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Staff at EMBL

Dr. Bruno Galy

Staff Scientist
Hentze Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Publications

Total: 25 publication(s)

2014

Altamura S, Kessler R, Gröne HJ, Gretz N, Hentze MW, Galy B, Muckenthaler MU. (2014)
Resistance of Ferroportin to Hepcidin Binding causes Exocrine Pancreatic Failure and Fatal Iron Overload
Cell Metab. 20(2):359-367. doi:10.1016/j.cmet.2014.07.007
Europe PMC | doi

Chung J, Anderson SA, Gwynn B, Deck KM, Chen MJ, Langer NB, Shaw GC, Huston NC, Boyer LF, Datta S, Paradkar PN, Li L, Wei Z, Lambert AJ, Sahr K, Wittig JG, Chen W, Lu W, Galy B, Schlaeger TM, Hentze MW, Ward DM, Kaplan J, Eisenstein RS, Peters LL, Paw BH. (2014)
Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria
J. Biol. Chem. 289(11):7835-7843. doi:10.1074/jbc.m114.547778
Europe PMC | doi


2013

Casarrubea D, Viatte L, Hallas T, Vasanthakumar A, Eisenstein RS, Schümann K, Hentze MW, Galy B. (2013)
Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function
J. Mol. Med. 91(7):871-881. doi:10.1007/s00109-013-1008-2
Europe PMC | doi

Galy B, Ferring-Appel D, Becker C, Gretz N, Gröne HJ, Schümann K, Hentze MW. (2013)
Iron regulatory proteins control a mucosal block to intestinal iron absorption
Cell Rep 3(3):844-857. doi:10.1016/j.celrep.2013.02.026
Europe PMC | doi

Anderson SA, Nizzi CP, Chang YI, Deck KM, Schmidt PJ, Galy B, Damnernsawad A, Broman AT, Kendziorski C, Hentze MW, Fleming MD, Zhang J, Eisenstein RS. (2013)
The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption
Cell Metab. 17(2):282-290. doi:10.1016/j.cmet.2013.01.007
Europe PMC | doi


2011

Styś A, Galy B, Starzyński RR, Smuda E, Drapier JC, Lipiński P, Bouton C. (2011)
Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide
J. Biol. Chem. 286(26):22846-22854. doi:10.1074/jbc.m111.231902
Europe PMC | doi


2010

Cohen LA, Gutierrez L, Weiss A, Leichtmann-Bardoogo Y, Zhang DL, Crooks DR, Sougrat R, Morgenstern A, Galy B, Hentze MW, Lazaro FJ, Rouault TA, Meyron-Holtz EG. (2010)
Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway
Blood 116(9):1574-1584. doi:10.1182/blood-2009-11-253815
Europe PMC | doi

Galy B, Ferring-Appel D, Sauer SW, Kaden S, Lyoumi S, Puy H, Kölker S, Gröne HJ, Hentze MW. (2010)
Iron regulatory proteins secure mitochondrial iron sufficiency and function
Cell Metab. 12(2):194-201. doi:10.1016/j.cmet.2010.06.007
Europe PMC | doi

Hentze MW, Muckenthaler MU, Galy B, Camaschella C. (2010)
Two to tango: regulation of Mammalian iron metabolism
Cell 142(1):24-38. doi:10.1016/j.cell.2010.06.028
Europe PMC | doi


2009

Viatte L, Gröne HJ, Hentze MW, Galy B. (2009)
In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation
J. Mol. Med. 87(9):913-921. doi:10.1007/s00109-009-0494-8
Europe PMC | doi


2008

Vujić Spasić M, Kiss J, Herrmann T, Galy B, Martinache S, Stolte J, Gröne HJ, Stremmel W, Hentze MW, Muckenthaler MU. (2008)
Hfe acts in hepatocytes to prevent hemochromatosis
Cell Metab. 7(2):173-178. doi:10.1016/j.cmet.2007.11.014
Europe PMC | doi

Galy B, Ferring-Appel D, Kaden S, Gröne HJ, Hentze MW. (2008)
Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum
Cell Metab. 7(1):79-85. doi:10.1016/j.cmet.2007.10.006
Europe PMC | doi

Muckenthaler MU, Galy B, Hentze MW. (2008)
Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network
Annu. Rev. Nutr. 28:197-213. doi:10.1146/annurev.nutr.28.061807.155521
Europe PMC | doi


2007

Sanchez M, Galy B, Muckenthaler MU, Hentze MW. (2007)
Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency
Nat. Struct. Mol. Biol. 14(5):420-426. doi:10.1038/nsmb1222
Europe PMC | doi

Vujic Spasic M, Kiss J, Herrmann T, Kessler R, Stolte J, Galy B, Rathkolb B, Wolf E, Stremmel W, Hentze MW, Muckenthaler MU. (2007)
Physiologic systemic iron metabolism in mice deficient for duodenal Hfe
Blood 109(10):4511-4517. doi:10.1182/blood-2006-07-036186
Europe PMC | doi

Sanchez M, Galy B, Hentze MW, Muckenthaler MU. (2007)
Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays
Nat Protoc 2(8):2033-2042. doi:10.1038/nprot.2007.293
Europe PMC | doi


2006

Galy B, Hölter SM, Klopstock T, Ferring D, Becker L, Kaden S, Wurst W, Gröne HJ, Hentze MW. (2006)
Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse
Nat. Genet. 38(9):967-9; discussion 969-70. doi:10.1038/ng0906-967
Europe PMC | doi

Sanchez M, Galy B, Dandekar T, Bengert P, Vainshtein Y, Stolte J, Muckenthaler MU, Hentze MW. (2006)
Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy
J. Biol. Chem. 281(32):22865-22874. doi:10.1074/jbc.m603876200
Europe PMC | doi

Corna G, Galy B, Hentze MW, Cairo G. (2006)
IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice
J. Mol. Med. 84(7):551-560. doi:10.1007/s00109-006-0068-y
Europe PMC | doi


2005

Galy B, Ferring D, Hentze MW. (2005)
Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes
Genesis 43(4):181-188. doi:10.1002/gene.20169
Europe PMC | doi

Galy B, Ferring D, Minana B, Bell O, Janser HG, Muckenthaler M, Schümann K, Hentze MW. (2005)
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)
Blood 106(7):2580-2589. doi:10.1182/blood-2005-04-1365
Europe PMC | doi


2004

Thoma C, Bergamini G, Galy B, Hundsdoerfer P, Hentze MW. (2004)
Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP
Mol. Cell 15(6):925-935. doi:10.1016/j.molcel.2004.08.021
Europe PMC | doi

Galy B, Ferring D, Benesova M, Benes V, Hentze MW. (2004)
Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo
RNA 10(7):1019-1025. doi:10.1261/rna.7220704
Europe PMC | doi

Wang J, Chen G, Muckenthaler M, Galy B, Hentze MW, Pantopoulos K. (2004)
Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity
Mol. Cell. Biol. 24(3):954-965. doi:10.1128/mcb.24.3.954-965.2004
Europe PMC | doi


2001

Vagner S, Galy B, Pyronnet S. (2001)
Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites
EMBO Rep. 2(10):893-898. doi:10.1093/embo-reports/kve208
Europe PMC | doi