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Staff at EMBL


Prof. Maria Leptin

Director EMBO
Leptin Group

EMBO, Meyerhofstraße 1, 69117 Heidelberg, Germany

E-mail: send a mail
Web page:


PhD 1983, Basel Institute for Immunology.
Postdoctoral research then Staff Scientist at the MRC Laboratory for Molecular Biology, Cambridge, UK.
Group Leader at the MPI for Developmental Biology, Tübingen.
Professor, University of Cologne, Institute of Genetics.
Director of EMBO and Group Leader at EMBL since 2010.


Total: 27 publication(s)


Sigurbjörnsdóttir S, Mathew R, Leptin M. (2014)
Molecular mechanisms of de novo lumen formation
Nat. Rev. Mol. Cell Biol. 15(10):665-676. doi:10.1038/nrm3871
Europe PMC | doi

Banerjee S, Leptin M. (2014)
Systemic Response to Ultraviolet Radiation Involves Induction of Leukocytic IL-1β and Inflammation in Zebrafish
J. Immunol. 193(3):1408-1415. doi:10.4049/jimmunol.1400232
Europe PMC | doi

Ukken FP, Aprill I, JayaNandanan N, Leptin M. (2014)
Slik and the Receptor Tyrosine Kinase Breathless Mediate Localized Activation of Moesin in Terminal Tracheal Cells
PLoS ONE 9(7) doi:10.1371/journal.pone.0103323
Europe PMC | doi

Schafer G, Narasimha M, Vogelsang E, Leptin M. (2014)
Cadherin switching during the formation and differentiation of the Drosophila mesoderm - implications for epithelial-to-mesenchymal transitions
J CELL SCI 127(7):1511-1522. doi:10.1242/jcs.139485
Europe PMC | doi

Rembold M, Ciglar L, Yáñez-Cuna JO, Zinzen RP, Girardot C, Jain A, Welte MA, Stark A, Leptin M, Furlong EE. (2014)
A conserved role for Snail as a potentiator of active transcription
Genes Dev. 28(2):167-181. doi:10.1101/gad.230953.113
Europe PMC | doi

Jayanandanan N, Mathew R, Leptin M. (2014)
Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin
Nat Commun 5:3036. doi:10.1038/ncomms4036
Europe PMC | doi


Rauzi M, Hočevar Brezavšček A, Ziherl P, Leptin M. (2013)
Physical models of mesoderm invagination in Drosophila embryo
Biophys. J. 105(1):3-10. doi:10.1016/j.bpj.2013.05.039
Europe PMC | doi


Baer MM, Palm W, Eaton S, Leptin M, Affolter M. (2012)
Microsomal triacylglycerol transfer protein (MTP) is required to expand tracheal lumen in Drosophila in a cell-autonomous manner
J. Cell. Sci. 125(Pt 24):6038-6048. doi:10.1242/jcs.110452
Europe PMC | doi

Hočevar Brezavšček A, Rauzi M, Leptin M, Ziherl P. (2012)
A model of epithelial invagination driven by collective mechanics of identical cells
Biophys. J. 103(5):1069-1077. doi:10.1016/j.bpj.2012.07.018
Europe PMC | doi

Leptin M. (2012)
Open access--pass the buck
Science 335(6074):1279. doi:10.1126/science.1220395
Europe PMC | doi


Mathew SJ, Rembold M, Leptin M. (2011)
Role for Traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes
Mol. Cell. Biol. 31(24):4978-4993. doi:10.1128/mcb.05542-11
Europe PMC | doi

JayaNandanan N, Gavis ER, Riechmann V, Leptin M. (2011)
A genetic in vivo system to detect asymmetrically distributed RNA
EMBO Rep. 12(11):1167-1174. doi:10.1038/embor.2011.178
Europe PMC | doi

Clark IB, Muha V, Klingseisen A, Leptin M, Müller HA. (2011)
Fibroblast growth factor signalling controls successive cell behaviours during mesoderm layer formation in Drosophila
Development 138(13):2705-2715. doi:10.1242/dev.060277
Europe PMC | doi


Aggad D, Stein C, Sieger D, Mazel M, Boudinot P, Herbomel P, Levraud JP, Lutfalla G, Leptin M. (2010)
In vivo analysis of Ifn-γ1 and Ifn-γ2 signaling in zebrafish
J. Immunol. 185(11):6774-6782. doi:10.4049/jimmunol.1000549
Europe PMC | doi

Csiszar A, Vogelsang E, Beug H, Leptin M. (2010)
A novel conserved phosphotyrosine motif in the Drosophila fibroblast growth factor signaling adaptor Dof with a redundant role in signal transmission
Mol. Cell. Biol. 30(8):2017-2027. doi:10.1128/mcb.01436-09
Europe PMC | doi

Baer MM, Bilstein A, Caussinus E, Csiszar A, Affolter M, Leptin M. (2010)
The role of apoptosis in shaping the tracheal system in the Drosophila embryo
Mech. Dev. 127(1-2):28-35. doi:10.1016/j.mod.2009.11.003
Europe PMC | doi


Mathew SJ, Haubert D, Krönke M, Leptin M. (2009)
Looking beyond death: a morphogenetic role for the TNF signalling pathway
J. Cell. Sci. 122(Pt 12):1939-1946. doi:10.1242/jcs.044487
Europe PMC | doi

Mathew SJ, Kerridge S, Leptin M. (2009)
A small genomic region containing several loci required for gastrulation in Drosophila
PLoS ONE 4(10):e7437. doi:10.1371/journal.pone.0007437
Europe PMC | doi

Sieger D, Stein C, Neifer D, van der Sar AM, Leptin M. (2009)
The role of gamma interferon in innate immunity in the zebrafish embryo
Dis Model Mech 2(11-12):571-581. doi:10.1242/dmm.003509
Europe PMC | doi


Baer MM, Bilstein A, Leptin M. (2007)
A clonal genetic screen for mutants causing defects in larval tracheal morphogenesis in Drosophila
Genetics 176(4):2279-2291. doi:10.1534/genetics.107.074088
Europe PMC | doi

Chanut-Delalande H, Jung AC, Lin L, Baer MM, Bilstein A, Cabernard C, Leptin M, Affolter M. (2007)
A genetic mosaic analysis with a repressible cell marker screen to identify genes involved in tracheal cell migration during Drosophila air sac morphogenesis
Genetics 176(4):2177-2187. doi:10.1534/genetics.107.073890
Europe PMC | doi

Seher TC, Narasimha M, Vogelsang E, Leptin M. (2007)
Analysis and reconstitution of the genetic cascade controlling early mesoderm morphogenesis in the Drosophila embryo
Mech. Dev. 124(3):167-179. doi:10.1016/j.mod.2006.12.004
Europe PMC | doi

Stein C, Caccamo M, Laird G, Leptin M. (2007)
Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish
Genome Biol. 8(11):R251. doi:10.1186/gb-2007-8-11-r251
Europe PMC | doi

Kölsch V, Seher T, Fernandez-Ballester GJ, Serrano L, Leptin M. (2007)
Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2
Science 315(5810):384-386. doi:10.1126/science.1134833
Europe PMC | doi


Zhu MY, Wilson R, Leptin M. (2005)
A screen for genes that influence fibroblast growth factor signal transduction in Drosophila
Genetics 170(2):767-777. doi:10.1534/genetics.104.039750
Europe PMC | doi

Leptin M. (2005)
Gastrulation movements: the logic and the nuts and bolts
Dev. Cell 8(3):305-320. doi:10.1016/j.devcel.2005.02.007
Europe PMC | doi

Bekpen C, Hunn JP, Rohde C, Parvanova I, Guethlein L, Dunn DM, Glowalla E, Leptin M, Howard JC. (2005)
The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage
Genome Biol. 6(11):R92. doi:10.1186/gb-2005-6-11-r92
Europe PMC | doi