

Holbrook JA, Neu-Yilik G, Gehring NH, Kulozik AE, Hentze MW. (2006)
Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay
EMBO Rep. 7(7):722-726. doi:10.1038/sj.embor.7400721
Europe PMC | doi

Corna G, Galy B, Hentze MW, Cairo G. (2006)
IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice
J. Mol. Med. 84(7):551-560. doi:10.1007/s00109-006-0068-y
Europe PMC | doi

Kunz JB, Neu-Yilik G, Hentze MW, Kulozik AE, Gehring NH. (2006)
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation
RNA 12(6):1015-1022. doi:10.1261/rna.12506
Europe PMC | doi

Castoldi M, Schmidt S, Benes V, Noerholm M, Kulozik AE, Hentze MW, Muckenthaler MU. (2006)
A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA)
RNA 12(5):913-920. doi:10.1261/rna.2332406
Europe PMC | doi

Danckwardt S, Hartmann K, Katz B, Hentze MW, Levy Y, Eichele R, Deutsch V, Kulozik AE, Ben-Tal O. (2006)
The prothrombin 20209 C-->T mutation in Jewish-Moroccan Caucasians: molecular analysis of gain-of-function of 3' end processing
J. Thromb. Haemost. 4(5):1078-1085. doi:10.1111/j.1538-7836.2006.01885.x
Europe PMC | doi

Mok H, Mlodnicka AE, Hentze MW, Muckenthaler M, Schumacher A. (2006)
The molecular circuitry regulating the switch between iron deficiency and overload in mice
J. Biol. Chem. 281(12):7946-7951. doi:10.1074/jbc.m509857200
Europe PMC | doi

Chekulaeva M, Hentze MW, Ephrussi A. (2006)
Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles
Cell 124(3):521-533. doi:10.1016/j.cell.2006.01.031
Europe PMC | doi

Duncan K, Grskovic M, Strein C, Beckmann K, Niggeweg R, Abaza I, Gebauer F, Wilm M, Hentze MW. (2006)
Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation
Genes Dev. 20(3):368-379. doi:10.1101/gad.371406
Europe PMC | doi

Danckwardt S, Hartmann K, Gehring NH, Hentze MW, Kulozik AE. (2006)
3' end processing of the prothrombin mRNA in thrombophilia
Acta Haematol. 115(3-4):192-197. doi:10.1159/000090934
Europe PMC | doi

Stockklausner C, Breit S, Neu-Yilik G, Echner N, Hentze MW, Kulozik AE, Gehring NH. (2006)
The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD)
Nucleic Acids Res. 34(8):2355-2363. doi:10.1093/nar/gkl277
Europe PMC | doi


2005

Galy B, Ferring D, Hentze MW. (2005)
Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes
Genesis 43(4):181-188. doi:10.1002/gene.20169
Europe PMC | doi

Galy B, Ferring D, Minana B, Bell O, Janser HG, Muckenthaler M, Schümann K, Hentze MW. (2005)
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)
Blood 106(7):2580-2589. doi:10.1182/blood-2005-04-1365
Europe PMC | doi

Gehring NH, Kunz JB, Neu-Yilik G, Breit S, Viegas MH, Hentze MW, Kulozik AE. (2005)
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements
Mol. Cell 20(1):65-75. doi:10.1016/j.molcel.2005.08.012
Europe PMC | doi

Hundsdoerfer P, Thoma C, Hentze MW. (2005)
Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation
Proc. Natl. Acad. Sci. U.S.A. 102(38):13421-13426. doi:10.1073/pnas.0506536102
Europe PMC | doi

Beckmann K, Grskovic M, Gebauer F, Hentze MW. (2005)
A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila
Cell 122(4):529-540. doi:10.1016/j.cell.2005.06.011
Europe PMC | doi

Fillebeen C, Rivas-Estilla AM, Bisaillon M, Ponka P, Muckenthaler M, Hentze MW, Koromilas AE, Pantopoulos K. (2005)
Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus
J. Biol. Chem. 280(10):9049-9057. doi:10.1074/jbc.m412687200
Europe PMC | doi


2004

Gebauer F, Hentze MW. (2004)
Molecular mechanisms of translational control
Nat. Rev. Mol. Cell Biol. 5(10):827-835. doi:10.1038/nrm1488
Europe PMC | doi

Thoma C, Bergamini G, Galy B, Hundsdoerfer P, Hentze MW. (2004)
Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP
Mol. Cell 15(6):925-935. doi:10.1016/j.molcel.2004.08.021
Europe PMC | doi

Holbrook JA, Neu-Yilik G, Hentze MW, Kulozik AE. (2004)
Nonsense-mediated decay approaches the clinic
Nat. Genet. 36(8):801-808. doi:10.1038/ng1403
Europe PMC | doi

Galy B, Ferring D, Benesova M, Benes V, Hentze MW. (2004)
Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo
RNA 10(7):1019-1025. doi:10.1261/rna.7220704
Europe PMC | doi

Danckwardt S, Gehring NH, Neu-Yilik G, Hundsdoerfer P, Pforsich M, Frede U, Hentze MW, Kulozik AE. (2004)
The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations
Blood 104(2):428-435. doi:10.1182/blood-2003-08-2894
Europe PMC | doi

Roy CN, Custodio AO, de Graaf J, Schneider S, Akpan I, Montross LK, Sanchez M, Gaudino A, Hentze MW, Andrews NC, Muckenthaler MU. (2004)
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice
Nat. Genet. 36(5):481-485. doi:10.1038/ng1350
Europe PMC | doi

Bonnah RA, Muckenthaler MU, Carlson H, Minana B, Enns CA, Hentze MW, So M. (2004)
Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis
Cell. Microbiol. 6(5):473-484. doi:10.1111/j.1462-5822.2004.00376.x
Europe PMC | doi

Hentze MW, Muckenthaler MU, Andrews NC. (2004)
Balancing acts: molecular control of mammalian iron metabolism
Cell 117(3):285-297. doi:10.1016/s0092-8674(04)00343-5
Europe PMC | doi

Schümann K, Brennan K, Weiss M, Pantopoulos K, Hentze MW. (2004)
Rat duodenal IRP1 activity and iron absorption in iron deficiency and after H2O2 perfusion
Eur. J. Clin. Invest. 34(4):275-282. doi:10.1111/j.1365-2362.2004.01335.x
Europe PMC | doi

Wang J, Chen G, Muckenthaler M, Galy B, Hentze MW, Pantopoulos K. (2004)
Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity
Mol. Cell. Biol. 24(3):954-965. doi:10.1128/mcb.24.3.954-965.2004
Europe PMC | doi