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Staff at EMBL

Dr. Bruno Galy

Staff Scientist
Hentze Group

EMBL Heidelberg, Meyerhofstra├če 1, 69117 Heidelberg, Germany

E-mail: send a mail


Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function. Casarrubea, D., Viatte, L., Hallas, T., Vasanthakumar, A., Eisenstein, R.S., Schumann, K., Hentze, M.W. & Galy, B. J Mol Med (Berl). 2013 Jul;91(7):871-81. doi: 10.1007/s00109-013-1008-2. Epub2013 Mar 1. Europe PMC

Iron regulatory proteins control a mucosal block to intestinal iron absorption. Galy, B., Ferring-Appel, D., Becker, C., Gretz, N., Grone, H.J., Schumann, K. & Hentze, M.W. Cell Rep. 2013 Mar 28;3(3):844-57. doi: 10.1016/j.celrep.2013.02.026. Epub 2013Mar 21. Europe PMC

The IRP1-HIF-2alpha axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. Anderson, S.A., Nizzi, C.P., Chang, Y.I., Deck, K.M., Schmidt, P.J., Galy, B., Damnernsawad, A., Broman, A.T., Kendziorski, C., Hentze, M.W., Fleming, M.D., Zhang, J. & Eisenstein, R.S. Cell Metab. 2013 Feb 5;17(2):282-90. doi: 10.1016/j.cmet.2013.01.007. Europe PMC

Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Cohen, L.A., Gutierrez, L., Weiss, A., Leichtmann-Bardoogo, Y., Zhang, D.L., Crooks, D.R., Sougrat, R., Morgenstern, A., Galy, B., Hentze, M.W., Lazaro, F.J., Rouault, T.A. & Meyron-Holtz, E.G. Blood. 2010 Sep 2;116(9):1574-84. doi: 10.1182/blood-2009-11-253815. Epub 2010May 14. Europe PMC

Iron regulatory proteins secure mitochondrial iron sufficiency and function. Galy, B., Ferring-Appel, D., Sauer, S.W., Kaden, S., Lyoumi, S., Puy, H., Kolker, S., Grone, H.J. & Hentze, M.W. Cell Metab. 2010 Aug 4;12(2):194-201. Europe PMC

Two to tango: regulation of Mammalian iron metabolism. Hentze, M.W., Muckenthaler, M.U., Galy, B. & Camaschella, C. Cell. 2010 Jul 9;142(1):24-38. Europe PMC

In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation. Viatte, L., Grone, H.J., Hentze, M.W. & Galy, B. J Mol Med. 2009 Sep;87(9):913-21. Epub 2009 Jun 17. Europe PMC

Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism. Ferring-Appel, D., Hentze, M.W. & Galy, B. Blood. 2009 Jan 15;113(3):679-87. Europe PMC

Hfe acts in hepatocytes to prevent hemochromatosis. Vujic Spasic, M., Kiss, J., Herrmann, T., Galy, B., Martinache, S., Stolte, J., Grone, H.J., Stremmel, W., Hentze, M.W. & Muckenthaler, M.U. Cell Metab. 2008 Feb;7(2):173-8. Europe PMC

Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Galy, B., Ferring-Appel, D., Kaden, S., Grone, H.J. & Hentze, M.W. Cell Metab. 2008 Jan;7(1):79-85. Europe PMC

Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Muckenthaler, M.U., Galy, B. & Hentze, M.W. Annu Rev Nutr. 2008;28:197-213. Europe PMC

Identification of target mRNAs of regulatory RNA-binding proteins using mRNP immunopurification and microarrays. Sanchez, M., Galy, B., Hentze, M.W. & Muckenthaler, M.U. Nat Protoc. 2007 Aug;2(8):2033-2042. Europe PMC

Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Sanchez, M., Galy, B., Muckenthaler, M.U. & Hentze, M.W. Nat Struct Mol Biol. 2007 May;14(5):420-6. Epub 2007 Apr 8. Europe PMC

Physiologic systemic iron metabolism in mice deficient for duodenal Hfe. Spasic, M.V., Kiss, J., Herrmann, T., Kessler, R., Stolte, J., Galy, B., Rathkolb, B., Wolf, E., Stremmel, W., Hentze, M.W. & Muckenthaler, M.U. Blood. 2007 May 15;109(10):4511-7. Epub 2007 Jan 30. Europe PMC

Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse. Galy, B., Holter, S.M., Klopstock, T., Ferring, D., Becker, L., Kaden, S., Wurst, W., Grone, H.J. & Hentze, M.W. Nat Genet. 2006 Sep;38(9):967-9. Europe PMC

Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. Sanchez, M., Galy, B., Dandekar, T., Bengert, P., Vainshtein, Y., Stolte, J., Muckenthaler, M.U. & Hentze, M.W. J Biol Chem. 2006 Aug 11;281(32):22865-74. Epub 2006 Jun 7. Europe PMC

IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice. Corna, G., Galy, B., Hentze, M.W. & Cairo, G. J Mol Med. 2006 Jul;84(7):551-60. Epub 2006 Jun 13. Europe PMC

Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes. Galy, B., Ferring, D. & Hentze, M.W. Genesis. 2005 Dec;43(4):181-8. Europe PMC

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Galy, B., Ferring, D., Minana, B., Bell, O., Janser, H.G., Muckenthaler, M., Schumann, K. & Hentze, M.W. Blood 2005 Oct 1;106(7):2580-9. Epub 2005 Jun 14. Europe PMC

Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP. Thoma, C., Bergamini, G., Galy, B., Hundsdoerfer, P. & Hentze, M.W. Mol Cell 2004 Sep 24;15(6):925-35. Europe PMC

Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo. Galy, B., Ferring, D., Benesova, M., Benes, V. & Hentze, M.W. RNA 2004 Jul;10(7):1019-25. Europe PMC

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity. Wang, J., Chen, G., Muckenthaler, M., Galy, B., Hentze, M.W. & Pantopoulos, K. Mol Cell Biol 2004 Feb;24(3):954-65. Europe PMC