Staff at EMBL

Prof. Maria Leptin

Director EMBO
Leptin Group

EMBO, Meyerhofstraße 1, 69117 Heidelberg, Germany

Biography

PhD 1983, Basel Institute for Immunology.
Postdoctoral research then Staff Scientist at the MRC
Laboratory for Molecular Biology, Cambridge, UK.
Group Leader at the MPI for Developmental Biology, Tübingen.
Professor, University of Cologne, Institute of Genetics.
Director of EMBO and Group Leader at EMBL since 2010.

Publications

Microsomal triacylglycerol transfer protein (MTP) is required to expand tracheal lumen in Drosophila in a cell-autonomous manner. Baer, M.M., Palm, W., Eaton, S., Leptin, M. & Affolter, M. J Cell Sci. 2012 Dec 15;125(Pt 24):6038-48. doi: 10.1242/jcs.110452. Epub 2012Nov 6. PubMed

A model of epithelial invagination driven by collective mechanics of identical cells. Hocevar Brezavscek, A., Rauzi, M., Leptin, M. & Ziherl, P. Biophys J. 2012 Sep 5;103(5):1069-77. PubMed

Open access--pass the buck. Leptin, M. Science. 2012 Mar 16;335(6074):1279. doi: 10.1126/science.1220395. PubMed

A role for Traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes. Mathew, S.J., Rembold, M. & Leptin, M. Mol Cell Biol. 2011 Dec;31(24):4978-93. doi: 10.1128/MCB.05542-11. Epub 2011 Oct10. PubMed

A genetic in vivo system to detect asymmetrically distributed RNA. Jayanandanan, N., Gavis, E.R., Riechmann, V. & Leptin, M. EMBO Rep. 2011 Sep 16. doi: 10.1038/embor.2011.178. PubMed

Fibroblast growth factor signalling controls successive cell behaviours during mesoderm layer formation in Drosophila. Clark, I.B., Muha, V., Klingseisen, A., Leptin, M. & Muller, H.A. Development. 2011 Jul;138(13):2705-15. Epub 2011 May 25. PubMed

In Vivo Analysis of Ifn-{gamma}1 and Ifn-{gamma}2 Signaling in Zebrafish. Aggad, D., Stein, C., Sieger, D., Mazel, M., Boudinot, P., Herbomel, P., Levraud, J.P., Lutfalla, G. & Leptin, M. J Immunol. 2010 Dec 1;185(11):6774-82. Epub 2010 Nov 3. PubMed

A novel conserved phosphotyrosine motif in the Drosophila fibroblast growth factor signaling adaptor Dof with a redundant role in signal transmission. Csiszar, A., Vogelsang, E., Beug, H. & Leptin, M. Mol Cell Biol. 2010 Apr;30(8):2017-27. Epub 2010 Feb 12. PubMed

The role of apoptosis in shaping the tracheal system in the Drosophila embryo. Baer, M.M., Bilstein, A., Caussinus, E., Csiszar, A., Affolter, M. & Leptin, M. Mech Dev. 2010 Jan-Feb;127(1-2):28-35. Epub 2009 Dec 6. PubMed

The role of gamma interferon in innate immunity in the zebrafish embryo. Sieger, D., Stein, C., Neifer, D., van der Sar, A.M. & Leptin, M. Dis Model Mech. 2009 Nov-Dec;2(11-12):571-81. doi: 10.1242/dmm.003509. Epub 2009Sep 24. PubMed

Looking beyond death: a morphogenetic role for the TNF signalling pathway. Mathew, S.J., Haubert, D., Kronke, M. & Leptin, M. J Cell Sci. 2009 Jun 15;122(Pt 12):1939-46. PubMed

A small genomic region containing several loci required for gastrulation in Drosophila. Mathew, S.J., Kerridge, S. & Leptin, M. PLoS One. 2009 Oct 13;4(10):e7437. PubMed

A genetic mosaic analysis with a repressible cell marker screen to identify genes involved in tracheal cell migration during Drosophila air sac morphogenesis. Chanut-Delalande, H., Jung, A.C., Lin, L., Baer, M.M., Bilstein, A., Cabernard, C., Leptin, M. & Affolter, M. Genetics. 2007 Aug;176(4):2177-87. Epub 2007 Jul 1. PubMed

A clonal genetic screen for mutants causing defects in larval tracheal morphogenesis in Drosophila. Baer, M.M., Bilstein, A. & Leptin, M. Genetics. 2007 Aug;176(4):2279-91. Epub 2007 Jul 1. PubMed

Analysis and reconstitution of the genetic cascade controlling early mesoderm morphogenesis in the Drosophila embryo. Seher, T.C., Narasimha, M., Vogelsang, E. & Leptin, M. Mech Dev. 2007 Mar;124(3):167-79. Epub 2006 Dec 27. PubMed

Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2. Kolsch, V., Seher, T., Fernandez-Ballester, G.J., Serrano, L. & Leptin, M. Science. 2007 Jan 19;315(5810):384-6. PubMed

Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish. Stein, C., Caccamo, M., Laird, G. & Leptin, M. Genome Biol. 2007;8(11):R251. PubMed

A screen for genes that influence fibroblast growth factor signal transduction in Drosophila. Zhu, M.Y., Wilson, R. & Leptin, M. Genetics. 2005 Jun;170(2):767-77. Epub 2005 Apr 16. PubMed

Gastrulation movements: the logic and the nuts and bolts. Leptin, M. Dev Cell. 2005 Mar;8(3):305-20. PubMed

The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Bekpen, C., Hunn, J.P., Rohde, C., Parvanova, I., Guethlein, L., Dunn, D.M., Glowalla, E., Leptin, M. & Howard, J.C. Genome Biol. 2005;6(11):R92. Epub 2005 Oct 31. PubMed