Staff at EMBL

Alfredo Castello Palomares

Staff Scientist
Hentze Group

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

Publications

System-wide identification of RNA-binding proteins by interactome capture. Castello, A., Horos, R., Strein, C., Fischer, B., Eichelbaum, K., Steinmetz, L.M., Krijgsveld, J. & Hentze, M.W. Nat Protoc. 2013 Feb 14;8(3):491-500. doi: 10.1038/nprot.2013.020. Epub 2013 Feb14. PubMed

African swine fever virus controls the host transcription and cellular machinery of protein synthesis. Sanchez, E.G., Quintas, A., Nogal, M., Castello, A. & Revilla, Y. Virus Res. 2013 Apr;173(1):58-75. doi: 10.1016/j.virusres.2012.10.025. Epub 2012Nov 12. PubMed

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins. Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B.M., Strein, C., Davey, N.E., Humphreys, D.T., Preiss, T., Steinmetz, L.M., Krijgsveld, J. & Hentze, M.W. Cell. 2012 Jun 8;149(6):1393-406. Epub 2012 May 31. PubMed

A non-infectious cell-based phenotypic assay for the assessment of HIV-1 susceptibility to protease inhibitors. Buzon, M.J., Erkizia, I., Pou, C., Minuesa, G., Puertas, M.C., Esteve, A., Castello, A., Santos, J.R., Prado, J.G., Izquierdo-Useros, N., Pattery, T., Van Houtte, M., Carrasco, L., Clotet, B., Ruiz, L. & Martinez-Picado, J. J Antimicrob Chemother. 2012 Jan;67(1):32-8. Epub 2011 Oct 12. PubMed

GCN2 Has Inhibitory Effect on Human Immunodeficiency Virus-1 Protein Synthesis and Is Cleaved upon Viral Infection. Del Pino, J., Jimenez, J.L., Ventoso, I., Castello, A., Munoz-Fernandez, M.A., de Haro, C. & Berlanga, J.J. PLoS One. 2012;7(10):e47272. doi: 10.1371/journal.pone.0047272. Epub 2012 Oct 23. PubMed

Alternative splicing, a new target to block cellular gene expression by poliovirus 2A protease. Alvarez, E., Castello, A., Carrasco, L. & Izquierdo, J.M. Biochem Biophys Res Commun. 2011 Oct 14;414(1):142-7. Epub 2011 Sep 16. PubMed

Functional impairment of eIF4A and eIF4G factors correlates with inhibition of influenza virus mRNA translation. Yanguez, E., Castello, A., Welnowska, E., Carrasco, L., Goodfellow, I. & Nieto, A. Virology. 2011 Apr 25;413(1):93-102. Epub 2011 Mar 5. PubMed

The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases. Castello, A., Alvarez, E. & Carrasco, L. J Biomed Biotechnol. 2011;2011:369648. Epub 2011 Apr 14. PubMed

Translation of mRNAs from vesicular stomatitis virus and vaccinia virus is differentially blocked in cells with depletion of eIF4GI and/or eIF4GII. Welnowska, E., Castello, A., Moral, P. & Carrasco, L. J Mol Biol. 2009 Dec 4;394(3):506-21. Epub 2009 Sep 19. PubMed

RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage. Castello, A., Izquierdo, J.M., Welnowska, E. & Carrasco, L. J Cell Sci. 2009 Oct 15;122(Pt 20):3799-809. Epub 2009 Sep 29. PubMed

Regulation of host translational machinery by african Swine Fever virus. Castello, A., Quintas, A., Sanchez, E.G., Sabina, P., Nogal, M., Carrasco, L. & Revilla, Y. PLoS Pathog. 2009 Aug;5(8):e1000562. Epub 2009 Aug 28. PubMed

Dual mechanism for the translation of subgenomic mRNA from Sindbis virus in infected and uninfected cells. Sanz, M.A., Castello, A., Ventoso, I., Berlanga, J.J. & Carrasco, L. PLoS One. 2009;4(3):e4772. Epub 2009 Mar 10. PubMed

HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage. Castello, A., Franco, D., Moral-Lopez, P., Berlanga, J.J., Alvarez, E., Wimmer, E. & Carrasco, L. PLoS One. 2009 Nov 24;4(11):e7997. PubMed

Viroporins from RNA viruses induce caspase-dependent apoptosis. Madan, V., Castello, A. & Carrasco, L. Cell Microbiol. 2008 Feb;10(2):437-51. Epub 2007 Oct 24. PubMed

Differential inhibition of cellular and Sindbis virus translation by brefeldin A. Molina, S., Sanz, M.A., Madan, V., Ventoso, I., Castello, A. & Carrasco, L. Virology. 2007 Jul 5;363(2):430-6. Epub 2007 Mar 23. PubMed

Viral translation is coupled to transcription in Sindbis virus-infected cells. Sanz, M.A., Castello, A. & Carrasco, L. J Virol. 2007 Jul;81(13):7061-8. Epub 2007 Apr 18. PubMed

Differential cleavage of eIF4GI and eIF4GII in mammalian cells. Effects on translation. Castello, A., Alvarez, E. & Carrasco, L. J Biol Chem. 2006 Nov 3;281(44):33206-16. Epub 2006 Sep 7. PubMed

HIV protease cleaves poly(A)-binding protein. Alvarez, E., Castello, A., Menendez-Arias, L. & Carrasco, L. Biochem J. 2006 Jun 1;396(2):219-26. PubMed

Translation of Sindbis virus 26S mRNA does not require intact eukariotic initiation factor 4G. Castello, A., Sanz, M.A., Molina, S. & Carrasco, L. J Mol Biol. 2006 Feb 3;355(5):942-56. Epub 2005 Nov 28. PubMed