Staff at EMBL

Personal Assistant
Andrea Washington
Room: 209-212
Tel: +49 6221 387- 8201
Fax: +49 6221 387- 8211
E-mail: dg-office@embl.org

Biography

PhD 1979, University of Leeds, UK.
Postdoctoral work at the Friedrich Miescher Institute and the Biocenter, Basel, Switzerland.
Group Leader at EMBL since 1985.
Programme Coordinator since 1990.
Scientific Director of EMBL 1999–2005.
Director General since 2005.

Publications

Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans. Gorjanacz, M. & Mattaj, I.W. J Cell Sci. 2009 Jun 15;122(Pt 12):1963-9. PubMed

Hepatoma up-regulated protein is required for chromatin-induced microtubule assembly independently of TPX2. Casanova, C.M., Rybina, S., Yokoyama, H., Karsenti, E. & Mattaj, I.W. Mol Biol Cell. 2008 Nov;19(11):4900-8. Epub 2008 Sep 17. PubMed

Comments from the European Molecular Biology Laboratory. Mattaj, I. Dis Model Mech. 2008 Jul-Aug;1(1):16. PubMed

Nup53 is required for nuclear envelope and nuclear pore complex assembly. Hawryluk-Gara, L.A., Platani, M., Santarella, R., Wozniak, R.W. & Mattaj, I.W. Mol Biol Cell. 2008 Apr;19(4):1753-62. Epub 2008 Feb 6. PubMed

Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate. Yokoyama, H., Gruss, O.J., Rybina, S., Caudron, M., Schelder, M., Wilm, M., Mattaj, I.W. & Karsenti, E. J Cell Biol. 2008 Mar 10;180(5):867-75. Epub 2008 Mar 3. PubMed

A role for gp210 in mitotic nuclear-envelope breakdown. Galy, V., Antonin, W., Jaedicke, A., Sachse, M., Santarella, R., Haselmann, U. & Mattaj, I. J Cell Sci. 2008 Feb 1;121(Pt 3):317-28. PubMed

A compartmentalized phosphorylation/dephosphorylation system that regulates U snRNA export from the nucleus. Kitao, S., Segref, A., Kast, J., Wilm, M., Mattaj, I.W. & Ohno, M. Mol Cell Biol. 2008 Jan;28(1):487-97. Epub 2007 Oct 29. PubMed

Electron microscopy of lamin and the nuclear lamina in Caenorhabditis elegans. Cohen, M., Santarella, R., Wiesel, N., Mattaj, I. & Gruenbaum, Y. Methods Cell Biol. 2008;88:411-29. PubMed

The future of research universities. Is the model of research-intensive universities still valid at the beginning of the twenty-first century? Arai, K., Cech, T., Chameau, J.L., Horn, P., Mattaj, I., Potocnik, J. & Wiley, J. EMBO Rep. 2007 Sep;8(9):804-10. PubMed

Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation. Fortes, P., Longman, D., McCracken, S., Ip, J.Y., Poot, R., Mattaj, I.W., Caceres, J.F. & Blencowe, B.J. FEBS Lett. 2007 Jun 26;581(16):3087-97. Epub 2007 Jun 4. PubMed

What can Caenorhabditis elegans tell us about the nuclear envelope? Gorjanacz, M., Jaedicke, A. & Mattaj, I.W. FEBS Lett. 2007 Jun 19;581(15):2794-801. Epub 2007 Mar 30. PubMed

Laying solid foundations for Europe. Mattaj, I.W. & Tocchini-Valentini, G.P. Nature. 2007 May 24;447(7143):377-8. PubMed

A role for NuSAP in linking microtubules to mitotic chromosomes. Ribbeck, K., Raemaekers, T., Carmeliet, G. & Mattaj, I.W. Curr Biol. 2007 Feb 6;17(3):230-6. PubMed

MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. Franz, C., Walczak, R., Yavuz, S., Santarella, R., Gentzel, M., Askjaer, P., Galy, V., Hetzer, M., Mattaj, I.W. & Antonin, W. EMBO Rep. 2007 Feb;8(2):165-72. Epub 2007 Jan 19. PubMed

Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly. Gorjanacz, M., Klerkx, E.P., Galy, V., Santarella, R., Lopez-Iglesias, C., Askjaer, P. & Mattaj, I.W. EMBO J. 2007 Jan 10;26(1):132-43. Epub 2006 Dec 14. PubMed

The inner nuclear membrane protein Lem2 is critical for normal nuclear envelope morphology. Ulbert, S., Antonin, W., Platani, M. & Mattaj, I.W. FEBS Lett. 2006 Nov 27;580(27):6435-41. Epub 2006 Nov 3. PubMed

MEL-28, a novel nuclear-envelope and kinetochore protein essential for zygotic nuclear-envelope assembly in C. elegans. Galy, V., Askjaer, P., Franz, C., Lopez-Iglesias, C. & Mattaj, I.W. Curr Biol. 2006 Sep 5;16(17):1748-56. PubMed

NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. Ribbeck, K., Groen, A.C., Santarella, R., Bohnsack, M.T., Raemaekers, T., Kocher, T., Gentzel, M., Gorlich, D., Wilm, M., Carmeliet, G., Mitchison, T.J., Ellenberg, J., Hoenger, A. & Mattaj, I.W. Mol Biol Cell. 2006 Jun;17(6):2646-60. Epub 2006 Mar 29. PubMed

Direct membrane protein-DNA interactions required early in nuclear envelope assembly. Ulbert, S., Platani, M., Boue, S. & Mattaj, I.W. J Cell Biol. 2006 May 22;173(4):469-76. PubMed

The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. Mansfeld, J., Guttinger, S., Hawryluk-Gara, L.A., Pante, N., Mall, M., Galy, V., Haselmann, U., Muhlhausser, P., Wozniak, R.W., Mattaj, I.W., Kutay, U. & Antonin, W. Mol Cell. 2006 Apr 7;22(1):93-103. PubMed

HURP is part of a ran-dependent complex involved in spindle formation. Koffa, M.D., Casanova, C.M., Santarella, R., Kocher, T., Wilm, M. & Mattaj, I.W. Curr Biol. 2006 Apr 18;16(8):743-54. PubMed

40LoVe interacts with Vg1RBP/Vera and hnRNP I in binding the Vg1-localization element. Czaplinski, K. & Mattaj, I.W. RNA. 2006 Feb;12(2):213-22. Epub 2005 Dec 22. PubMed

Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegans. Schetter, A., Askjaer, P., Piano, F., Mattaj, I. & Kemphues, K. Dev Biol. 2006 Jan 15;289(2):360-71. Epub 2005 Dec 2. PubMed

Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates. Franz, C., Askjaer, P., Antonin, W., Iglesias, C.L., Haselmann, U., Schelder, M., de Marco, A., Wilm, M., Antony, C. & Mattaj, I.W. EMBO J 2005 Oct 19;24(20):3519-31. Epub 2005 Sep 29. PubMed

Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis. Czaplinski, K., Kocher, T., Schelder, M., Segref, A., Wilm, M. & Mattaj, I.W. Dev Cell 2005 Apr;8(4):505-15. PubMed

Quantitative models of nuclear transport. Becskei, A. & Mattaj, I.W. Curr Opin Cell Biol 2005 Feb;17(1):27-34. PubMed

The integral membrane nucleoporin pom121 functionally links nuclear pore complex assembly and nuclear envelope formation. Antonin, W., Franz, C., Haselmann, U., Antony, C. & Mattaj, I.W. Mol Cell 2005 Jan 7;17(1):83-92. PubMed

Nuclear pore complexes: Round the bend? Antonin, W. & Mattaj, I.W. Nat Cell Biol 2005 Jan;7(1):10-2. PubMed

Pushing the envelope: structure, function, and dynamics of the nuclear periphery. Hetzer, M.W., Walther, T.C. & Mattaj, I.W. Annu Rev Cell Dev Biol. 2005;21:347-80. PubMed

An ATP-dependent activity that releases RanGDP from NTF2. Yamada, M., Mattaj, I.W. & Yoneda, Y. J Biol Chem 2004 May 20;. PubMed

Importin alpha associates with membranes and participates in nuclear envelope assembly in vitro. Hachet, V., Kocher, T., Wilm, M. & Mattaj, I.W. EMBO J 2004 Apr 7;23(7):1526-35. Epub 2004 Mar 11. PubMed

Sorting out the nuclear envelope from the endoplasmic reticulum. Mattaj, I.W. Nat Rev Mol Cell Biol 2004 Jan;5(1):65-9. PubMed

Caenorhabditis elegans nucleoporins Nup93 and Nup205 determine the limit of nuclear pore complex size exclusion in vivo. Galy, V., Mattaj, I.W. & Askjaer, P. Mol Biol Cell 2003 Dec;14(12):5104-15. PubMed

RanGTP mediates nuclear pore complex assembly. Walther, T.C., Askjaer, P., Gentzel, M., Habermann, A., Griffiths, G., Wilm, M., Mattaj, I.W. & Hetzer, M. Nature 2003 Aug 7;424(6949):689-94. PubMed

Importin alpha-regulated nucleation of microtubules by TPX2. Schatz, C.A., Santarella, R., Hoenger, A., Karsenti, E., Mattaj, I.W., Gruss, O.J. & Carazo-Salas, R.E. EMBO J 2003 May 1;22(9):2060-70. PubMed

The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Walther, T.C., Alves, A., Pickersgill, H., Loiodice, I., Hetzer, M., Galy, V., Hulsmann, B.B., Kocher, T., Wilm, M., Allen, T., Mattaj, I.W. & Doye, V. Cell 2003 Apr 18;113(2):195-206. PubMed

The strategy for coupling the RanGTP gradient to nuclear protein export. Becskei, A. & Mattaj, I.W. Proc Natl Acad Sci U S A 2003 Feb 18;100(4):1717-22. PubMed

Co-crystallization of the human nuclear cap-binding complex with a m7GpppG cap analogue using protein engineering. Mazza, C., Segref, A., Mattaj, I.W. & Cusack, S. Acta Crystallogr D Biol Crystallogr 2002 Dec;58(Pt 12):2194-7. PubMed

Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Askjaer, P., Galy, V., Hannak, E. & Mattaj, I.W. Mol Biol Cell 2002 Dec;13(12):4355-70. PubMed

Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells. Gruss, O.J., Wittmann, M., Yokoyama, H., Pepperkok, R., Kufer, T., Sillje, H., Karsenti, E., Mattaj, I.W. & Vernos, I. Nat Cell Biol 2002 Nov;4(11):871-9. PubMed

Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex. Mazza, C., Segref, A., Mattaj, I.W. & Cusack, S. EMBO J 2002 Oct 15;21(20):5548-57. PubMed

The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway. Massenet, S., Pellizzoni, L., Paushkin, S., Mattaj, I.W. & Dreyfuss, G. Mol Cell Biol 2002 Sep;22(18):6533-41. PubMed

Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. Kuersten, S., Arts, G.J., Walther, T.C., Englmeier, L. & Mattaj, I.W. Mol Cell Biol 2002 Aug;22(16):5708-20. PubMed

Ran binds to chromatin by two distinct mechanisms. Bilbao-Cortes, D., Hetzer, M., Langst, G., Becker, P.B. & Mattaj, I.W. Curr Biol 2002 Jul 9;12(13):1151-6. PubMed

The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import. Walther, T.C., Pickersgill, H.S., Cordes, V.C., Goldberg, M.W., Allen, T.D., Mattaj, I.W. & Fornerod, M. J Cell Biol 2002 Jul 8;158(1):63-77. PubMed

The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Hetzer, M., Gruss, O.J. & Mattaj, I.W. Nat Cell Biol 2002 Jul;4(7):E177-84. PubMed

Identity elements used in export of mRNAs. Ohno, M., Segref, A., Kuersten, S. & Mattaj, I.W. Mol Cell 2002 Mar;9(3):659-71. PubMed

Nucleocytoplasmic transport: Ran, beta and beyond. Kuersten, S., Ohno, M. & Mattaj, I.W. Trends Cell Biol 2001 Dec;11(12):497-503. PubMed

Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Hetzer, M., Meyer, H.H., Walther, T.C., Bilbao-Cortes, D., Warren, G. & Mattaj, I.W. Nat Cell Biol 2001 Dec;3(12):1086-91. PubMed

The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. Walther, T.C., Fornerod, M., Pickersgill, H., Goldberg, M., Allen, T.D. & Mattaj, I.W. EMBO J 2001 Oct 15;20(20):5703-14. PubMed

Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway. Koffa, M.D., Clements, J.B., Izaurralde, E., Wadd, S., Wilson, S.A., Mattaj, I.W. & Kuersten, S. EMBO J 2001 Oct 15;20(20):5769-78. PubMed

RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. Englmeier, L., Fornerod, M., Bischoff, F.R., Petosa, C., Mattaj, I.W. & Kutay, U. EMBO Rep 2001 Oct;2(10):926-32. PubMed

Crystal structure of the human nuclear cap binding complex. Mazza, C., Ohno, M., Segref, A., Mattaj, I.W. & Cusack, S. Mol Cell 2001 Aug;8(2):383-96. PubMed

The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export. Segref, A., Mattaj, I.W. & Ohno, M. RNA 2001 Mar;7(3):351-60. PubMed

Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly. Carazo-Salas, R.E., Gruss, O.J., Mattaj, I.W. & Karsenti, E. Nat Cell Biol 2001 Mar;3(3):228-34. PubMed

Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity. Gruss, O.J., Carazo-Salas, R.E., Schatz, C.A., Guarguaglini, G., Kast, J., Wilm, M., Le Bot, N., Vernos, I., Karsenti, E. & Mattaj, I.W. Cell 2001 Jan 12;104(1):83-93. PubMed

The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation. Fortes, P., Inada, T., Preiss, T., Hentze, M.W., Mattaj, I.W. & Sachs, A.B. Mol Cell 2000 Jul;6(1):191-6 PubMed

GTP hydrolysis by Ran is required for nuclear envelope assembly. Hetzer, M., Bilbao-Cortes, D., Walther, T.C., Gruss, O.J. & Mattaj, I.W. Mol Cell 2000 Jun;5(6):1013-24 PubMed

PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Ohno, M., Segref, A., Bachi, A., Wilm, M. & Mattaj, I.W. Cell 2000 Apr 14;101(2):187-98 PubMed

The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein Varani, L., Gunderson, S.I., Mattaj, I.W., Kay, L.E., Neuhaus, D. & Varani, G. Nat Struct Biol 2000 Apr;7(4):329-35 PubMed

The carboxyl terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3'-end processing and splicing. Vagner, S., Vagner, C. & Mattaj, I.W. Genes Dev 2000 Feb 15;14(4):403-13 PubMed

Position-dependent inhibition of the cleavage step of pre-mRNA 3'-end processing by U1 snRNP. Vagner, S., Ruegsegger, U., Gunderson, S.I., Keller, W. & Mattaj, I.W. RNA 2000 Feb;6(2):178-88 PubMed

An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins. Hetzer, M. & Mattaj, I.W. J Cell Biol 2000 Jan 24;148(2):293-303 PubMed

Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition. Fortes, P., Bilbao-Cortes, D., Fornerod, M., Rigaut, G., Raymond, W., Seraphin, B. & Mattaj, I.W. Genes Dev 1999 Sep 15;13(18):2425-38 PubMed

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Carazo-Salas, R.E., Guarguaglini, G., Gruss, O.J., Segref, A., Karsenti, E. & Mattaj, I.W. Nature 1999 Jul 8;400(6740):178-81 PubMed

Cell biology. Snail mail to the nucleus Mattaj, I.W. & Conti, E. Nature 1999 May 20;399(6733):208-10 PubMed

Conserved loop I of U5 small nuclear RNA is dispensable for both catalytic steps of pre-mRNA splicing in HeLa nuclear extracts Segault, V., Will, C.L., Polycarpou-Schwarz, M., Mattaj, I.W., Branlant, C. & Luhrmann, R. Mol Cell Biol 1999 Apr 19(4) 2782-2790 PubMed

The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction. Wilson, K.F., Fortes, P., Singh, U.S., Ohno, M., Mattaj, I.W. & Cerione, R.A. J Biol Chem 1999 Feb 12 274(7) 4166-4173 PubMed

MeiRNA hits the spot. Ohno, M. & Mattaj, I.W. Curr Biol 1999 Jan 28 9(2) R66-R69 PubMed

Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis. Englmeier, L., Olivo, J.C. & Mattaj, I.W. Curr Biol 1999 Jan 14 9(1) 30-41 PubMed

The role of exportin-t in selective nuclear export of mature tRNAs. Arts, G.J., Kuersten, S., Romby, P., Ehresmann, B. & Mattaj, I.W. EMBO J 1998 Dec 15 17(24) 7430-7441 PubMed

Identification of a nuclear export receptor for tRNA. Arts, G.J., Fornerod, M. & Mattaj, I.W. Curr Biol 1998 Mar 12 8(6) 305-314 PubMed

Nucleocytoplasmic transport: the last 200 nanometers. Ohno, M., Fornerod, M. & Mattaj, I.W. Cell 1998 Feb 6 92(3) 327-336 PubMed

Ribonucleoprotein assembly: clues from spinal muscular atrophy. Mattaj, I.W. Curr Biol 1998 Jan 29 8(3) R93-R95 PubMed

U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase. Gunderson, S.I., Polycarpou-Schwarz, M. & Mattaj, I.W. Mol Cell 1998 Jan 1(2) 255-264 PubMed

Nucleocytoplasmic transport: the soluble phase. Mattaj, I.W. & Englmeier, L. Annu Rev Biochem 1998 67 265-306 PubMed

CRM1 is an export receptor for leucine-rich nuclear export signals Fornerod, M., Ohno, M., Yoshida, M. & Mattaj, I.W. Cell 1997 Sep 19 90(6) 1051-1060 PubMed

Only two of the four sites of interaction with nuclear factors within the Xenopus U2 gene promoter are necessary for efficient transcription. Tebb, G., Bohmann, D. & Mattaj, I.W. Nucleic Acids Res 1987 Aug 25;15(16):6437-53 PubMed

A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes. Bohmann, D., Keller, W., Dale, T., Scholer, H.R., Tebb, G. & Mattaj, I.W. Nature 1987 Jan 15-21;325(6101):268-72 PubMed