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Staff at EMBL

Alfredo Castello Palomares

Staff Scientist
Hentze Group

EMBL Heidelberg, Meyerhofstra├če 1, 69117 Heidelberg, Germany

E-mail: send a mail


A versatile assay for RNA-binding proteins in living cells. Strein, C., Alleaume, A.M., Rothbauer, U., Hentze, M.W. & Castello, A. RNA. 2014 Mar 24. Europe PMC

The RNA-binding protein repertoire of embryonic stem cells. Kwon, S.C., Yi, H., Eichelbaum, K., Fohr, S., Fischer, B., You, K.T., Castello, A., Krijgsveld, J., Hentze, M.W. & Kim, V.N. Nat Struct Mol Biol. 2013 Sep;20(9):1122-30. doi: 10.1038/nsmb.2638. Epub 2013Aug 4. Europe PMC

RNA-binding proteins in Mendelian disease. Castello, A., Fischer, B., Hentze, M.W. & Preiss, T. Trends Genet. 2013 May;29(5):318-27. doi: 10.1016/j.tig.2013.01.004. Epub 2013Feb 15. Europe PMC

System-wide identification of RNA-binding proteins by interactome capture. Castello, A., Horos, R., Strein, C., Fischer, B., Eichelbaum, K., Steinmetz, L.M., Krijgsveld, J. & Hentze, M.W. Nat Protoc. 2013 Feb 14;8(3):491-500. doi: 10.1038/nprot.2013.020. Epub 2013 Feb14. Europe PMC

African swine fever virus controls the host transcription and cellular machinery of protein synthesis. Sanchez, E.G., Quintas, A., Nogal, M., Castello, A. & Revilla, Y. Virus Res. 2013 Apr;173(1):58-75. doi: 10.1016/j.virusres.2012.10.025. Epub 2012Nov 12. Europe PMC

Poliovirus 2A Protease Triggers a Selective Nucleo-Cytoplasmic Redistribution of Splicing Factors to Regulate Alternative Pre-mRNA Splicing. Alvarez, E., Castello, A., Carrasco, L. & Izquierdo, J.M. PLoS One. 2013 Sep 16;8(9):e73723. doi: 10.1371/journal.pone.0073723. Europe PMC

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins. Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B.M., Strein, C., Davey, N.E., Humphreys, D.T., Preiss, T., Steinmetz, L.M., Krijgsveld, J. & Hentze, M.W. Cell. 2012 Jun 8;149(6):1393-406. Epub 2012 May 31. Europe PMC

A non-infectious cell-based phenotypic assay for the assessment of HIV-1 susceptibility to protease inhibitors. Buzon, M.J., Erkizia, I., Pou, C., Minuesa, G., Puertas, M.C., Esteve, A., Castello, A., Santos, J.R., Prado, J.G., Izquierdo-Useros, N., Pattery, T., Van Houtte, M., Carrasco, L., Clotet, B., Ruiz, L. & Martinez-Picado, J. J Antimicrob Chemother. 2012 Jan;67(1):32-8. Epub 2011 Oct 12. Europe PMC

GCN2 Has Inhibitory Effect on Human Immunodeficiency Virus-1 Protein Synthesis and Is Cleaved upon Viral Infection. Del Pino, J., Jimenez, J.L., Ventoso, I., Castello, A., Munoz-Fernandez, M.A., de Haro, C. & Berlanga, J.J. PLoS One. 2012;7(10):e47272. doi: 10.1371/journal.pone.0047272. Epub 2012 Oct 23. Europe PMC

Alternative splicing, a new target to block cellular gene expression by poliovirus 2A protease. Alvarez, E., Castello, A., Carrasco, L. & Izquierdo, J.M. Biochem Biophys Res Commun. 2011 Oct 14;414(1):142-7. Epub 2011 Sep 16. Europe PMC

Functional impairment of eIF4A and eIF4G factors correlates with inhibition of influenza virus mRNA translation. Yanguez, E., Castello, A., Welnowska, E., Carrasco, L., Goodfellow, I. & Nieto, A. Virology. 2011 Apr 25;413(1):93-102. Epub 2011 Mar 5. Europe PMC

The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases. Castello, A., Alvarez, E. & Carrasco, L. J Biomed Biotechnol. 2011;2011:369648. Epub 2011 Apr 14. Europe PMC

Translation of mRNAs from vesicular stomatitis virus and vaccinia virus is differentially blocked in cells with depletion of eIF4GI and/or eIF4GII. Welnowska, E., Castello, A., Moral, P. & Carrasco, L. J Mol Biol. 2009 Dec 4;394(3):506-21. Epub 2009 Sep 19. Europe PMC

RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage. Castello, A., Izquierdo, J.M., Welnowska, E. & Carrasco, L. J Cell Sci. 2009 Oct 15;122(Pt 20):3799-809. Epub 2009 Sep 29. Europe PMC

Regulation of host translational machinery by african Swine Fever virus. Castello, A., Quintas, A., Sanchez, E.G., Sabina, P., Nogal, M., Carrasco, L. & Revilla, Y. PLoS Pathog. 2009 Aug;5(8):e1000562. Epub 2009 Aug 28. Europe PMC

Dual mechanism for the translation of subgenomic mRNA from Sindbis virus in infected and uninfected cells. Sanz, M.A., Castello, A., Ventoso, I., Berlanga, J.J. & Carrasco, L. PLoS One. 2009;4(3):e4772. Epub 2009 Mar 10. Europe PMC

HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage. Castello, A., Franco, D., Moral-Lopez, P., Berlanga, J.J., Alvarez, E., Wimmer, E. & Carrasco, L. PLoS One. 2009 Nov 24;4(11):e7997. Europe PMC

Viroporins from RNA viruses induce caspase-dependent apoptosis. Madan, V., Castello, A. & Carrasco, L. Cell Microbiol. 2008 Feb;10(2):437-51. Epub 2007 Oct 24. Europe PMC

Differential inhibition of cellular and Sindbis virus translation by brefeldin A. Molina, S., Sanz, M.A., Madan, V., Ventoso, I., Castello, A. & Carrasco, L. Virology. 2007 Jul 5;363(2):430-6. Epub 2007 Mar 23. Europe PMC

Viral translation is coupled to transcription in Sindbis virus-infected cells. Sanz, M.A., Castello, A. & Carrasco, L. J Virol. 2007 Jul;81(13):7061-8. Epub 2007 Apr 18. Europe PMC

Differential cleavage of eIF4GI and eIF4GII in mammalian cells. Effects on translation. Castello, A., Alvarez, E. & Carrasco, L. J Biol Chem. 2006 Nov 3;281(44):33206-16. Epub 2006 Sep 7. Europe PMC

HIV protease cleaves poly(A)-binding protein. Alvarez, E., Castello, A., Menendez-Arias, L. & Carrasco, L. Biochem J. 2006 Jun 1;396(2):219-26. Europe PMC

Translation of Sindbis virus 26S mRNA does not require intact eukariotic initiation factor 4G. Castello, A., Sanz, M.A., Molina, S. & Carrasco, L. J Mol Biol. 2006 Feb 3;355(5):942-56. Epub 2005 Nov 28. Europe PMC