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Staff at EMBL

Dr. François Nédélec

Group Leader
Nédélec Group Joint appointment: Structural and Computational Biology Unit

EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail

Biography

PhD 1998, Université Paris-Sud II.
Postdoctoral Research at EMBL.
Group Leader since 2005.
Joint Appointment with the Stuctural and Computational Biology Unit.

Publications

Collective behavior of minus-ended motors in mitotic microtubule asters gliding toward DNA. Athale, C.A., Dinarina, A., Nedelec, F. & Karsenti, E. Phys Biol. 2014 Jan 29;11(1):016008. Europe PMC

Mitotic Spindle Assembly on Chromatin Patterns Made with Deep UV Photochemistry. Tarnawska, K., Pugieux, C. & Nedelec, F. Methods Cell Biol. 2014;120:3-17. doi: 10.1016/B978-0-12-417136-7.00001-X. Europe PMC

Spindle assembly on immobilized chromatin micropatterns. Pugieux, C., Dmitrieff, S., Tarnawska, K. & Nedelec, F. Methods Enzymol. 2014;540:435-48. doi: 10.1016/B978-0-12-397924-7.00024-8. Europe PMC

A self-organization framework for symmetry breaking in the mammalian embryo. Wennekamp, S., Mesecke, S., Nedelec, F. & Hiiragi, T. Nat Rev Mol Cell Biol. 2013 Jul;14(7):452-9. doi: 10.1038/nrm3602. Epub 2013 Jun19. Europe PMC

Spindle pole body-anchored Kar3 drives the nucleus along microtubules from another nucleus in preparation for nuclear fusion during yeast karyogamy. Gibeaux, R., Politi, A.Z., Nedelec, F., Antony, C. & Knop, M. Genes Dev. 2013 Feb 1;27(3):335-49. doi: 10.1101/gad.206318.112. Europe PMC

Patterns of molecular motors that guide and sort filaments. Rupp, B. & Nedelec, F. Lab Chip. 2012 Nov 21;12(22):4903-10. doi: 10.1039/c2lc40250e. Europe PMC

Katanin contributes to interspecies spindle length scaling in Xenopus. Loughlin, R., Wilbur, J.D., McNally, F.J., Nedelec, F.J. & Heald, R. Cell. 2011 Dec 9;147(6):1397-407. Europe PMC

Augmin promotes meiotic spindle formation and bipolarity in Xenopus egg extracts. Petry, S., Pugieux, C., Nedelec, F.J. & Vale, R.D. Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14473-8. Epub 2011 Aug 15. Europe PMC

A computational model predicts Xenopus meiotic spindle organization. Loughlin, R., Heald, R. & Nedelec, F. J Cell Biol. 2010 Dec 27;191(7):1239-49. Epub 2010 Dec 20. Europe PMC

Condensins promote chromosome recoiling during early anaphase to complete sister chromatid separation. Renshaw, M.J., Ward, J.J., Kanemaki, M., Natsume, K., Nedelec, F.J. & Tanaka, T.U. Dev Cell. 2010 Aug 17;19(2):232-44. Europe PMC

Computational cell biology at the home of the helix. Ward, J.J. & Nedelec, F.J. EMBO Rep. 2010 Jun;11(6):413-5. Epub 2010 May 21. Europe PMC

La chromatine façonne le fuseau mitotique [Mitotic spindle assembly depends on chromatin geometry]. Pugieux, C. & Nedelec, F. Med Sci (Paris). 2010 Feb;26(2):139-42. doi: 10.1051/medsci/2010262139.
[This review in French summarises the results of Chromatin shapes the mitotic spindle.] Europe PMC

A theory of microtubule catastrophes and their regulation. Brun, L., Rupp, B., Ward, J.J. & Nedelec, F. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21173-8. Epub 2009 Nov 30. Europe PMC

Chromatin shapes the mitotic spindle. Dinarina, A., Pugieux, C., Corral, M.M., Loose, M., Spatz, J., Karsenti, E. & Nedelec, F. Cell. 2009 Aug 7;138(3):502-13. Europe PMC

Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation. Fu, C., Ward, J.J., Loiodice, I., Velve-Casquillas, G., Nedelec, F.J. & Tran, P.T. Dev Cell. 2009 Aug;17(2):257-67. Europe PMC

Effects of confinement on the self-organization of microtubules and motors. Pinot, M., Chesnel, F., Kubiak, J.Z., Arnal, I., Nedelec, F.J. & Gueroui, Z. Curr Biol. 2009 Jun 9;19(11):954-60. Epub 2009 May 7. Europe PMC

Force- and length-dependent catastrophe activities explain interphase microtubule organization in fission yeast. Foethke, D., Makushok, T., Brunner, D. & Nedelec, F. Mol Syst Biol. 2009;5:241. Epub 2009 Mar 17. Europe PMC

Regulation of microtubule dynamics by reaction cascades around chromosomes. Athale, C.A., Dinarina, A., Mora-Coral, M., Pugieux, C., Nedelec, F. & Karsenti, E. Science. 2008 Nov 21;322(5905):1243-1247. Epub 2008 Oct 23. Europe PMC

Mechanism of phototaxis in marine zooplankton. Jekely, G., Colombelli, J., Hausen, H., Guy, K., Stelzer, E.H.K., Nedelec, F. & Arendt, D. Nature. 2008 Nov 20;456(7220):395-9. Europe PMC

Spatial regulation improves antiparallel microtubule overlap during mitotic spindle assembly. Channels, W.E., Nedelec, F., Zheng, Y. & Iglesias, P.A. Biophys J. 2008 Apr 1;94(7):2598-609. Epub 2007 Dec 20. Europe PMC

Cortical microtubule contacts position the spindle in C. elegans embryos. Kozlowski, C., Srayko, M. & Nedelec, F. Cell. 2007 May 4;129(3):499-510. Europe PMC

Crosslinkers and motors organize dynamic microtubules to form stable bipolar arrays in fission yeast. Janson, M.E., Loughlin, R., Loiodice, I., Fu, C., Brunner, D., Nedelec, F. & Tran, P.T. Cell. 2007 Jan 26;128(2):357-68. Europe PMC

Modelling microtubule patterns. Karsenti, E., Nedelec, F. & Surrey, T. Nat Cell Biol. 2006 Nov;8(11):1204-11. Europe PMC

Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins. Goshima, G., Nédélec, F. & Vale, R.D. J Cell Biol 2005 Oct 24;171(2):229-40. Europe PMC

The mitotic spindle and actin tails. Karsenti, E. & Nedelec, F. Biol Cell 2004 Apr;96(3):237-40. Europe PMC

Self-organisation and forces in the microtubule cytoskeleton. Nedelec, F., Surrey, T. & Karsenti, E. Curr Opin Cell Biol. 2003 Feb;15(1):118-24. Europe PMC

Computer simulations reveal motor properties generating stable antiparallel microtubule interactions. Nedelec, F. J Cell Biol. 2002 Sep 16;158(6):1005-15. Epub 2002 Sep 16. Europe PMC

Physical properties determining self-organization of motors and microtubules. Surrey, T., Nédélec, F., Leibler, S. & Karsenti, E. Science 2001 May 11;292(5519):1167-71. Europe PMC

Dynamic concentration of motors in microtubule arrays. Nedelec, F., Surrey, T. & Maggs, A.C. Phys Rev Lett 2001 Apr 2;86(14):3192-5. Europe PMC

Dynamics of microtubule aster formation by motor complexes. Nédélec, F. & Surrey, T. C. R. Acad. Sci 2001; 2 (IV); 841-847.

De l'action collective des moteurs à l'ordre cellulaire. Nédélec, F. & Surrey, T. Médecine/Science 2000; 16:739 - 744.

Chromophore-assisted light inactivation and self-organization of microtubules and motors. Surrey, T., Elowitz, M.B., Wolf, P.E., Yang, F., Nédélec, F., Shokat, K. & Leibler, S. Proc Natl Acad Sci U S A 1998 Apr 14;95(8):4293-8. Europe PMC

Self-organization of microtubules and motors. Nedelec, Fr., Surrey, T., Maggs, A.C. & Leibler, S. Nature 1997 Sep 18;389(6648):305-8. Europe PMC