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Staff at EMBL

Prof. Maria Leptin

Director EMBO
Leptin Group

EMBO, Meyerhofstra├če 1, 69117 Heidelberg, Germany

E-mail: send a mail
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PhD 1983, Basel Institute for Immunology.
Postdoctoral research then Staff Scientist at the MRC Laboratory for Molecular Biology, Cambridge, UK.
Group Leader at the MPI for Developmental Biology, T├╝bingen.
Professor, University of Cologne, Institute of Genetics.
Director of EMBO and Group Leader at EMBL since 2010.


Molecular mechanisms of de novo lumen formation. Sigurbjornsdottir, S., Mathew, R. & Leptin, M. Nat Rev Mol Cell Biol. 2014 Sep 4. doi: 10.1038/nrm3871. Europe PMC

Slik and the Receptor Tyrosine Kinase Breathless Mediate Localized Activation of Moesin in Terminal Tracheal Cells. Ukken, F.P., Aprill, I., JayaNandanan, N. & Leptin, M. PLoS One. 2014 Jul 25;9(7):e103323. doi: 10.1371/journal.pone.0103323.eCollection 2014. Europe PMC

Systemic Response to Ultraviolet Radiation Involves Induction of Leukocytic IL-1beta and Inflammation in Zebrafish. Banerjee, S. & Leptin, M. J Immunol. 2014 Jun 25. pii: 1400232. Europe PMC

Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin. Jayanandanan, N., Mathew, R. & Leptin, M. Nat Commun. 2014 Jan 13;5:3036. doi: 10.1038/ncomms4036. Europe PMC

Physical models of mesoderm invagination in Drosophila embryo. Rauzi, M., Hocevar Brezavscek, A., Ziherl, P. & Leptin, M. Biophys J. 2013 Jul 2;105(1):3-10. doi: 10.1016/j.bpj.2013.05.039. Europe PMC

Microsomal triacylglycerol transfer protein (MTP) is required to expand tracheal lumen in Drosophila in a cell-autonomous manner. Baer, M.M., Palm, W., Eaton, S., Leptin, M. & Affolter, M. J Cell Sci. 2012 Dec 15;125(Pt 24):6038-48. doi: 10.1242/jcs.110452. Epub 2012Nov 6. Europe PMC

A model of epithelial invagination driven by collective mechanics of identical cells. Hocevar Brezavscek, A., Rauzi, M., Leptin, M. & Ziherl, P. Biophys J. 2012 Sep 5;103(5):1069-77. Europe PMC

Open access--pass the buck. Leptin, M. Science. 2012 Mar 16;335(6074):1279. doi: 10.1126/science.1220395. Europe PMC

A role for Traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes. Mathew, S.J., Rembold, M. & Leptin, M. Mol Cell Biol. 2011 Dec;31(24):4978-93. doi: 10.1128/MCB.05542-11. Epub 2011 Oct10. Europe PMC

A genetic in vivo system to detect asymmetrically distributed RNA. JayaNandanan, N., Gavis, E.R., Riechmann, V. & Leptin, M. EMBO Rep. 2011 Oct 28;12(11):1167-74. doi: 10.1038/embor.2011.178. Europe PMC

Fibroblast growth factor signalling controls successive cell behaviours during mesoderm layer formation in Drosophila. Clark, I.B., Muha, V., Klingseisen, A., Leptin, M. & Muller, H.A. Development. 2011 Jul;138(13):2705-15. Epub 2011 May 25. Europe PMC

In Vivo Analysis of Ifn-{gamma}1 and Ifn-{gamma}2 Signaling in Zebrafish. Aggad, D., Stein, C., Sieger, D., Mazel, M., Boudinot, P., Herbomel, P., Levraud, J.P., Lutfalla, G. & Leptin, M. J Immunol. 2010 Dec 1;185(11):6774-82. Epub 2010 Nov 3. Europe PMC

A novel conserved phosphotyrosine motif in the Drosophila fibroblast growth factor signaling adaptor Dof with a redundant role in signal transmission. Csiszar, A., Vogelsang, E., Beug, H. & Leptin, M. Mol Cell Biol. 2010 Apr;30(8):2017-27. Epub 2010 Feb 12. Europe PMC

The role of apoptosis in shaping the tracheal system in the Drosophila embryo. Baer, M.M., Bilstein, A., Caussinus, E., Csiszar, A., Affolter, M. & Leptin, M. Mech Dev. 2010 Jan-Feb;127(1-2):28-35. Epub 2009 Dec 6. Europe PMC

The role of gamma interferon in innate immunity in the zebrafish embryo. Sieger, D., Stein, C., Neifer, D., van der Sar, A.M. & Leptin, M. Dis Model Mech. 2009 Nov-Dec;2(11-12):571-81. doi: 10.1242/dmm.003509. Epub 2009Sep 24. Europe PMC

Looking beyond death: a morphogenetic role for the TNF signalling pathway. Mathew, S.J., Haubert, D., Kronke, M. & Leptin, M. J Cell Sci. 2009 Jun 15;122(Pt 12):1939-46. Europe PMC

A small genomic region containing several loci required for gastrulation in Drosophila. Mathew, S.J., Kerridge, S. & Leptin, M. PLoS One. 2009 Oct 13;4(10):e7437. Europe PMC

A genetic mosaic analysis with a repressible cell marker screen to identify genes involved in tracheal cell migration during Drosophila air sac morphogenesis. Chanut-Delalande, H., Jung, A.C., Lin, L., Baer, M.M., Bilstein, A., Cabernard, C., Leptin, M. & Affolter, M. Genetics. 2007 Aug;176(4):2177-87. Epub 2007 Jul 1. Europe PMC

A clonal genetic screen for mutants causing defects in larval tracheal morphogenesis in Drosophila. Baer, M.M., Bilstein, A. & Leptin, M. Genetics. 2007 Aug;176(4):2279-91. Epub 2007 Jul 1. Europe PMC

Analysis and reconstitution of the genetic cascade controlling early mesoderm morphogenesis in the Drosophila embryo. Seher, T.C., Narasimha, M., Vogelsang, E. & Leptin, M. Mech Dev. 2007 Mar;124(3):167-79. Epub 2006 Dec 27. Europe PMC

Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2. Kolsch, V., Seher, T., Fernandez-Ballester, G.J., Serrano, L. & Leptin, M. Science. 2007 Jan 19;315(5810):384-6. Europe PMC

Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish. Stein, C., Caccamo, M., Laird, G. & Leptin, M. Genome Biol. 2007;8(11):R251. Europe PMC

A screen for genes that influence fibroblast growth factor signal transduction in Drosophila. Zhu, M.Y., Wilson, R. & Leptin, M. Genetics. 2005 Jun;170(2):767-77. Epub 2005 Apr 16. Europe PMC

Gastrulation movements: the logic and the nuts and bolts. Leptin, M. Dev Cell. 2005 Mar;8(3):305-20. Europe PMC

The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Bekpen, C., Hunn, J.P., Rohde, C., Parvanova, I., Guethlein, L., Dunn, D.M., Glowalla, E., Leptin, M. & Howard, J.C. Genome Biol. 2005;6(11):R92. Epub 2005 Oct 31. Europe PMC